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The map label for this gene is cobQ [H]

Identifier: 226948186

GI number: 226948186

Start: 1111035

End: 1112516

Strand: Direct

Name: cobQ [H]

Synonym: CLM_1061

Alternate gene names: 226948186

Gene position: 1111035-1112516 (Clockwise)

Preceding gene: 226948185

Following gene: 226948187

Centisome position: 26.74

GC content: 30.16

Gene sequence:

>1482_bases
ATGGCTAAAATAATGATTCAGGGAACGGCCTCTTCTGTAGGAAAGAGTCTTATAGTGGCTGCCCTTTGTAGAATATTTAA
ACAGGATGGATATAGTGTTTGTCCTTTTAAATCGCAAAACATGTCTTTAAATTCTTATATAACTTTAGATGGAAAAGAAA
TGGGAAGAGCACAAGTGCTTCAGGCTTATGCAGCAGGTTTAGAACCAGAAGTTTATATGAATCCTATACTTTTAAAGCCT
ACTTCCGATAAGAAATGTCAAATAATAGTTAATGGTAAAGTGTACGGAAATAGTACAGCTATGGGATATCATAATTTAAA
ACTAAAGTTTAAAAATATGTTAAAAGGGCATTTTAATAAATTAGAAGAAGATTTTGATATAGTTGTTATGGAGGGAGCAG
GAAGTCCTGCAGAAATAAATTTAAGAGATAGAGATATAGTAAATATGGGTATGGCAGAACTTGTGGATGCGCCTGTACTT
TTAGTTGGAGATATAGATAAAGGAGGGGTTTTTGCATCTTTAGCAGGAACTATGCTTCTTTTGAATGAAGGAGAAAAGAA
AAGAGTAAAAGGAACTATAATAAACAAGTTTAGAGGAGATGTAGAAATACTAAAGCCAGGTTTAGATATGCTAGAAGATA
TAATACATATACCTTGTTTAGGGGTAGTACCTTATACTAGATTACAGTTAGAAGATGAAGATGGAGCAGTGGAATTTAAT
AAAAAAGCTTATGCACCAATCGATATAGCTGTAATAAAAATGCCTCATATATCAAATTTTACAGACTTAGATGCTTTAAA
GTCAGAAGAAGATGTATCTATAAGATTTATAACTTCGAAAGAGGAATTTAAAGAGCCAGATTTATTAGTAATACCAGGAA
GTAAAAATACTATAGAAGACTTACTTTATTTAAGAAAGTGTGGTTTAGAAGAAAGTATAAAAGAATATAGTAAGGATGGC
AAAATAATAGGTATCTGTGGAGGATATCAAGTATTAGGCAGCAAAATTAAAGATCCACATAATGTAGAAACAGATTTAGG
AGAGATTGATGGATTAAATCTTTTAGATATGGAAACTACCTTTGAAAAAGAAAAGGTTACTACACGAGTTTCTGCAAAAC
TTTTAAATGAAGAAACTAAAAATACTGTTTATGGTTATGAAATACATATGGGAATAAGTAAGTATGGCGAAAATATCAAA
CCATTATTTAAAATCTATGATAAAAATGGAGAAAAAGTAGATTATTTTGATGGAGCCATAAATGAAAAAGGAAATGTAAT
GGGAACTTATATCCATGGAGTTTTTGATGGAGTAGTTTTTAGGGAAAAAATAATAAATGAGTTAAGAGTTAAAAAAGGAT
TAAAAAAGAAAAAATCACAAATGTATGAACATATGAGAGAAAAAGAGTTAGATAAGCTTGCGGATATAGTAAGGCATAGC
TTAGATATGGAAAAAATTTATTCTATTATAGGGATGAAATAA

Upstream 100 bases:

>100_bases
AGGCGTAGTATGCCTATTTTTAACAATGCATTGGCTATAAACTCTAAAGTTTATAGCCAATTTTTATATTGAAAAATAAA
TTGAAATTGGAGAGAATTTT

Downstream 100 bases:

>100_bases
GATGTATCTAAATATAACTACAAATTTTATAGATATAATTATAGCGGTTTTTATAGATTGGATTATTGGAGATCCTTATT
GGTTTCCCCATCCAGTTATA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MAKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVLQAYAAGLEPEVYMNPILLKP
TSDKKCQIIVNGKVYGNSTAMGYHNLKLKFKNMLKGHFNKLEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVL
LVGDIDKGGVFASLAGTMLLLNEGEKKRVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFN
KKAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIEDLLYLRKCGLEESIKEYSKDG
KIIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMETTFEKEKVTTRVSAKLLNEETKNTVYGYEIHMGISKYGENIK
PLFKIYDKNGEKVDYFDGAINEKGNVMGTYIHGVFDGVVFREKIINELRVKKGLKKKKSQMYEHMREKELDKLADIVRHS
LDMEKIYSIIGMK

Sequences:

>Translated_493_residues
MAKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVLQAYAAGLEPEVYMNPILLKP
TSDKKCQIIVNGKVYGNSTAMGYHNLKLKFKNMLKGHFNKLEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVL
LVGDIDKGGVFASLAGTMLLLNEGEKKRVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFN
KKAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIEDLLYLRKCGLEESIKEYSKDG
KIIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMETTFEKEKVTTRVSAKLLNEETKNTVYGYEIHMGISKYGENIK
PLFKIYDKNGEKVDYFDGAINEKGNVMGTYIHGVFDGVVFREKIINELRVKKGLKKKKSQMYEHMREKELDKLADIVRHS
LDMEKIYSIIGMK
>Mature_492_residues
AKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVLQAYAAGLEPEVYMNPILLKPT
SDKKCQIIVNGKVYGNSTAMGYHNLKLKFKNMLKGHFNKLEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVLL
VGDIDKGGVFASLAGTMLLLNEGEKKRVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFNK
KAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIEDLLYLRKCGLEESIKEYSKDGK
IIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMETTFEKEKVTTRVSAKLLNEETKNTVYGYEIHMGISKYGENIKP
LFKIYDKNGEKVDYFDGAINEKGNVMGTYIHGVFDGVVFREKIINELRVKKGLKKKKSQMYEHMREKELDKLADIVRHSL
DMEKIYSIIGMK

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 55165; Mature: 55034

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVL
CCEEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCHHCCHHHHH
QAYAAGLEPEVYMNPILLKPTSDKKCQIIVNGKVYGNSTAMGYHNLKLKFKNMLKGHFNK
HHHHCCCCCCEEECCEEEECCCCCCEEEEECCEEECCCEECCEEEEEEHHHHHHHHHHHH
LEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVLLVGDIDKGGVFASLAGTMLL
HCCCCCEEEEECCCCCCEEEECCCHHHHCCHHHHCCCCEEEEECCCCCCCHHHHHCEEEE
LNEGEKKRVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFN
ECCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEC
KKAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIED
CCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCEEEEEECHHHHCCCCEEEECCCCCHHHH
LLYLRKCGLEESIKEYSKDGKIIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMETT
HHHHHHCCCHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHH
FEKEKVTTRVSAKLLNEETKNTVYGYEIHMGISKYGENIKPLFKIYDKNGEKVDYFDGAI
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHCCCCCEEHHEECCCCCEEEEECCCC
NEKGNVMGTYIHGVFDGVVFREKIINELRVKKGLKKKKSQMYEHMREKELDKLADIVRHS
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDMEKIYSIIGMK
CCHHHHHHHHCCC
>Mature Secondary Structure 
AKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVL
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCHHCCHHHHH
QAYAAGLEPEVYMNPILLKPTSDKKCQIIVNGKVYGNSTAMGYHNLKLKFKNMLKGHFNK
HHHHCCCCCCEEECCEEEECCCCCCEEEEECCEEECCCEECCEEEEEEHHHHHHHHHHHH
LEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVLLVGDIDKGGVFASLAGTMLL
HCCCCCEEEEECCCCCCEEEECCCHHHHCCHHHHCCCCEEEEECCCCCCCHHHHHCEEEE
LNEGEKKRVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFN
ECCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEC
KKAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIED
CCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCEEEEEECHHHHCCCCEEEECCCCCHHHH
LLYLRKCGLEESIKEYSKDGKIIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMETT
HHHHHHCCCHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHH
FEKEKVTTRVSAKLLNEETKNTVYGYEIHMGISKYGENIKPLFKIYDKNGEKVDYFDGAI
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHCCCCCEEHHEECCCCCEEEEECCCC
NEKGNVMGTYIHGVFDGVVFREKIINELRVKKGLKKKKSQMYEHMREKELDKLADIVRHS
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDMEKIYSIIGMK
CCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA