Click here to switch to the map view.

The map label for this gene is fhuA [H]

Identifier: 227080421

GI number: 227080421

Start: 192425

End: 194581

Strand: Direct

Name: fhuA [H]

Synonym: VCM66_0188

Alternate gene names: 227080421

Gene position: 192425-194581 (Clockwise)

Preceding gene: 227080419

Following gene: 227080422

Centisome position: 6.65

GC content: 50.02

Gene sequence:

>2157_bases
TTGCGTAAAATTAATACTAATAAAAATGATTCTCAAATCTATAGCAGAGGTTTTATCATGCGCAATATTCGCCCGAGTCA
GATCGGACAATACATTCGTCGTGCGCTTCGCTTGCACTTCATCCCTGTCGTTTTGGTTGCTGCACCGAGTGTAATGGCCA
ATACCAACCAAGAAACTGAGCAGTTAGAAACCTTAGTGGTGACCGCTTCAGCCTTGAAAGTGGAAACACCCGCTCAAGAA
ACGCCAAAAGCGCTATCGATTGTCACTCAAGAAGAGATTGTGGCTCGCGCGCCACAAAAATTGGATGAAGCGCTGCGCTA
TACCTCCGGCGTCACCGCTCAACCTTATGGCGCGGACAATGATACTGATTGGCTCAAAGTGCGTGGTTTTGATGCTGCTA
CCTATCAAGATGGCAGCCGCCTGTTCCGTGATGGTTACTACACTTGGCTTATCGAACCTTACGCTTTAGAGCGCATTGAA
GTGCTGAAAGGTCCTGCTTCGATTTTGTATGGTGAGGCGCCTCCGGGTGGGGTGGTCAATGCGGTGCAGAAGAAACCGAC
CGACATTCCACAAGGTGAGGTTGGCCTACAAGTGGGCAATGATGCGCTGCGTACGCTAGCCTTAGACATTTCCGATTACG
CGAATCAAGACGGTTCCGTGCGTTACCGTTTAGTCGCGTTGATGAAAGAGAATGATGGGCAGTTGAACGGTACGCAAACC
AGCCGCAACTATCTTGCGCCCAGTCTCAGCATCGATATTTCTGAGCAAACCCGTTTAACCCTGTTGGCGAGCTTTTTGGA
AGACAGCGGTGTGCCGACTAACCCGTTTTTCCCTGCGGCGGGCACCTTAATCGATTCCAACTTTGGTCATATCGATCCCT
CTACCAACTTAGGGCAACCGGATTACGACAAGTATGAGCGTCGTCAGGTGTCATTGGGTTACTTGTTCGAACATGATCTT
AATGATGTCTGGGCGCTGTCACAGACCTTCAATTACGGCGATAACGATCTCTATCTGCGCAGCAGCTACGCTTTCTCGAA
TGATGACCCAAGTAAAGACACATTAACGCAAGGCATAGTGTTCCGTGATGGTTCAACCGAAAGCTTGAGCTTAGATAACA
AAGCGGTGGCGAAGTGGGATTCTGCCCGTGTTGAAAACACGCTGTTGATGGGCTTAGAGCTGCAACGCCACCAGACTCAA
GGTGTTGAGTTAGATAACTACAGCTTTGGCACCATCAATCCGTTCAACCCGATTTATGGCAATTTCACGCCTATCGATGA
ATCTTCCGCAGCGGATCGCACCATTACCAAAGAGCAAGCGAGTTTGTACGCGCAGTACCAAATCAAGCTGGATCAGCAGT
GGATTGGCCTGATTGGCGGCCGTATGGATTGGGTCGATACTGAAAACGAAAGCCAAAAGAACATGCAGCGTAAAAGCCGC
AGCGATGCGGAGTTTTCATTCAATGCGGGTTTGATGTATCTGGCCAGCAATGGTGTATCGCCTTACCTCAGCTATTCACA
ATCGTTTGATGTGCTCAGCACCATCGATAGCGCGACGGGTGAGTTGTATAAGCCACTGAAAGGGGAGCAAACCGAGGTGG
GTGTGAAGTATCAGCCAGAGTTTTATGATGGTTACATCAACTTGGCTTGGTTTGATATCACCCAACAAAATGCGCTGGTG
ACCAACCCAACGACTTTTGTGGCAACGCAAACGGGCGAAATGACCGCCCAAGGTATTGAAGTCGAAAGCGTGGGTTATGT
CACCGATAGCTTGAAACTGACCGCCTGCTACACCTTCACCGATGCCAAAACCGATGAAACGGGTGGCAAGGGCACGCAAC
AAGCTGGTTTGATCCCGAAACATCAAGCGTCAGCGTGGCTGGATTACGATGCGGCGCAGCTTGGTCTGCAAGGTTGGACG
TTTGGCTCCGGCGTACGTTACATCGGTGAGTCGAAAGATAATCCGCGTTCGAGCGATCGTACGGTGCCGAGTGTAACCTT
GGTCGATCTGATGGCGGGCTATGAAATCACAGAAAACTGGCAAGCGCAGCTCAACATCAACAACCTGTTTGATCGCGAGT
TCGTTTCTGGGTGTGATTACTGGTGTTACTACGGCCAATCACGCAGTGCTGTGCTCAGTGCCAACTATCGCTGGTAG

Upstream 100 bases:

>100_bases
AGTTTTTCAAACCATTGGAACATGAACAAGGTGCCTTAATGAAAGTAATTGAGAAAGATTCGCAATTTTTTGCTTTTAAT
TAAGATAATTATCACTAAAA

Downstream 100 bases:

>100_bases
TCGGCAATTGTTGTGAACTTGCCGTTTGGGGTAGCCAATTGTCCGTATTCTTGGATGATTGGCTGCCAGACAACTCCCGC
TTCTGGCGGGATTTGTTGTT

Product: iron(III) compound receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MRKINTNKNDSQIYSRGFIMRNIRPSQIGQYIRRALRLHFIPVVLVAAPSVMANTNQETEQLETLVVTASALKVETPAQE
TPKALSIVTQEEIVARAPQKLDEALRYTSGVTAQPYGADNDTDWLKVRGFDAATYQDGSRLFRDGYYTWLIEPYALERIE
VLKGPASILYGEAPPGGVVNAVQKKPTDIPQGEVGLQVGNDALRTLALDISDYANQDGSVRYRLVALMKENDGQLNGTQT
SRNYLAPSLSIDISEQTRLTLLASFLEDSGVPTNPFFPAAGTLIDSNFGHIDPSTNLGQPDYDKYERRQVSLGYLFEHDL
NDVWALSQTFNYGDNDLYLRSSYAFSNDDPSKDTLTQGIVFRDGSTESLSLDNKAVAKWDSARVENTLLMGLELQRHQTQ
GVELDNYSFGTINPFNPIYGNFTPIDESSAADRTITKEQASLYAQYQIKLDQQWIGLIGGRMDWVDTENESQKNMQRKSR
SDAEFSFNAGLMYLASNGVSPYLSYSQSFDVLSTIDSATGELYKPLKGEQTEVGVKYQPEFYDGYINLAWFDITQQNALV
TNPTTFVATQTGEMTAQGIEVESVGYVTDSLKLTACYTFTDAKTDETGGKGTQQAGLIPKHQASAWLDYDAAQLGLQGWT
FGSGVRYIGESKDNPRSSDRTVPSVTLVDLMAGYEITENWQAQLNINNLFDREFVSGCDYWCYYGQSRSAVLSANYRW

Sequences:

>Translated_718_residues
MRKINTNKNDSQIYSRGFIMRNIRPSQIGQYIRRALRLHFIPVVLVAAPSVMANTNQETEQLETLVVTASALKVETPAQE
TPKALSIVTQEEIVARAPQKLDEALRYTSGVTAQPYGADNDTDWLKVRGFDAATYQDGSRLFRDGYYTWLIEPYALERIE
VLKGPASILYGEAPPGGVVNAVQKKPTDIPQGEVGLQVGNDALRTLALDISDYANQDGSVRYRLVALMKENDGQLNGTQT
SRNYLAPSLSIDISEQTRLTLLASFLEDSGVPTNPFFPAAGTLIDSNFGHIDPSTNLGQPDYDKYERRQVSLGYLFEHDL
NDVWALSQTFNYGDNDLYLRSSYAFSNDDPSKDTLTQGIVFRDGSTESLSLDNKAVAKWDSARVENTLLMGLELQRHQTQ
GVELDNYSFGTINPFNPIYGNFTPIDESSAADRTITKEQASLYAQYQIKLDQQWIGLIGGRMDWVDTENESQKNMQRKSR
SDAEFSFNAGLMYLASNGVSPYLSYSQSFDVLSTIDSATGELYKPLKGEQTEVGVKYQPEFYDGYINLAWFDITQQNALV
TNPTTFVATQTGEMTAQGIEVESVGYVTDSLKLTACYTFTDAKTDETGGKGTQQAGLIPKHQASAWLDYDAAQLGLQGWT
FGSGVRYIGESKDNPRSSDRTVPSVTLVDLMAGYEITENWQAQLNINNLFDREFVSGCDYWCYYGQSRSAVLSANYRW
>Mature_718_residues
MRKINTNKNDSQIYSRGFIMRNIRPSQIGQYIRRALRLHFIPVVLVAAPSVMANTNQETEQLETLVVTASALKVETPAQE
TPKALSIVTQEEIVARAPQKLDEALRYTSGVTAQPYGADNDTDWLKVRGFDAATYQDGSRLFRDGYYTWLIEPYALERIE
VLKGPASILYGEAPPGGVVNAVQKKPTDIPQGEVGLQVGNDALRTLALDISDYANQDGSVRYRLVALMKENDGQLNGTQT
SRNYLAPSLSIDISEQTRLTLLASFLEDSGVPTNPFFPAAGTLIDSNFGHIDPSTNLGQPDYDKYERRQVSLGYLFEHDL
NDVWALSQTFNYGDNDLYLRSSYAFSNDDPSKDTLTQGIVFRDGSTESLSLDNKAVAKWDSARVENTLLMGLELQRHQTQ
GVELDNYSFGTINPFNPIYGNFTPIDESSAADRTITKEQASLYAQYQIKLDQQWIGLIGGRMDWVDTENESQKNMQRKSR
SDAEFSFNAGLMYLASNGVSPYLSYSQSFDVLSTIDSATGELYKPLKGEQTEVGVKYQPEFYDGYINLAWFDITQQNALV
TNPTTFVATQTGEMTAQGIEVESVGYVTDSLKLTACYTFTDAKTDETGGKGTQQAGLIPKHQASAWLDYDAAQLGLQGWT
FGSGVRYIGESKDNPRSSDRTVPSVTLVDLMAGYEITENWQAQLNINNLFDREFVSGCDYWCYYGQSRSAVLSANYRW

Specific function: Ferrioxamine binding and uptake, in association with the tonB protein. May play a role in intestinal colonization [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1786344, Length=686, Percent_Identity=32.798833819242, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1787024, Length=748, Percent_Identity=23.2620320855615, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1787344, Length=751, Percent_Identity=23.1691078561917, Blast_Score=109, Evalue=8e-25,
Organism=Escherichia coli, GI1788478, Length=134, Percent_Identity=35.8208955223881, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010105 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 79995; Mature: 79995

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKINTNKNDSQIYSRGFIMRNIRPSQIGQYIRRALRLHFIPVVLVAAPSVMANTNQETE
CCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHH
QLETLVVTASALKVETPAQETPKALSIVTQEEIVARAPQKLDEALRYTSGVTAQPYGADN
HHHHHEEEEHHEEECCCCHHCCHHHEEHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCC
DTDWLKVRGFDAATYQDGSRLFRDGYYTWLIEPYALERIEVLKGPASILYGEAPPGGVVN
CCCEEEEECCCCCCCCCCHHHHHCCCEEEEECHHHHHHHHHHCCCHHEEECCCCCCHHHH
AVQKKPTDIPQGEVGLQVGNDALRTLALDISDYANQDGSVRYRLVALMKENDGQLNGTQT
HHHCCCCCCCCCCEEEEECCHHHHEEEEEHHHHCCCCCCEEEEEEEEEECCCCCCCCCCC
SRNYLAPSLSIDISEQTRLTLLASFLEDSGVPTNPFFPAAGTLIDSNFGHIDPSTNLGQP
CCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
DYDKYERRQVSLGYLFEHDLNDVWALSQTFNYGDNDLYLRSSYAFSNDDPSKDTLTQGIV
CCHHHHHHEEEEEEEEECCCCHHEEHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHCCEE
FRDGSTESLSLDNKAVAKWDSARVENTLLMGLELQRHQTQGVELDNYSFGTINPFNPIYG
EECCCCCEEECCCHHHHCCCCHHHCCEEEEEEEEHHHHCCCCEECCCCCCCCCCCCCCCC
NFTPIDESSAADRTITKEQASLYAQYQIKLDQQWIGLIGGRMDWVDTENESQKNMQRKSR
CCCCCCCCCCCCCHHHHHHHHEEEEEEEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
SDAEFSFNAGLMYLASNGVSPYLSYSQSFDVLSTIDSATGELYKPLKGEQTEVGVKYQPE
CCCCEEECCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEECEEECCC
FYDGYINLAWFDITQQNALVTNPTTFVATQTGEMTAQGIEVESVGYVTDSLKLTACYTFT
HHCCEEEEEEEEEECCCEEEECCCEEEEECCCCCEECCEEEEEECEEECCEEEEEEEEEE
DAKTDETGGKGTQQAGLIPKHQASAWLDYDAAQLGLQGWTFGSGVRYIGESKDNPRSSDR
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHCCCCEECCCCCEEECCCCCCCCCCCC
TVPSVTLVDLMAGYEITENWQAQLNINNLFDREFVSGCDYWCYYGQSRSAVLSANYRW
CCCCCHHHHHHHCCEECCCCEEEEECCHHHHHHHHCCCCEEEEECCCCCEEEECCCCC
>Mature Secondary Structure
MRKINTNKNDSQIYSRGFIMRNIRPSQIGQYIRRALRLHFIPVVLVAAPSVMANTNQETE
CCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHH
QLETLVVTASALKVETPAQETPKALSIVTQEEIVARAPQKLDEALRYTSGVTAQPYGADN
HHHHHEEEEHHEEECCCCHHCCHHHEEHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCC
DTDWLKVRGFDAATYQDGSRLFRDGYYTWLIEPYALERIEVLKGPASILYGEAPPGGVVN
CCCEEEEECCCCCCCCCCHHHHHCCCEEEEECHHHHHHHHHHCCCHHEEECCCCCCHHHH
AVQKKPTDIPQGEVGLQVGNDALRTLALDISDYANQDGSVRYRLVALMKENDGQLNGTQT
HHHCCCCCCCCCCEEEEECCHHHHEEEEEHHHHCCCCCCEEEEEEEEEECCCCCCCCCCC
SRNYLAPSLSIDISEQTRLTLLASFLEDSGVPTNPFFPAAGTLIDSNFGHIDPSTNLGQP
CCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
DYDKYERRQVSLGYLFEHDLNDVWALSQTFNYGDNDLYLRSSYAFSNDDPSKDTLTQGIV
CCHHHHHHEEEEEEEEECCCCHHEEHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHCCEE
FRDGSTESLSLDNKAVAKWDSARVENTLLMGLELQRHQTQGVELDNYSFGTINPFNPIYG
EECCCCCEEECCCHHHHCCCCHHHCCEEEEEEEEHHHHCCCCEECCCCCCCCCCCCCCCC
NFTPIDESSAADRTITKEQASLYAQYQIKLDQQWIGLIGGRMDWVDTENESQKNMQRKSR
CCCCCCCCCCCCCHHHHHHHHEEEEEEEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
SDAEFSFNAGLMYLASNGVSPYLSYSQSFDVLSTIDSATGELYKPLKGEQTEVGVKYQPE
CCCCEEECCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEECEEECCC
FYDGYINLAWFDITQQNALVTNPTTFVATQTGEMTAQGIEVESVGYVTDSLKLTACYTFT
HHCCEEEEEEEEEECCCEEEECCCEEEEECCCCCEECCEEEEEECEEECCEEEEEEEEEE
DAKTDETGGKGTQQAGLIPKHQASAWLDYDAAQLGLQGWTFGSGVRYIGESKDNPRSSDR
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHCCCCEECCCCCEEECCCCCCCCCCCC
TVPSVTLVDLMAGYEITENWQAQLNINNLFDREFVSGCDYWCYYGQSRSAVLSANYRW
CCCCCHHHHHHHCCEECCCCEEEEECCHHHHHHHHCCCCEEEEECCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258; 7642488 [H]