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The map label for this gene is acoL [H]

Identifier: 226948961

GI number: 226948961

Start: 1915808

End: 1917199

Strand: Direct

Name: acoL [H]

Synonym: CLM_1875

Alternate gene names: 226948961

Gene position: 1915808-1917199 (Clockwise)

Preceding gene: 226948960

Following gene: 226948962

Centisome position: 46.11

GC content: 32.04

Gene sequence:

>1392_bases
ATGAAGCTAGTAGTTATTGGAGGAGGACCAGGAGGATATGTGGCAGCTATCCGTGGAGCGCAATTAGGAGCAGAGGTTAC
TCTTATTGAAAAAGAAAAGTTAGGCGGAACTTGTTTAAATATTGGTTGTATACCTACTAAAGTTTTATTACATTCTTCAG
AATTATTAAATGAAATAAAAGAAGCTAGAACTTTAGGAATAGAGGTGAATAATGAAGTAAAAATCAATTGGACTCAGCTT
CAAAATAGAAAAAATACTGTAGTAAACACATTAGTTTCAGGGGTATCATCATTACTTGAACATAATAAAGTTAAAGTAAT
TAATGGAACTGCAGCCTTTGAAGGAAAAAGTAGTATAAAAGTAACAAAGGATCAGGGAGAAAGTGAAAATATCCAATTTG
ATAATGTGATAATTTCATCTGGTTCCGTTCCCTTTATACCTCCTATAAAAGGAAGAGAATTAGAGGGAGTAATTGATAGT
ACTGGAGCCTTAAGCTTAGATTCTATTCCTAAAAGTATGGTGATAATTGGTGGAGGCGTTATAGGAATAGAATTTGCAAA
TATTTTTAATTCCCTTGGGTGCAAAGTAACAGTTATTGAAATGTTACCATATATATTGCCTCCAGTGGATAGAGAAATTT
CTGAGATTCTTAAGGAAAAGCTTAAAAAGGACGGAATTGATATATATAATAACTGTAAGGTAACTAAAATTGAAAATAAC
AATGAAAATTTAAATGTAAGTTTTGAAGAAGATAATGACAAATTAAATATAGAGGCACAAAAAGTTTTAATAGCAGTAGG
AAGAAGAGCAAATATAAGTAATCTAAATTTAGAAAGTACTGGAGTATATATAGAAAAAGGATGCATTTGGGTAAATGATA
ATATGGAAACAAATATAAAAGGAATTTATGCCATAGGTGACTGTACAGGAAAAAATATGCTTGCTCATGTAGCTTCAGAT
CAAGGAATAATAGCTGTAGAAAATATTATGGGTAAAAATAAGAAAATGGATTATAAAACTGTACCAGCTTGTGTGTATAC
TAAACCAGAGTTAGCTTCTGTAGGATTAACGGAAGAACAAGCAAAACAAAAAGGAGTTGATTACAAAATAGGAAAGTTCC
CTCTAATTTATAATGGCAAATCACTTATAATGAATGATACAGAGGGATTTATAAAAATAATAGCGGATAAAAAATATGAA
GAGATATTAGGAGTTCATATACTTGGACCTAGGGCAACGGATTTAATAACAGAGGCAGCCTTAGCTCTAAGACTGGAAGC
TACCCTAGAGGAAATAATTACAACAGTACATGCTCATCCCACAATAGGAGAAGCGATGAAGGAGGCAGCTCTTGCAGTAA
ACAAAGAAGCAATTCATATGGTGAATAAATAA

Upstream 100 bases:

>100_bases
CCATAGGGCGGTAGATGGTGCTGTAGCGGCTCAATTCTTAAAAGCAGTTAAAAAATATATGGAAAAGCCAGAGTTGCTTA
TATTGTAGGAGGGATAAAAA

Downstream 100 bases:

>100_bases
AATCAAGTTATGGAGGTAAAAGTAATGCAGTTTTTAGTAAATAAATCAACAAATCCTTTTTTCAATTTAGCTTTAGAAGA
ATATCTTTTAAAAAATGTAG

Product: TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKLVVIGGGPGGYVAAIRGAQLGAEVTLIEKEKLGGTCLNIGCIPTKVLLHSSELLNEIKEARTLGIEVNNEVKINWTQL
QNRKNTVVNTLVSGVSSLLEHNKVKVINGTAAFEGKSSIKVTKDQGESENIQFDNVIISSGSVPFIPPIKGRELEGVIDS
TGALSLDSIPKSMVIIGGGVIGIEFANIFNSLGCKVTVIEMLPYILPPVDREISEILKEKLKKDGIDIYNNCKVTKIENN
NENLNVSFEEDNDKLNIEAQKVLIAVGRRANISNLNLESTGVYIEKGCIWVNDNMETNIKGIYAIGDCTGKNMLAHVASD
QGIIAVENIMGKNKKMDYKTVPACVYTKPELASVGLTEEQAKQKGVDYKIGKFPLIYNGKSLIMNDTEGFIKIIADKKYE
EILGVHILGPRATDLITEAALALRLEATLEEIITTVHAHPTIGEAMKEAALAVNKEAIHMVNK

Sequences:

>Translated_463_residues
MKLVVIGGGPGGYVAAIRGAQLGAEVTLIEKEKLGGTCLNIGCIPTKVLLHSSELLNEIKEARTLGIEVNNEVKINWTQL
QNRKNTVVNTLVSGVSSLLEHNKVKVINGTAAFEGKSSIKVTKDQGESENIQFDNVIISSGSVPFIPPIKGRELEGVIDS
TGALSLDSIPKSMVIIGGGVIGIEFANIFNSLGCKVTVIEMLPYILPPVDREISEILKEKLKKDGIDIYNNCKVTKIENN
NENLNVSFEEDNDKLNIEAQKVLIAVGRRANISNLNLESTGVYIEKGCIWVNDNMETNIKGIYAIGDCTGKNMLAHVASD
QGIIAVENIMGKNKKMDYKTVPACVYTKPELASVGLTEEQAKQKGVDYKIGKFPLIYNGKSLIMNDTEGFIKIIADKKYE
EILGVHILGPRATDLITEAALALRLEATLEEIITTVHAHPTIGEAMKEAALAVNKEAIHMVNK
>Mature_463_residues
MKLVVIGGGPGGYVAAIRGAQLGAEVTLIEKEKLGGTCLNIGCIPTKVLLHSSELLNEIKEARTLGIEVNNEVKINWTQL
QNRKNTVVNTLVSGVSSLLEHNKVKVINGTAAFEGKSSIKVTKDQGESENIQFDNVIISSGSVPFIPPIKGRELEGVIDS
TGALSLDSIPKSMVIIGGGVIGIEFANIFNSLGCKVTVIEMLPYILPPVDREISEILKEKLKKDGIDIYNNCKVTKIENN
NENLNVSFEEDNDKLNIEAQKVLIAVGRRANISNLNLESTGVYIEKGCIWVNDNMETNIKGIYAIGDCTGKNMLAHVASD
QGIIAVENIMGKNKKMDYKTVPACVYTKPELASVGLTEEQAKQKGVDYKIGKFPLIYNGKSLIMNDTEGFIKIIADKKYE
EILGVHILGPRATDLITEAALALRLEATLEEIITTVHAHPTIGEAMKEAALAVNKEAIHMVNK

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=42.4242424242424, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI50301238, Length=451, Percent_Identity=29.0465631929047, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI148277065, Length=464, Percent_Identity=29.5258620689655, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI33519430, Length=464, Percent_Identity=29.5258620689655, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI33519428, Length=464, Percent_Identity=29.5258620689655, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI33519426, Length=464, Percent_Identity=29.5258620689655, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI148277071, Length=464, Percent_Identity=29.5258620689655, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI22035672, Length=455, Percent_Identity=27.6923076923077, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI291045266, Length=430, Percent_Identity=29.3023255813954, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI291045268, Length=424, Percent_Identity=26.6509433962264, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=37.0044052863436, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=32.15859030837, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=29.295154185022, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=30.5239179954442, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789065, Length=244, Percent_Identity=26.2295081967213, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=42.1397379912664, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=30.0639658848614, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71983429, Length=441, Percent_Identity=28.3446712018141, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71983419, Length=441, Percent_Identity=28.3446712018141, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71982272, Length=434, Percent_Identity=28.110599078341, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=42.5847457627119, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6325166, Length=447, Percent_Identity=27.2930648769575, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=27.9569892473118, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=41.3943355119826, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=32.0083682008368, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=32.0083682008368, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=32.0083682008368, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=28.9308176100629, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50218; Mature: 50218

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVIGGGPGGYVAAIRGAQLGAEVTLIEKEKLGGTCLNIGCIPTKVLLHSSELLNEIK
CEEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHH
EARTLGIEVNNEVKINWTQLQNRKNTVVNTLVSGVSSLLEHNKVKVINGTAAFEGKSSIK
HHHEEEEEECCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCEE
VTKDQGESENIQFDNVIISSGSVPFIPPIKGRELEGVIDSTGALSLDSIPKSMVIIGGGV
EECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCEECCCCCCEEEEEECCE
IGIEFANIFNSLGCKVTVIEMLPYILPPVDREISEILKEKLKKDGIDIYNNCKVTKIENN
EEEEHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCEEEEEEECC
NENLNVSFEEDNDKLNIEAQKVLIAVGRRANISNLNLESTGVYIEKGCIWVNDNMETNIK
CCEEEEEEECCCCEEEEEHEEEEEEECCCCCCCCCCCCCCCEEEEECEEEECCCCCCCCE
GIYAIGDCTGKNMLAHVASDQGIIAVENIMGKNKKMDYKTVPACVYTKPELASVGLTEEQ
EEEEEECCCCCCCEEEECCCCCEEEEHHHCCCCCCCCCCCCCEEEECCCCHHCCCCCHHH
AKQKGVDYKIGKFPLIYNGKSLIMNDTEGFIKIIADKKYEEILGVHILGPRATDLITEAA
HHHCCCCEECCCEEEEECCCEEEEECCCCEEEEEECCCHHHHEEEEEECCCHHHHHHHHH
LALRLEATLEEIITTVHAHPTIGEAMKEAALAVNKEAIHMVNK
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MKLVVIGGGPGGYVAAIRGAQLGAEVTLIEKEKLGGTCLNIGCIPTKVLLHSSELLNEIK
CEEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHH
EARTLGIEVNNEVKINWTQLQNRKNTVVNTLVSGVSSLLEHNKVKVINGTAAFEGKSSIK
HHHEEEEEECCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCEE
VTKDQGESENIQFDNVIISSGSVPFIPPIKGRELEGVIDSTGALSLDSIPKSMVIIGGGV
EECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCEECCCCCCEEEEEECCE
IGIEFANIFNSLGCKVTVIEMLPYILPPVDREISEILKEKLKKDGIDIYNNCKVTKIENN
EEEEHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCEEEEEEECC
NENLNVSFEEDNDKLNIEAQKVLIAVGRRANISNLNLESTGVYIEKGCIWVNDNMETNIK
CCEEEEEEECCCCEEEEEHEEEEEEECCCCCCCCCCCCCCCEEEEECEEEECCCCCCCCE
GIYAIGDCTGKNMLAHVASDQGIIAVENIMGKNKKMDYKTVPACVYTKPELASVGLTEEQ
EEEEEECCCCCCCEEEECCCCCEEEEHHHCCCCCCCCCCCCCEEEECCCCHHCCCCCHHH
AKQKGVDYKIGKFPLIYNGKSLIMNDTEGFIKIIADKKYEEILGVHILGPRATDLITEAA
HHHCCCCEECCCEEEEECCCEEEEECCCCEEEEEECCCHHHHEEEEEECCCHHHHHHHHH
LALRLEATLEEIITTVHAHPTIGEAMKEAALAVNKEAIHMVNK
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA