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The map label for this gene is tlpC [H]

Identifier: 226947996

GI number: 226947996

Start: 917556

End: 919022

Strand: Direct

Name: tlpC [H]

Synonym: CLM_0857

Alternate gene names: 226947996

Gene position: 917556-919022 (Clockwise)

Preceding gene: 226947994

Following gene: 226947997

Centisome position: 22.08

GC content: 28.7

Gene sequence:

>1467_bases
ATGGATTACAAAAAAAATGCGGAATTGAAAAATAAAATTATGTTGGCAGGATTTATAGCATCCGTAGTACTAAGGGCAAT
TTTTGATATAATTTTAAAGGTAGATAGGAATGCCATATTAATATTAGTTGGACTTTCCATACCTTTAGCTATAATCGATT
TTATATTAATAAAAAAGAAATGTATTATCCAAACAATGTATTATACGGTAATGATGTACACTGCTGTTATATGTATAATG
TTTATATCAGACCCAAATTGGGCTAATTTTATTTTGATATATTATGGTGTTATATTAATGAGTGTATATCAAGATTTAAG
GATATTAATTATTGAAGCAATTTTGGCTACAGTACTTGTAGTGTATTTCTTCTTAGGCTATAAAACAACACTCTTTGCTT
CCGTAGGATACTATGAATTAGTATTTTATATATCATACATAGTAGCAGGATCAGCTATATTGTCCATTAATGCCATTACT
ACCAAAAGTATTTATAAAGATTTAGAAGAAACTCATAAAGCTACTGAAGAAGCTAAATCTAGAGCAGAGTTATTGCTGGA
AAAAATATATAGTACCATAAAAGTTTTAACAGCAACTAATGAGAAAATAAAAAGTGGAATTTCTGTAGCGGGACAAATAG
CAGAAGAAATTACTAGTTCTACAAGCGACGTTGCTAATAGTGCAGCCAAAGAAGTTGATGTAATGATTGGAATGAAATCC
TCAATAGAGGGCGGAGCAGAAAAGGCAGAAGAAGTTACGAATGCTATTAAAACTATGGAGGAATTATCTAAGTCGACTGA
AAATGTTGTATTAGAAGGTAATAATAAAGTAGATATATTATCTTCGGAAATGAATAAGGTAAATAAAAATATTTTAAGTG
TGGTATACATGATAAATGAATTAAGTGACGAAAATGCAAAAATAGTTCATATTATTAACAGTATTACAAAAATATCAGAG
CAAACCAATCTATTAGCCCTTAATGCATCAATAGAAGCAGCTAGAGCTGGAGAGTATGGAAAAAGTTTTGCTGTAGTTGC
AGAAGAAGTAAGAAAACTTGCTGAGGATTCGAAAGAATCTACAGATCAAATAGAATTAATATTGAATAATATATCTAATA
AAACAAAGGTAGTTGCAGAAGAAATATTAAAAGAAGAAAAGTCAATCGAATTATGTAATGAGCATACAAATGATGTTAAA
GAGTTATTTAAAGATGTTAATAAGAATACTTCTAATGTATTAAGTTATTCAAGCAGTGTTGGATCACAATCTATATTGCT
TGAAAGTACGATGAAAAATACATTAAGTTCAGTAAATAATATTAGCGAAACTGTAGAATCCACTGCAACTGCTATGGAAG
AAATTTTTACGGCTATTGATGAGCTTAATAATAGCATAATTGGTATAACAAGTAGTTATGATGAAATAGATGATATATGT
AATGAATTAAACTCTATAAGTGAATAA

Upstream 100 bases:

>100_bases
AATGATTAAAAAAGATGAAATATAAATAAGTATATTAATAATAAAGTTATATGGCGATGCTACGAATAATAATATAGAAT
TCAATAAGAGGTGAGTAGTA

Downstream 100 bases:

>100_bases
AGTAGATAATATAAACAGAGTTCTTGGCTTCAGAGGGAGTTTTTACTCCCACTGAAGCTTAGAAATCGTTATCCAGGGAC
GTAACCACTCTTTACTCCCA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MDYKKNAELKNKIMLAGFIASVVLRAIFDIILKVDRNAILILVGLSIPLAIIDFILIKKKCIIQTMYYTVMMYTAVICIM
FISDPNWANFILIYYGVILMSVYQDLRILIIEAILATVLVVYFFLGYKTTLFASVGYYELVFYISYIVAGSAILSINAIT
TKSIYKDLEETHKATEEAKSRAELLLEKIYSTIKVLTATNEKIKSGISVAGQIAEEITSSTSDVANSAAKEVDVMIGMKS
SIEGGAEKAEEVTNAIKTMEELSKSTENVVLEGNNKVDILSSEMNKVNKNILSVVYMINELSDENAKIVHIINSITKISE
QTNLLALNASIEAARAGEYGKSFAVVAEEVRKLAEDSKESTDQIELILNNISNKTKVVAEEILKEEKSIELCNEHTNDVK
ELFKDVNKNTSNVLSYSSSVGSQSILLESTMKNTLSSVNNISETVESTATAMEEIFTAIDELNNSIIGITSSYDEIDDIC
NELNSISE

Sequences:

>Translated_488_residues
MDYKKNAELKNKIMLAGFIASVVLRAIFDIILKVDRNAILILVGLSIPLAIIDFILIKKKCIIQTMYYTVMMYTAVICIM
FISDPNWANFILIYYGVILMSVYQDLRILIIEAILATVLVVYFFLGYKTTLFASVGYYELVFYISYIVAGSAILSINAIT
TKSIYKDLEETHKATEEAKSRAELLLEKIYSTIKVLTATNEKIKSGISVAGQIAEEITSSTSDVANSAAKEVDVMIGMKS
SIEGGAEKAEEVTNAIKTMEELSKSTENVVLEGNNKVDILSSEMNKVNKNILSVVYMINELSDENAKIVHIINSITKISE
QTNLLALNASIEAARAGEYGKSFAVVAEEVRKLAEDSKESTDQIELILNNISNKTKVVAEEILKEEKSIELCNEHTNDVK
ELFKDVNKNTSNVLSYSSSVGSQSILLESTMKNTLSSVNNISETVESTATAMEEIFTAIDELNNSIIGITSSYDEIDDIC
NELNSISE
>Mature_488_residues
MDYKKNAELKNKIMLAGFIASVVLRAIFDIILKVDRNAILILVGLSIPLAIIDFILIKKKCIIQTMYYTVMMYTAVICIM
FISDPNWANFILIYYGVILMSVYQDLRILIIEAILATVLVVYFFLGYKTTLFASVGYYELVFYISYIVAGSAILSINAIT
TKSIYKDLEETHKATEEAKSRAELLLEKIYSTIKVLTATNEKIKSGISVAGQIAEEITSSTSDVANSAAKEVDVMIGMKS
SIEGGAEKAEEVTNAIKTMEELSKSTENVVLEGNNKVDILSSEMNKVNKNILSVVYMINELSDENAKIVHIINSITKISE
QTNLLALNASIEAARAGEYGKSFAVVAEEVRKLAEDSKESTDQIELILNNISNKTKVVAEEILKEEKSIELCNEHTNDVK
ELFKDVNKNTSNVLSYSSSVGSQSILLESTMKNTLSSVNNISETVESTATAMEEIFTAIDELNNSIIGITSSYDEIDDIC
NELNSISE

Specific function: Receptor For The Attractant L-Serine And Related Amino Acids. Is Also Responsible For Chemotaxis Away From A Wide Range Of Repellents, Including Leucine, Indole, And Weak Acids. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of At

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788195, Length=193, Percent_Identity=28.4974093264249, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789453, Length=118, Percent_Identity=33.8983050847458, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787690, Length=277, Percent_Identity=26.3537906137184, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788194, Length=200, Percent_Identity=28.5, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 53929; Mature: 53929

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKKNAELKNKIMLAGFIASVVLRAIFDIILKVDRNAILILVGLSIPLAIIDFILIKKK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHH
CIIQTMYYTVMMYTAVICIMFISDPNWANFILIYYGVILMSVYQDLRILIIEAILATVLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYFFLGYKTTLFASVGYYELVFYISYIVAGSAILSINAITTKSIYKDLEETHKATEEAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHH
RAELLLEKIYSTIKVLTATNEKIKSGISVAGQIAEEITSSTSDVANSAAKEVDVMIGMKS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHH
SIEGGAEKAEEVTNAIKTMEELSKSTENVVLEGNNKVDILSSEMNKVNKNILSVVYMINE
HCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHH
LSDENAKIVHIINSITKISEQTNLLALNASIEAARAGEYGKSFAVVAEEVRKLAEDSKES
HCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
TDQIELILNNISNKTKVVAEEILKEEKSIELCNEHTNDVKELFKDVNKNTSNVLSYSSSV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCC
GSQSILLESTMKNTLSSVNNISETVESTATAMEEIFTAIDELNNSIIGITSSYDEIDDIC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
NELNSISE
HHHHCCCC
>Mature Secondary Structure
MDYKKNAELKNKIMLAGFIASVVLRAIFDIILKVDRNAILILVGLSIPLAIIDFILIKKK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHH
CIIQTMYYTVMMYTAVICIMFISDPNWANFILIYYGVILMSVYQDLRILIIEAILATVLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYFFLGYKTTLFASVGYYELVFYISYIVAGSAILSINAITTKSIYKDLEETHKATEEAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHH
RAELLLEKIYSTIKVLTATNEKIKSGISVAGQIAEEITSSTSDVANSAAKEVDVMIGMKS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHH
SIEGGAEKAEEVTNAIKTMEELSKSTENVVLEGNNKVDILSSEMNKVNKNILSVVYMINE
HCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHH
LSDENAKIVHIINSITKISEQTNLLALNASIEAARAGEYGKSFAVVAEEVRKLAEDSKES
HCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
TDQIELILNNISNKTKVVAEEILKEEKSIELCNEHTNDVKELFKDVNKNTSNVLSYSSSV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCC
GSQSILLESTMKNTLSSVNNISETVESTATAMEEIFTAIDELNNSIIGITSSYDEIDDIC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
NELNSISE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]