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The map label for this gene is ung2 [H]

Identifier: 226223827

GI number: 226223827

Start: 1233346

End: 1234020

Strand: Direct

Name: ung2 [H]

Synonym: Lm4b_01232

Alternate gene names: 226223827

Gene position: 1233346-1234020 (Clockwise)

Preceding gene: 226223826

Following gene: 226223829

Centisome position: 42.34

GC content: 38.81

Gene sequence:

>675_bases
ATGATAAAACTCGGAAATGACTGGGATGAGTTACTAAAAGATGAGTTTAACCAACCGTATTATTTAACCCTTCGCCAGTT
CCTAAAAAAAGAATACCAAACGAAAAAAGTATTTCCGGATATGTACGACATTTTCAATGCGTTAAAATATACCGCTTGTA
AGGATGTCAAAGTGGTAATACTCGGTCAAGACCCATATCATGGACCAGGTCAAGCACACGGGCTCTCATTTTCCGTTCAA
CAAGGAGTGCAGATTCCACCATCACTGCAGAATATTTATTTGGAATTACATAACGACTTGAATTGTGAGATTCCAAACAA
TGGTTATTTGATACGGTGGGCAGATCAAGGAGTGCTACTATTAAATACGGTTCTAACTGTTCGCGCCGGTCAAGCCAACT
CACACCGAGGACAAGGCTGGGAAATACTAACAAACCGCATTATTGAAATCATTAACCAAAAAGAAGAGCCCGTAGTCTTT
TTACTATGGGGAAACAATGCGAAAGAAAAGTTGCAATTGTTAACAAATCCGAAACATACTGCGTTTACATCCGTACATCC
CAGTCCACTCTCAGCATCGCGCGGTTTTATGGGATGCAAACATTTTTCTAAGACGAATCAATTTTTAGAACAAAATGGTG
TAAAACCAATTGATTGGCAAATTCCTTCTATATAA

Upstream 100 bases:

>100_bases
AATAAACCGCATTCCTTTAAAAAAGGGGATGCGGTTTTTAGTTTGCTTCCAAAGACTATTTTGCTAAGATATAGTTAGAT
GAATGAAGGAGGAAAAAATC

Downstream 100 bases:

>100_bases
ATAAAAACATCTCGCCATTTATTGACGAGATGTTTTTTTACTTTTTAACCATTTTTAATGCTTTCTCTGTATTAGCGAAA
TGCTGTTTTGTATATTTCGC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG 2 [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIKLGNDWDELLKDEFNQPYYLTLRQFLKKEYQTKKVFPDMYDIFNALKYTACKDVKVVILGQDPYHGPGQAHGLSFSVQ
QGVQIPPSLQNIYLELHNDLNCEIPNNGYLIRWADQGVLLLNTVLTVRAGQANSHRGQGWEILTNRIIEIINQKEEPVVF
LLWGNNAKEKLQLLTNPKHTAFTSVHPSPLSASRGFMGCKHFSKTNQFLEQNGVKPIDWQIPSI

Sequences:

>Translated_224_residues
MIKLGNDWDELLKDEFNQPYYLTLRQFLKKEYQTKKVFPDMYDIFNALKYTACKDVKVVILGQDPYHGPGQAHGLSFSVQ
QGVQIPPSLQNIYLELHNDLNCEIPNNGYLIRWADQGVLLLNTVLTVRAGQANSHRGQGWEILTNRIIEIINQKEEPVVF
LLWGNNAKEKLQLLTNPKHTAFTSVHPSPLSASRGFMGCKHFSKTNQFLEQNGVKPIDWQIPSI
>Mature_224_residues
MIKLGNDWDELLKDEFNQPYYLTLRQFLKKEYQTKKVFPDMYDIFNALKYTACKDVKVVILGQDPYHGPGQAHGLSFSVQ
QGVQIPPSLQNIYLELHNDLNCEIPNNGYLIRWADQGVLLLNTVLTVRAGQANSHRGQGWEILTNRIIEIINQKEEPVVF
LLWGNNAKEKLQLLTNPKHTAFTSVHPSPLSASRGFMGCKHFSKTNQFLEQNGVKPIDWQIPSI

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=220, Percent_Identity=50.4545454545455, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI6224979, Length=220, Percent_Identity=50.4545454545455, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=56.0747663551402, Blast_Score=248, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=48.6238532110092, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323620, Length=235, Percent_Identity=46.3829787234043, Blast_Score=196, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25635; Mature: 25635

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLGNDWDELLKDEFNQPYYLTLRQFLKKEYQTKKVFPDMYDIFNALKYTACKDVKVVI
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEE
LGQDPYHGPGQAHGLSFSVQQGVQIPPSLQNIYLELHNDLNCEIPNNGYLIRWADQGVLL
ECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHEECCCCCEEECCCCEEEEECCCCEEE
LNTVLTVRAGQANSHRGQGWEILTNRIIEIINQKEEPVVFLLWGNNAKEKLQLLTNPKHT
EEHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCC
AFTSVHPSPLSASRGFMGCKHFSKTNQFLEQNGVKPIDWQIPSI
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure
MIKLGNDWDELLKDEFNQPYYLTLRQFLKKEYQTKKVFPDMYDIFNALKYTACKDVKVVI
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEE
LGQDPYHGPGQAHGLSFSVQQGVQIPPSLQNIYLELHNDLNCEIPNNGYLIRWADQGVLL
ECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHEECCCCCEEECCCCEEEEECCCCEEE
LNTVLTVRAGQANSHRGQGWEILTNRIIEIINQKEEPVVFLLWGNNAKEKLQLLTNPKHT
EEHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCC
AFTSVHPSPLSASRGFMGCKHFSKTNQFLEQNGVKPIDWQIPSI
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]