| Definition | Exiguobacterium sp. AT1b, complete genome. |
|---|---|
| Accession | NC_012673 |
| Length | 2,999,895 |
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The map label for this gene is menD [H]
Identifier: 229918094
GI number: 229918094
Start: 2326123
End: 2327772
Strand: Reverse
Name: menD [H]
Synonym: EAT1b_2374
Alternate gene names: 229918094
Gene position: 2327772-2326123 (Counterclockwise)
Preceding gene: 229918095
Following gene: 229918093
Centisome position: 77.6
GC content: 50.36
Gene sequence:
>1650_bases ATGAATAAGGTTTTGACCGAATGGGTCGCATCCATGGTAAATCGGCTTGTTACGTCCGGTGTAAAAGACGTGGTCATCAG CCCAGGGTCCCGCTCGACTCCGCTCGCTGTAGCGGCATATCTTCACCCTCAGATTCGTCATCACATCATCGTCGATGAAC GATCTGCCGGATTTTTCGCTCTTGGACTGACCCGTGCGTCCGAAACGGTTCGCCCGGTCGCATTGATTTGCACAAGTGGA ACGGCAGCCACAAACTACTATTCGGCTGTGACGGAAGCGTTTATATCGCAGTTGCCACTTGTCGTACTGACGACCGATCG TCCCCATGAACTGCGTAATGTCGGGGCTCCACAAGCGATCAATCAAGTCCGCCTCTACGGGGAACAAGTGAAGACGAGCG TTGATTTGCCCGTTCCAGAGGAGGCGACGTTATCGTTTATGCAACAAACGATTACCCGTTTCACGAATCTGTCGATGCAA GCACCGATGGGACCCGTTCATTTGAATGTGCCGTTCCGAGAACCTCTGCTTCCGGACATCGAGTCATTGAAACAGATATT GAAGGCTGACCCTGTCTTGCCAGAACGACAGCGTATCCGGCCGACACAGGCGGACAAAGACATTTTCTCAGAACGGACGA GTCACAAACAACTCGCCTTCGTCGTCGGACCTTACACCCCGACATCTTGGCAGAAATCCATCGTTGAATATGCTTCCGAG CGACAGATCCCGATTTTCGCCGATCCTCTAAGTGGCATGCGACGTTTCGACGGCGTCTTGACCAACTATGACACGTGGCT TGCAAGTGAGCATCGGACCGATTGGCTACCCGAGGTGTTCGTCCGTTTCGGGGCTGCACCTGTTTCGAAACGATTCAATC AATGGATGGCCATGGCGGACCAACTCGTCATCGATGAACCGGGATCTTATCGCGACCCAAGTAGCCGTGCCACGATTTGT TACGGCGACGCACTCGATTTTCTACCGCTCATCGCATCGGCAAACGAACCTCGGTATCTTGAGCGTTTACGCTTTTTTGA AGAGATTGCCGAGTCTGCAAAATCGTCACTTCAAGGTGAGGTAGAATTGACGAAACGATTGCTCGATACATCAATCGAGC TTCTATTCGTCAGTAATAGCATGCCGATTCGAGATGTAGATATATCACTGTCTGCTGGCACGAACATCCACGTTCTCGCC AATCGAGGCGCAAACGGGATTGATGGTGTGTTATCTACTGCACTCGGAAGCAGTTATGATACGTCTCACGGCGCTCTATT GATCGGTGATTTGGCGTTCTATCACGATAGCAATGCCTTGCAACTGTTAAAGCATCATCCCGGGAAGTTTTCCGTTGTGA TTGCAAACAATAATGGTGGAGGAATTTTCTCCTTCCTCCCGCAGGCTGCTGTCGACACACAGTTGTTCGAAGATTTATTC GGAACACCGCTTGATTTAAATATCCGCGGATTCGCTGACACCTATGGCTTAACGTATCGTCTAATCGAACGACCGGATGA AATTCAAGAAGCGATTGAAGATGGCATTCATTTAATCGAATTCCCATCGAATCGTGAGGAGAATGTGATGATCCATCGGG GGTGGACTCAATCGGTCTGCAGTCGTCTCATTACGGAGAACGAATCATGA
Upstream 100 bases:
>100_bases GACTCTGCACTTGAGCAAGAGCTCGAAGAAACAGAAATGAAAATGAGTCCAATCAAACAAGCTTTGCAGTTTGATTTACA CAATCAAGGAGGCACCCTAG
Downstream 100 bases:
>100_bases ACATCGATTTACGTGGCGTACGTTATGAAGTGATTCATCGCGGTGAGGGAAAACCGGTGTTATGTTTACACGGATTCACC GGAAACGCCCATTGGGTCGA
Product: 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 549; Mature: 549
Protein sequence:
>549_residues MNKVLTEWVASMVNRLVTSGVKDVVISPGSRSTPLAVAAYLHPQIRHHIIVDERSAGFFALGLTRASETVRPVALICTSG TAATNYYSAVTEAFISQLPLVVLTTDRPHELRNVGAPQAINQVRLYGEQVKTSVDLPVPEEATLSFMQQTITRFTNLSMQ APMGPVHLNVPFREPLLPDIESLKQILKADPVLPERQRIRPTQADKDIFSERTSHKQLAFVVGPYTPTSWQKSIVEYASE RQIPIFADPLSGMRRFDGVLTNYDTWLASEHRTDWLPEVFVRFGAAPVSKRFNQWMAMADQLVIDEPGSYRDPSSRATIC YGDALDFLPLIASANEPRYLERLRFFEEIAESAKSSLQGEVELTKRLLDTSIELLFVSNSMPIRDVDISLSAGTNIHVLA NRGANGIDGVLSTALGSSYDTSHGALLIGDLAFYHDSNALQLLKHHPGKFSVVIANNNGGGIFSFLPQAAVDTQLFEDLF GTPLDLNIRGFADTYGLTYRLIERPDEIQEAIEDGIHLIEFPSNREENVMIHRGWTQSVCSRLITENES
Sequences:
>Translated_549_residues MNKVLTEWVASMVNRLVTSGVKDVVISPGSRSTPLAVAAYLHPQIRHHIIVDERSAGFFALGLTRASETVRPVALICTSG TAATNYYSAVTEAFISQLPLVVLTTDRPHELRNVGAPQAINQVRLYGEQVKTSVDLPVPEEATLSFMQQTITRFTNLSMQ APMGPVHLNVPFREPLLPDIESLKQILKADPVLPERQRIRPTQADKDIFSERTSHKQLAFVVGPYTPTSWQKSIVEYASE RQIPIFADPLSGMRRFDGVLTNYDTWLASEHRTDWLPEVFVRFGAAPVSKRFNQWMAMADQLVIDEPGSYRDPSSRATIC YGDALDFLPLIASANEPRYLERLRFFEEIAESAKSSLQGEVELTKRLLDTSIELLFVSNSMPIRDVDISLSAGTNIHVLA NRGANGIDGVLSTALGSSYDTSHGALLIGDLAFYHDSNALQLLKHHPGKFSVVIANNNGGGIFSFLPQAAVDTQLFEDLF GTPLDLNIRGFADTYGLTYRLIERPDEIQEAIEDGIHLIEFPSNREENVMIHRGWTQSVCSRLITENES >Mature_549_residues MNKVLTEWVASMVNRLVTSGVKDVVISPGSRSTPLAVAAYLHPQIRHHIIVDERSAGFFALGLTRASETVRPVALICTSG TAATNYYSAVTEAFISQLPLVVLTTDRPHELRNVGAPQAINQVRLYGEQVKTSVDLPVPEEATLSFMQQTITRFTNLSMQ APMGPVHLNVPFREPLLPDIESLKQILKADPVLPERQRIRPTQADKDIFSERTSHKQLAFVVGPYTPTSWQKSIVEYASE RQIPIFADPLSGMRRFDGVLTNYDTWLASEHRTDWLPEVFVRFGAAPVSKRFNQWMAMADQLVIDEPGSYRDPSSRATIC YGDALDFLPLIASANEPRYLERLRFFEEIAESAKSSLQGEVELTKRLLDTSIELLFVSNSMPIRDVDISLSAGTNIHVLA NRGANGIDGVLSTALGSSYDTSHGALLIGDLAFYHDSNALQLLKHHPGKFSVVIANNNGGGIFSFLPQAAVDTQLFEDLF GTPLDLNIRGFADTYGLTYRLIERPDEIQEAIEDGIHLIEFPSNREENVMIHRGWTQSVCSRLITENES
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=529, Percent_Identity=32.1361058601134, Blast_Score=211, Evalue=1e-55,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 61009; Mature: 61009
Theoretical pI: Translated: 5.24; Mature: 5.24
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNKVLTEWVASMVNRLVTSGVKDVVISPGSRSTPLAVAAYLHPQIRHHIIVDERSAGFFA CCHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCEEEHHHHCHHHHEEEEEECCCCCEEE LGLTRASETVRPVALICTSGTAATNYYSAVTEAFISQLPLVVLTTDRPHELRNVGAPQAI EEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHCCCCHHH NQVRLYGEQVKTSVDLPVPEEATLSFMQQTITRFTNLSMQAPMGPVHLNVPFREPLLPDI HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCH ESLKQILKADPVLPERQRIRPTQADKDIFSERTSHKQLAFVVGPYTPTSWQKSIVEYASE HHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHC RQIPIFADPLSGMRRFDGVLTNYDTWLASEHRTDWLPEVFVRFGAAPVSKRFNQWMAMAD CCCCEEECCHHHHHHHCCHHHCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH QLVIDEPGSYRDPSSRATICYGDALDFLPLIASANEPRYLERLRFFEEIAESAKSSLQGE HEEEECCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCH VELTKRLLDTSIELLFVSNSMPIRDVDISLSAGTNIHVLANRGANGIDGVLSTALGSSYD HHHHHHHHHCCEEEEEEECCCCEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCC TSHGALLIGDLAFYHDSNALQLLKHHPGKFSVVIANNNGGGIFSFLPQAAVDTQLFEDLF CCCCEEEEEEEEEEECCCHHHHHHCCCCEEEEEEEECCCCCHHHHCCHHHHHHHHHHHHC GTPLDLNIRGFADTYGLTYRLIERPDEIQEAIEDGIHLIEFPSNREENVMIHRGWTQSVC CCCEEEEEECCHHHHCCCHHHHCCCHHHHHHHHCCCEEEECCCCCCCCEEEECCCHHHHH SRLITENES HHHHCCCCC >Mature Secondary Structure MNKVLTEWVASMVNRLVTSGVKDVVISPGSRSTPLAVAAYLHPQIRHHIIVDERSAGFFA CCHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCEEEHHHHCHHHHEEEEEECCCCCEEE LGLTRASETVRPVALICTSGTAATNYYSAVTEAFISQLPLVVLTTDRPHELRNVGAPQAI EEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHCCCCHHH NQVRLYGEQVKTSVDLPVPEEATLSFMQQTITRFTNLSMQAPMGPVHLNVPFREPLLPDI HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCH ESLKQILKADPVLPERQRIRPTQADKDIFSERTSHKQLAFVVGPYTPTSWQKSIVEYASE HHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHC RQIPIFADPLSGMRRFDGVLTNYDTWLASEHRTDWLPEVFVRFGAAPVSKRFNQWMAMAD CCCCEEECCHHHHHHHCCHHHCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH QLVIDEPGSYRDPSSRATICYGDALDFLPLIASANEPRYLERLRFFEEIAESAKSSLQGE HEEEECCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCH VELTKRLLDTSIELLFVSNSMPIRDVDISLSAGTNIHVLANRGANGIDGVLSTALGSSYD HHHHHHHHHCCEEEEEEECCCCEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCC TSHGALLIGDLAFYHDSNALQLLKHHPGKFSVVIANNNGGGIFSFLPQAAVDTQLFEDLF CCCCEEEEEEEEEEECCCHHHHHHCCCCEEEEEEEECCCCCHHHHCCHHHHHHHHHHHHC GTPLDLNIRGFADTYGLTYRLIERPDEIQEAIEDGIHLIEFPSNREENVMIHRGWTQSVC CCCEEEEEECCHHHHCCCHHHHCCCHHHHHHHHCCCEEEECCCCCCCCEEEECCCHHHHH SRLITENES HHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11679669 [H]