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The map label for this gene is dinB [H]

Identifier: 226224573

GI number: 226224573

Start: 2036182

End: 2037252

Strand: Reverse

Name: dinB [H]

Synonym: Lm4b_01987

Alternate gene names: 226224573

Gene position: 2037252-2036182 (Counterclockwise)

Preceding gene: 226224574

Following gene: 226224570

Centisome position: 69.94

GC content: 39.68

Gene sequence:

>1071_bases
ATGGATACGAGTAGAAAAATTATTCATATTGATATGGACGCTTTTTATGCATCTGTGGAACAACGCGACCATCCTGAGTT
TCGAGGGAAGCCACTTATTATTGGTGGAGACCCTAATAAACGCGGAGTTGTTGCGACTTGTTCTTATGAAGCGCGCAAAT
TCGGTGTGCATTCAGCTATGCCCACCAGGCAAGCTGCTAAACTTTGTCCGAACGGTATTTTTATTCACGGCAATATGGCT
CATTATGTAGAGGTTTCTAATCAAATCCGCGAGATCTTTTCCAGATATACGGATATTATCGAACCGCTCTCTTTAGATGA
AGCTTATCTGGATGTAACTGAAAACAAAAAAGGAATGAAATCCGCCACAATGGTTGCACGCGAGATTCAGCAGACGATTT
ACCAAGAGCTTGGTCTAACTGCTTCTGCCGGCGTATCATTTAATAAATTTATCGCAAAAATCGCTTCTGATTTTAAGAAA
CCTGCTGGTATTACGGTAGTTACACCAGAAGAAGCAGAAGCCTTCTTAGAACAAATACCAGTCACTAAATTTTATGGGGT
AGGGAAAGTAACCGCAGAAAAATTGCATCGTTTAGGAATTGAAACGGGAGCAGATTTGAAGAAGTGGAGCGAGTGGGACC
TTATTCGCGAATTACACAAACATGGCTATCATTTATATCGACATGTTCGAGGTCGTTCTAACAACATTGTGAATCCGCAT
CGTGATCGCAAGTCCGTTGGTAAAGAAACTACTTTTGAATTTAATGTGTTAGATAGCCGAGTTCTCGAACAAAGCCTCAT
GCAATTTGCCAAAAAAGTAGAAGAACGGCTCATTAAACTACAAAAACATGGTAAGACGGTAGTACTAAAACTACGCTACA
GTGACTTTACAACCATTACTAAGCGGCTTACTTTAAACGAATATACCAATGATGCAAGTCAAATTTATCAAGCGGCGGCC
CTTCTTTTAAGAGAAAGCTATACTGGTCAGGATAGTATTCGTTTGATTGGGCTTACTGTAACCAATTTAAAACCCGTTTA
TTTTGAAAATTTACGTTTAGAAGGACTATAA

Upstream 100 bases:

>100_bases
AAAATATCTTATGAAAATAGGGTATTTTTTTCTTGTAATTAATGAGGATAACCTTTATAATTGAATAAGAACGTTTGTTC
GTTTCGGAGGAGATGCAGTT

Downstream 100 bases:

>100_bases
AAAAGGCTAGCACGATTTAGGTGCTAGCCTTTTTGATTATTTCATTTCCAGTAAACGTTCTTTAAGTTCTTGTTCCATTG
TTACAAGTTCTTTCTCAGCC

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAMPTRQAAKLCPNGIFIHGNMA
HYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMKSATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKK
PAGITVVTPEEAEAFLEQIPVTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPH
RDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTITKRLTLNEYTNDASQIYQAAA
LLLRESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL

Sequences:

>Translated_356_residues
MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAMPTRQAAKLCPNGIFIHGNMA
HYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMKSATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKK
PAGITVVTPEEAEAFLEQIPVTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPH
RDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTITKRLTLNEYTNDASQIYQAAA
LLLRESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL
>Mature_356_residues
MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAMPTRQAAKLCPNGIFIHGNMA
HYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMKSATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKK
PAGITVVTPEEAEAFLEQIPVTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPH
RDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTITKRLTLNEYTNDASQIYQAAA
LLLRESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=408, Percent_Identity=27.2058823529412, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI7706681, Length=409, Percent_Identity=27.1393643031785, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI154350220, Length=252, Percent_Identity=31.3492063492063, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI5729982, Length=374, Percent_Identity=28.6096256684492, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI7705344, Length=111, Percent_Identity=45.045045045045, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786425, Length=347, Percent_Identity=45.821325648415, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI1787432, Length=324, Percent_Identity=24.6913580246914, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193205700, Length=411, Percent_Identity=28.4671532846715, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17537959, Length=369, Percent_Identity=26.5582655826558, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193205702, Length=356, Percent_Identity=26.9662921348315, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115534089, Length=122, Percent_Identity=36.8852459016393, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324921, Length=205, Percent_Identity=27.8048780487805, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19923006, Length=405, Percent_Identity=24.9382716049383, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355641, Length=312, Percent_Identity=27.2435897435897, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24644984, Length=312, Percent_Identity=27.2435897435897, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24668444, Length=167, Percent_Identity=30.5389221556886, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40523; Mature: 40523

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAM
CCCCCEEEEEEHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCHHHHHCCCCCC
PTRQAAKLCPNGIFIHGNMAHYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMK
CHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCHH
SATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKKPAGITVVTPEEAEAFLEQIP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCC
VTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPH
CHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTIT
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHH
KRLTLNEYTNDASQIYQAAALLLRESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECEEECCC
>Mature Secondary Structure
MDTSRKIIHIDMDAFYASVEQRDHPEFRGKPLIIGGDPNKRGVVATCSYEARKFGVHSAM
CCCCCEEEEEEHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCHHHHHCCCCCC
PTRQAAKLCPNGIFIHGNMAHYVEVSNQIREIFSRYTDIIEPLSLDEAYLDVTENKKGMK
CHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCHH
SATMVAREIQQTIYQELGLTASAGVSFNKFIAKIASDFKKPAGITVVTPEEAEAFLEQIP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCC
VTKFYGVGKVTAEKLHRLGIETGADLKKWSEWDLIRELHKHGYHLYRHVRGRSNNIVNPH
CHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RDRKSVGKETTFEFNVLDSRVLEQSLMQFAKKVEERLIKLQKHGKTVVLKLRYSDFTTIT
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHH
KRLTLNEYTNDASQIYQAAALLLRESYTGQDSIRLIGLTVTNLKPVYFENLRLEGL
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]