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The map label for this gene is atpB [H]

Identifier: 226947374

GI number: 226947374

Start: 180318

End: 180998

Strand: Direct

Name: atpB [H]

Synonym: CLM_0194

Alternate gene names: 226947374

Gene position: 180318-180998 (Clockwise)

Preceding gene: 226947373

Following gene: 226947375

Centisome position: 4.34

GC content: 27.46

Gene sequence:

>681_bases
TTGGAGAAGTTTTCACCATTATTTTATATTAACTTATTTGGATATAAATTTGGTATTACCTCAAGTTTAGTAATTCAATG
GGTAATTATTGCAATAGTAGCGTTATTAAGTATTATATTAACAAGAAATTTAAAAAAAGTTCCAGACAAAAGACAAACAG
TTATGGAAATGATGCTGGATTTAGTTAGAAATCTAGTTAATGAAAATATGGGAGAAGAATTTAAAAGTTTTATTCCCTTT
ATAGGAACACTTATGATATACTTATTGCTTATGAATTTAGTTGGGTTATTAGGCTTGAAACCACCAACTTTAGATTATAG
CGTAGTGTTAGGAATGGCATTAATATCTTTTGTGGTAATACAAGGATATGCTATAAGAAAGACTGGATTAAAAAGTTATT
TTCTAGGATATGGTAAGCCATATTTATTTTTATTGCCTTTAAACGTAATAGAGAGAGTTATGCTTCCAGTATCTTTGAGT
TTAAGATTATTTGGTAATATAACAGCGGCAGTACTTATTATGGATTTGGTTTATTCAGCTTTAGCTAGTATAAGTTGGTT
TGCTCAATTAGTAGTTCCTATTCCACTTCACATATATTTTGATTTGTTTGATGGAACTATTCAAATGGTTATATTTGTTA
TGTTAACTATGATTAATATAAAAGTAATAGCAGAACATTAA

Upstream 100 bases:

>100_bases
ATATTATTCCTTTTTTACTTGGATATAGTTCAAATTTTATATCTATAATATTTTATGGAACCAATTTAGGTAAAAATAAA
GTATAAAAGGAAGTGATGAA

Downstream 100 bases:

>100_bases
TAAAAAAACATGAATTTTTAAATTTAAGGAGGAATTTGGTATGGATCCAAAAGCATTTGTATCAGGAATGGCGGCTTTAG
GAGCAGGAATAGCAGCATTA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MEKFSPLFYINLFGYKFGITSSLVIQWVIIAIVALLSIILTRNLKKVPDKRQTVMEMMLDLVRNLVNENMGEEFKSFIPF
IGTLMIYLLLMNLVGLLGLKPPTLDYSVVLGMALISFVVIQGYAIRKTGLKSYFLGYGKPYLFLLPLNVIERVMLPVSLS
LRLFGNITAAVLIMDLVYSALASISWFAQLVVPIPLHIYFDLFDGTIQMVIFVMLTMINIKVIAEH

Sequences:

>Translated_226_residues
MEKFSPLFYINLFGYKFGITSSLVIQWVIIAIVALLSIILTRNLKKVPDKRQTVMEMMLDLVRNLVNENMGEEFKSFIPF
IGTLMIYLLLMNLVGLLGLKPPTLDYSVVLGMALISFVVIQGYAIRKTGLKSYFLGYGKPYLFLLPLNVIERVMLPVSLS
LRLFGNITAAVLIMDLVYSALASISWFAQLVVPIPLHIYFDLFDGTIQMVIFVMLTMINIKVIAEH
>Mature_226_residues
MEKFSPLFYINLFGYKFGITSSLVIQWVIIAIVALLSIILTRNLKKVPDKRQTVMEMMLDLVRNLVNENMGEEFKSFIPF
IGTLMIYLLLMNLVGLLGLKPPTLDYSVVLGMALISFVVIQGYAIRKTGLKSYFLGYGKPYLFLLPLNVIERVMLPVSLS
LRLFGNITAAVLIMDLVYSALASISWFAQLVVPIPLHIYFDLFDGTIQMVIFVMLTMINIKVIAEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Escherichia coli, GI1790176, Length=216, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 25595; Mature: 25595

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFSPLFYINLFGYKFGITSSLVIQWVIIAIVALLSIILTRNLKKVPDKRQTVMEMMLD
CCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LVRNLVNENMGEEFKSFIPFIGTLMIYLLLMNLVGLLGLKPPTLDYSVVLGMALISFVVI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
QGYAIRKTGLKSYFLGYGKPYLFLLPLNVIERVMLPVSLSLRLFGNITAAVLIMDLVYSA
CCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASISWFAQLVVPIPLHIYFDLFDGTIQMVIFVMLTMINIKVIAEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MEKFSPLFYINLFGYKFGITSSLVIQWVIIAIVALLSIILTRNLKKVPDKRQTVMEMMLD
CCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LVRNLVNENMGEEFKSFIPFIGTLMIYLLLMNLVGLLGLKPPTLDYSVVLGMALISFVVI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
QGYAIRKTGLKSYFLGYGKPYLFLLPLNVIERVMLPVSLSLRLFGNITAAVLIMDLVYSA
CCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASISWFAQLVVPIPLHIYFDLFDGTIQMVIFVMLTMINIKVIAEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10902917; 11466286 [H]