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The map label for this gene is yhcA [H]

Identifier: 227827037

GI number: 227827037

Start: 645872

End: 647290

Strand: Direct

Name: yhcA [H]

Synonym: M1425_0696

Alternate gene names: 227827037

Gene position: 645872-647290 (Clockwise)

Preceding gene: 227827036

Following gene: 227827038

Centisome position: 24.76

GC content: 36.79

Gene sequence:

>1419_bases
ATGGACTCTAAAGAAGCAATGCGTACTTTAATTACCCTCACTCTAATGTTAACTTTAGTAAATTACGTTGAGACAATGGT
TATACCTGCATTGCCGAAAATCGAAACACAATTCTCTACTACAGCCACAACGGTTGCATGGGTAACATCAGCCTATCTCA
TAGTTGGTGCAATTGCATCACCACTTTTTGGAAAACTTGGTGATAGATATGGGAAGAAGAAAGTTTACCTCTTATCTATT
GGGTTTTACTCGTTAGCTGTATTATTAGCTGGGTTCTCAACTAACATCTACTTTTTAATTTTCGCTAGGGCGATTCAAGG
ATTAGGCTATGCAACGTTTCCTCTTGCAATAGCCATTATAACTGACCTATTTCCCAAAGAGCGAGTTGCATGGGCTCAAG
GTATTTTAAGTGCCACACTCGCAGCCGGTCCAGCCTTAGGATTATTAGTAGGTTCCTATATAGTTCAAGATCTTGGATGG
CCTTATGCGTTTCATACCGCATTTTTACTATCAATAATTCTAGTAATAATTTCCGCAAAGTACATAGTTGAGATCCCCGA
GAAGACTAGGGAGAAGATAGATTATTTAGGGGCAACATTTCTTATGCTAACAGTAGTTCCGTTATTAGTATATTTATCTA
ATGGTCCTAATGTTGGTTGGACTTCACTTAGTCAATTGTTATTAATTGCGATTTCAGTAATAGCATTTCCCATATTTTTA
TTGGTAGAGAGAAGAGCCAATGAACCCTTGATGAGACTTGATTTATTTGGAGTAAGAAATATAATAGTAGCAAATATAGC
TGGGCTAATATCTGGAGCTGGAATGTTTTTAATGTTTACAGGGTTAGTTTATTATCTTCAATTACCTCAACCCTATGGAC
TAGGCTTATCCATAATAGAATCTGGGCTGTTAATGGCACCTGTAGCTTTAGTAATGATGATTGTCGGACCGATAGTAGGT
AGATTGATTAACGCTACTGGACCTAAGCCATTACTTATCATAGGTTCTGTAATTAGCATTTTTGGTTATTTGCTTCTAGA
TACTTTAAGGTATAGCGTATATGAAGTTGTACTTGATGTCATGATAACTGCTGTAGGGTTAGTTAATATTATGATTCCAT
TAGTTAATATGGTCGCAGTATCTTTACCAGAGGAACAAAGAGGAATAGGAATAGGCATGAACACTTTAATAAGAACTATC
GGAAGTTCAATTGGCCCAGTAATCTCAACAGTATTTATGGACACCTACACTACATGGATAATATACGATTTTAACGATCA
AATTGTACCGTTAGCTCAAGTACCATCTTATTCAGCCTTTCATTACATGTATACTGCTGCAGTCGGTATAATGTTCCTAA
ACCTTATCGTTGCTTTATTCACTAGGAATTACGTAATTAAGACGGGGCAACATGCGTGA

Upstream 100 bases:

>100_bases
TTACTATTTATGGTAAAGAGTTAACACTATATCATTCTTTTATGTTCATTGAAAAAGATATATCGAAAAATTTATTTGTC
TTTATATCGCTCTTTTCTTT

Downstream 100 bases:

>100_bases
CCTTTCTACTTATCTTTTCTATTTAAGTATTGCAGTATAAATTGCATAAATCCTATATACTTCTTATGGAATATTATACA
TGTATACTTATTAACATAGA

Product: major facilitator superfamily MFS_1

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDSKEAMRTLITLTLMLTLVNYVETMVIPALPKIETQFSTTATTVAWVTSAYLIVGAIASPLFGKLGDRYGKKKVYLLSI
GFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGW
PYAFHTAFLLSIILVIISAKYIVEIPEKTREKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSLSQLLLIAISVIAFPIFL
LVERRANEPLMRLDLFGVRNIIVANIAGLISGAGMFLMFTGLVYYLQLPQPYGLGLSIIESGLLMAPVALVMMIVGPIVG
RLINATGPKPLLIIGSVISIFGYLLLDTLRYSVYEVVLDVMITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTI
GSSIGPVISTVFMDTYTTWIIYDFNDQIVPLAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKTGQHA

Sequences:

>Translated_472_residues
MDSKEAMRTLITLTLMLTLVNYVETMVIPALPKIETQFSTTATTVAWVTSAYLIVGAIASPLFGKLGDRYGKKKVYLLSI
GFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGW
PYAFHTAFLLSIILVIISAKYIVEIPEKTREKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSLSQLLLIAISVIAFPIFL
LVERRANEPLMRLDLFGVRNIIVANIAGLISGAGMFLMFTGLVYYLQLPQPYGLGLSIIESGLLMAPVALVMMIVGPIVG
RLINATGPKPLLIIGSVISIFGYLLLDTLRYSVYEVVLDVMITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTI
GSSIGPVISTVFMDTYTTWIIYDFNDQIVPLAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKTGQHA
>Mature_472_residues
MDSKEAMRTLITLTLMLTLVNYVETMVIPALPKIETQFSTTATTVAWVTSAYLIVGAIASPLFGKLGDRYGKKKVYLLSI
GFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGW
PYAFHTAFLLSIILVIISAKYIVEIPEKTREKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSLSQLLLIAISVIAFPIFL
LVERRANEPLMRLDLFGVRNIIVANIAGLISGAGMFLMFTGLVYYLQLPQPYGLGLSIIESGLLMAPVALVMMIVGPIVG
RLINATGPKPLLIIGSVISIFGYLLLDTLRYSVYEVVLDVMITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTI
GSSIGPVISTVFMDTYTTWIIYDFNDQIVPLAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKTGQHA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=410, Percent_Identity=25.609756097561, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789042, Length=415, Percent_Identity=25.3012048192771, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081983, Length=395, Percent_Identity=25.3164556962025, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790195, Length=412, Percent_Identity=24.5145631067961, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788392, Length=316, Percent_Identity=28.4810126582279, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994889, Length=162, Percent_Identity=29.0123456790123, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=397, Percent_Identity=25.1889168765743, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319770, Length=218, Percent_Identity=29.8165137614679, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323735, Length=299, Percent_Identity=26.4214046822742, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654039, Length=172, Percent_Identity=26.1627906976744, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17864456, Length=172, Percent_Identity=26.1627906976744, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24654041, Length=172, Percent_Identity=26.1627906976744, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51454; Mature: 51454

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSKEAMRTLITLTLMLTLVNYVETMVIPALPKIETQFSTTATTVAWVTSAYLIVGAIAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PLFGKLGDRYGKKKVYLLSIGFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAII
HHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGWPYAFHTAFLLSIILVIISAK
HHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCH
YIVEIPEKTREKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSLSQLLLIAISVIAFPIFL
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVERRANEPLMRLDLFGVRNIIVANIAGLISGAGMFLMFTGLVYYLQLPQPYGLGLSIIE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
SGLLMAPVALVMMIVGPIVGRLINATGPKPLLIIGSVISIFGYLLLDTLRYSVYEVVLDV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTIGSSIGPVISTVFMDTYTTWI
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYDFNDQIVPLAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKTGQHA
EEECCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCC
>Mature Secondary Structure
MDSKEAMRTLITLTLMLTLVNYVETMVIPALPKIETQFSTTATTVAWVTSAYLIVGAIAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PLFGKLGDRYGKKKVYLLSIGFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAII
HHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGWPYAFHTAFLLSIILVIISAK
HHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCH
YIVEIPEKTREKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSLSQLLLIAISVIAFPIFL
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVERRANEPLMRLDLFGVRNIIVANIAGLISGAGMFLMFTGLVYYLQLPQPYGLGLSIIE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
SGLLMAPVALVMMIVGPIVGRLINATGPKPLLIIGSVISIFGYLLLDTLRYSVYEVVLDV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTIGSSIGPVISTVFMDTYTTWI
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYDFNDQIVPLAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKTGQHA
EEECCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]