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The map label for this gene is pncB [H]

Identifier: 226223703

GI number: 226223703

Start: 1121139

End: 1122629

Strand: Direct

Name: pncB [H]

Synonym: Lm4b_01105

Alternate gene names: 226223703

Gene position: 1121139-1122629 (Clockwise)

Preceding gene: 226223702

Following gene: 226223704

Centisome position: 38.49

GC content: 38.9

Gene sequence:

>1491_bases
ATGACAAATTTATTTCAAGATGATAGTCTAACGCTGCATACAGACTTATATCAACTAAATATGATGAAAGCGTATTTTGA
CGATGGACTTCATGAGCGTAGATCGGTATTTGAAGTGTTTTTCCGAGATATGCCATTTGATTCGGGTTTTGTTGTGTTTG
CGGGGCTAGAACGAATTATTCATTATATGCAAAATTTACGTTTTACAGAAACGGATATTGCTTATTTACACGACGAACTT
GGTTTTGATGGACCTTTTCTAGAATATTTACGTAATTTTAAATTTAAAGGAAATATTCTTGCTGCGAAAGAAGGGGAATT
TGTTTTTAAAACAGAGCCAATCCTTCAAGTAGAAGCAAGCTTGGCGGAAGCACAATTAATTGAAACAGCTTTGCTTAATA
TTGTGAATTTCCAAACGCTGATTGCAACAAAAGCGGCGCGAATCCGTTCTGTTATTGATGACGAAACGTTTGCAGAATTC
GGTACAAGACGTGCACAAGAAATGGATGCGGCTATTTGGGGCACACGAGCGGCTTACATCGGCGGTTGTGATTCGACGAG
TAATGTTCGCGCTGGAAAAATTTTCGGTATTCCTGTGTCTGGTACGATGGCACATGCGATGGTTCAAGCTTATCGCGACG
AACTAGAAGCATTTAGAAGTTACGCAAAAACGCATTTTGATTCGATTTTCTTAGTAGATACATACGATACGCTAAAATCT
GGCGTACCAAATGCGATTAAAGTGGCGAAAGAAATGGGCGATAAAATTAACTTTATCGGCATTCGTTTAGATAGCGGGGA
TATGGCTTTCTTATCTAAAAAAGCACGCCAAATGTTAGATGAGGCTGGTTTTACAGAAGCAAAAATCTTTGCTTCGAGTG
ACTTAGACGAACATACTATTTTATCGTTAAAAGCGCAAAAAGCAAAAATCGATTCTTGGGGCGTTGGCACAAAACTAATC
ACCGCTTACGACCAACCAGCATTAGGTGCCGTTTACAAAATGGCGGCAATTGCTGATGAAAATGATATTTTACAAGATTC
GATTAAACTTTCGAGTAACACCGAAAAAGTGTCGACTCCTGGTAAAAAGAAAGTTTACCGGATTATTACGAATGAAGATG
GCTTGAAAGCGGAAGGCGATTATATTGCTTTAGCGGACGAATCACTCGAAAATGTGGATAAACTAACGATGTTCCACCCA
GTTCATACGTATATTATGAAAACAGTCGAGAACTTCACCGCGCGTGAGCTACTTGTACCGATTTTCCAAAACGGAGAACT
TGTATATGATATGCCTTCACTAGATGAAATTAAAGCATATAAAGAAGAGAACTTGGCGCTACTTTGGGACGAGTACAAAC
GAACAGTTCGTCCGGAGCAATACCCAGTTGATTTAAGTGTAAAATGTTGGAAAAATAAGATGCGTAATATCGAAAAGGTA
CGTAAAAGTGTCCAGCTTCATTCACCAGTTGAACTAGATATGCCGTTTTAG

Upstream 100 bases:

>100_bases
CAGACCAGTAATGTTCAATTATTAGGTGGTGGGCTTGTTTTGTGCTATTATTATGTATAAATAATAACGCAAAGAACTAG
TTATGATAGGAGCAGAAGAA

Downstream 100 bases:

>100_bases
GAGGAATTATAATGGAAATCAGAGAAAGAATTTTAGCAGATATGCAAGTGGCAGAAACGATTGATGCACACGAAGAAATC
CGAAAAAGTGTCGAGTTTTT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERIIHYMQNLRFTETDIAYLHDEL
GFDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEASLAEAQLIETALLNIVNFQTLIATKAARIRSVIDDETFAEF
GTRRAQEMDAAIWGTRAAYIGGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHFDSIFLVDTYDTLKS
GVPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTILSLKAQKAKIDSWGVGTKLI
TAYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTPGKKKVYRIITNEDGLKAEGDYIALADESLENVDKLTMFHP
VHTYIMKTVENFTARELLVPIFQNGELVYDMPSLDEIKAYKEENLALLWDEYKRTVRPEQYPVDLSVKCWKNKMRNIEKV
RKSVQLHSPVELDMPF

Sequences:

>Translated_496_residues
MTNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERIIHYMQNLRFTETDIAYLHDEL
GFDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEASLAEAQLIETALLNIVNFQTLIATKAARIRSVIDDETFAEF
GTRRAQEMDAAIWGTRAAYIGGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHFDSIFLVDTYDTLKS
GVPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTILSLKAQKAKIDSWGVGTKLI
TAYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTPGKKKVYRIITNEDGLKAEGDYIALADESLENVDKLTMFHP
VHTYIMKTVENFTARELLVPIFQNGELVYDMPSLDEIKAYKEENLALLWDEYKRTVRPEQYPVDLSVKCWKNKMRNIEKV
RKSVQLHSPVELDMPF
>Mature_495_residues
TNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERIIHYMQNLRFTETDIAYLHDELG
FDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEASLAEAQLIETALLNIVNFQTLIATKAARIRSVIDDETFAEFG
TRRAQEMDAAIWGTRAAYIGGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHFDSIFLVDTYDTLKSG
VPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTILSLKAQKAKIDSWGVGTKLIT
AYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTPGKKKVYRIITNEDGLKAEGDYIALADESLENVDKLTMFHPV
HTYIMKTVENFTARELLVPIFQNGELVYDMPSLDEIKAYKEENLALLWDEYKRTVRPEQYPVDLSVKCWKNKMRNIEKVR
KSVQLHSPVELDMPF

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=515, Percent_Identity=31.0679611650485, Blast_Score=238, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71997952, Length=530, Percent_Identity=34.7169811320755, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71997947, Length=530, Percent_Identity=34.7169811320755, Blast_Score=282, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71997955, Length=216, Percent_Identity=42.5925925925926, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24581587, Length=514, Percent_Identity=35.2140077821012, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=41.6666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=41.6666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=41.6666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=41.6666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=41.6666666666667, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56267; Mature: 56136

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERII
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
HYMQNLRFTETDIAYLHDELGFDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEAS
HHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHH
LAEAQLIETALLNIVNFQTLIATKAARIRSVIDDETFAEFGTRRAQEMDAAIWGTRAAYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEE
GGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHFDSIFLVDTYDTLKS
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHH
GVPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTI
CCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCE
LSLKAQKAKIDSWGVGTKLITAYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTP
EEEEHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
GKKKVYRIITNEDGLKAEGDYIALADESLENVDKLTMFHPVHTYIMKTVENFTARELLVP
CHHEEEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFQNGELVYDMPSLDEIKAYKEENLALLWDEYKRTVRPEQYPVDLSVKCWKNKMRNIEKV
HCCCCCEEEECCCHHHHHHHHHCCEEEEEHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHH
RKSVQLHSPVELDMPF
HHHHHCCCCEEECCCC
>Mature Secondary Structure 
TNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERII
CCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
HYMQNLRFTETDIAYLHDELGFDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEAS
HHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHH
LAEAQLIETALLNIVNFQTLIATKAARIRSVIDDETFAEFGTRRAQEMDAAIWGTRAAYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEE
GGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHFDSIFLVDTYDTLKS
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHH
GVPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTI
CCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCE
LSLKAQKAKIDSWGVGTKLITAYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTP
EEEEHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
GKKKVYRIITNEDGLKAEGDYIALADESLENVDKLTMFHPVHTYIMKTVENFTARELLVP
CHHEEEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFQNGELVYDMPSLDEIKAYKEENLALLWDEYKRTVRPEQYPVDLSVKCWKNKMRNIEKV
HCCCCCEEEECCCHHHHHHHHHCCEEEEEHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHH
RKSVQLHSPVELDMPF
HHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]