| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
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The map label for this gene is uvrA [H]
Identifier: 226950233
GI number: 226950233
Start: 3206079
End: 3208337
Strand: Reverse
Name: uvrA [H]
Synonym: CLM_3187
Alternate gene names: 226950233
Gene position: 3208337-3206079 (Counterclockwise)
Preceding gene: 226950235
Following gene: 226950232
Centisome position: 77.21
GC content: 30.19
Gene sequence:
>2259_bases ATGGATATAAAAGAAAGTATTTATGTAGCGGGAGCTAGAGAAAAAAATTTGAAAAATATTGATATTGAAATACCCAAGAA AAAAATTACCGTGTTTACTGGGGTTTCTGGTTCAGGTAAATCATCTTTAGTTTTTGATACTATTGCTGCAGAATCACAAA GGCAGCTAAACGAAACTTATTCTAGCTTTATAAGGCATCGTTTGCCCCATTATGGACAACCGGATGTAGATTCTATTAAA AATTTATCTGTTGCTATTATTATAAATCAAAAAAGAATTGGTGGAAATTCAAGATCAACTGTAGGGACTATTACAGATAT AGCGCCATTATTAAGGCTCCTTTTTTCACGAATAGGAAAACCTTTTGTTGGATATTCTGATGTTTTTTCTTTTAATAATC CTAATGGAATGTGTATGAATTGCGATGGATTAGGTAAGGTTGATAGCATTAATATTGATAAATTATTAGATAAAAATAAA TCTCTTAATGAAGGAGCTATCTTGTTCCCTACCTTTAAACCTGGCGGATGGCGTTTAAAGAGATATATACATTCAGGATT ATTTGACAATAATAAAAAAATAAAAGATTATGATGAAAAAGAATTAGATTTACTTTTAAATAAAACTGATATAAAGATTG AAAAAGGTGATCCAGAATGGCCAAAGACATCTTTGTACGAAGGTCTTATACCAAGAATTGAAAGAAGCTTTTTAAAAAAA GAAGGTGGAGAAAGAGAGAAATATAAAAAAGAAATTAATAAAATTGTTACTAAAGAAATATGTCCTGTGTGTAGAGGTGC AAGATTAAATGAAAAAATATTATCTTGCAAAATTAATGGGAAAAATATTGCGGATTGTACAAAGATGCAAATAAATGATT TAATAATATTTATGAAAGAAATTAAAGAACAATCTGCTCAAACTGTATTAAAAGCCCTAATTAGCCGATTAGAGCATTTA GAGTACATAGGATTGGGATATTTGAGTTTAGATCGTGAAACTTCATCACTTTCTGGTGGTGAATCACAGAGAATTAAAAT GGTTAAACAATTGGGAAGCAGTTTAACAGGACTTACTTATATTTTTGATGAGCCTAGTATTGGATTACATCCGCATGATA TTGGTAGAATAAATAAATTGTTAAAGATGTTAAGAGATAAAGGAAACACTGTTCTCATTGTTGAGCATGATCCTGATATA ATAAAGATTGCAGACTATATTATTGATATGGGCCCAAAGGCTGGTATAGAAGGTGGTAACATTGTTTATAAAGGAACTCC AGAAGGATTATTACAATCCAATACTCTAACAGGTAAGGCTTTGCAGTATAAACCACAAATAAAACTTCATACTAGGAAAG CAAAAGGATGGTTATCAATTAAAAATGCAAATTTACATAATCTAAAAAATATTAACGTAGATATTCCCAAAGGTGTTATG ACTGTAGTAACAGGTGTAGCTGGCTCAGGTAAGAGTACTCTTATTAATGGATTATTGCCAAAAATTTATCCAGAAACAAT TTTTATAGATCAAGGAGCAATACATGCTTCAATACGTTCCAATATTGCCACTTATACAGGTATATTTGATTTTATAAGAA ATTTATTTGCTAAAGAAAATAATGTTAAATCCTCTCTTTTTAGTTTTAACTCAGAAGGAGCATGCCCAGAGTGCAAAGGA TTAGGTGTTACTTATACTGATTTAGCTTTTATGGATACTGTTATAAGTACCTGTGAAGTTTGTGAAGGAAATAGATTTAC AGATAAAGTATTAAATTTTAAATTTAGGGGAAAAAATATAAGCCAAGTTTTAAAGATGACTGTTGCTGAGGCAATTGACT TTTTTAAAGAAGATGAAATATATTTAGTGTTAAGAAGGTTAGTTGATGTAGGAATTGATTATATAGCTTTAGGGCAACCA TTGAATACTTTATCAGGAGGAGAATTACAGAGATTAAAATTAGCTGCTCAATTAGATAGTAAAGGTAATATTTATGTATT GGATGAGCCTACAACAGGACTTCACATATCTGATATAACAAAGTTAGTGGCTATTATGAATAGGTTAGTTAATCAAGAAA GTACTTTAATTGTAATAGAGCATAATTTAGATGTAATGACTCAAGCCGATTGGATAATTGACCTTGGTCCAGAAGCTGGA GAAAATGGTGGTAGAATTATGTTTGAAGGGGAACCAAAAGATATAATTACCAATGAGAATTCAATTACCGGGAAATATTT AAAAAGATACATTCTCTAA
Upstream 100 bases:
>100_bases TGAAATATACAAGTAGTAAAATATAATTAACCTGTTTATATATTAACTAGATTAATTATATTTCGATTAAAAGTATAAAT TATTTGGAGGTGAATACTTT
Downstream 100 bases:
>100_bases AAGAAAGGGTGAAGATAATGCTTAGGGAAGAATTAGAAGAAAATTATATGCCTTTCCAATGTATGATCATTAGCAGTGTA AATAGATTTAATTTAGAAGG
Product: putative excinuclease ABC subunit A
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 752; Mature: 752
Protein sequence:
>752_residues MDIKESIYVAGAREKNLKNIDIEIPKKKITVFTGVSGSGKSSLVFDTIAAESQRQLNETYSSFIRHRLPHYGQPDVDSIK NLSVAIIINQKRIGGNSRSTVGTITDIAPLLRLLFSRIGKPFVGYSDVFSFNNPNGMCMNCDGLGKVDSINIDKLLDKNK SLNEGAILFPTFKPGGWRLKRYIHSGLFDNNKKIKDYDEKELDLLLNKTDIKIEKGDPEWPKTSLYEGLIPRIERSFLKK EGGEREKYKKEINKIVTKEICPVCRGARLNEKILSCKINGKNIADCTKMQINDLIIFMKEIKEQSAQTVLKALISRLEHL EYIGLGYLSLDRETSSLSGGESQRIKMVKQLGSSLTGLTYIFDEPSIGLHPHDIGRINKLLKMLRDKGNTVLIVEHDPDI IKIADYIIDMGPKAGIEGGNIVYKGTPEGLLQSNTLTGKALQYKPQIKLHTRKAKGWLSIKNANLHNLKNINVDIPKGVM TVVTGVAGSGKSTLINGLLPKIYPETIFIDQGAIHASIRSNIATYTGIFDFIRNLFAKENNVKSSLFSFNSEGACPECKG LGVTYTDLAFMDTVISTCEVCEGNRFTDKVLNFKFRGKNISQVLKMTVAEAIDFFKEDEIYLVLRRLVDVGIDYIALGQP LNTLSGGELQRLKLAAQLDSKGNIYVLDEPTTGLHISDITKLVAIMNRLVNQESTLIVIEHNLDVMTQADWIIDLGPEAG ENGGRIMFEGEPKDIITNENSITGKYLKRYIL
Sequences:
>Translated_752_residues MDIKESIYVAGAREKNLKNIDIEIPKKKITVFTGVSGSGKSSLVFDTIAAESQRQLNETYSSFIRHRLPHYGQPDVDSIK NLSVAIIINQKRIGGNSRSTVGTITDIAPLLRLLFSRIGKPFVGYSDVFSFNNPNGMCMNCDGLGKVDSINIDKLLDKNK SLNEGAILFPTFKPGGWRLKRYIHSGLFDNNKKIKDYDEKELDLLLNKTDIKIEKGDPEWPKTSLYEGLIPRIERSFLKK EGGEREKYKKEINKIVTKEICPVCRGARLNEKILSCKINGKNIADCTKMQINDLIIFMKEIKEQSAQTVLKALISRLEHL EYIGLGYLSLDRETSSLSGGESQRIKMVKQLGSSLTGLTYIFDEPSIGLHPHDIGRINKLLKMLRDKGNTVLIVEHDPDI IKIADYIIDMGPKAGIEGGNIVYKGTPEGLLQSNTLTGKALQYKPQIKLHTRKAKGWLSIKNANLHNLKNINVDIPKGVM TVVTGVAGSGKSTLINGLLPKIYPETIFIDQGAIHASIRSNIATYTGIFDFIRNLFAKENNVKSSLFSFNSEGACPECKG LGVTYTDLAFMDTVISTCEVCEGNRFTDKVLNFKFRGKNISQVLKMTVAEAIDFFKEDEIYLVLRRLVDVGIDYIALGQP LNTLSGGELQRLKLAAQLDSKGNIYVLDEPTTGLHISDITKLVAIMNRLVNQESTLIVIEHNLDVMTQADWIIDLGPEAG ENGGRIMFEGEPKDIITNENSITGKYLKRYIL >Mature_752_residues MDIKESIYVAGAREKNLKNIDIEIPKKKITVFTGVSGSGKSSLVFDTIAAESQRQLNETYSSFIRHRLPHYGQPDVDSIK NLSVAIIINQKRIGGNSRSTVGTITDIAPLLRLLFSRIGKPFVGYSDVFSFNNPNGMCMNCDGLGKVDSINIDKLLDKNK SLNEGAILFPTFKPGGWRLKRYIHSGLFDNNKKIKDYDEKELDLLLNKTDIKIEKGDPEWPKTSLYEGLIPRIERSFLKK EGGEREKYKKEINKIVTKEICPVCRGARLNEKILSCKINGKNIADCTKMQINDLIIFMKEIKEQSAQTVLKALISRLEHL EYIGLGYLSLDRETSSLSGGESQRIKMVKQLGSSLTGLTYIFDEPSIGLHPHDIGRINKLLKMLRDKGNTVLIVEHDPDI IKIADYIIDMGPKAGIEGGNIVYKGTPEGLLQSNTLTGKALQYKPQIKLHTRKAKGWLSIKNANLHNLKNINVDIPKGVM TVVTGVAGSGKSTLINGLLPKIYPETIFIDQGAIHASIRSNIATYTGIFDFIRNLFAKENNVKSSLFSFNSEGACPECKG LGVTYTDLAFMDTVISTCEVCEGNRFTDKVLNFKFRGKNISQVLKMTVAEAIDFFKEDEIYLVLRRLVDVGIDYIALGQP LNTLSGGELQRLKLAAQLDSKGNIYVLDEPTTGLHISDITKLVAIMNRLVNQESTLIVIEHNLDVMTQADWIIDLGPEAG ENGGRIMFEGEPKDIITNENSITGKYLKRYIL
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=709, Percent_Identity=35.8251057827927, Blast_Score=400, Evalue=1e-112,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR003593 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 83787; Mature: 83787
Theoretical pI: Translated: 9.00; Mature: 9.00
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDIKESIYVAGAREKNLKNIDIEIPKKKITVFTGVSGSGKSSLVFDTIAAESQRQLNETY CCCCCCEEEECCCCCCCCEEEEEECCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHH SSFIRHRLPHYGQPDVDSIKNLSVAIIINQKRIGGNSRSTVGTITDIAPLLRLLFSRIGK HHHHHHHCCCCCCCCHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC PFVGYSDVFSFNNPNGMCMNCDGLGKVDSINIDKLLDKNKSLNEGAILFPTFKPGGWRLK CCCCHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCHHHH RYIHSGLFDNNKKIKDYDEKELDLLLNKTDIKIEKGDPEWPKTSLYEGLIPRIERSFLKK HHHHHCCCCCCCCCCCCCHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH EGGEREKYKKEINKIVTKEICPVCRGARLNEKILSCKINGKNIADCTKMQINDLIIFMKE CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH IKEQSAQTVLKALISRLEHLEYIGLGYLSLDRETSSLSGGESQRIKMVKQLGSSLTGLTY HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEE IFDEPSIGLHPHDIGRINKLLKMLRDKGNTVLIVEHDPDIIKIADYIIDMGPKAGIEGGN EECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCC IVYKGTPEGLLQSNTLTGKALQYKPQIKLHTRKAKGWLSIKNANLHNLKNINVDIPKGVM EEECCCCCHHHCCCCCCCCEEEECCCEEEEEECCCCEEEEECCCCCCCCCCCEECCCHHH TVVTGVAGSGKSTLINGLLPKIYPETIFIDQGAIHASIRSNIATYTGIFDFIRNLFAKEN HHHHCCCCCCHHHHHHHCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC NVKSSLFSFNSEGACPECKGLGVTYTDLAFMDTVISTCEVCEGNRFTDKVLNFKFRGKNI CHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEECCCCH SQVLKMTVAEAIDFFKEDEIYLVLRRLVDVGIDYIALGQPLNTLSGGELQRLKLAAQLDS HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHEECCCC KGNIYVLDEPTTGLHISDITKLVAIMNRLVNQESTLIVIEHNLDVMTQADWIIDLGPEAG CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEECCCCCC ENGGRIMFEGEPKDIITNENSITGKYLKRYIL CCCCEEEECCCCCCEECCCCCCCHHHHHHHCC >Mature Secondary Structure MDIKESIYVAGAREKNLKNIDIEIPKKKITVFTGVSGSGKSSLVFDTIAAESQRQLNETY CCCCCCEEEECCCCCCCCEEEEEECCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHH SSFIRHRLPHYGQPDVDSIKNLSVAIIINQKRIGGNSRSTVGTITDIAPLLRLLFSRIGK HHHHHHHCCCCCCCCHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC PFVGYSDVFSFNNPNGMCMNCDGLGKVDSINIDKLLDKNKSLNEGAILFPTFKPGGWRLK CCCCHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCHHHH RYIHSGLFDNNKKIKDYDEKELDLLLNKTDIKIEKGDPEWPKTSLYEGLIPRIERSFLKK HHHHHCCCCCCCCCCCCCHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH EGGEREKYKKEINKIVTKEICPVCRGARLNEKILSCKINGKNIADCTKMQINDLIIFMKE CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH IKEQSAQTVLKALISRLEHLEYIGLGYLSLDRETSSLSGGESQRIKMVKQLGSSLTGLTY HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEE IFDEPSIGLHPHDIGRINKLLKMLRDKGNTVLIVEHDPDIIKIADYIIDMGPKAGIEGGN EECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCC IVYKGTPEGLLQSNTLTGKALQYKPQIKLHTRKAKGWLSIKNANLHNLKNINVDIPKGVM EEECCCCCHHHCCCCCCCCEEEECCCEEEEEECCCCEEEEECCCCCCCCCCCEECCCHHH TVVTGVAGSGKSTLINGLLPKIYPETIFIDQGAIHASIRSNIATYTGIFDFIRNLFAKEN HHHHCCCCCCHHHHHHHCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC NVKSSLFSFNSEGACPECKGLGVTYTDLAFMDTVISTCEVCEGNRFTDKVLNFKFRGKNI CHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEECCCCH SQVLKMTVAEAIDFFKEDEIYLVLRRLVDVGIDYIALGQPLNTLSGGELQRLKLAAQLDS HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHEECCCC KGNIYVLDEPTTGLHISDITKLVAIMNRLVNQESTLIVIEHNLDVMTQADWIIDLGPEAG CCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEECCCCCC ENGGRIMFEGEPKDIITNENSITGKYLKRYIL CCCCEEEECCCCCCEECCCCCCCHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8675016 [H]