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The map label for this gene is vanR [H]

Identifier: 226947464

GI number: 226947464

Start: 285196

End: 285897

Strand: Direct

Name: vanR [H]

Synonym: CLM_0295

Alternate gene names: 226947464

Gene position: 285196-285897 (Clockwise)

Preceding gene: 226947463

Following gene: 226947465

Centisome position: 6.86

GC content: 28.49

Gene sequence:

>702_bases
ATGGATAAAAAGGCTAAGATTTTAGTAGTTGAAGATGACAATGATATTAATAAATTACTTTGTAGTATTTTTGAAAATAA
GGGGTATAAATCTAGAGCGGCTTTTTCAGGAACAGAAGCTTTAATGTGTGTAGAAAATGAAAAGTGGGATATGATTTTAT
TAGATTTGATGATTCCAGGTATTAGTGGAGAAGAAGCCATATTAAAAATAAGAAAAATCACAAAAGCTCCAATCATTATT
GTGAGTGCAAAAACATCTAAAAAGACTAAGTTAGAATTATTAGAAAAAGGAGCTGATGATTTTATTTGTAAGCCTTTTGA
CCCAGATGAAGTAGTTGCAAGGGTTAATTCTAACTTGAGAAGATATTTAGAATTTTCTACAGATAAGGAAAAGAAAGGTA
ACATTTTGATTTATAAAGATATTACTCTAAATAAAGAAAGTAAGGAAGTAAAAGTTGGACAAACTATCGTTATCTTAACT
GCAAGAGAATTTGCAGTATTAGAGTTATTATTAAATAATCCTAATAAGGTGTACAGTAAAGCTAATATTTTTGAAAGTAT
ATGGGGAGAAGAATTTCTAGGTGATGATAATACTGTAAATGTGCATGTAAGTAGAATGAGAAGTAAATTATCTAGAGCTA
ATAATAATGGAGAAGATTACATAGAAACAGTTTGGGCAATGGGATATAGATTAAGAAAATAG

Upstream 100 bases:

>100_bases
TTTGAAAAAAAGGTTCTCTAGAAACAAGTTATGGTAAAATATACATATAGAAATTACAAAATAAAAAATAACTTTATATA
GATTTAGAAGGGGAGAAATT

Downstream 100 bases:

>100_bases
TCAATTGAAATTTAACATAAAAGTATCTAGTAAAAAGATTTAATACTTTTGAAAGGGTTTGGTAAAGTTTTCTTATAAAA
CATTGTTTATTATAAAAGCA

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MDKKAKILVVEDDNDINKLLCSIFENKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPGISGEEAILKIRKITKAPIII
VSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLRRYLEFSTDKEKKGNILIYKDITLNKESKEVKVGQTIVILT
AREFAVLELLLNNPNKVYSKANIFESIWGEEFLGDDNTVNVHVSRMRSKLSRANNNGEDYIETVWAMGYRLRK

Sequences:

>Translated_233_residues
MDKKAKILVVEDDNDINKLLCSIFENKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPGISGEEAILKIRKITKAPIII
VSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLRRYLEFSTDKEKKGNILIYKDITLNKESKEVKVGQTIVILT
AREFAVLELLLNNPNKVYSKANIFESIWGEEFLGDDNTVNVHVSRMRSKLSRANNNGEDYIETVWAMGYRLRK
>Mature_233_residues
MDKKAKILVVEDDNDINKLLCSIFENKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPGISGEEAILKIRKITKAPIII
VSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLRRYLEFSTDKEKKGNILIYKDITLNKESKEVKVGQTIVILT
AREFAVLELLLNNPNKVYSKANIFESIWGEEFLGDDNTVNVHVSRMRSKLSRANNNGEDYIETVWAMGYRLRK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=32.1739130434783, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=30.7359307359307, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=30.9734513274336, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=31.6017316017316, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=28.8888888888889, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=29.0178571428571, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=31.0043668122271, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=29.0748898678414, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=29.646017699115, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=29.0748898678414, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=27.8969957081545, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=220, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=244, Percent_Identity=23.3606557377049, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=25.8620689655172, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=32.4561403508772, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26555; Mature: 26555

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKAKILVVEDDNDINKLLCSIFENKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPG
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCC
ISGEEAILKIRKITKAPIIIVSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLR
CCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
RYLEFSTDKEKKGNILIYKDITLNKESKEVKVGQTIVILTAREFAVLELLLNNPNKVYSK
HHHHCCCCCCCCCCEEEEEEEEECCCCCEEECCCEEEEEECCHHHHHHHHHCCCHHHHHH
ANIFESIWGEEFLGDDNTVNVHVSRMRSKLSRANNNGEDYIETVWAMGYRLRK
HHHHHHHCCHHHCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKKAKILVVEDDNDINKLLCSIFENKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPG
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCC
ISGEEAILKIRKITKAPIIIVSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLR
CCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
RYLEFSTDKEKKGNILIYKDITLNKESKEVKVGQTIVILTAREFAVLELLLNNPNKVYSK
HHHHCCCCCCCCCCEEEEEEEEECCCCCEEECCCEEEEEECCHHHHHHHHHCCCHHHHHH
ANIFESIWGEEFLGDDNTVNVHVSRMRSKLSRANNNGEDYIETVWAMGYRLRK
HHHHHHHCCHHHCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]