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The map label for this gene is folP [H]

Identifier: 226948106

GI number: 226948106

Start: 1031347

End: 1032534

Strand: Direct

Name: folP [H]

Synonym: CLM_0970

Alternate gene names: 226948106

Gene position: 1031347-1032534 (Clockwise)

Preceding gene: 226948105

Following gene: 226948107

Centisome position: 24.82

GC content: 29.97

Gene sequence:

>1188_bases
ATGATTATAGAATTAAATAAAAATAGTTTCCCAGAAGAGTTCAATAAGATAGAAGTACATGAGGGTAGTGTGAATATATT
TATGAATAAAAATAGTATTACCCCTTTAAAAATTTTTAATGTGCTAGCTCCTGCGGCCAATATAATAAAGCAAGAAATAC
TGGCTTTAGGTGGAGATTGTGCTGTAAATAAATATTGTATAAATTGCAAAGTGGAAACTTCAGATATAATTTTATTAGGA
ACCAAAAGACAGTACAAAAAATTATTGCAAAAGCTTAAATGCATGACTTTTTTTAGAATAGAAGAAATAGTAGGGGAATT
AGAAAATTATATTAACAATCATAAAAAAATTAAAACGGTTTTAAGAGATGGAAGAGAAATAAACTATGAGAATTTAAAGG
TTATGGGAATTATAAATTGTACTCCAGATTCTTTTTATGAGGGCTCTAGAAAAAATTCTATAGAAGAAGCTTTAAAAACT
GCAGAAAAGATGTTAAAAGAAGGGGCAGAAATTTTAGATATAGGTGGAGAATCCACAAGACCAGGTTCTGACCCAGTAGA
TGAAGAGGAAGAAATAAAAAGAGTAGTTCCTGTTATAAGAGAGATAAAGAATAAATTTAAGGATGTCATAATTTCCATAG
ATACTTATAGAGCAAATACGGCAAAGGCTGCCATAGAGGCAGGTGCAGACATAGTAAATGATATAAGTGCTATGAAGTAT
GATGAAAATATGGTGAAAGTAGTTAAAGAATACAATATACCTGTAATACTTATGCATGTAAAAGGAAAACCAAAGGATAT
GCAAATAGATCCAGTTTATGAGAATTTAATGAAAGAAATTCATCTTTATTTTAATGAGAGAATAGAGTACTGCAAATCTC
ATGGCATAACAGAGGATAAAATAATATTAGATCCAGGCATAGGTTTTGGAAAAACTGTAGAGCATAATCTAAAAATAATG
AACAGATTAGAAGAATTGAAAAGCTTTAATCTTCCAGTACTTTTAGCAGCCTCAAGAAAAGCCACAATAGGAAAAGTTTT
AGGAAACTTATCTACAGAAGAAAGATTAGAAGGAACTATAGCTTTATCCTGTTTAGCTGTAAATTCAGGACTTCAAATGG
TGAGAGTACACGATGTTAAAGAAAATGTAAGAGCCATAAGAATGTTAGAGGCAGTAAGAAAAATATAA

Upstream 100 bases:

>100_bases
TAAAGAATTTATGAGAAATAATTAAAGTAAATTTCAGTTTGAGATAGTTCAATGTTTATATAACTTAACAGAATGGTTAT
AAAGAAAAGGAGCGTTAAAA

Downstream 100 bases:

>100_bases
ATTATATTATAAAAATATATTTTAAAATCTAGAAAATATAATCAAAATTAAATTATAATTTAAATTGTATCTTCTGATTT
TTAGGGCTGTAAGATAAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLG
TKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTVLRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALKT
AEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
DENMVKVVKEYNIPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIM
NRLEELKSFNLPVLLAASRKATIGKVLGNLSTEERLEGTIALSCLAVNSGLQMVRVHDVKENVRAIRMLEAVRKI

Sequences:

>Translated_395_residues
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLG
TKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTVLRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALKT
AEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
DENMVKVVKEYNIPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIM
NRLEELKSFNLPVLLAASRKATIGKVLGNLSTEERLEGTIALSCLAVNSGLQMVRVHDVKENVRAIRMLEAVRKI
>Mature_395_residues
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDIILLG
TKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTVLRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALKT
AEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
DENMVKVVKEYNIPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIM
NRLEELKSFNLPVLLAASRKATIGKVLGNLSTEERLEGTIALSCLAVNSGLQMVRVHDVKENVRAIRMLEAVRKI

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=273, Percent_Identity=42.8571428571429, Blast_Score=244, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=34.1772151898734, Blast_Score=159, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 44727; Mature: 44727

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEILALGGDC
CEEEECCCCCCHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTV
EECEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALKTAEKMLKEGAEILDIGGESTR
HHCCCCCCCCCEEEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCHHHHHHHHHHHH
DENMVKVVKEYNIPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDK
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IILDPGIGFGKTVEHNLKIMNRLEELKSFNLPVLLAASRKATIGKVLGNLSTEERLEGTI
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCHHHHHCHHE
ALSCLAVNSGLQMVRVHDVKENVRAIRMLEAVRKI
EEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEILALGGDC
CEEEECCCCCCHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTV
EECEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALKTAEKMLKEGAEILDIGGESTR
HHCCCCCCCCCEEEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCHHHHHHHHHHHH
DENMVKVVKEYNIPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDK
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IILDPGIGFGKTVEHNLKIMNRLEELKSFNLPVLLAASRKATIGKVLGNLSTEERLEGTI
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCHHHHHCHHE
ALSCLAVNSGLQMVRVHDVKENVRAIRMLEAVRKI
EEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]