Click here to switch to the map view.

The map label for this gene is arsA [H]

Identifier: 226948046

GI number: 226948046

Start: 965964

End: 967709

Strand: Direct

Name: arsA [H]

Synonym: CLM_0907

Alternate gene names: 226948046

Gene position: 965964-967709 (Clockwise)

Preceding gene: 226948045

Following gene: 226948047

Centisome position: 23.25

GC content: 31.73

Gene sequence:

>1746_bases
ATGTTTAAAAAATTTAATGTGGAAGATATAAACTTAACAAAATATTTGTTCTTTACTGGCAAAGGTGGAGTTGGTAAGAC
TTCAACAGCTTGTGCCATAGCAGTGGCTTTAGCTGATAGCGGTAAAAAAATTATGCTTGTTAGTACAGATCCAGCTTCAA
ATCTTCAAGATGTATTTAATACAAAATTAAATAATAAGGGAGTTTATATAAAAGAAGTTCCTAATTTGGTAGTTGCAAAC
TTTGAACCAGAAGAAGCAGCTGCTGAATATAGAGAAAGCGTAATAGCACCTTATCGTGGAAAACTACCAGAAGTAGTTTT
GAAAAATATGGAGGAACAGCTTTCAGGTTCATGTACTGTTGAGATTGCTGCATTTAATGAATTTTCAACCTTTATAACTG
ATGAAAAAGTAGAAAAAGAGTATGATCATATTATATTTGATACAGCACCAACAGGCCATACACTAAGGATGTTGCAGCTT
CCTTCAGCATGGAGTAATTTTATTAATGAAAGTACACATGGTGCTTCATGTTTAGGACAGCTTTCAGGACTTGAAAGTAA
AAGAGAAGTTTATAAAAATGCAGTAAATACTCTAGCGGATAAGGATAAAACTACACTTATACTTGTATCACGTCCAGAAG
TATCACCTTTAAAGGAAGCTGAAAGAGCCTCTAAGGAACTTCAAGATATAGGTGTAAACAATCAAGTTTTAGTTATTAAT
GGAGTACTTGAAGAACATGAAGATTATCTTTCCAATGCTATTTATACTAAACAGCAAAAAGCATTAGAAGATATTCCAGA
ATCACTAAAGACTGTTGAAACTTTTCAAATTCCATTAAGACCGTATAATGTAACAGGTTTAGAAAATGTAAGAGCTTTTT
TAAGGAATAATAATATTAAATATAATGATGAAAAACTAAACACTACTAATATACCTAAATTAAATGAGGTAATAGAAGAT
TTATATAATACTGATAAAAAAGTAATATTTACAATGGGTAAAGGTGGCGTAGGTAAAACTACAATAGCTGCTGCAATAGC
TGTAGGACTAGCTAAAAAAGGGAAGAAAGTACATTTAACAACTACTGATCCGGCAGATCACTTAAAGTTTGTATTAGATG
AAGATTATGGAATTACTTTAAGCCATATAGATGAAAAAGAAGAACTAGAAAAATACAAAGAAGAGGTATTAAGTAAAGCA
CGAAAAACTATGAGTGAAGATGATATTGCTTATGTTGAAGAAGATCTAAGATCACCTTGTACTCAAGAAATTGCAGTATT
TAGGGCCTTTGCAGAAATAGTTGAAAGGTCAGAAAATGAGGTTGTAGTTATTGATACAGCACCAACAGGACATACTTTAT
TACTTTTAGACTCTACTCAAAGTTATAATAAAGAAATTCAACGTTCACAAGGAGATATTCCAGAATCAGTTAAGAAGCTT
TTACCTAAGCTTAGAAATGAGGAAAATACAGAAGTAATCATCGTAACACTAGCTGAAACAACTCCAGTTTATGAGGCTAT
GAGACTTCAAGAAGATTTGAATAGAGCTGGTATTCACAGTAAATGGTGGGTTATCAATTCAAGTTTTTATGTAGCTGATA
CAACAAATTCTATCTTAAAGGTAAAAGCCAACAATGAGGTACAGTGGATTAATAAAGTGAATGAAATATCTAAAGGTAAT
TTTGCAGTTATAGAGTGGATTCCTAAGGAAGTTAAAGGCGAAATACTTAATGATTTAATCAACTAG

Upstream 100 bases:

>100_bases
GTTAGATATACCAGAGGATTATTTAAAAATTACTATAAAAAACCCATCTAAAGGTTGTAATTGTAAAGGTGGATGTTGCT
AAAAAGAAAAGGGGGATATG

Downstream 100 bases:

>100_bases
GCATAATTCCACTGCAAAATTTAAGAACCAATTTTGCAGTGGAATTATATATACACATGGTTATATAAAAATAATTTGTA
CGGAGGATAATTTCATGAAA

Product: putative arsenite-transporting ATPase ArsA

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MFKKFNVEDINLTKYLFFTGKGGVGKTSTACAIAVALADSGKKIMLVSTDPASNLQDVFNTKLNNKGVYIKEVPNLVVAN
FEPEEAAAEYRESVIAPYRGKLPEVVLKNMEEQLSGSCTVEIAAFNEFSTFITDEKVEKEYDHIIFDTAPTGHTLRMLQL
PSAWSNFINESTHGASCLGQLSGLESKREVYKNAVNTLADKDKTTLILVSRPEVSPLKEAERASKELQDIGVNNQVLVIN
GVLEEHEDYLSNAIYTKQQKALEDIPESLKTVETFQIPLRPYNVTGLENVRAFLRNNNIKYNDEKLNTTNIPKLNEVIED
LYNTDKKVIFTMGKGGVGKTTIAAAIAVGLAKKGKKVHLTTTDPADHLKFVLDEDYGITLSHIDEKEELEKYKEEVLSKA
RKTMSEDDIAYVEEDLRSPCTQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLDSTQSYNKEIQRSQGDIPESVKKL
LPKLRNEENTEVIIVTLAETTPVYEAMRLQEDLNRAGIHSKWWVINSSFYVADTTNSILKVKANNEVQWINKVNEISKGN
FAVIEWIPKEVKGEILNDLIN

Sequences:

>Translated_581_residues
MFKKFNVEDINLTKYLFFTGKGGVGKTSTACAIAVALADSGKKIMLVSTDPASNLQDVFNTKLNNKGVYIKEVPNLVVAN
FEPEEAAAEYRESVIAPYRGKLPEVVLKNMEEQLSGSCTVEIAAFNEFSTFITDEKVEKEYDHIIFDTAPTGHTLRMLQL
PSAWSNFINESTHGASCLGQLSGLESKREVYKNAVNTLADKDKTTLILVSRPEVSPLKEAERASKELQDIGVNNQVLVIN
GVLEEHEDYLSNAIYTKQQKALEDIPESLKTVETFQIPLRPYNVTGLENVRAFLRNNNIKYNDEKLNTTNIPKLNEVIED
LYNTDKKVIFTMGKGGVGKTTIAAAIAVGLAKKGKKVHLTTTDPADHLKFVLDEDYGITLSHIDEKEELEKYKEEVLSKA
RKTMSEDDIAYVEEDLRSPCTQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLDSTQSYNKEIQRSQGDIPESVKKL
LPKLRNEENTEVIIVTLAETTPVYEAMRLQEDLNRAGIHSKWWVINSSFYVADTTNSILKVKANNEVQWINKVNEISKGN
FAVIEWIPKEVKGEILNDLIN
>Mature_581_residues
MFKKFNVEDINLTKYLFFTGKGGVGKTSTACAIAVALADSGKKIMLVSTDPASNLQDVFNTKLNNKGVYIKEVPNLVVAN
FEPEEAAAEYRESVIAPYRGKLPEVVLKNMEEQLSGSCTVEIAAFNEFSTFITDEKVEKEYDHIIFDTAPTGHTLRMLQL
PSAWSNFINESTHGASCLGQLSGLESKREVYKNAVNTLADKDKTTLILVSRPEVSPLKEAERASKELQDIGVNNQVLVIN
GVLEEHEDYLSNAIYTKQQKALEDIPESLKTVETFQIPLRPYNVTGLENVRAFLRNNNIKYNDEKLNTTNIPKLNEVIED
LYNTDKKVIFTMGKGGVGKTTIAAAIAVGLAKKGKKVHLTTTDPADHLKFVLDEDYGITLSHIDEKEELEKYKEEVLSKA
RKTMSEDDIAYVEEDLRSPCTQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLDSTQSYNKEIQRSQGDIPESVKKL
LPKLRNEENTEVIIVTLAETTPVYEAMRLQEDLNRAGIHSKWWVINSSFYVADTTNSILKVKANNEVQWINKVNEISKGN
FAVIEWIPKEVKGEILNDLIN

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI50428938, Length=304, Percent_Identity=26.9736842105263, Blast_Score=91, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320103, Length=324, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24586297, Length=321, Percent_Identity=24.9221183800623, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 65088; Mature: 65088

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKFNVEDINLTKYLFFTGKGGVGKTSTACAIAVALADSGKKIMLVSTDPASNLQDVFN
CCCCCCCCCCEEEEEEEEECCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCHHHHHHHH
TKLNNKGVYIKEVPNLVVANFEPEEAAAEYRESVIAPYRGKLPEVVLKNMEEQLSGSCTV
CCCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEE
EIAAFNEFSTFITDEKVEKEYDHIIFDTAPTGHTLRMLQLPSAWSNFINESTHGASCLGQ
EEEEECCHHHHHCHHHHHHHHCEEEEECCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHH
LSGLESKREVYKNAVNTLADKDKTTLILVSRPEVSPLKEAERASKELQDIGVNNQVLVIN
HHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
GVLEEHEDYLSNAIYTKQQKALEDIPESLKTVETFQIPLRPYNVTGLENVRAFLRNNNIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHCCCCE
YNDEKLNTTNIPKLNEVIEDLYNTDKKVIFTMGKGGVGKTTIAAAIAVGLAKKGKKVHLT
ECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEE
TTDPADHLKFVLDEDYGITLSHIDEKEELEKYKEEVLSKARKTMSEDDIAYVEEDLRSPC
ECCCHHHHEEEECCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCH
TQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLDSTQSYNKEIQRSQGDIPESVKKL
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHH
LPKLRNEENTEVIIVTLAETTPVYEAMRLQEDLNRAGIHSKWWVINSSFYVADTTNSILK
HHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECEEEEEECCCCEEE
VKANNEVQWINKVNEISKGNFAVIEWIPKEVKGEILNDLIN
EECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MFKKFNVEDINLTKYLFFTGKGGVGKTSTACAIAVALADSGKKIMLVSTDPASNLQDVFN
CCCCCCCCCCEEEEEEEEECCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCHHHHHHHH
TKLNNKGVYIKEVPNLVVANFEPEEAAAEYRESVIAPYRGKLPEVVLKNMEEQLSGSCTV
CCCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEE
EIAAFNEFSTFITDEKVEKEYDHIIFDTAPTGHTLRMLQLPSAWSNFINESTHGASCLGQ
EEEEECCHHHHHCHHHHHHHHCEEEEECCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHH
LSGLESKREVYKNAVNTLADKDKTTLILVSRPEVSPLKEAERASKELQDIGVNNQVLVIN
HHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
GVLEEHEDYLSNAIYTKQQKALEDIPESLKTVETFQIPLRPYNVTGLENVRAFLRNNNIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHCCCCE
YNDEKLNTTNIPKLNEVIEDLYNTDKKVIFTMGKGGVGKTTIAAAIAVGLAKKGKKVHLT
ECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEE
TTDPADHLKFVLDEDYGITLSHIDEKEELEKYKEEVLSKARKTMSEDDIAYVEEDLRSPC
ECCCHHHHEEEECCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCH
TQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLDSTQSYNKEIQRSQGDIPESVKKL
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHH
LPKLRNEENTEVIIVTLAETTPVYEAMRLQEDLNRAGIHSKWWVINSSFYVADTTNSILK
HHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECEEEEEECCCCEEE
VKANNEVQWINKVNEISKGNFAVIEWIPKEVKGEILNDLIN
EECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3021763; 1704144 [H]