Click here to switch to the map view.

The map label for this gene is hisA [H]

Identifier: 226948901

GI number: 226948901

Start: 1842326

End: 1843054

Strand: Direct

Name: hisA [H]

Synonym: CLM_1811

Alternate gene names: 226948901

Gene position: 1842326-1843054 (Clockwise)

Preceding gene: 226948900

Following gene: 226948902

Centisome position: 44.34

GC content: 29.49

Gene sequence:

>729_bases
ATGATAATTTTACCTGCCATAGATTTAAAAGAGGGTAAATGTATTAGATTATACCAAGGAGATTTTAAAGCTTCAAAGGT
GGTAGCAGAAGATCCTATAGAGGTAGCACTAAAATTTAAAGAGAATGGAGCGGAATATATACATATAGTGGATTTAGACG
GAGCTCTTACTGGAGAAATTAAAAATTTATCTATAATTTCTTCCATAATAAAAACAATTAATATACCTGTAGAGCTTGGA
GGTGGAATAAGAAATTTAAATACAATAGATATGCTTATAGGCGCAGGAATTGAAAGGATAATATTAGGTACAGCTGCATT
AAATAATAGAGGACTTGTTGAAGAGGCTGTGAAAAAATATGATGAAAAAATTGCCATAGGAATAGATGCTAAAAATGAAA
AGGTAGCTATAAATGGATGGTTAAATGTAAGTAGTATAAACTATATAGATTTTGCTAAGGAAATGGAAAAGATAGGAGTT
AGAAATATTATATTCACGGATATTAGTAAAGATGGAACTTTAAAGGGACCTAATTTAAAACAGCTTGAAAAACTAAATGA
GAGTATAAGTTGTAATGTTATAGCCTCAGGAGGGATTAAAGATATAGAGGATTTAAAGGTTATAAAAGAAATGGATGTTT
ATGGAGCTATTGTAGGTAAAGCTATATATTCAGGGAATATTAATTTGAATGAAGCTATTAAAATTATAAACAAGGGGAGT
TCTAAATGA

Upstream 100 bases:

>100_bases
GGATAGTAAGTAAAAATAATATTTATGGAATACAGTTTCATCCTGAAAAAAGTGGGGATATAGGACTCAAAATATTAAGT
AATTTTGGGGAGCTGATAAA

Downstream 100 bases:

>100_bases
GTAAATATTGGAGCAATATAACTAAAGATATAGAACCCTATGTATGTGGAGAGCAACCTAAGAATAAAAAAATTATAAAG
TTAAATACTAATGAAAATCC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKNLSIISSIIKTINIPVELG
GGIRNLNTIDMLIGAGIERIILGTAALNNRGLVEEAVKKYDEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGV
RNIIFTDISKDGTLKGPNLKQLEKLNESISCNVIASGGIKDIEDLKVIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGS
SK

Sequences:

>Translated_242_residues
MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKNLSIISSIIKTINIPVELG
GGIRNLNTIDMLIGAGIERIILGTAALNNRGLVEEAVKKYDEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGV
RNIIFTDISKDGTLKGPNLKQLEKLNESISCNVIASGGIKDIEDLKVIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGS
SK
>Mature_242_residues
MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKNLSIISSIIKTINIPVELG
GGIRNLNTIDMLIGAGIERIILGTAALNNRGLVEEAVKKYDEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGV
RNIIFTDISKDGTLKGPNLKQLEKLNESISCNVIASGGIKDIEDLKVIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGS
SK

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=30.5439330543933, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1788336, Length=241, Percent_Identity=25.7261410788382, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26252; Mature: 26252

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEI
CEEECCEECCCCCEEEEEECCCCCCEEEECCCEEEEEEEECCCCCEEEEEEECCCCCCCC
KNLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERIILGTAALNNRGLVEEAVKKY
CHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCHHHEEEEHHCCCCCCHHHHHHHHH
DEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLKGPNLK
CCEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHH
QLEKLNESISCNVIASGGIKDIEDLKVIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGS
HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHEECCCC
SK
CC
>Mature Secondary Structure
MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEI
CEEECCEECCCCCEEEEEECCCCCCEEEECCCEEEEEEEECCCCCEEEEEEECCCCCCCC
KNLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERIILGTAALNNRGLVEEAVKKY
CHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCHHHEEEEHHCCCCCCHHHHHHHHH
DEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLKGPNLK
CCEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHH
QLEKLNESISCNVIASGGIKDIEDLKVIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGS
HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHEECCCC
SK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA