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The map label for this gene is lexA [H]

Identifier: 226948181

GI number: 226948181

Start: 1105805

End: 1107400

Strand: Direct

Name: lexA [H]

Synonym: CLM_1055

Alternate gene names: 226948181

Gene position: 1105805-1107400 (Clockwise)

Preceding gene: 226948180

Following gene: 226948182

Centisome position: 26.61

GC content: 26.19

Gene sequence:

>1596_bases
ATGAAACTAGAAAGTGGACAAAATAGAATAGTTAAAAGTAAACATTTAGGATACGGATTATTAAGAGGATCATTAGGTAC
TGGAAAAACTACTGCAGCTATATATAGAGGTATTTATTTAAAAAATCAATATTGCATGTATGATAAAGATAAAGTATTAA
TACTATCAAAGAATGAAGAAAATTCAAACTATATTAAGAACATATATGATGAGGCAGAAAAAACAGGGGTTCAATACATT
ACTTTGTTTTCATATATTGAAGACAAGCTATATTTTAGTGTTATATATAAAATTATAAACAAGTATTTTTGGGAGTACAT
AGAAAATAACAATCTACAATGTAAAATAGCAAGTGAAGAAGAAAAACTAGCTATAATTGAAGAATGTATAAATGATATAA
AAAATGAGTATAAAAAACTAAAATATATAGACATAAAATATAGCAAATTCTTTTTAGAAGAAATACAATGGATGAAAGAT
TGTATGTATTATGAACTAGAGGAATATAAAAAAGCAGATAGAATAGGTAGAAAAACAAAAAAAGGTGAAGGACCTCAAAG
AATTATAAAAAACTCAAAAATTAGAGAAGCAGTATTTAAAATTATGCTTTTATATAATGAAAAATTAAAGGATAAAAATT
TGGTAGACTACAGTGATGTAGTGTTTATGTCCTTAAAAGAAGCTTGCAAAAATAAAGAAAATAAATTTAATCACATAATA
GTAGATGAGGCACAAAATTTTACTAAACTAGAATTAAAATTTATAGAAGCTTTAGGAAGAAAAAATATATATTCAAGCAT
ACTATTTATTGCAGATAAAGAGAAAAATTCAAATCCTAAAGGATGGATAACTAAGGGACGGAAATTAAATAATCTTCAAT
TAGGGTTTGAATTTAAAAGATTTAATTTAAATAAAAAAATATCTATTAATCTCAAAGAAAATATAGATGATTGCGATCTT
AAAAGGAAAGTTTCAAATATTGATACAAAAAATGAAGATATTTCTAATATAGATAATGCTAATTCAGAAGATAAGGTTTT
AGATAAAAACATTAAAAATGAATGGCATAAAGCTAAGGTGAACTATAATATGGATAAGTTTGAATATGTAGATATAAAGC
ATAGAAGATCTTATGAATTTTTTAGAGATTTAGGTAGTAATGAAGAAATTATTGTAGAAGATCAAGGGAGCAAAGAGGAG
TACAAAGAGAATGAGTTAACAAAACTACCAGTATTTAATGATATAGCAGCAGGAGAACCTATACTTATGAACCCTTGTGT
AGAAGGAGAATTTAATATACCTAAATATTGGGTAAGGGGTATGAAAGATTGCTTCATATTAAAGGTAAAAGGGGATAGTA
TGATAGGTGCTAACATAGAAGATGGAGATCATGTGGTAATAAAGAGGCAGCAAATGGCTGAAAATAAAGATATAGTAGCT
GTTAACTTAGAGGGGAACGCAACCCTTAAAAGGTTATTAATAAAAAAATCTGGAGCAGTACTTATGCCAGAAAATAAAAA
ATATAAACCAATTGAAATACGAGAAGAAGGCGCAAATATTATAGGGATAGCAGTGGGAATAATAAAAGGAAAATAG

Upstream 100 bases:

>100_bases
GTGGTTATGCAATGGCATTGTTATTATAATAATTAAAATTTTGGCCAAAGTGTTATATATAATGTTTTTGAGGTGAAAAA
TGGGATAAGGAGGTGAAAAA

Downstream 100 bases:

>100_bases
TAATATATAATTATTGAACTGCCTTATATTTGTTATAATATAATAAATATAAGGCAGTTTTTGTTAGTATGCTTTTTAAA
AAAGAAAAAGATTATGTTTT

Product: putative LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKLESGQNRIVKSKHLGYGLLRGSLGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENSNYIKNIYDEAEKTGVQYI
TLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIIEECINDIKNEYKKLKYIDIKYSKFFLEEIQWMKD
CMYYELEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVFMSLKEACKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCDL
KRKVSNIDTKNEDISNIDNANSEDKVLDKNIKNEWHKAKVNYNMDKFEYVDIKHRRSYEFFRDLGSNEEIIVEDQGSKEE
YKENELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKDCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
VNLEGNATLKRLLIKKSGAVLMPENKKYKPIEIREEGANIIGIAVGIIKGK

Sequences:

>Translated_531_residues
MKLESGQNRIVKSKHLGYGLLRGSLGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENSNYIKNIYDEAEKTGVQYI
TLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIIEECINDIKNEYKKLKYIDIKYSKFFLEEIQWMKD
CMYYELEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVFMSLKEACKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCDL
KRKVSNIDTKNEDISNIDNANSEDKVLDKNIKNEWHKAKVNYNMDKFEYVDIKHRRSYEFFRDLGSNEEIIVEDQGSKEE
YKENELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKDCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
VNLEGNATLKRLLIKKSGAVLMPENKKYKPIEIREEGANIIGIAVGIIKGK
>Mature_531_residues
MKLESGQNRIVKSKHLGYGLLRGSLGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENSNYIKNIYDEAEKTGVQYI
TLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIIEECINDIKNEYKKLKYIDIKYSKFFLEEIQWMKD
CMYYELEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVFMSLKEACKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCDL
KRKVSNIDTKNEDISNIDNANSEDKVLDKNIKNEWHKAKVNYNMDKFEYVDIKHRRSYEFFRDLGSNEEIIVEDQGSKEE
YKENELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKDCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
VNLEGNATLKRLLIKKSGAVLMPENKKYKPIEIREEGANIIGIAVGIIKGK

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=125, Percent_Identity=36, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1787431, Length=128, Percent_Identity=28.125, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 62047; Mature: 62047

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLESGQNRIVKSKHLGYGLLRGSLGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEE
CCCCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEECCEEEECCCEEEEEECCCC
NSNYIKNIYDEAEKTGVQYITLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEE
CCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
EKLAIIEECINDIKNEYKKLKYIDIKYSKFFLEEIQWMKDCMYYELEEYKKADRIGRKTK
HHHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVFMSLKEACKNKENKFNHII
CCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKR
EECCCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCCEECCCEECCEEEEEEEEE
FNLNKKISINLKENIDDCDLKRKVSNIDTKNEDISNIDNANSEDKVLDKNIKNEWHKAKV
ECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHEEEE
NYNMDKFEYVDIKHRRSYEFFRDLGSNEEIIVEDQGSKEEYKENELTKLPVFNDIAAGEP
CCCCCCEEEEECHHCCCHHHHHHCCCCCEEEEECCCCHHHHHCCCCEECCCCCCCCCCCC
ILMNPCVEGEFNIPKYWVRGMKDCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
EEECCCCCCCCCCCHHHHCCCCCEEEEEECCCCEEECCCCCCCEEEEEEHHHCCCCCEEE
VNLEGNATLKRLLIKKSGAVLMPENKKYKPIEIREEGANIIGIAVGIIKGK
EEECCCHHHHHHHHHCCCCEEECCCCCCCCEEEECCCCCEEEEEEEEEECC
>Mature Secondary Structure
MKLESGQNRIVKSKHLGYGLLRGSLGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEE
CCCCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEECCEEEECCCEEEEEECCCC
NSNYIKNIYDEAEKTGVQYITLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEE
CCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
EKLAIIEECINDIKNEYKKLKYIDIKYSKFFLEEIQWMKDCMYYELEEYKKADRIGRKTK
HHHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVFMSLKEACKNKENKFNHII
CCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKR
EECCCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCCEECCCEECCEEEEEEEEE
FNLNKKISINLKENIDDCDLKRKVSNIDTKNEDISNIDNANSEDKVLDKNIKNEWHKAKV
ECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHEEEE
NYNMDKFEYVDIKHRRSYEFFRDLGSNEEIIVEDQGSKEEYKENELTKLPVFNDIAAGEP
CCCCCCEEEEECHHCCCHHHHHHCCCCCEEEEECCCCHHHHHCCCCEECCCCCCCCCCCC
ILMNPCVEGEFNIPKYWVRGMKDCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
EEECCCCCCCCCCCHHHHCCCCCEEEEEECCCCEEECCCCCCCEEEEEEHHHCCCCCEEE
VNLEGNATLKRLLIKKSGAVLMPENKKYKPIEIREEGANIIGIAVGIIKGK
EEECCCHHHHHHHHHCCCCEEECCCCCCCCEEEECCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA