Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 226947956

GI number: 226947956

Start: 877491

End: 878603

Strand: Direct

Name: gcvT [H]

Synonym: CLM_0815

Alternate gene names: 226947956

Gene position: 877491-878603 (Clockwise)

Preceding gene: 226947953

Following gene: 226947957

Centisome position: 21.12

GC content: 30.91

Gene sequence:

>1113_bases
ATGGAAGGTTTAAAAGTTACGCCTTTAAGAGGTGTGTATGAAGAGTATGGTGGGAAAATTGTAGATTTTGCAGGATATGA
ACTTCCAACACAATTTAAAGGCTTTTTACATGAGCATCATACTGTAAGAGAAAAAGCAGGTCTTTTTGATGTTTCTCATA
TGGGAGAAGCTATGGTAACAGGAAAAGATGCTGGAAAATTCATTCAATATTTAATGACTAATGACATAAATGTTCTTAAA
GATAATGAGGTTTTGTACACATTCATGTGTAATGAAGATGGTGGAGTGATAGATGATTTATTGGTTTACAAATTTGCAGA
GGATGAGTTTTTTTTAGTTATTAATGCAAGTAATAAAGATAAAGATGTTAAGTGGATAATGGATCACAAAGGGGATTTTG
ATGTTGAAATTGTTGATGTATCAGATAGCATTGCGCAACTTGCATTCCAAGGCCCTTTGGCAGAGGAAATACTTCAAAAA
ATAGTAGATGTAGATTTACAAGAAATAAAATTCTTTAAACTTAAAAGAGATGTTTTAGTTGATGGGAAAAAATGCTTAGT
ATCAAGAACCGGTTATACTGGAGAAGATGGTTTTGAAATTTATTGTAAACCAGAGGATGCAAAAGAACTATGGCATGCTA
TATTAAATGCAGGAAAAGAAGAAGGTGCACAGCCAATAGGATTAGGTGCTAGAGATACTTTAAGATTTGAAGCTAGTCTT
CTTTTATATGGAAATGAAATGGATGAAACAATTACGCCATTAGAAGTAGGTATGGGATTCTTTGTAAAATTAAAAGTTGA
AGAAGACTTTATAGGAAAAGATGCTTTAATAAAACAAAAAGCAGAAGGTGTAACTAGAAAATTGGTAGGGTTTGAACTTT
TAGATAAGGGTATTCCAAGACATGGTTATGAGGTCATTAAAGATGGAAAAGTTATTGGACATGTTACAACTGGATATAAA
TCTCCTACATTAAACAAAGCAATTGGATTAGCTTTAGTAGAAGAACAATATTCTAAAATAGGAACAGAGTTTAATATAAA
AGTTAGAAAAAAAAAATTAAAAGCTGTTGCTATAGATAAAAGATTCTATACTAAAAAAACAAAAACCAAATAA

Upstream 100 bases:

>100_bases
AACTTTACAACTTGGTTTTACACTAAATTATTTTCATAATTTTACTAAAAAATATATATAAATGTTTATAGGTAAATAAT
TTTAATTGGGGGTAGAGCGC

Downstream 100 bases:

>100_bases
TATATTAACGGTTAATTTGTAGATTATTTTTTAATATATATAAATTCACACTAATGTTTAGTTTTCAGGTTAAAATGTCA
TTGGTAATCAATATATAATA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MEGLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTNDINVLK
DNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQK
IVDVDLQEIKFFKLKRDVLVDGKKCLVSRTGYTGEDGFEIYCKPEDAKELWHAILNAGKEEGAQPIGLGARDTLRFEASL
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYK
SPTLNKAIGLALVEEQYSKIGTEFNIKVRKKKLKAVAIDKRFYTKKTKTK

Sequences:

>Translated_370_residues
MEGLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTNDINVLK
DNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQK
IVDVDLQEIKFFKLKRDVLVDGKKCLVSRTGYTGEDGFEIYCKPEDAKELWHAILNAGKEEGAQPIGLGARDTLRFEASL
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYK
SPTLNKAIGLALVEEQYSKIGTEFNIKVRKKKLKAVAIDKRFYTKKTKTK
>Mature_370_residues
MEGLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVTGKDAGKFIQYLMTNDINVLK
DNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKDKDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQK
IVDVDLQEIKFFKLKRDVLVDGKKCLVSRTGYTGEDGFEIYCKPEDAKELWHAILNAGKEEGAQPIGLGARDTLRFEASL
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYK
SPTLNKAIGLALVEEQYSKIGTEFNIKVRKKKLKAVAIDKRFYTKKTKTK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=35.4497354497354, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI257796258, Length=355, Percent_Identity=35.4929577464789, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI24797151, Length=345, Percent_Identity=32.7536231884058, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI257796254, Length=375, Percent_Identity=32.8, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=34.375, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI197927446, Length=325, Percent_Identity=28, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI21361378, Length=325, Percent_Identity=28, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI194306651, Length=372, Percent_Identity=25.5376344086022, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789272, Length=369, Percent_Identity=39.2953929539295, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=352, Percent_Identity=38.6363636363636, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32563613, Length=327, Percent_Identity=27.82874617737, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71994045, Length=350, Percent_Identity=26.2857142857143, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=350, Percent_Identity=26.2857142857143, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320222, Length=371, Percent_Identity=35.8490566037736, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129441, Length=364, Percent_Identity=34.6153846153846, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI28571104, Length=286, Percent_Identity=29.7202797202797, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI20130091, Length=338, Percent_Identity=23.9644970414201, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41659; Mature: 41659

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVT
CCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEE
GKDAGKFIQYLMTNDINVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKD
CCCHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCHHHHHEEEECCCCEEEEEECCCCC
KDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQKIVDVDLQEIKFFKLKRDVLV
CCEEEEECCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHC
DGKKCLVSRTGYTGEDGFEIYCKPEDAKELWHAILNAGKEEGAQPIGLGARDTLRFEASL
CCCHHEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEEEE
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPR
EEECCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
HGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKKLKAVAIDK
CCHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEECH
RFYTKKTKTK
HHHCCCCCCC
>Mature Secondary Structure
MEGLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEAMVT
CCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEE
GKDAGKFIQYLMTNDINVLKDNEVLYTFMCNEDGGVIDDLLVYKFAEDEFFLVINASNKD
CCCHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCHHHHHEEEECCCCEEEEEECCCCC
KDVKWIMDHKGDFDVEIVDVSDSIAQLAFQGPLAEEILQKIVDVDLQEIKFFKLKRDVLV
CCEEEEECCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHC
DGKKCLVSRTGYTGEDGFEIYCKPEDAKELWHAILNAGKEEGAQPIGLGARDTLRFEASL
CCCHHEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEEEE
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPR
EEECCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
HGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKKLKAVAIDK
CCHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEECH
RFYTKKTKTK
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA