Click here to switch to the map view.

The map label for this gene is ttcA [H]

Identifier: 226947572

GI number: 226947572

Start: 429636

End: 430502

Strand: Direct

Name: ttcA [H]

Synonym: CLM_0409

Alternate gene names: 226947572

Gene position: 429636-430502 (Clockwise)

Preceding gene: 226947571

Following gene: 226947574

Centisome position: 10.34

GC content: 26.99

Gene sequence:

>867_bases
ATGAGTGGTATAGCTGGTAAAGGTTGTGAGGTTTTAGTACCTTTTAATGAAAGAATACCTCTTAAAGATATAGAAAGAAG
TATTGTTAAAAAATATAGAAAGCATATATGGAGTAAATTTGTTAAAGCTATTAAAGAATATAATCTTGTAGAAGACGGTG
ATAAAATAGCCGTAGCAGTTTCTGGTGGAAAAGATAGTATTTTAATGGCCAAATTATTTCAAGAGTTAAAAAAGCATGGT
CAGATAAATTTTGAAATAGAATTTATTTCAATGGACCCTGGTTATCATGAAGATATAAGAAAATTATTAATAGATAACTG
CGATTATTTAAATATACCTATTAATTTGTTTGATTCTGATATCTTTAAAGTTATAGACGATATAGCTAAGGATTATCCCT
GTTATATGTGTGCTAGAATGAGAAGAGGAGCTCTTTATTCTAAAGCTCAGGAATTAGGATGTAATAAATTAGCTTTAGGT
CATCATTTTAATGATGTTATAGAAACTATTTTATTGAACGTGCTTTATGCAGGAAATTTTAAAACTATGTTGCCTAAATT
TAGATCCACAAACTTTGAAGGTTTGGAATTAATAAGGCCATTGTATTATATAGAAGAAGAATATATACAAAAATTCATAC
AAAATAGTGGAATTTGGCCTTTAAACTGTGCTTGTATGGTGGCAGCAGGTAAAATAGGAAATAAAAGACATGAAATAAAA
GATTTAATTAAAGAATTAAAGAAAAACTTTAAGGACGTAGATAAATCTATATTTATGTCATCTAAAAATGTTAATATGGA
AGCTATATTAGGATGGGAAAAGAATAAAGAAAAATATTCTTACTTAGATTTTTATGATGAAGATTAA

Upstream 100 bases:

>100_bases
TTAAAAAAATATAATATAGCTTATTTTTGATTTATTAAAAATCTTTTAACACAAAATAATATAAAAGTGTTATAATATTT
TGCATAAGTGAGGTGAAAAT

Downstream 100 bases:

>100_bases
TATACTTAAATAGGACATAAATAATTAAAAAGATTTCCAAATATTTGTAAATATAAATTTACTTTAATATTTGGAAATCT
TTTATCTATAAATAGCACAT

Product: PP-loop family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAVSGGKDSILMAKLFQELKKHG
QINFEIEFISMDPGYHEDIRKLLIDNCDYLNIPINLFDSDIFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALG
HHFNDVIETILLNVLYAGNFKTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED

Sequences:

>Translated_288_residues
MSGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAVSGGKDSILMAKLFQELKKHG
QINFEIEFISMDPGYHEDIRKLLIDNCDYLNIPINLFDSDIFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALG
HHFNDVIETILLNVLYAGNFKTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED
>Mature_287_residues
SGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAVSGGKDSILMAKLFQELKKHGQ
INFEIEFISMDPGYHEDIRKLLIDNCDYLNIPINLFDSDIFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALGH
HFNDVIETILLNVLYAGNFKTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIKD
LIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=241, Percent_Identity=30.7053941908714, Blast_Score=137, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI193211090, Length=264, Percent_Identity=29.9242424242424, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540090, Length=226, Percent_Identity=26.5486725663717, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24651972, Length=216, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 33384; Mature: 33253

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAV
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
SGGKDSILMAKLFQELKKHGQINFEIEFISMDPGYHEDIRKLLIDNCDYLNIPINLFDSD
ECCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCHHHHHHH
IFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALGHHFNDVIETILLNVLYAGNF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCH
KTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCHHHHHH
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
SGGKDSILMAKLFQELKKHGQINFEIEFISMDPGYHEDIRKLLIDNCDYLNIPINLFDSD
ECCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCHHHHHHH
IFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALGHHFNDVIETILLNVLYAGNF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCH
KTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCHHHHHH
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA