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The map label for this gene is cysM [H]

Identifier: 227080720

GI number: 227080720

Start: 526135

End: 527022

Strand: Reverse

Name: cysM [H]

Synonym: VCM66_0495

Alternate gene names: 227080720

Gene position: 527022-526135 (Counterclockwise)

Preceding gene: 227080738

Following gene: 227080718

Centisome position: 18.22

GC content: 52.14

Gene sequence:

>888_bases
GTGTCTGATTTCCCCACTCTTGAAGATTATGTAGGTCAAACGCCCTTGGTGCGTTTACAGCGCCTCAATGCAGGCCGCTC
TACAGTATTGGTGAAGCTCGAAGGCAATAATCCAGCGGGTTCCGTGAAAGATAGACCAGCGCTTAATATGATTGTGCAAG
CCGAAGCGCGCGGCAGTTTGCAGCCCGGCGATACCATTATTGAAGCCACCAGTGGTAATACTGGCATAGCGTTGGCTATG
GCTGCCGCCATCAAAGGCTACAAGATGATTCTGATCATGCCCGATAACGCCACTCAAGAGCGCAAAGATTCGATGCGCGC
CTATGGCGCTGAGCTGATTTTGGTTAGCAAAGAACAAGGGATGGAAGGCGCACGCGATTTAGCCTTACAGATGCAGCAAG
AAGGCAAAGGTAAGGTATTGGATCAATTCAATAACTTGGATAACCCTGACGCGCATTATCGCTCAACCGGGCCGGAAATC
TGGCAGCAAAGCCAAGGCAAAATCACTCATTTTGTTTCAAGCATGGGCACCACAGGCACCATAATGGGCGTCTCTCGTTA
TCTGAAGCAACAAAATCCGCAGATTCAGATCATCGGCTTACAACCCTCGGAAGGCAGCGCGATTCCGGGTATTCGCCGTT
GGCCGCAAGCCTACCTCCCCGGCATTTTTGATGCTGCACGAGTCGATCAGGTGCTGGACGTAACTCAAACTGACGCCGAA
CAGACCGCTCGCGCCCTTGCGCGTGAAGAAGGAATTTGCGCCGGCGTCAGCTCTGGCGGAGCCGTGTTTGCCGCTTTGCA
GATTGCCCAACAAAATCCGGGATCCGTAGTGGTAGCGATTGTGTGCGATCGTGGCGACCGTTATTTATCCTCAGGATTAT
TTTCCTAA

Upstream 100 bases:

>100_bases
TAGACTATGTGATTGGGGTGAACAAACGTAGCCAACACCGCTGCAGCTTCAAGTAGGAAGGGTATATCGGTTGTCACTAT
TAGAATAGAAGGATCGCTCT

Downstream 100 bases:

>100_bases
CCGAGCTTTCCGACACTCGGCTTAGGCTGAGTGTCGAAACCGGTTTGACTTGGTATCCATATCACGCTCCCTACGCGCTT
TTCGGTAAACCTCTTGCGGC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSDFPTLEDYVGQTPLVRLQRLNAGRSTVLVKLEGNNPAGSVKDRPALNMIVQAEARGSLQPGDTIIEATSGNTGIALAM
AAAIKGYKMILIMPDNATQERKDSMRAYGAELILVSKEQGMEGARDLALQMQQEGKGKVLDQFNNLDNPDAHYRSTGPEI
WQQSQGKITHFVSSMGTTGTIMGVSRYLKQQNPQIQIIGLQPSEGSAIPGIRRWPQAYLPGIFDAARVDQVLDVTQTDAE
QTARALAREEGICAGVSSGGAVFAALQIAQQNPGSVVVAIVCDRGDRYLSSGLFS

Sequences:

>Translated_295_residues
MSDFPTLEDYVGQTPLVRLQRLNAGRSTVLVKLEGNNPAGSVKDRPALNMIVQAEARGSLQPGDTIIEATSGNTGIALAM
AAAIKGYKMILIMPDNATQERKDSMRAYGAELILVSKEQGMEGARDLALQMQQEGKGKVLDQFNNLDNPDAHYRSTGPEI
WQQSQGKITHFVSSMGTTGTIMGVSRYLKQQNPQIQIIGLQPSEGSAIPGIRRWPQAYLPGIFDAARVDQVLDVTQTDAE
QTARALAREEGICAGVSSGGAVFAALQIAQQNPGSVVVAIVCDRGDRYLSSGLFS
>Mature_294_residues
SDFPTLEDYVGQTPLVRLQRLNAGRSTVLVKLEGNNPAGSVKDRPALNMIVQAEARGSLQPGDTIIEATSGNTGIALAMA
AAIKGYKMILIMPDNATQERKDSMRAYGAELILVSKEQGMEGARDLALQMQQEGKGKVLDQFNNLDNPDAHYRSTGPEIW
QQSQGKITHFVSSMGTTGTIMGVSRYLKQQNPQIQIIGLQPSEGSAIPGIRRWPQAYLPGIFDAARVDQVLDVTQTDAEQ
TARALAREEGICAGVSSGGAVFAALQIAQQNPGSVVVAIVCDRGDRYLSSGLFS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=37.2990353697749, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=37.2990353697749, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=37.2990353697749, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI2367138, Length=290, Percent_Identity=70, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=41.4473684210526, Blast_Score=203, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=41.8060200668896, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=42.320819112628, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=41.4715719063545, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=41.0774410774411, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=41.4715719063545, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=38.9671361502347, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=283, Percent_Identity=36.3957597173145, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=282, Percent_Identity=36.8794326241135, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=312, Percent_Identity=35.5769230769231, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=32.7160493827161, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=38.5113268608414, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=38.5113268608414, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31648; Mature: 31517

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFPTLEDYVGQTPLVRLQRLNAGRSTVLVKLEGNNPAGSVKDRPALNMIVQAEARGSL
CCCCCCHHHHHCCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHEEEEEECCCCCC
QPGDTIIEATSGNTGIALAMAAAIKGYKMILIMPDNATQERKDSMRAYGAELILVSKEQG
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCC
MEGARDLALQMQQEGKGKVLDQFNNLDNPDAHYRSTGPEIWQQSQGKITHFVSSMGTTGT
CCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCHH
IMGVSRYLKQQNPQIQIIGLQPSEGSAIPGIRRWPQAYLPGIFDAARVDQVLDVTQTDAE
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHCCHH
QTARALAREEGICAGVSSGGAVFAALQIAQQNPGSVVVAIVCDRGDRYLSSGLFS
HHHHHHHHHCCCEEECCCCCCEEEEEEHHCCCCCCEEEEEEECCCCHHHHCCCCC
>Mature Secondary Structure 
SDFPTLEDYVGQTPLVRLQRLNAGRSTVLVKLEGNNPAGSVKDRPALNMIVQAEARGSL
CCCCCHHHHHCCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHEEEEEECCCCCC
QPGDTIIEATSGNTGIALAMAAAIKGYKMILIMPDNATQERKDSMRAYGAELILVSKEQG
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCC
MEGARDLALQMQQEGKGKVLDQFNNLDNPDAHYRSTGPEIWQQSQGKITHFVSSMGTTGT
CCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCHH
IMGVSRYLKQQNPQIQIIGLQPSEGSAIPGIRRWPQAYLPGIFDAARVDQVLDVTQTDAE
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHCCHH
QTARALAREEGICAGVSSGGAVFAALQIAQQNPGSVVVAIVCDRGDRYLSSGLFS
HHHHHHHHHCCCEEECCCCCCEEEEEEHHCCCCCCEEEEEEECCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]