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The map label for this gene is glyQS [H]

Identifier: 227827123

GI number: 227827123

Start: 742656

End: 744110

Strand: Direct

Name: glyQS [H]

Synonym: M1425_0795

Alternate gene names: 227827123

Gene position: 742656-744110 (Clockwise)

Preceding gene: 227827122

Following gene: 227827124

Centisome position: 28.47

GC content: 34.3

Gene sequence:

>1455_bases
ATGAGACAATATAATAAGTTGAGTAAAATGATGAGTCAAAGTAAGTCCAAACAAGATATAGAAAGATTCTTAAGAAACTT
TTATGTTAACTCAGCAGAAATTTACAAAGGCAGGAACGTTTCTGGATTTATAGATTGGCTTCCACCAGGTGCAATGCTAA
GGCAGAAAATAATAGATAGTTGGATTAATTTCTTCATAAAGAAAATACCTAATATCTTCTTAATGGATGGAAGTACGATA
CTACCACTAAGTGTTTTTGAAGCATCTGGACATCTTGCCAATTTTACCGATCCTGTGATAAAATGTCCAAAATGCTCAAA
TACCTATAGAGTAGATCACTTACTAAAGGAGACTAATGGTAAACTAATCTGTCCTAGAGATTTGACTGATTTAAAGGATC
AAGAAATAAAACAAAAGAGTTTAATGTTAGAACTCACAGTAGGTTTAGCTGACGAGATAAATGCCGCATTAAGACCAGAG
ACTGCACAAAACATTTATATCAATTTCATGAATTTTAAAGCAATTGGACTAAAATTACCATTTGCTATAGCGCAAATAGG
CAGATCTTACAGAAATGAAATATCACCCCGTGGATCTAGGCTCAGAGAGTTCGTGCAGATGGAAATAGAGGAATTCGTTT
TACCTTTTCATTTAAATTCACATCCACTTTATGACAATGTTAAAGGGATCAGATTACCCATATTTTATGAAGAACAGACT
ATTGAAATGGAGTTAAATGAAGCCGTTAAAAAAGGTTTAGTACCAAACATTAGATTAGCCTTTTGGATAGGCAGAGAGTG
GCAATGGTTAACCAATGAACTAGGTTTACCTGGCAATAAGATTAGATTCAGAATAGTACCATCTGAGGAAAGGGCATTCT
ACTCTAAGGGTACGGTAGACGTGGAAGTAAATATGGAAGATGATTGGGTTGAAATAATAGGCAATGCTTATAGAACGGAT
TATGATCTCACTGTACACTCTAAACACTCTGGTGCGAATTTAAGTGAAAACGGTACTATCCCGCATGTAATAGAACCGTC
TTTTGGTCTTGATAGAATTGCAATTGCTGTCTTATTGCTAAACTATGATCCTAATCCATCGGATAGAAATTGGCCATTAT
TTAGAATACCATACAAAATAGCGCCATTAGAAATAGGTATAGCCTCTATACATCATAGTGATGAATATATTAACATTGCG
GAAAAAGTTGATTTAATATTAAGGTCTTTGGATTACGTTACATTTAAATTATTTGAAAGAGGTAAAATAGACGCTCAATA
TGCTAAAGCCGATACTCTAGGTATCCCATTAGTAATTACAATAGATTCTAAGACTTTAGAGGAAAATACAGTAACTATTA
GAAATAGGGATACGAAGGCACAAATAAGGGTAAATATTGGAGAAATAGCTCAGGCTGTAAAAAACCTTCTTTTAGGCGGT
GGCGGATATGGGTAA

Upstream 100 bases:

>100_bases
TTTTTGTAAACTAAATAAATTACGATAAACCTATTAGTCTAGTGAGTTAGTTGAACATATATAATAAGATAAAACTAACC
AGTTAAATTTATAAATTATA

Downstream 100 bases:

>100_bases
AATAATTAAGGAATCTTTTAAAAATGGAATACGTTCTGACTTTTTTAAGCAAGAATCTTTTAAAGAAGGAATTTATACAT
CTTTTTTTGCAACTATTGGA

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MRQYNKLSKMMSQSKSKQDIERFLRNFYVNSAEIYKGRNVSGFIDWLPPGAMLRQKIIDSWINFFIKKIPNIFLMDGSTI
LPLSVFEASGHLANFTDPVIKCPKCSNTYRVDHLLKETNGKLICPRDLTDLKDQEIKQKSLMLELTVGLADEINAALRPE
TAQNIYINFMNFKAIGLKLPFAIAQIGRSYRNEISPRGSRLREFVQMEIEEFVLPFHLNSHPLYDNVKGIRLPIFYEEQT
IEMELNEAVKKGLVPNIRLAFWIGREWQWLTNELGLPGNKIRFRIVPSEERAFYSKGTVDVEVNMEDDWVEIIGNAYRTD
YDLTVHSKHSGANLSENGTIPHVIEPSFGLDRIAIAVLLLNYDPNPSDRNWPLFRIPYKIAPLEIGIASIHHSDEYINIA
EKVDLILRSLDYVTFKLFERGKIDAQYAKADTLGIPLVITIDSKTLEENTVTIRNRDTKAQIRVNIGEIAQAVKNLLLGG
GGYG

Sequences:

>Translated_484_residues
MRQYNKLSKMMSQSKSKQDIERFLRNFYVNSAEIYKGRNVSGFIDWLPPGAMLRQKIIDSWINFFIKKIPNIFLMDGSTI
LPLSVFEASGHLANFTDPVIKCPKCSNTYRVDHLLKETNGKLICPRDLTDLKDQEIKQKSLMLELTVGLADEINAALRPE
TAQNIYINFMNFKAIGLKLPFAIAQIGRSYRNEISPRGSRLREFVQMEIEEFVLPFHLNSHPLYDNVKGIRLPIFYEEQT
IEMELNEAVKKGLVPNIRLAFWIGREWQWLTNELGLPGNKIRFRIVPSEERAFYSKGTVDVEVNMEDDWVEIIGNAYRTD
YDLTVHSKHSGANLSENGTIPHVIEPSFGLDRIAIAVLLLNYDPNPSDRNWPLFRIPYKIAPLEIGIASIHHSDEYINIA
EKVDLILRSLDYVTFKLFERGKIDAQYAKADTLGIPLVITIDSKTLEENTVTIRNRDTKAQIRVNIGEIAQAVKNLLLGG
GGYG
>Mature_484_residues
MRQYNKLSKMMSQSKSKQDIERFLRNFYVNSAEIYKGRNVSGFIDWLPPGAMLRQKIIDSWINFFIKKIPNIFLMDGSTI
LPLSVFEASGHLANFTDPVIKCPKCSNTYRVDHLLKETNGKLICPRDLTDLKDQEIKQKSLMLELTVGLADEINAALRPE
TAQNIYINFMNFKAIGLKLPFAIAQIGRSYRNEISPRGSRLREFVQMEIEEFVLPFHLNSHPLYDNVKGIRLPIFYEEQT
IEMELNEAVKKGLVPNIRLAFWIGREWQWLTNELGLPGNKIRFRIVPSEERAFYSKGTVDVEVNMEDDWVEIIGNAYRTD
YDLTVHSKHSGANLSENGTIPHVIEPSFGLDRIAIAVLLLNYDPNPSDRNWPLFRIPYKIAPLEIGIASIHHSDEYINIA
EKVDLILRSLDYVTFKLFERGKIDAQYAKADTLGIPLVITIDSKTLEENTVTIRNRDTKAQIRVNIGEIAQAVKNLLLGG
GGYG

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=355, Percent_Identity=33.5211267605634, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32564541, Length=379, Percent_Identity=31.6622691292876, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17554996, Length=379, Percent_Identity=31.6622691292876, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325338, Length=375, Percent_Identity=34.4, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319597, Length=205, Percent_Identity=38.5365853658537, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24664462, Length=362, Percent_Identity=32.3204419889503, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI21357965, Length=362, Percent_Identity=32.3204419889503, Blast_Score=168, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 55323; Mature: 55323

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQYNKLSKMMSQSKSKQDIERFLRNFYVNSAEIYKGRNVSGFIDWLPPGAMLRQKIIDS
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHEECCCCCCEEEECCCCHHHHHHHHHHH
WINFFIKKIPNIFLMDGSTILPLSVFEASGHLANFTDPVIKCPKCSNTYRVDHLLKETNG
HHHHHHHHCCCEEEECCCEEEEEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCC
KLICPRDLTDLKDQEIKQKSLMLELTVGLADEINAALRPETAQNIYINFMNFKAIGLKLP
CEECCCCCCCCCHHHHHHHHEEEEEEECCHHHCCHHCCCCCCCEEEEEEEEEEEEEEECH
FAIAQIGRSYRNEISPRGSRLREFVQMEIEEFVLPFHLNSHPLYDNVKGIRLPIFYEEQT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEEECCCE
IEMELNEAVKKGLVPNIRLAFWIGREWQWLTNELGLPGNKIRFRIVPSEERAFYSKGTVD
EEEHHHHHHHHCCCCCEEEEEEECCCHHHHHHCCCCCCCEEEEEEECCHHHHEECCCEEE
VEVNMEDDWVEIIGNAYRTDYDLTVHSKHSGANLSENGTIPHVIEPSFGLDRIAIAVLLL
EEECCCCHHHHHHCCHHCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHEEEEEEE
NYDPNPSDRNWPLFRIPYKIAPLEIGIASIHHSDEYINIAEKVDLILRSLDYVTFKLFER
ECCCCCCCCCCCEEECCEEECCEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHEEHHHC
GKIDAQYAKADTLGIPLVITIDSKTLEENTVTIRNRDTKAQIRVNIGEIAQAVKNLLLGG
CCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHHCCC
GGYG
CCCC
>Mature Secondary Structure
MRQYNKLSKMMSQSKSKQDIERFLRNFYVNSAEIYKGRNVSGFIDWLPPGAMLRQKIIDS
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHEECCCCCCEEEECCCCHHHHHHHHHHH
WINFFIKKIPNIFLMDGSTILPLSVFEASGHLANFTDPVIKCPKCSNTYRVDHLLKETNG
HHHHHHHHCCCEEEECCCEEEEEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCC
KLICPRDLTDLKDQEIKQKSLMLELTVGLADEINAALRPETAQNIYINFMNFKAIGLKLP
CEECCCCCCCCCHHHHHHHHEEEEEEECCHHHCCHHCCCCCCCEEEEEEEEEEEEEEECH
FAIAQIGRSYRNEISPRGSRLREFVQMEIEEFVLPFHLNSHPLYDNVKGIRLPIFYEEQT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEEECCCE
IEMELNEAVKKGLVPNIRLAFWIGREWQWLTNELGLPGNKIRFRIVPSEERAFYSKGTVD
EEEHHHHHHHHCCCCCEEEEEEECCCHHHHHHCCCCCCCEEEEEEECCHHHHEECCCEEE
VEVNMEDDWVEIIGNAYRTDYDLTVHSKHSGANLSENGTIPHVIEPSFGLDRIAIAVLLL
EEECCCCHHHHHHCCHHCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHEEEEEEE
NYDPNPSDRNWPLFRIPYKIAPLEIGIASIHHSDEYINIAEKVDLILRSLDYVTFKLFER
ECCCCCCCCCCCEEECCEEECCEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHEEHHHC
GKIDAQYAKADTLGIPLVITIDSKTLEENTVTIRNRDTKAQIRVNIGEIAQAVKNLLLGG
CCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHHCCC
GGYG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA