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The map label for this gene is napA [H]

Identifier: 226950267

GI number: 226950267

Start: 3250308

End: 3251525

Strand: Reverse

Name: napA [H]

Synonym: CLM_3227

Alternate gene names: 226950267

Gene position: 3251525-3250308 (Counterclockwise)

Preceding gene: 226950268

Following gene: 226950266

Centisome position: 78.25

GC content: 31.12

Gene sequence:

>1218_bases
TTGTTATCTTATGAATTCTTATTAGATCTTGCGCTTATATTATTAAGTACAAAAGTCTTAGGTATGGTTACTAAAAAATT
ACACATGCCTAGGGTTGTAGGTGCATTATTAGCAGGTCTTATACTAGGACCATGTGTACTAAATATAGTACATGAAACTG
ATTTTCTAGCGAAAATGGCCCAACTAGGAGTAATTATTTTAATGTTTTCAGCAGGCTTACAAACAGATCTGAAGGAATTA
AAAAAATGTGGTAGGGCTTCTTTGATTATTGCTATATTAGGAACGGTTGTCCCTTTATTAGGGGGATACTTTGTATCAGC
ACTATTCTTTGATTCTAATGGGATCTTTGATATAACTTCAAAAGTATTTATTAAGAATTTTTTTATTGGGGTAATATTAA
CTGCTACTTCTGTTAGTATTACTGTGGAAACTTTACAAGAACTAGGCAGATTGAAAACACGTTCTGGAACAGCTATATTA
GGGGCAGCAATTATTGATGATATTTTAGGAATAATCATTTTAACTATGGTTACAAGTTCTACAAATAATTCAACAAGTAT
TAATTTAGTGCTTCTAAAAATTGTAGCATTTTTTATATTATCTACTATCTGTGGAGCAGTGTTGCATCACATTTTCAATA
AAATTTATAAACGTTATGGTAATATAAGTGGAATTTCAGTTGTTATATTTTCTTTTTGTCTAATTATGGCCTTTATTGCA
GAGCACTTTTTTGGGGTAGCAGATATAACAGGTGCTTTTATAGCTGGAGTTATTATTTCAAATACGTCTTTTCGTGAGCA
TGCAGAAAAAAATTTCGAAGTAATTTCCTATATGCTTTTATCTCCTGTATTTTTTGCCAGTATAGGTTTAAATACAACAA
TCAAGCATATGAATAATAAAATGAGGCTGTTTACAATTGCATTATTACTAATAGCCATATTGGCAAAAATCATAGGGTGT
TTTATAGGAGGGAGAATTTGCAAATACACATATGCTGAATCTCTTAGAATCGGAATTGGAATGATATCACGTGGAGAAGT
TGCCCTAATAATTGCAAAGAAAGGTGCCGCATTAGGTTTGATAGAAGCACAATTCTTCGGACCAATAGTTTTTGTAGTTA
TAGCAACTACCCTTATAACACCTATATTATTAAAGATGGTGTATAGTACTAAATTCAATGATATTAAAGCATATGATTCT
TTGCATAGTGCTGCTTAA

Upstream 100 bases:

>100_bases
TTTGGAAAAAAGGTATCTATAAAAATTAATTGAACTTAGCGTTACAATTTTGCTTAACTAAGTCAAAACCTATAATAATA
CTTTAAAGGAGGAGTTAAAT

Downstream 100 bases:

>100_bases
TATTCATGAATAAGATAAATTTTATCCTAGAAACTTTATAAATGCTTTCAAAGGTAGAACTTAATTTATATATATCTTAA
CCTTTCAATGATTCAACTAG

Product: CPA2 family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLSYEFLLDLALILLSTKVLGMVTKKLHMPRVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKVFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTMVTSSTNNSTSINLVLLKIVAFFILSTICGAVLHHIFNKIYKRYGNISGISVVIFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHAEKNFEVISYMLLSPVFFASIGLNTTIKHMNNKMRLFTIALLLIAILAKIIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGPIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA

Sequences:

>Translated_405_residues
MLSYEFLLDLALILLSTKVLGMVTKKLHMPRVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKVFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTMVTSSTNNSTSINLVLLKIVAFFILSTICGAVLHHIFNKIYKRYGNISGISVVIFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHAEKNFEVISYMLLSPVFFASIGLNTTIKHMNNKMRLFTIALLLIAILAKIIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGPIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA
>Mature_405_residues
MLSYEFLLDLALILLSTKVLGMVTKKLHMPRVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKVFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTMVTSSTNNSTSINLVLLKIVAFFILSTICGAVLHHIFNKIYKRYGNISGISVVIFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHAEKNFEVISYMLLSPVFFASIGLNTTIKHMNNKMRLFTIALLLIAILAKIIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGPIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=382, Percent_Identity=24.3455497382199, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786232, Length=379, Percent_Identity=23.2189973614776, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789749, Length=410, Percent_Identity=21.9512195121951, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=417, Percent_Identity=27.0983213429257, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43866; Mature: 43866

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYEFLLDLALILLSTKVLGMVTKKLHMPRVVGALLAGLILGPCVLNIVHETDFLAKMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGVIILMFSAGLQTDLKELKKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITS
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
KVFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAILGAAIIDDILGIIILTMVTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TNNSTSINLVLLKIVAFFILSTICGAVLHHIFNKIYKRYGNISGISVVIFSFCLIMAFIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EHFFGVADITGAFIAGVIISNTSFREHAEKNFEVISYMLLSPVFFASIGLNTTIKHMNNK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCH
MRLFTIALLLIAILAKIIGCFIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEEH
IEAQFFGPIVFVVIATTLITPILLKMVYSTKFNDIKAYDSLHSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLSYEFLLDLALILLSTKVLGMVTKKLHMPRVVGALLAGLILGPCVLNIVHETDFLAKMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGVIILMFSAGLQTDLKELKKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITS
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
KVFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAILGAAIIDDILGIIILTMVTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TNNSTSINLVLLKIVAFFILSTICGAVLHHIFNKIYKRYGNISGISVVIFSFCLIMAFIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EHFFGVADITGAFIAGVIISNTSFREHAEKNFEVISYMLLSPVFFASIGLNTTIKHMNNK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCH
MRLFTIALLLIAILAKIIGCFIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEEH
IEAQFFGPIVFVVIATTLITPILLKMVYSTKFNDIKAYDSLHSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]