| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
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The map label for this gene is lytC [H]
Identifier: 226947610
GI number: 226947610
Start: 478128
End: 480197
Strand: Direct
Name: lytC [H]
Synonym: CLM_0447
Alternate gene names: 226947610
Gene position: 478128-480197 (Clockwise)
Preceding gene: 226947609
Following gene: 226947611
Centisome position: 11.51
GC content: 27.63
Gene sequence:
>2070_bases ATGGTGAAATCTAAAGAAAAAAACAAAATATTTTTTACCTTATTAGCCATTACTTTAATTTTTATTGTTAATTCTAATAA GGTAAAGGCTGATGATGAGATTAATTTTAAAAGGTTATATGGTAAGGACCGATATGAAACCTCAGCTTCTATATGTAGTG GTGGATGGGACACATCAGAGTATGCTGTTCTAGCAAGTGGAGAAGGCTTTGCAGATGCTTTAAGTGCGGCTCCATTAGCT AAGAAATATGATGCACCTATAATTTTAACAGGGAAAAATAAGTTGAATGATAATGCTAAGGATCAGTTAAAAAAATTAGA TACTAAAGAGGTAATAATAGTTGGAGGACCTGGGTCAATTTCAGAAGATATAGTAACAGAATTAAAAAATCTAGGAATAA AGGTTAATAGAATATATGGTGAAGATAGATATAAAACTAGTTTAAAAATTGCAAAGGAAATAGGAGTAAAAAACGGAGTA GTAGTTACAAATGGTTTAGGATTTGCTGATGCATTGGCTATGGCACCTATAGCAGCTAGTAAACAAATGCCTATTTTGTT AACACCTAGTGACAAATTAACAAGTGATACAATGGAGTTTTTAAAGAAAAGTTCTTATAATAAAAGCTATGTTTTGGGAG GAACTTCTACAGTTAGTGATTATATAAAAAATTCATTAAAGAATCCAACTAGATTAAGTGGAGCTGACAGATTTCAAACT AATATAGCTATATTAAATCATTTTAAAGGGGATTTAAACTTAGATGAAGTATATATTGCTTCAGGAGATGGATATGCAGA TGCTTTGTCTGGTTCAGTATTAGCTAGTAAAAATAAATCTCCAATAATATTAATAAATGATAATTTAAATAAAAGTACAA AAGATTTTGTAAGTACTAATAAGTCTAACTTTAAAAATGTAACAATATTTGGAGGAGAAGCAGTAGTAAAGGAGCCTACT ATAAGCAGTTTGTTTGGAGCATTTAGGTCTGGTGAAATAAGATCAGATACTAAAGAAGTTGCTGCAGAAAGATGGGATAG ATCCTATCTTAAAGATTACCATATTGATTTACCAGATAGCGGTAAACTGGATATAGAGTATGATATTAACAATTTTACTC GTTTTGATTTAATTGTTTTAGATATAAAGAATAATGAAATTATAAAAAAATCCTATAATTATTTGAAGAACAATAAGAGC ATTCATGATAACTATAATGATATAAGATTGCCTAAAGGAAAATATATCGTTAGGGTACATGCATTCAATATGGATGGAAC TTACACAATTAAAGCAAAATATACTCAAGAGGGAGAAGGATTTGAAAAGGAAAATAATAATGATATAAAAACTGCAAATG TTATAGAACCTAATAAAAGTATTATAGGAAGTATTCATAGTTATAATGATGTAGATTATTATAAATTTACATTAAATGAA AAAGGAAGTTTAAAAATAAATTTAAAACATAATCAATATGGTAGATATGGATTTAAGGTTAGTTTATTAGATGAAAATAA TAAATCAATATCGCAATTTATTAGTGGAGGAGAAGATATAAATTCTTATAGTAATAAATTAAGACTTCCTAAAGGAACTT ATTTTGTAAAAATAGAGTGTGAAAAATGGAATGATGAACCCTTACAGTATGAGCTAAATTTAGTTTATGATATTGAAGGT GAAAATTATGAGTCGGAGCCAAATGATTATATACAAGATGCTAATTATATAAAGTGTAATAAAGAGTATATAGGAAATAT ACAATCAAGAGATGATAGGGATTATTATAAGATAAATTTAAATTCAGATTCAAAAATAACAATCAACTTTAAACACGATG AAGGCTATGAAAAGTGGATTATTTATTTATATGATAAGGACAATAATCCAATACGACGCTTTAAGTCTTATGGTTATGAG ATCAATAAGGACTTTAATCCAATAGAATTAGAAGCAGGAGAGTATTATGTGTCAGTAGAAGGAAGAGATAGTTTAGATTA TACTATAAATGTAAAACGAGAAGCACCAGATAAATCTAATAATGAGAATAAAAAAGTAAAAAGAAGATAA
Upstream 100 bases:
>100_bases TATTTACATTTTATTCACAATGATTGGGTGAATTTTTATCCATGATTATGATAATATAGTATGGTGAACCATTATATGAA ATATTTAGGGGGTATACAAT
Downstream 100 bases:
>100_bases ATCATATCAAAAGACTATTAAATGAAATAATTCATTTAATAGTCTTTCATTTTCATGTAATTAATATTTATCTTAGATAA TAAGTAACGAATATGAATTT
Product: amidase domain-containing protein
Products: NA
Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]
Number of amino acids: Translated: 689; Mature: 689
Protein sequence:
>689_residues MVKSKEKNKIFFTLLAITLIFIVNSNKVKADDEINFKRLYGKDRYETSASICSGGWDTSEYAVLASGEGFADALSAAPLA KKYDAPIILTGKNKLNDNAKDQLKKLDTKEVIIVGGPGSISEDIVTELKNLGIKVNRIYGEDRYKTSLKIAKEIGVKNGV VVTNGLGFADALAMAPIAASKQMPILLTPSDKLTSDTMEFLKKSSYNKSYVLGGTSTVSDYIKNSLKNPTRLSGADRFQT NIAILNHFKGDLNLDEVYIASGDGYADALSGSVLASKNKSPIILINDNLNKSTKDFVSTNKSNFKNVTIFGGEAVVKEPT ISSLFGAFRSGEIRSDTKEVAAERWDRSYLKDYHIDLPDSGKLDIEYDINNFTRFDLIVLDIKNNEIIKKSYNYLKNNKS IHDNYNDIRLPKGKYIVRVHAFNMDGTYTIKAKYTQEGEGFEKENNNDIKTANVIEPNKSIIGSIHSYNDVDYYKFTLNE KGSLKINLKHNQYGRYGFKVSLLDENNKSISQFISGGEDINSYSNKLRLPKGTYFVKIECEKWNDEPLQYELNLVYDIEG ENYESEPNDYIQDANYIKCNKEYIGNIQSRDDRDYYKINLNSDSKITINFKHDEGYEKWIIYLYDKDNNPIRRFKSYGYE INKDFNPIELEAGEYYVSVEGRDSLDYTINVKREAPDKSNNENKKVKRR
Sequences:
>Translated_689_residues MVKSKEKNKIFFTLLAITLIFIVNSNKVKADDEINFKRLYGKDRYETSASICSGGWDTSEYAVLASGEGFADALSAAPLA KKYDAPIILTGKNKLNDNAKDQLKKLDTKEVIIVGGPGSISEDIVTELKNLGIKVNRIYGEDRYKTSLKIAKEIGVKNGV VVTNGLGFADALAMAPIAASKQMPILLTPSDKLTSDTMEFLKKSSYNKSYVLGGTSTVSDYIKNSLKNPTRLSGADRFQT NIAILNHFKGDLNLDEVYIASGDGYADALSGSVLASKNKSPIILINDNLNKSTKDFVSTNKSNFKNVTIFGGEAVVKEPT ISSLFGAFRSGEIRSDTKEVAAERWDRSYLKDYHIDLPDSGKLDIEYDINNFTRFDLIVLDIKNNEIIKKSYNYLKNNKS IHDNYNDIRLPKGKYIVRVHAFNMDGTYTIKAKYTQEGEGFEKENNNDIKTANVIEPNKSIIGSIHSYNDVDYYKFTLNE KGSLKINLKHNQYGRYGFKVSLLDENNKSISQFISGGEDINSYSNKLRLPKGTYFVKIECEKWNDEPLQYELNLVYDIEG ENYESEPNDYIQDANYIKCNKEYIGNIQSRDDRDYYKINLNSDSKITINFKHDEGYEKWIIYLYDKDNNPIRRFKSYGYE INKDFNPIELEAGEYYVSVEGRDSLDYTINVKREAPDKSNNENKKVKRR >Mature_689_residues MVKSKEKNKIFFTLLAITLIFIVNSNKVKADDEINFKRLYGKDRYETSASICSGGWDTSEYAVLASGEGFADALSAAPLA KKYDAPIILTGKNKLNDNAKDQLKKLDTKEVIIVGGPGSISEDIVTELKNLGIKVNRIYGEDRYKTSLKIAKEIGVKNGV VVTNGLGFADALAMAPIAASKQMPILLTPSDKLTSDTMEFLKKSSYNKSYVLGGTSTVSDYIKNSLKNPTRLSGADRFQT NIAILNHFKGDLNLDEVYIASGDGYADALSGSVLASKNKSPIILINDNLNKSTKDFVSTNKSNFKNVTIFGGEAVVKEPT ISSLFGAFRSGEIRSDTKEVAAERWDRSYLKDYHIDLPDSGKLDIEYDINNFTRFDLIVLDIKNNEIIKKSYNYLKNNKS IHDNYNDIRLPKGKYIVRVHAFNMDGTYTIKAKYTQEGEGFEKENNNDIKTANVIEPNKSIIGSIHSYNDVDYYKFTLNE KGSLKINLKHNQYGRYGFKVSLLDENNKSISQFISGGEDINSYSNKLRLPKGTYFVKIECEKWNDEPLQYELNLVYDIEG ENYESEPNDYIQDANYIKCNKEYIGNIQSRDDRDYYKINLNSDSKITINFKHDEGYEKWIIYLYDKDNNPIRRFKSYGYE INKDFNPIELEAGEYYVSVEGRDSLDYTINVKREAPDKSNNENKKVKRR
Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich
COG id: COG2247
COG function: function code M; Putative cell wall-binding domain
Gene ontology:
Cell location: Secreted, cell wall [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR007253 - InterPro: IPR002508 [H]
Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]
EC number: =3.5.1.28 [H]
Molecular weight: Translated: 78167; Mature: 78167
Theoretical pI: Translated: 7.57; Mature: 7.57
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 0.7 %Met (Translated Protein) 1.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 1.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVKSKEKNKIFFTLLAITLIFIVNSNKVKADDEINFKRLYGKDRYETSASICSGGWDTSE CCCCCCCCEEEHHHHHHHHEEEECCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCCCCCC YAVLASGEGFADALSAAPLAKKYDAPIILTGKNKLNDNAKDQLKKLDTKEVIIVGGPGSI EEEEECCCCHHHHHHCCCCHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCEEEECCCCCC SEDIVTELKNLGIKVNRIYGEDRYKTSLKIAKEIGVKNGVVVTNGLGFADALAMAPIAAS HHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCCC KQMPILLTPSDKLTSDTMEFLKKSSYNKSYVLGGTSTVSDYIKNSLKNPTRLSGADRFQT CCCCEEECCCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHC NIAILNHFKGDLNLDEVYIASGDGYADALSGSVLASKNKSPIILINDNLNKSTKDFVSTN EEEEEEECCCCCCCCEEEEECCCCCHHHCCCCEEECCCCCCEEEECCCCCCCHHHHHHCC KSNFKNVTIFGGEAVVKEPTISSLFGAFRSGEIRSDTKEVAAERWDRSYLKDYHIDLPDS CCCCCEEEEECCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHEEECCCCC GKLDIEYDINNFTRFDLIVLDIKNNEIIKKSYNYLKNNKSIHDNYNDIRLPKGKYIVRVH CCEEEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEE AFNMDGTYTIKAKYTQEGEGFEKENNNDIKTANVIEPNKSIIGSIHSYNDVDYYKFTLNE EECCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCEEEEEEECC KGSLKINLKHNQYGRYGFKVSLLDENNKSISQFISGGEDINSYSNKLRLPKGTYFVKIEC CCCEEEEEECCCCCCEEEEEEEEECCCHHHHHHHCCCCCHHHHHCEEECCCCCEEEEEEE EKWNDEPLQYELNLVYDIEGENYESEPNDYIQDANYIKCNKEYIGNIQSRDDRDYYKINL ECCCCCCEEEEEEEEEEECCCCCCCCCCHHHCCCCEEEECHHHCCCCCCCCCCCEEEEEE NSDSKITINFKHDEGYEKWIIYLYDKDNNPIRRFKSYGYEINKDFNPIELEAGEYYVSVE CCCCEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHCCEEECCCCCEEEEECCEEEEEEC GRDSLDYTINVKREAPDKSNNENKKVKRR CCCCCEEEEEEEECCCCCCCCCCCCCCCC >Mature Secondary Structure MVKSKEKNKIFFTLLAITLIFIVNSNKVKADDEINFKRLYGKDRYETSASICSGGWDTSE CCCCCCCCEEEHHHHHHHHEEEECCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCCCCCC YAVLASGEGFADALSAAPLAKKYDAPIILTGKNKLNDNAKDQLKKLDTKEVIIVGGPGSI EEEEECCCCHHHHHHCCCCHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCEEEECCCCCC SEDIVTELKNLGIKVNRIYGEDRYKTSLKIAKEIGVKNGVVVTNGLGFADALAMAPIAAS HHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCCC KQMPILLTPSDKLTSDTMEFLKKSSYNKSYVLGGTSTVSDYIKNSLKNPTRLSGADRFQT CCCCEEECCCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHC NIAILNHFKGDLNLDEVYIASGDGYADALSGSVLASKNKSPIILINDNLNKSTKDFVSTN EEEEEEECCCCCCCCEEEEECCCCCHHHCCCCEEECCCCCCEEEECCCCCCCHHHHHHCC KSNFKNVTIFGGEAVVKEPTISSLFGAFRSGEIRSDTKEVAAERWDRSYLKDYHIDLPDS CCCCCEEEEECCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHEEECCCCC GKLDIEYDINNFTRFDLIVLDIKNNEIIKKSYNYLKNNKSIHDNYNDIRLPKGKYIVRVH CCEEEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEE AFNMDGTYTIKAKYTQEGEGFEKENNNDIKTANVIEPNKSIIGSIHSYNDVDYYKFTLNE EECCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCEEEEEEECC KGSLKINLKHNQYGRYGFKVSLLDENNKSISQFISGGEDINSYSNKLRLPKGTYFVKIEC CCCEEEEEECCCCCCEEEEEEEEECCCHHHHHHHCCCCCHHHHHCEEECCCCCEEEEEEE EKWNDEPLQYELNLVYDIEGENYESEPNDYIQDANYIKCNKEYIGNIQSRDDRDYYKINL ECCCCCCEEEEEEEEEEECCCCCCCCCCHHHCCCCEEEECHHHCCCCCCCCCCCEEEEEE NSDSKITINFKHDEGYEKWIIYLYDKDNNPIRRFKSYGYEINKDFNPIELEAGEYYVSVE CCCCEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHCCEEECCCCCEEEEECCEEEEEEC GRDSLDYTINVKREAPDKSNNENKKVKRR CCCCCEEEEEEEECCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1357079; 1682302; 9384377 [H]