Click here to switch to the map view.

The map label for this gene is fes [H]

Identifier: 227814492

GI number: 227814492

Start: 1728228

End: 1729334

Strand: Direct

Name: fes [H]

Synonym: BAMEG_1900

Alternate gene names: 227814492

Gene position: 1728228-1729334 (Clockwise)

Preceding gene: 227814491

Following gene: 227814493

Centisome position: 33.04

GC content: 31.44

Gene sequence:

>1107_bases
GTGACTACAATAATCAGTCCTAAATTAGAGAAGCTTAAAAATCACTTAAAGAACGGAAATGAAAAAGCTCTTTATACTTT
TTTGCATGAAATCAAGTCAAATCATACACCACTAGTAGAACAATGTCCTATAGATAATCAGTATAAACTTATAACGTATA
TATGGTTAGGTGATCAAAATACTGAAAATGTTTATGTAGTCGGTAGTTTTCCTGGTTGGGATCTGTCTGTAAATCAATTA
CAACGATTATTACAGACAAATATTTGGTATGTTACGTTTAGGACGAATAAGAGGTTTATTTCAACTTATTATTTTACAGT
AAATGATTTTTTCAAAAATGATTGGATAAAGCGTAGTGAACAGTACCGACTAGACCCATTCAATGAAAATGTATTTGGAG
AAGGTGCCAATAAAGCGTCTGTGTTAAAAATAGATATGGACGTGCAGTATAGCAGTCGTTTTCCTTCAAATCATTATCCA
TCTGGAAAGATTGAAACATATTCTTTTTATAGTTCGATTTTAAATAACACACGTAAACTTCATATTTATACGCCTCATGA
TTATTCTCACACTTCACATCTTCAAGAACTTCTCATTGTATTTGATGGGAATTCATTCATTAATGACCTTTCAATCACAA
AAACACTTAATTATTTAATTTACGAAAAAGAAATCCCATCTTGTATTGCTGTTGCTATAGATCCTGTTGATCGATTAGAA
GAGCTAACTTATAACGATAAAATGAATACATTTTTAATGAAGGAATTACTTCCATGGATTCAAACTAAATATCATGTGTA
TCAAAAAGCAAAACATACAACAATTGCTGGTTTCAGCCTTGGTGGCTTAGCCGCTTTTTATGTAGCACTTCAAAATCCAC
ATATTTTCGGAAATGTGTTGTCAATGTCTGGATCCGTACATTGGAAAAAGGATGATTATGAAAATACAATTCCTTGGATT
GAAAATCAAATTTCATCAATAGATTCTAATGCGACTCATCTCAATTCTTACATAGCAGTAGGTGAACTTGAAAACGAATC
TCTTTTAAAGGCTAATAGACGGCTACATAAAGCTTTAGAAGAAAAGAAATACCCAAACCACTTATGA

Upstream 100 bases:

>100_bases
TCTAATCAATAACTTCTCTAAACACATAACTTACGACTACTTTTATATAGGGATTCTAATGAGAAAACTACATATAGAAT
ACTACAAAGGAGGAAGAGAG

Downstream 100 bases:

>100_bases
AGAGTTTCAAGGCGGACATGATAGCGTGTGGTGGCGAGAAAAGCTATTCGATGGATTAAGGGCATTAGAACTTACAAAAA
CGACACTAAAAAATAAAAAG

Product: putative esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQL
QRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYP
SGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWI
ENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKKYPNHL

Sequences:

>Translated_368_residues
MTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQL
QRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYP
SGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWI
ENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKKYPNHL
>Mature_367_residues
TTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQ
RLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPS
GKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEE
LTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIE
NQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKKYPNHL

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=345, Percent_Identity=24.6376811594203, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 42904; Mature: 42773

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQN
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCC
TENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSE
CCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEEHHHHHHHHHCCCC
QYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKL
CCCCCCCCCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEE
HIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
EEECCCCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHEEECCCCCCEEEEEECCHHHHH
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCCEEEEEE
SMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALE
ECCCCEEECCCCCCCCCCHHHHHHHHCCCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHH
EKKYPNHL
HCCCCCCC
>Mature Secondary Structure 
TTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQN
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCC
TENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSE
CCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEEHHHHHHHHHCCCC
QYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKL
CCCCCCCCCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEE
HIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
EEECCCCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHEEECCCCCCEEEEEECCHHHHH
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCCEEEEEE
SMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALE
ECCCCEEECCCCCCCCCCHHHHHHHHCCCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHH
EKKYPNHL
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]