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The map label for this gene is lon1 [H]

Identifier: 229918354

GI number: 229918354

Start: 2604106

End: 2606406

Strand: Direct

Name: lon1 [H]

Synonym: EAT1b_2639

Alternate gene names: 229918354

Gene position: 2604106-2606406 (Clockwise)

Preceding gene: 229918353

Following gene: 229918355

Centisome position: 86.81

GC content: 53.89

Gene sequence:

>2301_bases
ATGGAAAAATTACCAATCCTTCCTTTGCGAGGAGTCGTCGTATATCCGCTCATCGGTGTGACCATCGATGTCGGACGCCC
GTTATCCCTTCGGGCGCTCCTTGCCGCAAAGGAGCATGAAACAGATTTGATTGTCGTGACGCAGAAAGAAACAGGGAACG
AGTCACCGGAACCGGAAGACCTATACACGGTTGGAACGCGTGTCCATATTGCGAAGATGAGTGAACTGTCGAACGAGACG
ATTCGGGTTCGAATCGTCGGGAAAGAGCGCGTCCGTGTCGACTCGATCGAATCGACAGATGAAGGATGGTTCGCCAATAT
CGAGCCGGTCGAACTCGCAGAAGGGGAAGAGGTCGAACGTACGGCACTCGTCCGTCTGTTAAAAGAACAGTTCGGAAAAC
TTGTCGCAAACATTAAGGGCATGTCGCCAGATGAGCGTCGTCGTTTCGAGATGTATGAGCGGCTTGAATCGCTCACGGAC
TATATCACGTCAAAACTCGATGTCGACGTCGAGCTTCGCCAAGCGATGCTCGAAGAAGCAGATGCCGTCAAGCGAGGACT
TGAATTGCTTGAAATCATTGCACACGAGGTCGAAGTCATTGAGCTCGAGCAAGAGATGCGCGAGCGGACGAAGAAGTCGA
TTGAGCAGTCGCAGCGCGAGTATTACTTACGGGAACAGATGAAGACGATCCAGCAAGAACTCGGAGACCAGACGCAAGAG
TCAGAACCGAACCGCCTCCGTGAGAAGTTAGAGGCGCTCGACTTGCCAGAGACGACACGGAAGAACGTGATGCGTGAAGC
GGAACGATTGAACGTCGTGCCGCAGACGTCTCCGGAGTATGCGGTCATCCGTAACTACCTCGACTGGGTCACCTCTCTTC
CGTGGGGCATTGAGACGGAAGACAAGCTTGACGTGAAACATGCGGCAGACGTCCTCGACGATGACCATTACGGTTTGGAA
TCGGTAAAAGACCGTATCCTCGAGTATTTGGCCGTCCGTCAGTTGACGAACTCGCTTCGTGGACCGATCCTCTGTCTCGC
CGGACCTCCAGGGGTCGGGAAGACGTCGCTCGCCCGCTCGATCGCCTCGGCACTCGAACGTCACTTCGTTCGTGTCTCAC
TCGGTGGGGTGCGTGATGAGGCGGAAATCCGTGGGCACCGTCGTACGTATATCGGTGCGATGCCAGGACGGATCATCCGT
GGGCTGAAGCAAGCGGAAAGCAAAAACCCGGTCTTCTTGCTCGATGAGATCGACAAGATGGCTTCTGACTTCAGAGGGGA
CCCGGCGTCCGCGATGCTAGAAGTGCTCGACCCGGAACAAAACGTCTCCTTCTCGGACCACTACATCGAAGAACCGTTCG
ATTTGTCGAACGTTCTCTTTATCGCGACGGCAAACGATGTCTCACAAATCCCAGCACCGCTTCTTGACCGGATGGAATTG
ATTCAAATCGGTGGGTACACAGAGCTTGAGAAAGTAGAGATCGCGAAGCGCCACTTGGTGCCGAAACAATTGGCAGAGCA
CGGATTGAAGAAGAGTCAGTTGACGATTAAAGAAGATGCGCTCTATGAAGTCGTCCGTCGTTACACACGTGAAGCCGGCG
TCCGGAACTTAGAACGCGTCATCGGATCACTCTGCCGAAAAGCCGCGAAACAAATCGCCATCGGGGAGAAGAAACGGGTC
ACGATTTCGAAAAAGGCGATCATCACGTATCTCGGGAAGCCGAAGTATCGCTACGGAAAAGGGGAGACCGAGGACTCCAT
CGGTGCGGTGACAGGCCTTGCCTACACGGCGTTTGGTGGCGACACGCTCACAATCGAAGTGGCGCTCGCTCCAGGGAAAG
GCAAACTTCAGTTGACGGGGAAACTCGGTGATGTGATGCAGGAGTCGGCACAAACAGCATATAGCTATGTCCGTGCAAAC
GCAGAGCGGTTCGGGATTGACCCGACGTTCTATGAGCGACAAGACATTCACATTCACGTGCCAGAGGGTGCCGTGCCAAA
AGACGGACCGTCGGCGGGAATCACGATTGCGACGGCCTTGATTTCCGCATTGACCGGGAAGAAAGTCCATCGTGATGTCG
GGATGACAGGTGAGATCACACTCCGTGGACGTGTCTTGCCGATCGGCGGATTGAAAGAAAAAGCGCTCGCTGCTCATCGA
GCCGGGTTGACGACCATCGTCATTCCGAAAGATAATGAGCGAGACATCGATGATATTCAAGAGACGGTTCGTGAGAAATT
GACGTTCGTTCCCGTGACGACACTCGATGAAGTACTAGATGTAGCATTTGGAGGAAATTAA

Upstream 100 bases:

>100_bases
GACAGGGGACAACAAAGAGACAGCATAATTTGTTAACGAAGAAGGCTCAAACACTCGGCACATCCGAGTTTTGGGCCTTT
TTGCACAGGAGGCGTTGTAT

Downstream 100 bases:

>100_bases
ATGAAGATCAACAAAGCAGAGTTCGTGACGAGTGCCGTCGCGCCAGACCATTACCCGGTCCATGAATTGCCGGAAGTGGC
ACTTGCCGGGCGGTCGAACG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 766; Mature: 766

Protein sequence:

>766_residues
MEKLPILPLRGVVVYPLIGVTIDVGRPLSLRALLAAKEHETDLIVVTQKETGNESPEPEDLYTVGTRVHIAKMSELSNET
IRVRIVGKERVRVDSIESTDEGWFANIEPVELAEGEEVERTALVRLLKEQFGKLVANIKGMSPDERRRFEMYERLESLTD
YITSKLDVDVELRQAMLEEADAVKRGLELLEIIAHEVEVIELEQEMRERTKKSIEQSQREYYLREQMKTIQQELGDQTQE
SEPNRLREKLEALDLPETTRKNVMREAERLNVVPQTSPEYAVIRNYLDWVTSLPWGIETEDKLDVKHAADVLDDDHYGLE
SVKDRILEYLAVRQLTNSLRGPILCLAGPPGVGKTSLARSIASALERHFVRVSLGGVRDEAEIRGHRRTYIGAMPGRIIR
GLKQAESKNPVFLLDEIDKMASDFRGDPASAMLEVLDPEQNVSFSDHYIEEPFDLSNVLFIATANDVSQIPAPLLDRMEL
IQIGGYTELEKVEIAKRHLVPKQLAEHGLKKSQLTIKEDALYEVVRRYTREAGVRNLERVIGSLCRKAAKQIAIGEKKRV
TISKKAIITYLGKPKYRYGKGETEDSIGAVTGLAYTAFGGDTLTIEVALAPGKGKLQLTGKLGDVMQESAQTAYSYVRAN
AERFGIDPTFYERQDIHIHVPEGAVPKDGPSAGITIATALISALTGKKVHRDVGMTGEITLRGRVLPIGGLKEKALAAHR
AGLTTIVIPKDNERDIDDIQETVREKLTFVPVTTLDEVLDVAFGGN

Sequences:

>Translated_766_residues
MEKLPILPLRGVVVYPLIGVTIDVGRPLSLRALLAAKEHETDLIVVTQKETGNESPEPEDLYTVGTRVHIAKMSELSNET
IRVRIVGKERVRVDSIESTDEGWFANIEPVELAEGEEVERTALVRLLKEQFGKLVANIKGMSPDERRRFEMYERLESLTD
YITSKLDVDVELRQAMLEEADAVKRGLELLEIIAHEVEVIELEQEMRERTKKSIEQSQREYYLREQMKTIQQELGDQTQE
SEPNRLREKLEALDLPETTRKNVMREAERLNVVPQTSPEYAVIRNYLDWVTSLPWGIETEDKLDVKHAADVLDDDHYGLE
SVKDRILEYLAVRQLTNSLRGPILCLAGPPGVGKTSLARSIASALERHFVRVSLGGVRDEAEIRGHRRTYIGAMPGRIIR
GLKQAESKNPVFLLDEIDKMASDFRGDPASAMLEVLDPEQNVSFSDHYIEEPFDLSNVLFIATANDVSQIPAPLLDRMEL
IQIGGYTELEKVEIAKRHLVPKQLAEHGLKKSQLTIKEDALYEVVRRYTREAGVRNLERVIGSLCRKAAKQIAIGEKKRV
TISKKAIITYLGKPKYRYGKGETEDSIGAVTGLAYTAFGGDTLTIEVALAPGKGKLQLTGKLGDVMQESAQTAYSYVRAN
AERFGIDPTFYERQDIHIHVPEGAVPKDGPSAGITIATALISALTGKKVHRDVGMTGEITLRGRVLPIGGLKEKALAAHR
AGLTTIVIPKDNERDIDDIQETVREKLTFVPVTTLDEVLDVAFGGN
>Mature_766_residues
MEKLPILPLRGVVVYPLIGVTIDVGRPLSLRALLAAKEHETDLIVVTQKETGNESPEPEDLYTVGTRVHIAKMSELSNET
IRVRIVGKERVRVDSIESTDEGWFANIEPVELAEGEEVERTALVRLLKEQFGKLVANIKGMSPDERRRFEMYERLESLTD
YITSKLDVDVELRQAMLEEADAVKRGLELLEIIAHEVEVIELEQEMRERTKKSIEQSQREYYLREQMKTIQQELGDQTQE
SEPNRLREKLEALDLPETTRKNVMREAERLNVVPQTSPEYAVIRNYLDWVTSLPWGIETEDKLDVKHAADVLDDDHYGLE
SVKDRILEYLAVRQLTNSLRGPILCLAGPPGVGKTSLARSIASALERHFVRVSLGGVRDEAEIRGHRRTYIGAMPGRIIR
GLKQAESKNPVFLLDEIDKMASDFRGDPASAMLEVLDPEQNVSFSDHYIEEPFDLSNVLFIATANDVSQIPAPLLDRMEL
IQIGGYTELEKVEIAKRHLVPKQLAEHGLKKSQLTIKEDALYEVVRRYTREAGVRNLERVIGSLCRKAAKQIAIGEKKRV
TISKKAIITYLGKPKYRYGKGETEDSIGAVTGLAYTAFGGDTLTIEVALAPGKGKLQLTGKLGDVMQESAQTAYSYVRAN
AERFGIDPTFYERQDIHIHVPEGAVPKDGPSAGITIATALISALTGKKVHRDVGMTGEITLRGRVLPIGGLKEKALAAHR
AGLTTIVIPKDNERDIDDIQETVREKLTFVPVTTLDEVLDVAFGGN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=565, Percent_Identity=49.3805309734513, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI21396489, Length=601, Percent_Identity=45.5906821963394, Blast_Score=545, Evalue=1e-155,
Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=50.3276539973788, Blast_Score=768, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=635, Percent_Identity=41.4173228346457, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=530, Percent_Identity=43.3962264150943, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319449, Length=707, Percent_Identity=38.1895332390382, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=682, Percent_Identity=42.0821114369502, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24666867, Length=682, Percent_Identity=42.0821114369502, Blast_Score=540, Evalue=1e-153,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 85643; Mature: 85643

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLPILPLRGVVVYPLIGVTIDVGRPLSLRALLAAKEHETDLIVVTQKETGNESPEPED
CCCCCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCH
LYTVGTRVHIAKMSELSNETIRVRIVGKERVRVDSIESTDEGWFANIEPVELAEGEEVER
HEEECCEEEEHHHHHCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCCEECCCCCHHHH
TALVRLLKEQFGKLVANIKGMSPDERRRFEMYERLESLTDYITSKLDVDVELRQAMLEEA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DAVKRGLELLEIIAHEVEVIELEQEMRERTKKSIEQSQREYYLREQMKTIQQELGDQTQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SEPNRLREKLEALDLPETTRKNVMREAERLNVVPQTSPEYAVIRNYLDWVTSLPWGIETE
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
DKLDVKHAADVLDDDHYGLESVKDRILEYLAVRQLTNSLRGPILCLAGPPGVGKTSLARS
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
IASALERHFVRVSLGGVRDEAEIRGHRRTYIGAMPGRIIRGLKQAESKNPVFLLDEIDKM
HHHHHHHHEEEEECCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCEEEHHHHHHH
ASDFRGDPASAMLEVLDPEQNVSFSDHYIEEPFDLSNVLFIATANDVSQIPAPLLDRMEL
HHHCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCEEEEEECCCHHHCCHHHHHHHHH
IQIGGYTELEKVEIAKRHLVPKQLAEHGLKKSQLTIKEDALYEVVRRYTREAGVRNLERV
HHCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
IGSLCRKAAKQIAIGEKKRVTISKKAIITYLGKPKYRYGKGETEDSIGAVTGLAYTAFGG
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCEECCCCCCCCHHHHHHHHEEEEECC
DTLTIEVALAPGKGKLQLTGKLGDVMQESAQTAYSYVRANAERFGIDPTFYERQDIHIHV
CEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEEEEC
PEGAVPKDGPSAGITIATALISALTGKKVHRDVGMTGEITLRGRVLPIGGLKEKALAAHR
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHH
AGLTTIVIPKDNERDIDDIQETVREKLTFVPVTTLDEVLDVAFGGN
CCCEEEEECCCCCCCHHHHHHHHHHHHEECCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKLPILPLRGVVVYPLIGVTIDVGRPLSLRALLAAKEHETDLIVVTQKETGNESPEPED
CCCCCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCH
LYTVGTRVHIAKMSELSNETIRVRIVGKERVRVDSIESTDEGWFANIEPVELAEGEEVER
HEEECCEEEEHHHHHCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCCEECCCCCHHHH
TALVRLLKEQFGKLVANIKGMSPDERRRFEMYERLESLTDYITSKLDVDVELRQAMLEEA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DAVKRGLELLEIIAHEVEVIELEQEMRERTKKSIEQSQREYYLREQMKTIQQELGDQTQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SEPNRLREKLEALDLPETTRKNVMREAERLNVVPQTSPEYAVIRNYLDWVTSLPWGIETE
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
DKLDVKHAADVLDDDHYGLESVKDRILEYLAVRQLTNSLRGPILCLAGPPGVGKTSLARS
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
IASALERHFVRVSLGGVRDEAEIRGHRRTYIGAMPGRIIRGLKQAESKNPVFLLDEIDKM
HHHHHHHHEEEEECCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCEEEHHHHHHH
ASDFRGDPASAMLEVLDPEQNVSFSDHYIEEPFDLSNVLFIATANDVSQIPAPLLDRMEL
HHHCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCEEEEEECCCHHHCCHHHHHHHHH
IQIGGYTELEKVEIAKRHLVPKQLAEHGLKKSQLTIKEDALYEVVRRYTREAGVRNLERV
HHCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
IGSLCRKAAKQIAIGEKKRVTISKKAIITYLGKPKYRYGKGETEDSIGAVTGLAYTAFGG
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCEECCCCCCCCHHHHHHHHEEEEECC
DTLTIEVALAPGKGKLQLTGKLGDVMQESAQTAYSYVRANAERFGIDPTFYERQDIHIHV
CEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEEEEC
PEGAVPKDGPSAGITIATALISALTGKKVHRDVGMTGEITLRGRVLPIGGLKEKALAAHR
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHH
AGLTTIVIPKDNERDIDDIQETVREKLTFVPVTTLDEVLDVAFGGN
CCCEEEEECCCCCCCHHHHHHHHHHHHEECCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961402; 8969504; 9384377 [H]