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The map label for this gene is lctP [H]

Identifier: 226948280

GI number: 226948280

Start: 1202776

End: 1204299

Strand: Direct

Name: lctP [H]

Synonym: CLM_1160

Alternate gene names: 226948280

Gene position: 1202776-1204299 (Clockwise)

Preceding gene: 226948279

Following gene: 226948281

Centisome position: 28.95

GC content: 34.12

Gene sequence:

>1524_bases
ATGAATATGTATCTAACGTGTTTTATTGCTTTGGTGCCTATAGCTTGGTTAATGGTTTCATTAGGAATTTTAAAAATGCC
AGGTTATAAAACTTGTCCTGCAACATTGGTATTAACTGCAATTTTAGCAGTTATAGTATGGAAAATGCCAATTTTAGATG
CAGCTTCTGCAGCTTTAGAAGGAACGGCATTAGCTTTATGGCCTATAATACTTGTAATCGTTGCTGCAGTATTTACCTAT
AATTTATCAATTCATACTAAAAGTATGGATACTATAAAAAAGATGATGACTTCAATAACTACAGATAAGAGAATTTTGGT
TTTGATACTTGCTTGGGGATTTGGCGGATTTTTGGAGGCTATAGCAGGGTTTGGTACTGCAGTTGCTATTCCTGCAAGTA
TAATGGCAGCACTTGGATTTGACCCTGTTTTTGCAGCTATAATATGTCTTATAGCAAACACTACACCTACAGCTTTTGGA
GGTATAGGAATTCCAGTAACAACTCTTGCTAAGGTAACTAACATAGATGTAATTCAACTTAGTTATGCAGTAGGATTACA
GTTATCAGTTCTAATAGTCATAATTCCAATAGTTTTAGTAATGCTAACAGGAAAAAGTGTGAAATCTATTAAGGGTGTCT
TTGGAATAGCCTTAGCTTCAGGCCTTTCATTTGCAATACCAGAATTATTAATGGCTAAGTATATGGGGGCGGAATTACCA
GCTATATTAGGGTCAATAACATGTATGGTAGTAACTATAGCTATGGCAAAGATATTTTATAAAGATACTGCTTCTAAAAA
TGTAGAAAAAATACCTTTTAAAAAGGCAGTTATAGCATGGTTACCCTTTATATTAGTTTTTGTTTTCATAATTTTAACTA
GTCCATTGTTTCCAGCAATAAATAAAGGATTATCTCAAATACAAACAACTCTTTACATTTATACAGGTGCCCATGCTAAG
CCATTTACATTCTTGTGGCTTGCTACACCAGGAACATTAATTATAATAGCTACTTTTATAGGAGGATTAATACAAGGGGC
TAAGTTTTCTGAAATAGTTTCAGTATTAGTAAAAACTATAAAGCAAATGAGTAAATCTGCAATAACAATAATAGCCATAG
TAGCTATGGCAAAGATTATGGGATATAGCGGAATGATAAAATCAATAGCAGTTGTGTTAGTAGCGGTTACAGGTAGTTAC
TATCCTTTAATATCACCTATAATCGGGGCTTTAGGAACTTTTGTAACAGGCAGTGATACTTCATCTAATGTATTATTTGG
AGGACTTCAAGTTGAAGTAGCTAAGACTTTAGGATTAAATCCGTACTGGCTTGCAGCAGCTAATACTGGTGGTGCTACTG
CGGGTAAGATGATATCACCACAAAGTATAGCAGTGGCTACAGCAGCTACTGGACTTGTTGGAGCAGAAGGTAAAATATTA
AATGCGACTATAAAATTTTGTATAGTTTACGTAATTGTTTTAGGAATCATGGCTTATTTTATGGCACCTGTGTTTGGATT
CTAA

Upstream 100 bases:

>100_bases
ACCAAAGTTAAGAAAATAACTATTATAGAAATCTTATGAAAAATGGAGTAAAATGAAAACAATAAGAGGTCGTACCATAT
TACCGTAAGGGGGAACCTAT

Downstream 100 bases:

>100_bases
TTGCTTAAACTAATGAGGAGGATGAAATATGGCAAAGATAAAAATACCATATCACAAGAAAATGATTGAAATAGGGATAG
AAGATAAAAATTTAGTAGGG

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MNMYLTCFIALVPIAWLMVSLGILKMPGYKTCPATLVLTAILAVIVWKMPILDAASAALEGTALALWPIILVIVAAVFTY
NLSIHTKSMDTIKKMMTSITTDKRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG
GIGIPVTTLAKVTNIDVIQLSYAVGLQLSVLIVIIPIVLVMLTGKSVKSIKGVFGIALASGLSFAIPELLMAKYMGAELP
AILGSITCMVVTIAMAKIFYKDTASKNVEKIPFKKAVIAWLPFILVFVFIILTSPLFPAINKGLSQIQTTLYIYTGAHAK
PFTFLWLATPGTLIIIATFIGGLIQGAKFSEIVSVLVKTIKQMSKSAITIIAIVAMAKIMGYSGMIKSIAVVLVAVTGSY
YPLISPIIGALGTFVTGSDTSSNVLFGGLQVEVAKTLGLNPYWLAAANTGGATAGKMISPQSIAVATAATGLVGAEGKIL
NATIKFCIVYVIVLGIMAYFMAPVFGF

Sequences:

>Translated_507_residues
MNMYLTCFIALVPIAWLMVSLGILKMPGYKTCPATLVLTAILAVIVWKMPILDAASAALEGTALALWPIILVIVAAVFTY
NLSIHTKSMDTIKKMMTSITTDKRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG
GIGIPVTTLAKVTNIDVIQLSYAVGLQLSVLIVIIPIVLVMLTGKSVKSIKGVFGIALASGLSFAIPELLMAKYMGAELP
AILGSITCMVVTIAMAKIFYKDTASKNVEKIPFKKAVIAWLPFILVFVFIILTSPLFPAINKGLSQIQTTLYIYTGAHAK
PFTFLWLATPGTLIIIATFIGGLIQGAKFSEIVSVLVKTIKQMSKSAITIIAIVAMAKIMGYSGMIKSIAVVLVAVTGSY
YPLISPIIGALGTFVTGSDTSSNVLFGGLQVEVAKTLGLNPYWLAAANTGGATAGKMISPQSIAVATAATGLVGAEGKIL
NATIKFCIVYVIVLGIMAYFMAPVFGF
>Mature_507_residues
MNMYLTCFIALVPIAWLMVSLGILKMPGYKTCPATLVLTAILAVIVWKMPILDAASAALEGTALALWPIILVIVAAVFTY
NLSIHTKSMDTIKKMMTSITTDKRILVLILAWGFGGFLEAIAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFG
GIGIPVTTLAKVTNIDVIQLSYAVGLQLSVLIVIIPIVLVMLTGKSVKSIKGVFGIALASGLSFAIPELLMAKYMGAELP
AILGSITCMVVTIAMAKIFYKDTASKNVEKIPFKKAVIAWLPFILVFVFIILTSPLFPAINKGLSQIQTTLYIYTGAHAK
PFTFLWLATPGTLIIIATFIGGLIQGAKFSEIVSVLVKTIKQMSKSAITIIAIVAMAKIMGYSGMIKSIAVVLVAVTGSY
YPLISPIIGALGTFVTGSDTSSNVLFGGLQVEVAKTLGLNPYWLAAANTGGATAGKMISPQSIAVATAATGLVGAEGKIL
NATIKFCIVYVIVLGIMAYFMAPVFGF

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=546, Percent_Identity=36.6300366300366, Blast_Score=284, Evalue=9e-78,
Organism=Escherichia coli, GI1790031, Length=536, Percent_Identity=34.3283582089552, Blast_Score=265, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 53272; Mature: 53272

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMYLTCFIALVPIAWLMVSLGILKMPGYKTCPATLVLTAILAVIVWKMPILDAASAALE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTALALWPIILVIVAAVFTYNLSIHTKSMDTIKKMMTSITTDKRILVLILAWGFGGFLEA
CHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCHHEEEEEHHCHHHHHHH
IAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFGGIGIPVTTLAKVTNIDVIQL
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEE
SYAVGLQLSVLIVIIPIVLVMLTGKSVKSIKGVFGIALASGLSFAIPELLMAKYMGAELP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHH
AILGSITCMVVTIAMAKIFYKDTASKNVEKIPFKKAVIAWLPFILVFVFIILTSPLFPAI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
NKGLSQIQTTLYIYTGAHAKPFTFLWLATPGTLIIIATFIGGLIQGAKFSEIVSVLVKTI
HHHHHHHHHEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KQMSKSAITIIAIVAMAKIMGYSGMIKSIAVVLVAVTGSYYPLISPIIGALGTFVTGSDT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
SSNVLFGGLQVEVAKTLGLNPYWLAAANTGGATAGKMISPQSIAVATAATGLVGAEGKIL
CCCEEEECEEEEEHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHH
NATIKFCIVYVIVLGIMAYFMAPVFGF
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMYLTCFIALVPIAWLMVSLGILKMPGYKTCPATLVLTAILAVIVWKMPILDAASAALE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTALALWPIILVIVAAVFTYNLSIHTKSMDTIKKMMTSITTDKRILVLILAWGFGGFLEA
CHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCHHEEEEEHHCHHHHHHH
IAGFGTAVAIPASIMAALGFDPVFAAIICLIANTTPTAFGGIGIPVTTLAKVTNIDVIQL
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEE
SYAVGLQLSVLIVIIPIVLVMLTGKSVKSIKGVFGIALASGLSFAIPELLMAKYMGAELP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHH
AILGSITCMVVTIAMAKIFYKDTASKNVEKIPFKKAVIAWLPFILVFVFIILTSPLFPAI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
NKGLSQIQTTLYIYTGAHAKPFTFLWLATPGTLIIIATFIGGLIQGAKFSEIVSVLVKTI
HHHHHHHHHEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KQMSKSAITIIAIVAMAKIMGYSGMIKSIAVVLVAVTGSYYPLISPIIGALGTFVTGSDT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
SSNVLFGGLQVEVAKTLGLNPYWLAAANTGGATAGKMISPQSIAVATAATGLVGAEGKIL
CCCEEEECEEEEEHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHH
NATIKFCIVYVIVLGIMAYFMAPVFGF
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]