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The map label for this gene is capL [H]

Identifier: 226950538

GI number: 226950538

Start: 3536927

End: 3538243

Strand: Reverse

Name: capL [H]

Synonym: CLM_3514

Alternate gene names: 226950538

Gene position: 3538243-3536927 (Counterclockwise)

Preceding gene: 226950539

Following gene: 226950537

Centisome position: 85.15

GC content: 29.99

Gene sequence:

>1317_bases
ATGTCACAATTAAAAAAGGATTTAATAACTAAATTAGAAAATAAAACAGCTAAATTGGGTGTAGTAGGATTAGGATATGT
AGGACTTCCACTAGCTGTAGAAAAAGCTAAAGCTGGATTTGAAGTTATAGGTTTTGATGTTCAAGATAAAAAAGTAGAAT
CAGTTAACGAAGGTAAAAACTATATAGGTGATATAGTTGATAATGAATTAGCAGACTTAGTTAAAGAAGGAAAATTAAAA
GCAACAACAGACTTTTCCTTTGTTAGCGAAGTAGATGCAGTGGCTATATGTGTACCAACACCACTAGATTTATATAAACA
ACCAGATATATCTTATGTAGTTAGTTCGACTAAGAGTATTGCAAAATATCTTCATAAAGGTATGCTTGTAGTTCTTGAAA
GTACTACATATCCAGGAACAACAGAAGAAGTTTTAAAACCAATACTTGAAGAAACAGGTTTTAAATGTGGAGAGGATTTC
TTTTTGGGATTTTCACCAGAAAGAGTTGATCCAGGTAACAAGCAATTTAAAACTAAAAACACACCTAAAGTTGTAGGTGG
TTGTACAGAAGATTGTACAGAAGTAGCTGCTATGCTTTATAGAAGTGTTTTAGAAGGGGAAGTATATGTAGTATCTTCAC
CAGCAGTAGCTGAAATGGAAAAAATACTAGAAAACACATTTAGAAATATAAATATAGGATTAGCTAATGAAATGGCTATA
TTATGTAAAAAAATGAACATAGATGTATTTGAAGTTATAGATGCAGCTAAGACAAAACCTTATGGATTTATGGCATTCTA
TCCAGGTCCAGGTCTTGGTGGACACTGCATACCATTAGATCCTTTCTACTTAGAATGGAAAGCTAAAGAATATGACTTCC
ATACAAGATTAATTGAAGTATCAGGAGAAATAAATGATCGTATGCCTGAATTCGTAGTAGAAAATGCTATGAAATTATTA
AATGAAGATAAAAAAGCTATGAATGGATCAAAAGTTTTATTACTTGGATCTGCTTACAAAAATGATATAGATGATATGAG
AGAATCTCCAGCATTAAAAGTAATAGAGCATTTAGAAAAAAATGGAGCTAACGTACAGGTTAATGATCCATATATACCTG
AATTTAAACATAAAGGTAAATTATATAAATCACCAGATTTAGAAAAAGGATTAGAAGAAGCTGATATTGTAATTATAACT
ACAAATCATAGTTGTTATGATTATGAACATATAGTAGAAAAAGCTAAAATCTTATATGATACAAGAAATGCTACAAAGGA
TGTAAAGAATAATAGAGAAAAAATACACAAACTATAA

Upstream 100 bases:

>100_bases
TACAAAATTTAAATATAAAATAATAGTAGTTATGAAATAGTGACAAAAAATTAAAAATATATAAATTAAGCGTTTGTGCG
TTGTACTAGGAGGTATAAAA

Downstream 100 bases:

>100_bases
TATTTAATATTAGGATAAGTTCTTTTGGACTTATCCTAATTAATAAAATTTGGAGGTATAGTGATGAAAAAATTAAAATT
TGCTATTGTTGGTTGTGGAA

Product: UDP-glucose/GDP-mannose dehydrogenase family

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSQLKKDLITKLENKTAKLGVVGLGYVGLPLAVEKAKAGFEVIGFDVQDKKVESVNEGKNYIGDIVDNELADLVKEGKLK
ATTDFSFVSEVDAVAICVPTPLDLYKQPDISYVVSSTKSIAKYLHKGMLVVLESTTYPGTTEEVLKPILEETGFKCGEDF
FLGFSPERVDPGNKQFKTKNTPKVVGGCTEDCTEVAAMLYRSVLEGEVYVVSSPAVAEMEKILENTFRNINIGLANEMAI
LCKKMNIDVFEVIDAAKTKPYGFMAFYPGPGLGGHCIPLDPFYLEWKAKEYDFHTRLIEVSGEINDRMPEFVVENAMKLL
NEDKKAMNGSKVLLLGSAYKNDIDDMRESPALKVIEHLEKNGANVQVNDPYIPEFKHKGKLYKSPDLEKGLEEADIVIIT
TNHSCYDYEHIVEKAKILYDTRNATKDVKNNREKIHKL

Sequences:

>Translated_438_residues
MSQLKKDLITKLENKTAKLGVVGLGYVGLPLAVEKAKAGFEVIGFDVQDKKVESVNEGKNYIGDIVDNELADLVKEGKLK
ATTDFSFVSEVDAVAICVPTPLDLYKQPDISYVVSSTKSIAKYLHKGMLVVLESTTYPGTTEEVLKPILEETGFKCGEDF
FLGFSPERVDPGNKQFKTKNTPKVVGGCTEDCTEVAAMLYRSVLEGEVYVVSSPAVAEMEKILENTFRNINIGLANEMAI
LCKKMNIDVFEVIDAAKTKPYGFMAFYPGPGLGGHCIPLDPFYLEWKAKEYDFHTRLIEVSGEINDRMPEFVVENAMKLL
NEDKKAMNGSKVLLLGSAYKNDIDDMRESPALKVIEHLEKNGANVQVNDPYIPEFKHKGKLYKSPDLEKGLEEADIVIIT
TNHSCYDYEHIVEKAKILYDTRNATKDVKNNREKIHKL
>Mature_437_residues
SQLKKDLITKLENKTAKLGVVGLGYVGLPLAVEKAKAGFEVIGFDVQDKKVESVNEGKNYIGDIVDNELADLVKEGKLKA
TTDFSFVSEVDAVAICVPTPLDLYKQPDISYVVSSTKSIAKYLHKGMLVVLESTTYPGTTEEVLKPILEETGFKCGEDFF
LGFSPERVDPGNKQFKTKNTPKVVGGCTEDCTEVAAMLYRSVLEGEVYVVSSPAVAEMEKILENTFRNINIGLANEMAIL
CKKMNIDVFEVIDAAKTKPYGFMAFYPGPGLGGHCIPLDPFYLEWKAKEYDFHTRLIEVSGEINDRMPEFVVENAMKLLN
EDKKAMNGSKVLLLGSAYKNDIDDMRESPALKVIEHLEKNGANVQVNDPYIPEFKHKGKLYKSPDLEKGLEEADIVIITT
NHSCYDYEHIVEKAKILYDTRNATKDVKNNREKIHKL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=455, Percent_Identity=22.8571428571429, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=36.7647058823529, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI1788340, Length=392, Percent_Identity=22.7040816326531, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560350, Length=380, Percent_Identity=25.2631578947368, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136908, Length=379, Percent_Identity=23.4828496042216, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48862; Mature: 48730

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLKKDLITKLENKTAKLGVVGLGYVGLPLAVEKAKAGFEVIGFDVQDKKVESVNEGKN
CCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHH
YIGDIVDNELADLVKEGKLKATTDFSFVSEVDAVAICVPTPLDLYKQPDISYVVSSTKSI
HHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHH
AKYLHKGMLVVLESTTYPGTTEEVLKPILEETGFKCGEDFFLGFSPERVDPGNKQFKTKN
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCC
TPKVVGGCTEDCTEVAAMLYRSVLEGEVYVVSSPAVAEMEKILENTFRNINIGLANEMAI
CCCEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHH
LCKKMNIDVFEVIDAAKTKPYGFMAFYPGPGLGGHCIPLDPFYLEWKAKEYDFHTRLIEV
HHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCEEEEEECCCCCCEEEEEEE
SGEINDRMPEFVVENAMKLLNEDKKAMNGSKVLLLGSAYKNDIDDMRESPALKVIEHLEK
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHCCCHHHHHHHHHH
NGANVQVNDPYIPEFKHKGKLYKSPDLEKGLEEADIVIITTNHSCYDYEHIVEKAKILYD
CCCEEEECCCCCCCHHHCCCCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
TRNATKDVKNNREKIHKL
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQLKKDLITKLENKTAKLGVVGLGYVGLPLAVEKAKAGFEVIGFDVQDKKVESVNEGKN
CHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHH
YIGDIVDNELADLVKEGKLKATTDFSFVSEVDAVAICVPTPLDLYKQPDISYVVSSTKSI
HHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHH
AKYLHKGMLVVLESTTYPGTTEEVLKPILEETGFKCGEDFFLGFSPERVDPGNKQFKTKN
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCC
TPKVVGGCTEDCTEVAAMLYRSVLEGEVYVVSSPAVAEMEKILENTFRNINIGLANEMAI
CCCEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHH
LCKKMNIDVFEVIDAAKTKPYGFMAFYPGPGLGGHCIPLDPFYLEWKAKEYDFHTRLIEV
HHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCEEEEEECCCCCCEEEEEEE
SGEINDRMPEFVVENAMKLLNEDKKAMNGSKVLLLGSAYKNDIDDMRESPALKVIEHLEK
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHCCCHHHHHHHHHH
NGANVQVNDPYIPEFKHKGKLYKSPDLEKGLEEADIVIITTNHSCYDYEHIVEKAKILYD
CCCEEEECCCCCCCHHHCCCCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
TRNATKDVKNNREKIHKL
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]