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The map label for this gene is hemZ [H]

Identifier: 226950485

GI number: 226950485

Start: 3482401

End: 3483831

Strand: Reverse

Name: hemZ [H]

Synonym: CLM_3461

Alternate gene names: 226950485

Gene position: 3483831-3482401 (Counterclockwise)

Preceding gene: 226950486

Following gene: 226950484

Centisome position: 83.84

GC content: 27.18

Gene sequence:

>1431_bases
ATGAAGCTGAAAATAAATTTAAATGATATGCAGTATAGATACGATGTATATCAAATATTAAATATATATTATAATTTTTA
TGATATCACATTTGTTAATGAAGATTATGATATGAAAATAGAAATAACTGATGAAGGAATGTATATAAAAAAAGAAGATG
GAGAAATAGAATATGAAAAAGATACTAATTTAGCTAAAAAAGAATGGGTAAAAAAATTTCTTTTTTTATATTTAAAATCA
ATTACTAACAAAAATTTGCCTTGGGGGACTTTAGTAGGAATAAGACCAAGTAAGATAGCTTTAGATTTAATGAATAAAGG
AATGGGAGAAAAAGAAATAATAGATTGGTTTAAAAGGCATCGCAATACTAGAGCTGATAAAACTAAATTATGTATAGATA
TCGCTAATATGGAGAAATCCATTGTAAATAAGGATCAAAATACTATAAGTGTATATGTAGGTATGCCGTTTTGTCCAACT
AGATGTCTATATTGTTCCTTTACATCGAATCCAATAGGCAAGTGTAAGAACTTAGTGGAGCCTTATTTAAAGGCTCTTTA
TTATGAAATGGATATGCTTTCAAAATATATACAGCATAAGAGCTTAAAAATACAGTGTGTCTATTTTGGAGGTGGAACCC
CAACTTCTGTTAATAATGCTCAGTTTGAAAAAACATTAAATAAAATATATTATAATTTTGTACATAATAAAGAAGTAGAA
GAATTTACAGTGGAATGCGGAAGGCCAGATAGTATTACAGAGGAAAAATTACTATCAATGAAGAAATATAGTGTAGATAG
AATAAGCATAAATCCCCAAACGATGAATAATAGTACTTTAAAGAATATAGGGAGAACCCACTCTGTAGAAGATATAGAAA
GAATTTATTACTTAGCTAAGAGCATAGGATTTAAGAATATAAACATGGATTTAATAGTAGGTCTCCCAGGTGAGGGAATA
GAGGAAATAAAGAATACTTGCAGGAAGATTAAAAAATTAAATCCTGATAATATAACAGTTCATGGTATGTCAATAAAAAG
AGGCTCTATACTTCATGAAAAGTTAGTTAACAAAATGGAATTTAATATTCCTAAACAGGAAGAATTAAATAAAATGTATG
AAGAAACTGAAGCTTTAGCTAAAGATCTAGGCATGAAGCCTTATTATATGTATAGGCAAAAAAATATGTTGGGAAACATG
GAAAACGTAGGATATTCAAAAGAAAATAAAATAGGTATATATAATATACAAATGATAGAAGAAAGGCAAACCATAATAGC
CTTAGGAGCAGATGCTGTATCTAAAATAATATTTATGGATGAAAATAGGATTGAAAGATCACCTAATGTTAAGGATGTAA
TAGAATATACAAAAAGAGTAGAAGAAATGGTACATAGAAAGAAAAAAATATTAGATACTTTATATTTATAA

Upstream 100 bases:

>100_bases
TTACCAGGTCATGGTCCACAATCTACAATAGGCTATGAAAAAGATAATAATCCATTTTTTTAAATAGATATATCCCTTGA
AAAGCATTGGAGTGCATAAT

Downstream 100 bases:

>100_bases
TGGTTAGGAGGAATATAAATGTCATTGCAAGCGCCAAAAGGTACAAAAGATTTATTGCCTACGGAATCATATAAGTGGCA
ATATTTAGAGAATAAATTTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKLKINLNDMQYRYDVYQILNIYYNFYDITFVNEDYDMKIEITDEGMYIKKEDGEIEYEKDTNLAKKEWVKKFLFLYLKS
ITNKNLPWGTLVGIRPSKIALDLMNKGMGEKEIIDWFKRHRNTRADKTKLCIDIANMEKSIVNKDQNTISVYVGMPFCPT
RCLYCSFTSNPIGKCKNLVEPYLKALYYEMDMLSKYIQHKSLKIQCVYFGGGTPTSVNNAQFEKTLNKIYYNFVHNKEVE
EFTVECGRPDSITEEKLLSMKKYSVDRISINPQTMNNSTLKNIGRTHSVEDIERIYYLAKSIGFKNINMDLIVGLPGEGI
EEIKNTCRKIKKLNPDNITVHGMSIKRGSILHEKLVNKMEFNIPKQEELNKMYEETEALAKDLGMKPYYMYRQKNMLGNM
ENVGYSKENKIGIYNIQMIEERQTIIALGADAVSKIIFMDENRIERSPNVKDVIEYTKRVEEMVHRKKKILDTLYL

Sequences:

>Translated_476_residues
MKLKINLNDMQYRYDVYQILNIYYNFYDITFVNEDYDMKIEITDEGMYIKKEDGEIEYEKDTNLAKKEWVKKFLFLYLKS
ITNKNLPWGTLVGIRPSKIALDLMNKGMGEKEIIDWFKRHRNTRADKTKLCIDIANMEKSIVNKDQNTISVYVGMPFCPT
RCLYCSFTSNPIGKCKNLVEPYLKALYYEMDMLSKYIQHKSLKIQCVYFGGGTPTSVNNAQFEKTLNKIYYNFVHNKEVE
EFTVECGRPDSITEEKLLSMKKYSVDRISINPQTMNNSTLKNIGRTHSVEDIERIYYLAKSIGFKNINMDLIVGLPGEGI
EEIKNTCRKIKKLNPDNITVHGMSIKRGSILHEKLVNKMEFNIPKQEELNKMYEETEALAKDLGMKPYYMYRQKNMLGNM
ENVGYSKENKIGIYNIQMIEERQTIIALGADAVSKIIFMDENRIERSPNVKDVIEYTKRVEEMVHRKKKILDTLYL
>Mature_476_residues
MKLKINLNDMQYRYDVYQILNIYYNFYDITFVNEDYDMKIEITDEGMYIKKEDGEIEYEKDTNLAKKEWVKKFLFLYLKS
ITNKNLPWGTLVGIRPSKIALDLMNKGMGEKEIIDWFKRHRNTRADKTKLCIDIANMEKSIVNKDQNTISVYVGMPFCPT
RCLYCSFTSNPIGKCKNLVEPYLKALYYEMDMLSKYIQHKSLKIQCVYFGGGTPTSVNNAQFEKTLNKIYYNFVHNKEVE
EFTVECGRPDSITEEKLLSMKKYSVDRISINPQTMNNSTLKNIGRTHSVEDIERIYYLAKSIGFKNINMDLIVGLPGEGI
EEIKNTCRKIKKLNPDNITVHGMSIKRGSILHEKLVNKMEFNIPKQEELNKMYEETEALAKDLGMKPYYMYRQKNMLGNM
ENVGYSKENKIGIYNIQMIEERQTIIALGADAVSKIIFMDENRIERSPNVKDVIEYTKRVEEMVHRKKKILDTLYL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=241, Percent_Identity=26.1410788381743, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1789325, Length=299, Percent_Identity=24.7491638795987, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082341, Length=302, Percent_Identity=24.1721854304636, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 55834; Mature: 55834

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKINLNDMQYRYDVYQILNIYYNFYDITFVNEDYDMKIEITDEGMYIKKEDGEIEYEK
CEEEEECCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEEECCCEEEEECCCCEEECC
DTNLAKKEWVKKFLFLYLKSITNKNLPWGTLVGIRPSKIALDLMNKGMGEKEIIDWFKRH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
RNTRADKTKLCIDIANMEKSIVNKDQNTISVYVGMPFCPTRCLYCSFTSNPIGKCKNLVE
CCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHH
PYLKALYYEMDMLSKYIQHKSLKIQCVYFGGGTPTSVNNAQFEKTLNKIYYNFVHNKEVE
HHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
EFTVECGRPDSITEEKLLSMKKYSVDRISINPQTMNNSTLKNIGRTHSVEDIERIYYLAK
HHHHCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHH
SIGFKNINMDLIVGLPGEGIEEIKNTCRKIKKLNPDNITVHGMSIKRGSILHEKLVNKME
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHH
FNIPKQEELNKMYEETEALAKDLGMKPYYMYRQKNMLGNMENVGYSKENKIGIYNIQMIE
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHHCCCCCCCCEEEEEEEEEE
ERQTIIALGADAVSKIIFMDENRIERSPNVKDVIEYTKRVEEMVHRKKKILDTLYL
CCCEEEEECHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLKINLNDMQYRYDVYQILNIYYNFYDITFVNEDYDMKIEITDEGMYIKKEDGEIEYEK
CEEEEECCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEEECCCEEEEECCCCEEECC
DTNLAKKEWVKKFLFLYLKSITNKNLPWGTLVGIRPSKIALDLMNKGMGEKEIIDWFKRH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
RNTRADKTKLCIDIANMEKSIVNKDQNTISVYVGMPFCPTRCLYCSFTSNPIGKCKNLVE
CCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHH
PYLKALYYEMDMLSKYIQHKSLKIQCVYFGGGTPTSVNNAQFEKTLNKIYYNFVHNKEVE
HHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
EFTVECGRPDSITEEKLLSMKKYSVDRISINPQTMNNSTLKNIGRTHSVEDIERIYYLAK
HHHHCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHH
SIGFKNINMDLIVGLPGEGIEEIKNTCRKIKKLNPDNITVHGMSIKRGSILHEKLVNKME
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHH
FNIPKQEELNKMYEETEALAKDLGMKPYYMYRQKNMLGNMENVGYSKENKIGIYNIQMIE
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHHCCCCCCCCEEEEEEEEEE
ERQTIIALGADAVSKIIFMDENRIERSPNVKDVIEYTKRVEEMVHRKKKILDTLYL
CCCEEEEECHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]