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The map label for this gene is lacA [H]

Identifier: 226949441

GI number: 226949441

Start: 2445920

End: 2446534

Strand: Reverse

Name: lacA [H]

Synonym: CLM_2369

Alternate gene names: 226949441

Gene position: 2446534-2445920 (Counterclockwise)

Preceding gene: 226949443

Following gene: 226949440

Centisome position: 58.88

GC content: 32.68

Gene sequence:

>615_bases
ATGAATCAGAAAGATAGAATGTTAGCAGGGCTTCCATATAAAGCGTGCTTAGATGGATTACCAGAAGAACGAATGGAAAA
TAAAAAGAAAATTTATGAGTATAACCATTGCTTCCCAGATGAACATGAAAAAATCCATAAATTAATAAGAGATATTCTTG
GAGAAGCAGGTGCAGATGTACATATAGAGGCACCCTTTTATTGTGATTATGGAAAGAATATTCAGGTTGGAGATAACTTT
TTTGCAAATTACAACTGTACAATTCTAGATGTGGGAAAAGTAATTATAGGTAATAATGTACAATTTGCTCCAAATGTTTC
TTTGTATACAGCAGGTCATCCCATACATCCTGATTCACGAAATTCTGGATATGAATATGGAATTGGTATAACAATAGGAG
ATAATGTGTGGCTGGGAGGAAATGTTGTTGTAAATCCTGGAGTTCATATTGGAAATAACGTTGTTATTGGTTCGGGAAGT
GTTGTTACAAAAGACATTCCAGACAATGCGATAGCAATAGGAAATCCATGTAAAGTTATTCGTGAAATTACAGAAGAAGA
TCGTAAGTATTATTATAAAAATTATGAATTTGATGTTGATGATTATAAAGGTTAG

Upstream 100 bases:

>100_bases
AATGAGTTCTAGTATCCCTTTGAAAATGGTATAATGTAAGTTAAAAGATAAAGTGAAATTTATTTTCAATATTAATATAA
TGTGGAAGGTGGAGACAATT

Downstream 100 bases:

>100_bases
TTTATTTACAAATTAAAATTATTTATGCTGTAGTAGCCTACTTTTCAGGAGCTAAAAGTTTTTCAAAATCCTACATTCAT
GTATTTACTTTGTTTTTTGT

Product: O-acetyltransferase family protein

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MNQKDRMLAGLPYKACLDGLPEERMENKKKIYEYNHCFPDEHEKIHKLIRDILGEAGADVHIEAPFYCDYGKNIQVGDNF
FANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGS
VVTKDIPDNAIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKG

Sequences:

>Translated_204_residues
MNQKDRMLAGLPYKACLDGLPEERMENKKKIYEYNHCFPDEHEKIHKLIRDILGEAGADVHIEAPFYCDYGKNIQVGDNF
FANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGS
VVTKDIPDNAIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKG
>Mature_204_residues
MNQKDRMLAGLPYKACLDGLPEERMENKKKIYEYNHCFPDEHEKIHKLIRDILGEAGADVHIEAPFYCDYGKNIQVGDNF
FANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGS
VVTKDIPDNAIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKG

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=198, Percent_Identity=48.989898989899, Blast_Score=207, Evalue=3e-55,
Organism=Escherichia coli, GI1786664, Length=182, Percent_Identity=46.7032967032967, Blast_Score=188, Evalue=2e-49,
Organism=Escherichia coli, GI1788367, Length=141, Percent_Identity=29.7872340425532, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322243, Length=188, Percent_Identity=53.1914893617021, Blast_Score=195, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 22833; Mature: 22833

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKDRMLAGLPYKACLDGLPEERMENKKKIYEYNHCFPDEHEKIHKLIRDILGEAGADV
CCCCCCEEECCCHHHHHCCCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHCCCCCCE
HIEAPFYCDYGKNIQVGDNFFANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSR
EEECCEEECCCCEEEECCCEEECCCEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCC
NSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGSVVTKDIPDNAIAIGNPCKVI
CCCEEEEEEEEECCCEEECCEEEECCCEEECCEEEEECCCEEEECCCCCEEEECCHHHHH
REITEEDRKYYYKNYEFDVDDYKG
HHHHHHHHHEECCCCEECCCCCCC
>Mature Secondary Structure
MNQKDRMLAGLPYKACLDGLPEERMENKKKIYEYNHCFPDEHEKIHKLIRDILGEAGADV
CCCCCCEEECCCHHHHHCCCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHCCCCCCE
HIEAPFYCDYGKNIQVGDNFFANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSR
EEECCEEECCCCEEEECCCEEECCCEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCC
NSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGSVVTKDIPDNAIAIGNPCKVI
CCCEEEEEEEEECCCEEECCEEEECCCEEECCEEEEECCCEEEECCCCCEEEECCHHHHH
REITEEDRKYYYKNYEFDVDDYKG
HHHHHHHHHEECCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]