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The map label for this gene is malR [H]

Identifier: 226948931

GI number: 226948931

Start: 1877788

End: 1878789

Strand: Direct

Name: malR [H]

Synonym: CLM_1844

Alternate gene names: 226948931

Gene position: 1877788-1878789 (Clockwise)

Preceding gene: 226948930

Following gene: 226948932

Centisome position: 45.19

GC content: 28.74

Gene sequence:

>1002_bases
ATGAAGGTTACTATAAAAGATGTAGCTAAAGAAGCAAAAGTTTCACCATCTACAGTTTCAAGAGTACTATCATATAATCC
TAGAATAAGTGATGAAACGAAAGAAAAAGTATACAAAGTTATAGAAAAACTTAAATACAAACCCAATGCAATAGCTAGAG
GATTAGTTAATAATAAAACAAGAATATTAGGGGTTGTGCTTCCAGAGGAAGCGGAAAATTTGCTATCTAATCCTTTTTTT
ATACAAGCTATGAAAGGAATAAGTTCTTATGCTGAAAAAAGAGAATACTATATAACTTACGCCTTTAGTAGTAATAAAGA
AAACGAGAAAAAACATATAAAAGATTTAACAACTAGTGGATTAATAGAAGGTTTGCTTATTTTAAGACCAAAAGAAAATG
ATGAAAATATAAAATATCTAAAGGATATAAACTTTCCCTTTGTTATTATGGGACGCTTAAAAGATACAGAAGATGTGTTA
TGGGTTGATAATGATAATTTCCAAGCTATGTATAATATAGTTAATAAATTAATAGATAAAGGTCATACAAAAATAGCTCT
AATAGGAGCTAAAAAGGAGCTAAATGTATGTAAGGATAGAGAAAAGGGATATAAAGTAGCACTAGAGATGAACGGAATTA
GTTTTAGTGAAAAATTAGTTAGTTATGGAGAGGAATTTAAAGAAAAAGAAGGATATATACAAATGAATAAATTATTAGAA
AAAGTAAAGCCAACAGCAGTGGTGGCAATGGATGACTTGTTAGCAATAGGTGCTATGAAAGCGCTAAAAGAAAAATATTT
AACTGACCTTTCTATAGTGGGATTTAATAATATACCTTTAGGCGAATTTCAGAAACCTCAATTAGCTTCTGTAGATATAA
ATGGAGTAAAGCTTGGATATTATGCTACAAAATTGTTAATAGACAAGATAGAAGAAGTAGAAGATACTAGAGATCACTAC
ATTGTAGAAACTACTTTTGTAAAGAGAGAATCTTTTAAATAG

Upstream 100 bases:

>100_bases
TTATAAACTGCATTGTTTACATAGTTTATATGTATAAAATAAGAAAAATAAAGTTTTGTGTGGTTATATACAGGACATAT
TAAAAGGAGATTAATAAAAA

Downstream 100 bases:

>100_bases
ATTAATATTTTTAAGTAGGTAATAAAAAAAATTGAATTAAGCTTTGATATATGCACAAGCGTTTGCACATGTATGCATTA
AAAATAGTGAGTATTTTGTA

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Maltose operon transcriptional repressor [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKVTIKDVAKEAKVSPSTVSRVLSYNPRISDETKEKVYKVIEKLKYKPNAIARGLVNNKTRILGVVLPEEAENLLSNPFF
IQAMKGISSYAEKREYYITYAFSSNKENEKKHIKDLTTSGLIEGLLILRPKENDENIKYLKDINFPFVIMGRLKDTEDVL
WVDNDNFQAMYNIVNKLIDKGHTKIALIGAKKELNVCKDREKGYKVALEMNGISFSEKLVSYGEEFKEKEGYIQMNKLLE
KVKPTAVVAMDDLLAIGAMKALKEKYLTDLSIVGFNNIPLGEFQKPQLASVDINGVKLGYYATKLLIDKIEEVEDTRDHY
IVETTFVKRESFK

Sequences:

>Translated_333_residues
MKVTIKDVAKEAKVSPSTVSRVLSYNPRISDETKEKVYKVIEKLKYKPNAIARGLVNNKTRILGVVLPEEAENLLSNPFF
IQAMKGISSYAEKREYYITYAFSSNKENEKKHIKDLTTSGLIEGLLILRPKENDENIKYLKDINFPFVIMGRLKDTEDVL
WVDNDNFQAMYNIVNKLIDKGHTKIALIGAKKELNVCKDREKGYKVALEMNGISFSEKLVSYGEEFKEKEGYIQMNKLLE
KVKPTAVVAMDDLLAIGAMKALKEKYLTDLSIVGFNNIPLGEFQKPQLASVDINGVKLGYYATKLLIDKIEEVEDTRDHY
IVETTFVKRESFK
>Mature_333_residues
MKVTIKDVAKEAKVSPSTVSRVLSYNPRISDETKEKVYKVIEKLKYKPNAIARGLVNNKTRILGVVLPEEAENLLSNPFF
IQAMKGISSYAEKREYYITYAFSSNKENEKKHIKDLTTSGLIEGLLILRPKENDENIKYLKDINFPFVIMGRLKDTEDVL
WVDNDNFQAMYNIVNKLIDKGHTKIALIGAKKELNVCKDREKGYKVALEMNGISFSEKLVSYGEEFKEKEGYIQMNKLLE
KVKPTAVVAMDDLLAIGAMKALKEKYLTDLSIVGFNNIPLGEFQKPQLASVDINGVKLGYYATKLLIDKIEEVEDTRDHY
IVETTFVKRESFK

Specific function: Transcriptional repressor of the maltosaccharide utilization operons malxCD and malMP [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=314, Percent_Identity=30.5732484076433, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1787580, Length=310, Percent_Identity=29.3548387096774, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789068, Length=303, Percent_Identity=32.013201320132, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=27.8443113772455, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787948, Length=316, Percent_Identity=28.1645569620253, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790194, Length=315, Percent_Identity=26.984126984127, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789202, Length=294, Percent_Identity=28.2312925170068, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI48994940, Length=319, Percent_Identity=26.3322884012539, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790715, Length=317, Percent_Identity=24.2902208201893, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787906, Length=266, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789456, Length=316, Percent_Identity=26.8987341772152, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786540, Length=339, Percent_Identity=25.3687315634218, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790689, Length=310, Percent_Identity=24.1935483870968, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786268, Length=300, Percent_Identity=28.3333333333333, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38001; Mature: 38001

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTIKDVAKEAKVSPSTVSRVLSYNPRISDETKEKVYKVIEKLKYKPNAIARGLVNNKT
CEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCE
RILGVVLPEEAENLLSNPFFIQAMKGISSYAEKREYYITYAFSSNKENEKKHIKDLTTSG
EEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHH
LIEGLLILRPKENDENIKYLKDINFPFVIMGRLKDTEDVLWVDNDNFQAMYNIVNKLIDK
HHCCEEEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHC
GHTKIALIGAKKELNVCKDREKGYKVALEMNGISFSEKLVSYGEEFKEKEGYIQMNKLLE
CCCEEEEEECCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
KVKPTAVVAMDDLLAIGAMKALKEKYLTDLSIVGFNNIPLGEFQKPQLASVDINGVKLGY
HHCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEECCCEEEHH
YATKLLIDKIEEVEDTRDHYIVETTFVKRESFK
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MKVTIKDVAKEAKVSPSTVSRVLSYNPRISDETKEKVYKVIEKLKYKPNAIARGLVNNKT
CEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCE
RILGVVLPEEAENLLSNPFFIQAMKGISSYAEKREYYITYAFSSNKENEKKHIKDLTTSG
EEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHH
LIEGLLILRPKENDENIKYLKDINFPFVIMGRLKDTEDVLWVDNDNFQAMYNIVNKLIDK
HHCCEEEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHC
GHTKIALIGAKKELNVCKDREKGYKVALEMNGISFSEKLVSYGEEFKEKEGYIQMNKLLE
CCCEEEEEECCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
KVKPTAVVAMDDLLAIGAMKALKEKYLTDLSIVGFNNIPLGEFQKPQLASVDINGVKLGY
HHCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEECCCEEEHH
YATKLLIDKIEEVEDTRDHYIVETTFVKRESFK
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]