BacMap

Definition	Sulfolobus islandicus M.14.25 chromosome, complete genome.
Accession	NC_012588
Length	2,608,832

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The map label for this gene is caiD [C]

Identifier: 227827171

GI number: 227827171

Start: 806078

End: 806842

Strand: Direct

Name: caiD [C]

Synonym: M1425_0852

Alternate gene names: 227827171

Gene position: 806078-806842 (Clockwise)

Preceding gene: 227827170

Following gene: 227827172

Centisome position: 30.9

GC content: 39.61

Gene sequence:

>765_bases
ATGATAAAGGTTGAGTTAGAAAATGAAAATAAGATAGGCAAAATATTAATAGACAGACAAGAGAAGATGAACGCAATAAC
TGTAGCCATGAGAAGAGAGATCGGGGAGAAGATACTCGATCTGGAGAAGAATCAAGATGTAAGGGTAATAATCGTAAGAG
GAGTTGGAGGAAAGGCATTTAGCTCTGGTGGAGACATTAGTGAGTTCCTATCATTAACCCCAGAAACCCTACTAGACTGG
GGAGAAGATATTTCATCTTCAGAGCGAATTACCAAGCCTGTAATAGCTGCAATAGATGGATACACGTTTGGAGCTGGTTT
AGAGTTAGCCTTATCTTGTGATATAAGGATAGCAACTCCGAGAAGTGAATTTGCATTTCCGGAAATAAGGCTGGGAATGG
TTCCAGCTAGTGGAGGAATAACTAGAATAGTGAAAATGTTGGGTGTCTCTAGGGCAACGTATATGCTAATGTTAGGAAAG
AGGTTAGATGCTCAAACAGCATTACAATGGGGAATAGTTCACGAGATTGTAGAGCCAGAGAAGTTAGATGAGAAAGCAAT
GGAGATAGCCAAGGATTTAGCAAGTCTGTCACCGTTAGCACTTAAAGCCTTGAAGAAAGTTATCAGAGAGATAGCTGATT
CGCCTTTCTATGCAGGATTTGATATAGAGAGAAAAACCTTTGGTTTACTCAGATACAGTGAGGACTTCAAAGAGGGTGTA
GAGTCGTTCTTGAACAAGAAAAAGCCTAAATTTAATGGTAGATAA

Upstream 100 bases:

>100_bases
AACCCAGAAATTGTAAAGAAATCAAAAGAATAATAAAACCACTAATGCTAAAGAAAGACTTAAATATTTGATAATCACTT
TTAGAATCATGTGATAATAG

Downstream 100 bases:

>100_bases
TCATGTTTAAGGAAGGGTTGCGGTTTGTAAAGGGAGAAGGTAATTACATAGACGATTTTGTATTAAAAGAAGTAAAGAAT
TATTTTTCAGCCTCGATAGT

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MIKVELENENKIGKILIDRQEKMNAITVAMRREIGEKILDLEKNQDVRVIIVRGVGGKAFSSGGDISEFLSLTPETLLDW
GEDISSSERITKPVIAAIDGYTFGAGLELALSCDIRIATPRSEFAFPEIRLGMVPASGGITRIVKMLGVSRATYMLMLGK
RLDAQTALQWGIVHEIVEPEKLDEKAMEIAKDLASLSPLALKALKKVIREIADSPFYAGFDIERKTFGLLRYSEDFKEGV
ESFLNKKKPKFNGR

Sequences:

>Translated_254_residues
MIKVELENENKIGKILIDRQEKMNAITVAMRREIGEKILDLEKNQDVRVIIVRGVGGKAFSSGGDISEFLSLTPETLLDW
GEDISSSERITKPVIAAIDGYTFGAGLELALSCDIRIATPRSEFAFPEIRLGMVPASGGITRIVKMLGVSRATYMLMLGK
RLDAQTALQWGIVHEIVEPEKLDEKAMEIAKDLASLSPLALKALKKVIREIADSPFYAGFDIERKTFGLLRYSEDFKEGV
ESFLNKKKPKFNGR
>Mature_254_residues
MIKVELENENKIGKILIDRQEKMNAITVAMRREIGEKILDLEKNQDVRVIIVRGVGGKAFSSGGDISEFLSLTPETLLDW
GEDISSSERITKPVIAAIDGYTFGAGLELALSCDIRIATPRSEFAFPEIRLGMVPASGGITRIVKMLGVSRATYMLMLGK
RLDAQTALQWGIVHEIVEPEKLDEKAMEIAKDLASLSPLALKALKKVIREIADSPFYAGFDIERKTFGLLRYSEDFKEGV
ESFLNKKKPKFNGR

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=251, Percent_Identity=33.8645418326693, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI68989263, Length=167, Percent_Identity=35.3293413173653, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI157694516, Length=214, Percent_Identity=31.3084112149533, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI213417737, Length=214, Percent_Identity=31.3084112149533, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI31542718, Length=257, Percent_Identity=28.7937743190661, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI20127408, Length=203, Percent_Identity=31.0344827586207, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI157694520, Length=187, Percent_Identity=31.5508021390374, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=26.7441860465116, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI37594469, Length=193, Percent_Identity=31.0880829015544, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI37594471, Length=193, Percent_Identity=32.1243523316062, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI45643119, Length=250, Percent_Identity=27.6, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI260275230, Length=250, Percent_Identity=27.6, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI260274832, Length=250, Percent_Identity=27.6, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI70995211, Length=214, Percent_Identity=26.1682242990654, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI116235487, Length=211, Percent_Identity=25.1184834123223, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI221136756, Length=206, Percent_Identity=23.7864077669903, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI221136753, Length=206, Percent_Identity=23.7864077669903, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI221307494, Length=203, Percent_Identity=24.1379310344828, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI150378541, Length=258, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI221142681, Length=259, Percent_Identity=35.9073359073359, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787659, Length=256, Percent_Identity=32.03125, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=28.125, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790281, Length=188, Percent_Identity=35.6382978723404, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082183, Length=252, Percent_Identity=28.968253968254, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788682, Length=210, Percent_Identity=33.8095238095238, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=27.8884462151394, Blast_Score=101, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=243, Percent_Identity=32.5102880658436, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17554946, Length=261, Percent_Identity=29.1187739463602, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=28.2511210762332, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560910, Length=244, Percent_Identity=27.8688524590164, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17534483, Length=218, Percent_Identity=27.9816513761468, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=261, Percent_Identity=27.2030651340996, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=269, Percent_Identity=25.6505576208178, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17558304, Length=192, Percent_Identity=30.7291666666667, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=249, Percent_Identity=26.1044176706827, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25144276, Length=211, Percent_Identity=29.8578199052133, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=211, Percent_Identity=29.8578199052133, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=211, Percent_Identity=29.8578199052133, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144157, Length=212, Percent_Identity=26.8867924528302, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25144160, Length=212, Percent_Identity=26.8867924528302, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=205, Percent_Identity=23.9024390243902, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141363, Length=171, Percent_Identity=29.2397660818713, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=198, Percent_Identity=24.7474747474747, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129971, Length=253, Percent_Identity=30.8300395256917, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24653477, Length=253, Percent_Identity=30.8300395256917, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=26, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI19920382, Length=256, Percent_Identity=30.46875, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357171, Length=252, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922422, Length=262, Percent_Identity=24.4274809160305, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24650670, Length=257, Percent_Identity=26.0700389105058, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28571730, Length=186, Percent_Identity=32.258064516129, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571729, Length=186, Percent_Identity=32.258064516129, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583077, Length=296, Percent_Identity=30.4054054054054, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583079, Length=296, Percent_Identity=30.4054054054054, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921000, Length=296, Percent_Identity=30.4054054054054, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=26.2295081967213, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 28235; Mature: 28235

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVELENENKIGKILIDRQEKMNAITVAMRREIGEKILDLEKNQDVRVIIVRGVGGKAF
CEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCC
SSGGDISEFLSLTPETLLDWGEDISSSERITKPVIAAIDGYTFGAGLELALSCDIRIATP
CCCCCHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCCEEEEEEEEEEECC
RSEFAFPEIRLGMVPASGGITRIVKMLGVSRATYMLMLGKRLDAQTALQWGIVHEIVEPE
CCHHCCCCEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
KLDEKAMEIAKDLASLSPLALKALKKVIREIADSPFYAGFDIERKTFGLLRYSEDFKEGV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ESFLNKKKPKFNGR
HHHHHCCCCCCCCC
>Mature Secondary Structure
MIKVELENENKIGKILIDRQEKMNAITVAMRREIGEKILDLEKNQDVRVIIVRGVGGKAF
CEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCC
SSGGDISEFLSLTPETLLDWGEDISSSERITKPVIAAIDGYTFGAGLELALSCDIRIATP
CCCCCHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCCEEEEEEEEEEECC
RSEFAFPEIRLGMVPASGGITRIVKMLGVSRATYMLMLGKRLDAQTALQWGIVHEIVEPE
CCHHCCCCEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
KLDEKAMEIAKDLASLSPLALKALKKVIREIADSPFYAGFDIERKTFGLLRYSEDFKEGV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ESFLNKKKPKFNGR
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA