Click here to switch to the map view.

The map label for this gene is hisC1

Identifier: 227815635

GI number: 227815635

Start: 2783954

End: 2785066

Strand: Reverse

Name: hisC1

Synonym: BAMEG_3054

Alternate gene names: 227815635

Gene position: 2785066-2783954 (Counterclockwise)

Preceding gene: 227815636

Following gene: 227815634

Centisome position: 53.25

GC content: 36.39

Gene sequence:

>1113_bases
ATGAGAGTGAAAGAGCAATTGTTAACTTTGAGAGCATATGTACCTGGGAAAAATATTGAAGAAGTCAAAAGGGAATATGG
GTTATCGAAAATTGTGAAATTGGCATCGAACGAAAATCCGTTCGGTTGCTCAGCACGCGTAACAGAAGCATTAACTTCTT
TAGCGAGTCAATACGCTCTTTATCCAGATGGACATGCCTTTGAACTTCGAACACAAGTAGCAAAACATTTAGGTGTTAAA
GCGGAACAACTGTTATTTGGTAGTGGATTAGATGAAGTCATTCAAATGATTAGTCGTGCGTTACTACACGAGGGAACAAA
TGTTGTAATGGCGAATCCAACATTCTCGCAATACCATCACCATGCTGTTATTGAAGGAGCAGAAGTTCGTGAAGTATCAC
TTAAAGATGGCATTCACGATTTAGATGCGATGTTACAGCAAGTAGATGATCAAACGAAGATTGTATGGATTTGTAACCCG
AATAATCCGACAGGTACATATGTAGAAAAACAAAAATTACTTTCATTTTTAGAATCAGTTCCTAAGTCAGCGCTTGTTAT
TATGGACGAAGCATATTATGAATATGCGGGAGCAGAAGACTATCCGCAAACATTACCACTTCTTGAAAAGTATGAAAATC
TTATGGTATTACGTACGTTTTCAAAAGCATATGGTCTAGCTGCTTTCCGTATCGGATATGCAGTTGGTAATACGGAGTTA
ATCGGGCAGTTAGAAGTAGCGAGGTTACCATTTAATACATCGACTGTAGCGCAATCTGTAGCACTTGCTGCATTAGAAGA
TCAAGCATTTTTACAAGAATGTGTGAAAAAGAATGAAGAAGGATTACATCAATATTACGCATTTTGTAAGGAATATAACG
TATTCTATTATCCATCTCAAACAAATTTCATTTTCTTAAAACTCGGTATTCCTGGTAATGAAGCTTTCGAACGATTAATG
AAAAAAGGATATATTGTTCGTTCTGGTGCTGCATTTGGTATCGATGATGGCATTCGTATTACTGTCGGTTTGAAAGAAGA
AAATGATGAAATTATAGAGTTACTGAAAGAACTTGTAAATGAGCAAGTACAGAAAGAGGAAACATATTCTTAA

Upstream 100 bases:

>100_bases
TGAGGTGTTTTCGTAATAGTGACGGTTAGGATAAAAGATTACAGTAAAGGGCTAAAATTGTATTGTAATCGAATTCAATA
AAATGACTGGGGGAAGAAAA

Downstream 100 bases:

>100_bases
GAGATTGTGAAGGCTCCTATTAGAGGAGTCTTTTTTATCGCATTAAAAAAGTTGAAGTTTGGTAATTAAGTTGTTCTGTA
AATCACGATTTGTATGGCTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Sequences:

>Translated_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS
>Mature_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=342, Percent_Identity=30.4093567251462, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788722, Length=367, Percent_Identity=25.8855585831063, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788627, Length=239, Percent_Identity=25.1046025104602, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=333, Percent_Identity=30.03003003003, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_BACAN (Q81SV5)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843990.1
- RefSeq:   YP_018162.1
- RefSeq:   YP_027697.1
- ProteinModelPortal:   Q81SV5
- SMR:   Q81SV5
- EnsemblBacteria:   EBBACT00000011363
- EnsemblBacteria:   EBBACT00000017897
- EnsemblBacteria:   EBBACT00000022459
- GeneID:   1087402
- GeneID:   2817576
- GeneID:   2849454
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1539
- KEGG:   bar:GBAA_1539
- KEGG:   bat:BAS1428
- TIGR:   BA_1539
- TIGR:   GBAA_1539
- GeneTree:   EBGT00050000000787
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- ProtClustDB:   PRK03158
- BioCyc:   BANT260799:BAS1428-MONOMER
- BioCyc:   BANT261594:GBAA1539-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41603; Mature: 41603

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGHAFELRTQVAKHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLLSFLESV
HHHCCCCHHEEEHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
CCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQ
HCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC
>Mature Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGHAFELRTQVAKHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLLSFLESV
HHHCCCCHHEEEHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
CCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQ
HCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629