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The map label for this gene is mtbA [H]

Identifier: 226948825

GI number: 226948825

Start: 1759357

End: 1760409

Strand: Direct

Name: mtbA [H]

Synonym: CLM_1727

Alternate gene names: 226948825

Gene position: 1759357-1760409 (Clockwise)

Preceding gene: 226948824

Following gene: 226948826

Centisome position: 42.34

GC content: 33.43

Gene sequence:

>1053_bases
TTGATTAAAGAAGAGATGACACCTAAAGAAAGAATTGTAGCCTTTTCTAAAGGAGAAGAAATTGACAGAATAATATGTGT
TCCAGATATGGGAGTTACCATGGCACCTTTTATTGGGGTTACAGCTAGAGATTACTATCATTCAGCACAACTTATGGCAG
ATTTAGAAATAGCTTTATTTAAGAGGCTTCGTCATGATGGTGTAAGTATATCTACTAGTCTTAGAGGAGTTGCGGAAGCT
ATGGGTTCTAAAGTTGGTTATCCTGAATATGGAATTTCTTATTTAATAGAGCCAGCTATTAATTCTATAGACGAAATAGA
ATCTCTTAAAATTGTAGATCCTTTAAAAGATGGTAACTTACCAACTTTACTTGAGGCAATAAAACTGACTAGAGATGCAC
TTATGGATGAAGTAGATGTTGGTGCAGCTATGTCTGGACCTTTTAGTGTTGCGGCTTCTGTAGTAGGAACAGAAAATCTA
TTAAAATGGATGATTAAATATCCTAAAAAAGTGCATACATTAATGGATATAGTAGCAGAATCTAATAATAGATACATAGA
GGAAGTAGCAAAGCTTGGAGTCTCCATTGGATTTGCAGATCCAGTTTCATCTACTAGTCTTATAAGTCCAAAGCAGTTTA
GAGAGTTTTCATTACCAGCTTTAAGGAAAAATATTAATAAAATAAAAGAGAAGACTGGGGGAGCTCCTGGTATACATATT
TGTGGTAAGAGTAAGGAACTATGGGAAGATGTTGTAAATGCAGGGATTTCTAATTTTAGTATTGATAACGCAGAAGATTT
AGAAGAAGCTAAAAATATAATGGGAGACAGAGTTGTTATTACTGGAAACGTTCCCCCTGTAGATATAGTATATAGGGGAA
ATAAAGAAGCTATTTTCAAATCCGTTAAAGAATGTATTAAAAAAGGTCATGACTCTAAGAAAGGGTATATTTTAAGTACA
GGATGTCAAATCCCAATGCATACACCAATAGAAAATATTGAAATGTTTATGGAAGCAGGAAAAACTTATGGAAAATATCC
TATAGATCTATAA

Upstream 100 bases:

>100_bases
AATTTATTATTGCAATGCTAAAATACACAGTTGGAAGTAATAATTAGGAACTAAGGGTAATAATTTAAAAAATATTTTTA
TTTAGAAAGGAGTGTTTTAA

Downstream 100 bases:

>100_bases
TAAAGAATTTAGATCTATAATAAAGAATTTAGGTCTATAATAAAGAATTTAGAAAATAACTTTAAATTAAGATGAGGAGA
GTTTTAAATGGGAAATACCA

Product: uroporphyrinogen decarboxylase family protein

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIKEEMTPKERIVAFSKGEEIDRIICVPDMGVTMAPFIGVTARDYYHSAQLMADLEIALFKRLRHDGVSISTSLRGVAEA
MGSKVGYPEYGISYLIEPAINSIDEIESLKIVDPLKDGNLPTLLEAIKLTRDALMDEVDVGAAMSGPFSVAASVVGTENL
LKWMIKYPKKVHTLMDIVAESNNRYIEEVAKLGVSIGFADPVSSTSLISPKQFREFSLPALRKNINKIKEKTGGAPGIHI
CGKSKELWEDVVNAGISNFSIDNAEDLEEAKNIMGDRVVITGNVPPVDIVYRGNKEAIFKSVKECIKKGHDSKKGYILST
GCQIPMHTPIENIEMFMEAGKTYGKYPIDL

Sequences:

>Translated_350_residues
MIKEEMTPKERIVAFSKGEEIDRIICVPDMGVTMAPFIGVTARDYYHSAQLMADLEIALFKRLRHDGVSISTSLRGVAEA
MGSKVGYPEYGISYLIEPAINSIDEIESLKIVDPLKDGNLPTLLEAIKLTRDALMDEVDVGAAMSGPFSVAASVVGTENL
LKWMIKYPKKVHTLMDIVAESNNRYIEEVAKLGVSIGFADPVSSTSLISPKQFREFSLPALRKNINKIKEKTGGAPGIHI
CGKSKELWEDVVNAGISNFSIDNAEDLEEAKNIMGDRVVITGNVPPVDIVYRGNKEAIFKSVKECIKKGHDSKKGYILST
GCQIPMHTPIENIEMFMEAGKTYGKYPIDL
>Mature_350_residues
MIKEEMTPKERIVAFSKGEEIDRIICVPDMGVTMAPFIGVTARDYYHSAQLMADLEIALFKRLRHDGVSISTSLRGVAEA
MGSKVGYPEYGISYLIEPAINSIDEIESLKIVDPLKDGNLPTLLEAIKLTRDALMDEVDVGAAMSGPFSVAASVVGTENL
LKWMIKYPKKVHTLMDIVAESNNRYIEEVAKLGVSIGFADPVSSTSLISPKQFREFSLPALRKNINKIKEKTGGAPGIHI
CGKSKELWEDVVNAGISNFSIDNAEDLEEAKNIMGDRVVITGNVPPVDIVYRGNKEAIFKSVKECIKKGHDSKKGYILST
GCQIPMHTPIENIEMFMEAGKTYGKYPIDL

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=26.271186440678, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 38502; Mature: 38502

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEEMTPKERIVAFSKGEEIDRIICVPDMGVTMAPFIGVTARDYYHSAQLMADLEIALF
CCCCCCCCHHHEEEECCCCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KRLRHDGVSISTSLRGVAEAMGSKVGYPEYGISYLIEPAINSIDEIESLKIVDPLKDGNL
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHEEEECCCCCCCH
PTLLEAIKLTRDALMDEVDVGAAMSGPFSVAASVVGTENLLKWMIKYPKKVHTLMDIVAE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SNNRYIEEVAKLGVSIGFADPVSSTSLISPKQFREFSLPALRKNINKIKEKTGGAPGIHI
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEE
CGKSKELWEDVVNAGISNFSIDNAEDLEEAKNIMGDRVVITGNVPPVDIVYRGNKEAIFK
ECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCHHHHHH
SVKECIKKGHDSKKGYILSTGCQIPMHTPIENIEMFMEAGKTYGKYPIDL
HHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIKEEMTPKERIVAFSKGEEIDRIICVPDMGVTMAPFIGVTARDYYHSAQLMADLEIALF
CCCCCCCCHHHEEEECCCCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KRLRHDGVSISTSLRGVAEAMGSKVGYPEYGISYLIEPAINSIDEIESLKIVDPLKDGNL
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHEEEECCCCCCCH
PTLLEAIKLTRDALMDEVDVGAAMSGPFSVAASVVGTENLLKWMIKYPKKVHTLMDIVAE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SNNRYIEEVAKLGVSIGFADPVSSTSLISPKQFREFSLPALRKNINKIKEKTGGAPGIHI
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEE
CGKSKELWEDVVNAGISNFSIDNAEDLEEAKNIMGDRVVITGNVPPVDIVYRGNKEAIFK
ECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCHHHHHH
SVKECIKKGHDSKKGYILSTGCQIPMHTPIENIEMFMEAGKTYGKYPIDL
HHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8702528; 9642198; 7635826; 8617801; 9006042; 9195968; 10852929 [H]