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The map label for this gene is lysP [H]

Identifier: 226947470

GI number: 226947470

Start: 291523

End: 292986

Strand: Direct

Name: lysP [H]

Synonym: CLM_0302

Alternate gene names: 226947470

Gene position: 291523-292986 (Clockwise)

Preceding gene: 226947469

Following gene: 226947471

Centisome position: 7.02

GC content: 34.56

Gene sequence:

>1464_bases
ATGAGTACTACAAAAGAAAAAGATTTTAATTCACATAATCTTAAAAGAAGTTTACAAGCAAGACATCTTAATATGATTGC
CATGGGTGGAGCTATAGGAACAGGAATATTCCTAGCACTTGGTGCTACTATCAAGCAAGCAGGACCTGGTGGAGCACTTA
CTGCTTATGCTTGCATAGGAGTTATGGTTTACTTTCTAATGACAAGCTTAGGAGAAATGGCAACCTTTATGCCTGTATCA
GGTTCTTTCGAAACTTATGCTTCAAGATTCATCGATCCTGCATTTGGATTTGCGCTTGGTTGGAATTACTGGTATAACTG
GGCTATTACAGTTGCTGCTGAGATGGTGGCAGGTGCACTAATTATGAAATTTTGGTTTCCTAATGTTCCAGCTATTATTT
GGAGTGTTTTATTCCTTGTATTAATAGTTAGCCTTAACTTATTATCTACAAAAGCTTATGGTGAATCAGAATATTGGTTT
GCAGGTATTAAAGTATTTACTGTTATTGTATTTTTATTAATAGGTATTGCTACTATTTTAGGTATATTAGGTGGGCATAC
AGTAGGATTTCAGAACTTTACTATTAAGGATGCTCCATTTGTTGGAGGAGTTAAATCTATTTTTATGGTATTTTTAATTG
CAGGTTTTTCTTTCCAAGGTACAGAGCTTGTTGGTATAGCTGCTGGTGAAAGTGAAAACCCTAAGAAAACTATTCCCAAA
GCAATCAATACAATATTTTGGAGAATTATAGTTTTTTATTTAGGAACAATATTTGTTGTAAGTGCAATAATTCCTTATAC
AGATGCTGGAGTTAATACAAGTCCATTTACATTAGTATTTGAAAGAGCTGGTATTGCAGCTGCTGCATCGCTGATGAATG
CAGTTATTTTAACCTCAGTAATATCTTGTGGAAACTCAGGAATGTATGCTTCAAGTAGAATGCTGTATGCAATGGCTAAA
GAAGGGAAAGCGCCTAGTTGGTTAGGAAAACTTAATTCAAGAGGAGTTCCAGTAAATGCATTAGCATTAACTACTCTAGT
AGCATCAGCTTGCTTCTTAACAGGGCTTTATGCTGAAACCACTGTTTATGTGTGGCTAGTTGCAGCTTCAGGACTTGCAG
GTTTTATTGCTTGGGTTGGTATAGCATTATGTCATTATCGTTTCCGTAAAGCTTATGTTGCTCAAGGACGTCATTTAAAT
AAGCTTGTTTATAAAGCAAAGCTATTCCCACTTGGTCCAATAATAGCGCTAGTATTATGCATAATAGTTATTCTAGGACA
AGGTATTAGCTATTTTGAAGCTGCTAAAATTGACTGGAATGGAATAATAGCATCTTATATAGGATTACCAATATTCTTTG
GTTTATGGTTTAGCTATAAAAAGAAACATAAAACAAAAGTTGTTAACTTACAGGAGATAAGCTTTGATGTAGAAGATACT
CATTCAAAAACAGAAATTGTTTAA

Upstream 100 bases:

>100_bases
AAATACATTATTTAATATCCTGAGATAGCCTCAGGATATTTTTTTATGCTCGTCTTAGTTAATTCGCTTATCGGAAAATA
AAACCGATAAGGAGGAAAAA

Downstream 100 bases:

>100_bases
GATAAAAGATAAAGACTGCTGATATTTAATCAGCAGTCTTTATATTTATTAGGTGATAGTATGAAACAATATATAAGGTA
ATTCATAAATGAAGCTATAT

Product: putative lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSTTKEKDFNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVS
GSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWF
AGIKVFTVIVFLLIGIATILGILGGHTVGFQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSVISCGNSGMYASSRMLYAMAK
EGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRHLN
KLVYKAKLFPLGPIIALVLCIIVILGQGISYFEAAKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HSKTEIV

Sequences:

>Translated_487_residues
MSTTKEKDFNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVS
GSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWF
AGIKVFTVIVFLLIGIATILGILGGHTVGFQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSVISCGNSGMYASSRMLYAMAK
EGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRHLN
KLVYKAKLFPLGPIIALVLCIIVILGQGISYFEAAKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HSKTEIV
>Mature_486_residues
STTKEKDFNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVSG
SFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFA
GIKVFTVIVFLLIGIATILGILGGHTVGFQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPKA
INTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSVISCGNSGMYASSRMLYAMAKE
GKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRHLNK
LVYKAKLFPLGPIIALVLCIIVILGQGISYFEAAKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDTH
SKTEIV

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=485, Percent_Identity=55.0515463917526, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI87081708, Length=473, Percent_Identity=38.4778012684989, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI48994972, Length=421, Percent_Identity=39.1923990498812, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786789, Length=426, Percent_Identity=36.6197183098592, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1786302, Length=420, Percent_Identity=37.6190476190476, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1790653, Length=425, Percent_Identity=36, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789017, Length=396, Percent_Identity=35.3535353535354, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI87081915, Length=490, Percent_Identity=31.4285714285714, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1786602, Length=384, Percent_Identity=37.2395833333333, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87081869, Length=327, Percent_Identity=23.5474006116208, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=503, Percent_Identity=35.9840954274354, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=35.959595959596, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6324990, Length=504, Percent_Identity=34.7222222222222, Blast_Score=292, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6324059, Length=508, Percent_Identity=34.0551181102362, Blast_Score=279, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6324924, Length=489, Percent_Identity=33.3333333333333, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=31.5040650406504, Blast_Score=272, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6322892, Length=490, Percent_Identity=33.469387755102, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=500, Percent_Identity=33.4, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319824, Length=495, Percent_Identity=30.5050505050505, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=479, Percent_Identity=29.8538622129436, Blast_Score=253, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6321053, Length=490, Percent_Identity=32.2448979591837, Blast_Score=246, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6319542, Length=512, Percent_Identity=29.296875, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320251, Length=510, Percent_Identity=29.8039215686275, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319543, Length=471, Percent_Identity=30.1486199575372, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322967, Length=504, Percent_Identity=29.3650793650794, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6324981, Length=500, Percent_Identity=31.8, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=495, Percent_Identity=29.0909090909091, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=561, Percent_Identity=26.7379679144385, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI221512776, Length=427, Percent_Identity=22.9508196721311, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666159, Length=427, Percent_Identity=22.9508196721311, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52831; Mature: 52700

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTKEKDFNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIG
CCCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VMVYFLMTSLGEMATFMPVSGSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFAGIKVFTVIVFLLIGIATIL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILGGHTVGFQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
HHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ISCGNSGMYASSRMLYAMAKEGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAET
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRHLNKLVYKAKLFPLGPIIALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHH
IIVILGQGISYFEAAKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCC
HSKTEIV
CCCCCCC
>Mature Secondary Structure 
STTKEKDFNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIG
CCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VMVYFLMTSLGEMATFMPVSGSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFAGIKVFTVIVFLLIGIATIL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILGGHTVGFQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
HHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ISCGNSGMYASSRMLYAMAKEGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAET
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRHLNKLVYKAKLFPLGPIIALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHH
IIVILGQGISYFEAAKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCC
HSKTEIV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]