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The map label for this gene is lytC [H]

Identifier: 226947680

GI number: 226947680

Start: 572502

End: 573917

Strand: Direct

Name: lytC [H]

Synonym: CLM_0526

Alternate gene names: 226947680

Gene position: 572502-573917 (Clockwise)

Preceding gene: 226947679

Following gene: 226947683

Centisome position: 13.78

GC content: 31.78

Gene sequence:

>1416_bases
ATGAAAAAAAGATTGTTGAATATTACTTCTGCTGTAGTTGCATCTTGTGTGATGTTTTTTTTGTCAAATGTTGTAAGTGC
AGCAATGCTACAAGAGAGGCTATATGGAAATGATAGGTATCAAACTAATTCTAAAATTGTAGACTCAGGCTGGACATCAT
CGGAGTATGCAGTAGTAGCAAGTGGAGAAGATTTTGCAGATGCATTATGTGCTTCTCCTTTAGCTCAACAAAACAAAGCA
CCTATACTTTTAACTAATAAAGATAATTTAAGTATAGAAAACAAAAAACAATTATCAAGGCTAAAAGTAAAAAAAGTATT
TATTGTTGGTGGAACTGGGGTTATAACTGATAATGTGAAATTAGAAATAGAAAGCATGGGCATCGAAACTTCTAGAATAT
ATGGAGAAAATAGATTTGAAACATCTATAGAAGTAGCTAAAAATCTAAAAAATATAAGTGGAGTAGTGATAGCTAATGGT
TATGGATTTGCAGATGCGTTATCCATAGCTCCCGTTGCGGCACAAAAAGGTATGCCAATACTGCTTACTAATAGAGGAGA
CTTATCTAAAGCAGCTAAAGAATTTTTAGATACTAAAACGCCTACTGAAAGTTATGTAGTTGGTGGAACTGGAGTTGTAA
GTAGCAAGATTTCTTCACAATTAAATAATAATACAAGACTTGGAGGAGAAAATAGATATGAAACAAATTCAGCTGTATTA
AATCACTTTGCTGATAAGTTTAGTTATGATAAAGTTTATGTTGCATCAGGTGAGAATTATCCAGATGCACTATCTGGTAG
TGTATTAGCAGCAGTAAGCAAATCACCTTTAATTTTAGTGGGGGATTCTGTTAATTCCTCAGTAATGACTTCAGTAAAAG
CTCAACATGATAAGTATAATAATGTAATAGTCTTAGGTGGCACTGAAGTAGTTTCAGATGTATCAGCTAATAGTATTGTA
CATGGTATCAAATATTTAAATGATAGAGAAGCACTAACTCTTATAAATAATGCTGATAAGTTAGGATATCCAGTAGTGGA
AGCTAATCGTATGCCTGAAATATATATTGAAGGTAAGGCATATCAAAGATTTCAAGATGAGTTTAATAGCCCTGAAAAGC
TTTATGCTTATTTGAATAAATATTATACAAGGTCTGCTATAAATGAGATGATGAGTATGCTTAAAGTAAGGGAAATAGAT
GGAGCATATTGTAAAGCAATGGGTCAGCTAGGCAATTATTCTCCTGATATATTAAATGCTAAAATTAAAAGTAAATCAAT
TTCTAATAATAAGATAGATTTAGCTATATCAACTAGACATTCACAGGATGGTTATACGACTAATTATAAAGCTGAATTAT
TATATGAAAACGGAAAATGGCGTGTGAATTATTGGGAAGGTTTAATGCATAGATAG

Upstream 100 bases:

>100_bases
ATAATTCCCCCTCTATTTAATAATCAAAAAAATACATATTGTAATTAATATATTTAAATAGGCATAGTAATTATAGTGAT
TATAGATAGAGGAGGTAACT

Downstream 100 bases:

>100_bases
TGAAGTGTATTAAAATAAGAAATACTTTTAGAGAAAAGAGATATCTAGAAAAATAATAAGAATACTTTATTTGTGAATCA
ATATTTAAGCGTGAAGTAAA

Product: N-acetylmuramoyl-L-alanine amidase-like protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKKRLLNITSAVVASCVMFFLSNVVSAAMLQERLYGNDRYQTNSKIVDSGWTSSEYAVVASGEDFADALCASPLAQQNKA
PILLTNKDNLSIENKKQLSRLKVKKVFIVGGTGVITDNVKLEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVIANG
YGFADALSIAPVAAQKGMPILLTNRGDLSKAAKEFLDTKTPTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
NHFADKFSYDKVYVASGENYPDALSGSVLAAVSKSPLILVGDSVNSSVMTSVKAQHDKYNNVIVLGGTEVVSDVSANSIV
HGIKYLNDREALTLINNADKLGYPVVEANRMPEIYIEGKAYQRFQDEFNSPEKLYAYLNKYYTRSAINEMMSMLKVREID
GAYCKAMGQLGNYSPDILNAKIKSKSISNNKIDLAISTRHSQDGYTTNYKAELLYENGKWRVNYWEGLMHR

Sequences:

>Translated_471_residues
MKKRLLNITSAVVASCVMFFLSNVVSAAMLQERLYGNDRYQTNSKIVDSGWTSSEYAVVASGEDFADALCASPLAQQNKA
PILLTNKDNLSIENKKQLSRLKVKKVFIVGGTGVITDNVKLEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVIANG
YGFADALSIAPVAAQKGMPILLTNRGDLSKAAKEFLDTKTPTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
NHFADKFSYDKVYVASGENYPDALSGSVLAAVSKSPLILVGDSVNSSVMTSVKAQHDKYNNVIVLGGTEVVSDVSANSIV
HGIKYLNDREALTLINNADKLGYPVVEANRMPEIYIEGKAYQRFQDEFNSPEKLYAYLNKYYTRSAINEMMSMLKVREID
GAYCKAMGQLGNYSPDILNAKIKSKSISNNKIDLAISTRHSQDGYTTNYKAELLYENGKWRVNYWEGLMHR
>Mature_471_residues
MKKRLLNITSAVVASCVMFFLSNVVSAAMLQERLYGNDRYQTNSKIVDSGWTSSEYAVVASGEDFADALCASPLAQQNKA
PILLTNKDNLSIENKKQLSRLKVKKVFIVGGTGVITDNVKLEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVIANG
YGFADALSIAPVAAQKGMPILLTNRGDLSKAAKEFLDTKTPTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
NHFADKFSYDKVYVASGENYPDALSGSVLAAVSKSPLILVGDSVNSSVMTSVKAQHDKYNNVIVLGGTEVVSDVSANSIV
HGIKYLNDREALTLINNADKLGYPVVEANRMPEIYIEGKAYQRFQDEFNSPEKLYAYLNKYYTRSAINEMMSMLKVREID
GAYCKAMGQLGNYSPDILNAKIKSKSISNNKIDLAISTRHSQDGYTTNYKAELLYENGKWRVNYWEGLMHR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 51789; Mature: 51789

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLLNITSAVVASCVMFFLSNVVSAAMLQERLYGNDRYQTNSKIVDSGWTSSEYAVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCEEEECCCCCCCEEEEE
SGEDFADALCASPLAQQNKAPILLTNKDNLSIENKKQLSRLKVKKVFIVGGTGVITDNVK
CCCHHHHHHHHCHHHHCCCCCEEEECCCCCCCCCHHHHHHEEEEEEEEECCCEEEECCEE
LEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVIANGYGFADALSIAPVAAQKGMPI
EEEEECCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCHHHHHCCCEE
LLTNRGDLSKAAKEFLDTKTPTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
EEECCCCHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
NHFADKFSYDKVYVASGENYPDALSGSVLAAVSKSPLILVGDSVNSSVMTSVKAQHDKYN
HHHHHHCCCCEEEEECCCCCCCHHCCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCC
NVIVLGGTEVVSDVSANSIVHGIKYLNDREALTLINNADKLGYPVVEANRMPEIYIEGKA
CEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCEEEECCHH
YQRFQDEFNSPEKLYAYLNKYYTRSAINEMMSMLKVREIDGAYCKAMGQLGNYSPDILNA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHCC
KIKSKSISNNKIDLAISTRHSQDGYTTNYKAELLYENGKWRVNYWEGLMHR
EECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEHHHHCCCC
>Mature Secondary Structure
MKKRLLNITSAVVASCVMFFLSNVVSAAMLQERLYGNDRYQTNSKIVDSGWTSSEYAVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCEEEECCCCCCCEEEEE
SGEDFADALCASPLAQQNKAPILLTNKDNLSIENKKQLSRLKVKKVFIVGGTGVITDNVK
CCCHHHHHHHHCHHHHCCCCCEEEECCCCCCCCCHHHHHHEEEEEEEEECCCEEEECCEE
LEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVIANGYGFADALSIAPVAAQKGMPI
EEEEECCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCHHHHHCCCEE
LLTNRGDLSKAAKEFLDTKTPTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
EEECCCCHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
NHFADKFSYDKVYVASGENYPDALSGSVLAAVSKSPLILVGDSVNSSVMTSVKAQHDKYN
HHHHHHCCCCEEEEECCCCCCCHHCCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCC
NVIVLGGTEVVSDVSANSIVHGIKYLNDREALTLINNADKLGYPVVEANRMPEIYIEGKA
CEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCEEEECCHH
YQRFQDEFNSPEKLYAYLNKYYTRSAINEMMSMLKVREIDGAYCKAMGQLGNYSPDILNA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHCC
KIKSKSISNNKIDLAISTRHSQDGYTTNYKAELLYENGKWRVNYWEGLMHR
EECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]