| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
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The map label for this gene is polA [H]
Identifier: 226950437
GI number: 226950437
Start: 3440204
End: 3442831
Strand: Reverse
Name: polA [H]
Synonym: CLM_3411
Alternate gene names: 226950437
Gene position: 3442831-3440204 (Counterclockwise)
Preceding gene: 226950438
Following gene: 226950436
Centisome position: 82.85
GC content: 27.02
Gene sequence:
>2628_bases ATGAATAAAGAAAGATTATTAATATTAGATAGTAATAGTTTATTAAATAGAGCTTTTTATGCATTACCTGATCTTATGAC TGGAGAGGGAATTCATACTAATGCTATATATGGTTTTGTTAATATGCTTTTAAAAATGAAAGAAGAGATAAACCCAGATT ATATAGTTGCAGCTTTTGATAGAAAGGCACCTACCTTTAGACATGAAGAATATAAGGACTACAAAGCAGGTAGAAAAAAG ATGCCAGAGGAACTTGCACAGCAGTTTCCTATAGTAAAAGAGCTTTTGTCCGCATTAGCCATAAATATATTCGAAATTGA TGGATTTGAAGCAGACGATCTAATAGGAACTTTATCTGTATTTGCAGAGGAAAAAGGAATAGAAGTTTACATAGTTACAG GAGATAAAGATGCCCTACAATTGGCTACAGATAATGTAAAAGTAGTTATAACTAAAAAGGGTATTACAGAAAAAGAAATT TATGATAAAAATAGAATGATAGAAGAGTTTGGAGTTACTCCTAAAGAATTTATAGATGTAAAAGGTCTTATGGGAGACAC ATCTGACAATATACCTGGAGTACCTGGAATAGGTGAAAAAACCGCCTTTAAGCTTATAAAAGAATATAAAAGTATAGAAA CAGTACTTGAAAACATAGAGAATATAAAAGGGAAAAAATTAAAGGAAAATTTACATGAATATAGAGAACAGGCTATATTT AGCAAAAAATTAGCTACTATTATATGTAATGTTCCTATAGATATGAGTTTAGAAGATATAAAATCAAAGGAAGAATATGA TATAAACAAAGTTAGAAAAATGTTTGAAAGGTTAGAATTTAAATCTTTAATGAATAAAGTAAGCAAAAGTGATGAGGAAG AAACTGTAGAAGAGGAAGTTTCTTATAAAAATATAGTTTCTCTAGAAGAATTTAAAGATCTAAAAAATAATATAATAAAA TATAAAGAAAATGATTTATATCTGTATTTTGAATTAGAAGATATAGTTTTATTTTCTAAATCTAGAGTAAAAACATTATA TGCTAATTTTAAAGATGAAGTTTATAGAATAGACTTTGAAATGTTGCTAAATAATACTAAAGAACAATTTATAGAAGTAT GCAGGGAAATGTTTGAGAGTAAAGAAATTAAAAAAATTACCTATAATGCAAAAAATCCAAGGACTATACTAAGAAAATTA GGAATAGATTTTAATGGTATAAAATTTGATATAAATTTAGCTGCATACCTAATAGATCCAGTGAGGAAAGAATATGAGAT ATCTAGTTTAGCTTCAGAATATTTGTTTAAAAATATAAATAGAGAAGATGAATTTTTAAAAATAAAAGAAGTTAATATAA TGCCTAATTTATATAAAGTGCTGGAAGAAAAAATAAAAGATCAAGATATGGAAGAATTGCTATATAAGGTAGAACAACCT CTTACAGAAACATTATCAGCTATGGAAACAGAAGGTTTTAAAGTTGATAAAGATATACTTTTACAGCTAGAGAAAAAATT TAAAGGGGAAATAGAAAGTACTCAGCTAGAAATATATTCAATGTCTGAAGAAAAATTTAATATAAATTCTCCTAAACAGT TAGGGAAAATACTCTTTGAAAAATTAGATTTACCTGTTATAAAGAAAACAAAGACAGGATATTCTACTAATGCAGAGGTA CTGGATAAATTAAGAGATAAACATCCAATAATAGATAAAATAACTTATTATAGACAATTAACAAAAATATACTCTACTTA TATAGAAGGGCTAAAAGCTGCTATAGATGAGGATGGAAAAATACATTCAAATTTTAATCAAACTGTTACAGCTACAGGGA GATTATCTAGTACAGAGCCTAATCTTCAAAATATACCTATAAAATATGAAATGGGAAGAGAAATAAGAAAGGTATTTATC CCTAATACAGGGGATTCTGTAATACTTTCAGCGGATTATTCACAAATAGAATTAAGAGTATTAGCACATATATCTGATGA TAAAAATATGATAAGTGCATTTAATGAACATGATGATATTCATACTAAAACTGCATCAGAAGTGTTTAAAGTTCCAATAG AAGAAGTAACACCTCTTATGAGAAGTAACGCTAAAGCAGTTAATTTTGGTATAGTTTATGGTATAGGAGACTTTAGCTTA TCTCAAGATTTAAATATAACTAGAAAAGAAGCAAAGCAGTATATAGATGCTTATTTGGAGAGATATCCTAATGTAAAACT TTATTTAGAAAATATAGTAGAAGAAGCCGTTGAAAAAGGGTATGTAAGTACTATATTAAATAGAAGAAGATATATAAAAG AGGTTAAGTCTTCAAATAAAATAGTTAAAGCTGCAGGGGAAAGGCTAGCTATGAATAGTCCAATCCAAGGAAGTGCAGCA GATATAATAAAATTAGCTATGGTAAATGTTCATAGAAAATTAAAAGAAGATAATTTTAAAAGTAGTATAATATTACAAGT ACATGATGAATTAATATTAAATGTTCATAAAGATGAACTAGAAAGAATCAAAGCTTTAGTAAAAAAAGAAATGGAACAGG TTTTAGAATTAAAAGTTGGGTTAGACGTGGATATAAACATAGGTAATAATTGGTATGAAGCAAAGTAG
Upstream 100 bases:
>100_bases CATTTGAAATATTAAAAGAAATTTTGAATACATATCCCTGTGATGATTTCAATATGTTAAAAAAATACATGAGAGAAATG TAAAATTTGGAGGTTCATTT
Downstream 100 bases:
>100_bases GGAGTTGTTTTATGTATTGCTTAAAAAGTATTTTTAAAATTGGTCTTACAGGTGGTATAGGTGCTGGTAAAAGTACTATA TCAGAAATGATAAAAGAAAA
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 875; Mature: 875
Protein sequence:
>875_residues MNKERLLILDSNSLLNRAFYALPDLMTGEGIHTNAIYGFVNMLLKMKEEINPDYIVAAFDRKAPTFRHEEYKDYKAGRKK MPEELAQQFPIVKELLSALAINIFEIDGFEADDLIGTLSVFAEEKGIEVYIVTGDKDALQLATDNVKVVITKKGITEKEI YDKNRMIEEFGVTPKEFIDVKGLMGDTSDNIPGVPGIGEKTAFKLIKEYKSIETVLENIENIKGKKLKENLHEYREQAIF SKKLATIICNVPIDMSLEDIKSKEEYDINKVRKMFERLEFKSLMNKVSKSDEEETVEEEVSYKNIVSLEEFKDLKNNIIK YKENDLYLYFELEDIVLFSKSRVKTLYANFKDEVYRIDFEMLLNNTKEQFIEVCREMFESKEIKKITYNAKNPRTILRKL GIDFNGIKFDINLAAYLIDPVRKEYEISSLASEYLFKNINREDEFLKIKEVNIMPNLYKVLEEKIKDQDMEELLYKVEQP LTETLSAMETEGFKVDKDILLQLEKKFKGEIESTQLEIYSMSEEKFNINSPKQLGKILFEKLDLPVIKKTKTGYSTNAEV LDKLRDKHPIIDKITYYRQLTKIYSTYIEGLKAAIDEDGKIHSNFNQTVTATGRLSSTEPNLQNIPIKYEMGREIRKVFI PNTGDSVILSADYSQIELRVLAHISDDKNMISAFNEHDDIHTKTASEVFKVPIEEVTPLMRSNAKAVNFGIVYGIGDFSL SQDLNITRKEAKQYIDAYLERYPNVKLYLENIVEEAVEKGYVSTILNRRRYIKEVKSSNKIVKAAGERLAMNSPIQGSAA DIIKLAMVNVHRKLKEDNFKSSIILQVHDELILNVHKDELERIKALVKKEMEQVLELKVGLDVDINIGNNWYEAK
Sequences:
>Translated_875_residues MNKERLLILDSNSLLNRAFYALPDLMTGEGIHTNAIYGFVNMLLKMKEEINPDYIVAAFDRKAPTFRHEEYKDYKAGRKK MPEELAQQFPIVKELLSALAINIFEIDGFEADDLIGTLSVFAEEKGIEVYIVTGDKDALQLATDNVKVVITKKGITEKEI YDKNRMIEEFGVTPKEFIDVKGLMGDTSDNIPGVPGIGEKTAFKLIKEYKSIETVLENIENIKGKKLKENLHEYREQAIF SKKLATIICNVPIDMSLEDIKSKEEYDINKVRKMFERLEFKSLMNKVSKSDEEETVEEEVSYKNIVSLEEFKDLKNNIIK YKENDLYLYFELEDIVLFSKSRVKTLYANFKDEVYRIDFEMLLNNTKEQFIEVCREMFESKEIKKITYNAKNPRTILRKL GIDFNGIKFDINLAAYLIDPVRKEYEISSLASEYLFKNINREDEFLKIKEVNIMPNLYKVLEEKIKDQDMEELLYKVEQP LTETLSAMETEGFKVDKDILLQLEKKFKGEIESTQLEIYSMSEEKFNINSPKQLGKILFEKLDLPVIKKTKTGYSTNAEV LDKLRDKHPIIDKITYYRQLTKIYSTYIEGLKAAIDEDGKIHSNFNQTVTATGRLSSTEPNLQNIPIKYEMGREIRKVFI PNTGDSVILSADYSQIELRVLAHISDDKNMISAFNEHDDIHTKTASEVFKVPIEEVTPLMRSNAKAVNFGIVYGIGDFSL SQDLNITRKEAKQYIDAYLERYPNVKLYLENIVEEAVEKGYVSTILNRRRYIKEVKSSNKIVKAAGERLAMNSPIQGSAA DIIKLAMVNVHRKLKEDNFKSSIILQVHDELILNVHKDELERIKALVKKEMEQVLELKVGLDVDINIGNNWYEAK >Mature_875_residues MNKERLLILDSNSLLNRAFYALPDLMTGEGIHTNAIYGFVNMLLKMKEEINPDYIVAAFDRKAPTFRHEEYKDYKAGRKK MPEELAQQFPIVKELLSALAINIFEIDGFEADDLIGTLSVFAEEKGIEVYIVTGDKDALQLATDNVKVVITKKGITEKEI YDKNRMIEEFGVTPKEFIDVKGLMGDTSDNIPGVPGIGEKTAFKLIKEYKSIETVLENIENIKGKKLKENLHEYREQAIF SKKLATIICNVPIDMSLEDIKSKEEYDINKVRKMFERLEFKSLMNKVSKSDEEETVEEEVSYKNIVSLEEFKDLKNNIIK YKENDLYLYFELEDIVLFSKSRVKTLYANFKDEVYRIDFEMLLNNTKEQFIEVCREMFESKEIKKITYNAKNPRTILRKL GIDFNGIKFDINLAAYLIDPVRKEYEISSLASEYLFKNINREDEFLKIKEVNIMPNLYKVLEEKIKDQDMEELLYKVEQP LTETLSAMETEGFKVDKDILLQLEKKFKGEIESTQLEIYSMSEEKFNINSPKQLGKILFEKLDLPVIKKTKTGYSTNAEV LDKLRDKHPIIDKITYYRQLTKIYSTYIEGLKAAIDEDGKIHSNFNQTVTATGRLSSTEPNLQNIPIKYEMGREIRKVFI PNTGDSVILSADYSQIELRVLAHISDDKNMISAFNEHDDIHTKTASEVFKVPIEEVTPLMRSNAKAVNFGIVYGIGDFSL SQDLNITRKEAKQYIDAYLERYPNVKLYLENIVEEAVEKGYVSTILNRRRYIKEVKSSNKIVKAAGERLAMNSPIQGSAA DIIKLAMVNVHRKLKEDNFKSSIILQVHDELILNVHKDELERIKALVKKEMEQVLELKVGLDVDINIGNNWYEAK
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=571, Percent_Identity=31.3485113835377, Blast_Score=261, Evalue=2e-69, Organism=Homo sapiens, GI139394648, Length=646, Percent_Identity=25.8513931888545, Blast_Score=219, Evalue=1e-56, Organism=Escherichia coli, GI1790294, Length=933, Percent_Identity=35.6913183279743, Blast_Score=535, Evalue=1e-153, Organism=Escherichia coli, GI226510970, Length=212, Percent_Identity=32.5471698113208, Blast_Score=127, Evalue=4e-30, Organism=Caenorhabditis elegans, GI86563272, Length=392, Percent_Identity=30.1020408163265, Blast_Score=184, Evalue=1e-46, Organism=Drosophila melanogaster, GI17933644, Length=426, Percent_Identity=33.8028169014084, Blast_Score=231, Evalue=2e-60,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR003583 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 101125; Mature: 101125
Theoretical pI: Translated: 5.21; Mature: 5.21
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNKERLLILDSNSLLNRAFYALPDLMTGEGIHTNAIYGFVNMLLKMKEEINPDYIVAAFD CCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEC RKAPTFRHEEYKDYKAGRKKMPEELAQQFPIVKELLSALAINIFEIDGFEADDLIGTLSV CCCCCCCCHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH FAEEKGIEVYIVTGDKDALQLATDNVKVVITKKGITEKEIYDKNRMIEEFGVTPKEFIDV HHCCCCCEEEEEECCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHH KGLMGDTSDNIPGVPGIGEKTAFKLIKEYKSIETVLENIENIKGKKLKENLHEYREQAIF HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH SKKLATIICNVPIDMSLEDIKSKEEYDINKVRKMFERLEFKSLMNKVSKSDEEETVEEEV HHHHHHHEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH SYKNIVSLEEFKDLKNNIIKYKENDLYLYFELEDIVLFSKSRVKTLYANFKDEVYRIDFE HHHHHHHHHHHHHHHHHHCEEECCCEEEEEEEHHHHEECHHHHHHHHHHHCHHHHEEHHH MLLNNTKEQFIEVCREMFESKEIKKITYNAKNPRTILRKLGIDFNGIKFDINLAAYLIDP HHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHH VRKEYEISSLASEYLFKNINREDEFLKIKEVNIMPNLYKVLEEKIKDQDMEELLYKVEQP HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH LTETLSAMETEGFKVDKDILLQLEKKFKGEIESTQLEIYSMSEEKFNINSPKQLGKILFE HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH KLDLPVIKKTKTGYSTNAEVLDKLRDKHPIIDKITYYRQLTKIYSTYIEGLKAAIDEDGK HCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC IHSNFNQTVTATGRLSSTEPNLQNIPIKYEMGREIRKVFIPNTGDSVILSADYSQIELRV EECCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHEECCCCCCCEEEECCCCCEEEEE LAHISDDKNMISAFNEHDDIHTKTASEVFKVPIEEVTPLMRSNAKAVNFGIVYGIGDFSL EEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEEEECCCCC SQDLNITRKEAKQYIDAYLERYPNVKLYLENIVEEAVEKGYVSTILNRRRYIKEVKSSNK CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH IVKAAGERLAMNSPIQGSAADIIKLAMVNVHRKLKEDNFKSSIILQVHDELILNVHKDEL HHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCHHHH ERIKALVKKEMEQVLELKVGLDVDINIGNNWYEAK HHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCC >Mature Secondary Structure MNKERLLILDSNSLLNRAFYALPDLMTGEGIHTNAIYGFVNMLLKMKEEINPDYIVAAFD CCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEC RKAPTFRHEEYKDYKAGRKKMPEELAQQFPIVKELLSALAINIFEIDGFEADDLIGTLSV CCCCCCCCHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH FAEEKGIEVYIVTGDKDALQLATDNVKVVITKKGITEKEIYDKNRMIEEFGVTPKEFIDV HHCCCCCEEEEEECCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHH KGLMGDTSDNIPGVPGIGEKTAFKLIKEYKSIETVLENIENIKGKKLKENLHEYREQAIF HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH SKKLATIICNVPIDMSLEDIKSKEEYDINKVRKMFERLEFKSLMNKVSKSDEEETVEEEV HHHHHHHEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH SYKNIVSLEEFKDLKNNIIKYKENDLYLYFELEDIVLFSKSRVKTLYANFKDEVYRIDFE HHHHHHHHHHHHHHHHHHCEEECCCEEEEEEEHHHHEECHHHHHHHHHHHCHHHHEEHHH MLLNNTKEQFIEVCREMFESKEIKKITYNAKNPRTILRKLGIDFNGIKFDINLAAYLIDP HHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHH VRKEYEISSLASEYLFKNINREDEFLKIKEVNIMPNLYKVLEEKIKDQDMEELLYKVEQP HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH LTETLSAMETEGFKVDKDILLQLEKKFKGEIESTQLEIYSMSEEKFNINSPKQLGKILFE HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH KLDLPVIKKTKTGYSTNAEVLDKLRDKHPIIDKITYYRQLTKIYSTYIEGLKAAIDEDGK HCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC IHSNFNQTVTATGRLSSTEPNLQNIPIKYEMGREIRKVFIPNTGDSVILSADYSQIELRV EECCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHEECCCCCCCEEEECCCCCEEEEE LAHISDDKNMISAFNEHDDIHTKTASEVFKVPIEEVTPLMRSNAKAVNFGIVYGIGDFSL EEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEEEECCCCC SQDLNITRKEAKQYIDAYLERYPNVKLYLENIVEEAVEKGYVSTILNRRRYIKEVKSSNK CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH IVKAAGERLAMNSPIQGSAADIIKLAMVNVHRKLKEDNFKSSIILQVHDELILNVHKDEL HHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCHHHH ERIKALVKKEMEQVLELKVGLDVDINIGNNWYEAK HHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]