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The map label for this gene is gltT [H]

Identifier: 227815721

GI number: 227815721

Start: 2864428

End: 2865699

Strand: Reverse

Name: gltT [H]

Synonym: BAMEG_3142

Alternate gene names: 227815721

Gene position: 2865699-2864428 (Counterclockwise)

Preceding gene: 227815723

Following gene: 227815720

Centisome position: 54.79

GC content: 35.53

Gene sequence:

>1272_bases
ATGAAAAGAATAGGACTTGCATGGCAAATATTAATAGGACTTGCGCTTGGTATTGCAGTTGGGGCGATTTTCTTTGATAA
TCCAGCGGTTGTGAAATATTTACAACCAATTGGTGATATTTTCATCCGATTAATTAAAATGATCGTTGTACCGATTGTTG
TAGCAAGTATTGTTGTTGGGGTTGCTGGTGTTGGTGATGTTAAAAAATTAGGCCGACTAGGCGGAAAAACAATTATTTAC
TTTGAAATTATTACAACAATTGCAATTATTGTCGGTCTATTAATTGCGAATATTTTCCAACCAGGAAAAGGCGTAAATAT
GGAGCAGTTAACAAAGACAGACATTTCGAAATATACACATACGACAGAGCAAGTACAAAGTCATTCATTTGCAGATACAT
TTGTAAATATTGTTCCAACGAACATTATGAAGTCATTAGCTGACGGAGATATGCTTGCTATTATCTTCTTCTCAGTATTA
TTTGGTTTAGGTGTAGCAGCAATTGGTGAAAGAGGAAGACCGGTTCTTCAATTTTTCCAAGGTGTAGCTGATGCAATGTT
TTACGTAACGAACCAAGTTATGAAATTTGCACCATTTGGTGTGTTCGCATTGATTGGTGTTACAGTATCTACATTCGGTT
TAGCTTCATTAATTCCGTTAGGGAAATTATTAATTGTAGTATACGGGGCAATGATTTTCTTCGTTGTAGTTGTCTTAGGA
CTTACAGCGAAAATATTTGGAATTAACATTTTCCAATTCTTTAAAATTTTAAAAGACGAACTGATCTTAGCGTATTCAAC
AGCAAGTTCAGAAACAGTTTTACCGAAAATTATGGAGAAAATGGAGAAGTTCGGTTGTCCGAAAGCAATTACATCTTTCG
TTATTCCGACAGGTTATTCATTTAACTTAGATGGATCAACTTTATATCAAGCAATTGCAGCTATTTTCTTAGCGCAAATG
TACGGTATTGATTTATCTATTACAGAACAAATTACATTATTACTTGTATTAATGGTTACATCAAAAGGTATCGCAGGTGT
ACCGGGCGTATCATTCGTTGTATTATTAGCGACACTTGGTACAGTAGGTATTCCAGCTGAAGGCTTAGCCTTCATCGCCG
GTATTGACCGTATTTTAGATATGGCTCGTACAGCAGTTAACGTTGTAGGTAACTCTTTAGCAGCTGTAGTTATGTCTAAG
TGGGAAGGTCAATATGACGCTGAAAAAGGACAAGCTTATTTGAAAGAAATTTCTAATAAGCAAGCAGCTTAA

Upstream 100 bases:

>100_bases
GTAGTGAATTGTCGAATAATATGTAATACTCTTAATTTCAAGTTTTATAGAAATAGAATGAAAGGTAGAGTGACACATCG
AAGAGGGGGTTACAACAAGT

Downstream 100 bases:

>100_bases
TTATAATTTGAAAAAAGCTCTCACATAATATGTGAGGGCTTTTCTATATAGAAGGGAAGCGGACGTAATGAAACGTAAAT
ATGGTGACGGTTCTTCGTGG

Product: proton/glutamate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA

Sequences:

>Translated_423_residues
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA
>Mature_423_residues
MKRIGLAWQILIGLALGIAVGAIFFDNPAVVKYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=425, Percent_Identity=27.2941176470588, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4827012, Length=454, Percent_Identity=27.9735682819383, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI40254478, Length=458, Percent_Identity=27.292576419214, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI169790839, Length=457, Percent_Identity=28.0087527352298, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI66773030, Length=447, Percent_Identity=27.7404921700224, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI194239697, Length=442, Percent_Identity=27.6018099547511, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI5032093, Length=401, Percent_Identity=25.1870324189526, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=26.8115942028986, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=26.8115942028986, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=27.0053475935829, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI301601644, Length=185, Percent_Identity=30.8108108108108, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=62.3255813953488, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1789947, Length=418, Percent_Identity=39.4736842105263, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=27.3607748184019, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789473, Length=256, Percent_Identity=23.828125, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=29.2452830188679, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71996953, Length=464, Percent_Identity=28.0172413793103, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=436, Percent_Identity=25.9174311926606, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71983106, Length=436, Percent_Identity=25.9174311926606, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=417, Percent_Identity=28.537170263789, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=25.6218905472637, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193206654, Length=430, Percent_Identity=23.7209302325581, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24583025, Length=408, Percent_Identity=25.4901960784314, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17137668, Length=408, Percent_Identity=25.4901960784314, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24583023, Length=408, Percent_Identity=25.4901960784314, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281360483, Length=443, Percent_Identity=25.0564334085779, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137666, Length=443, Percent_Identity=25.0564334085779, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281360481, Length=443, Percent_Identity=25.0564334085779, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45302; Mature: 45302

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]