Click here to switch to the map view.

The map label for this gene is dxs [C]

Identifier: 226223651

GI number: 226223651

Start: 1063155

End: 1064102

Strand: Direct

Name: dxs [C]

Synonym: Lm4b_01053

Alternate gene names: 226223651

Gene position: 1063155-1064102 (Clockwise)

Preceding gene: 226223650

Following gene: 226223652

Centisome position: 36.5

GC content: 41.24

Gene sequence:

>948_bases
ATGAATAAAATAGCGAACCGCCAAGTAATGTGTGAAGTTTTAATGAAAGAAGCAACTCGTAACGATAGTAATTTAGTTGT
TTTAACAAGTGATTCAAGAGGATCCGCTTCGCTGGGGGCTTTTGCTGAGAAATTTCCAGAGCGACTAGTTGAGACTGGGA
TTGCCGAACAAAATATTGTTGGAATTGCAGCAGGCTTAGCACATAGTGGCAAGCGAGCTTTTGTCGCTTCACCAGCATGT
TTTCTAAGTATGCGCAGTATTGAACAGGTAAAAGTAGACGTGGCTTACTCAGACACGAATGTAAAATTGATTGGTATCAG
CGGTGGTGTTAGTTATGGTGCACTTGGTATGAGCCATCATTCGCTTCAAGATATTGCTGTTACTAGAGCGATTCCTAATT
TAGAAGTCATTCTACCAGCTGATCGTCTGGAAACGGAAGCTGTTTTTGACTATTTGCTTCAATCAAATCGGCCGGCGTAC
GTTCGTCTTGGCAGAAATGCGGTAGAAGATTGTTACGCAGAAAAACCAGTATTTCAAATTGGGAAAGCTGGAACCCTTAG
GAAAGGAAACGATGTGTCAATTTTAGCAACTGGTGAAATGGTACGAGTCGCACTTGATGCAAGGGAAGAATTGAAGTTGA
AAGGAATCAGCGCGCGTGTATTGAATTTTTCAACAATCAAACCATTTGACCAGGGAGCTGTAGAAGCGGCATTAGCTGAA
ACAAAACTACTTATTAGCATAGAAGAACATAGTATTTATGGTGGCTTAGGTGCAGCAGTGAGTGAAGTGGTAAGTAGTTC
GCCAACAAGTATTCGTCATTTGATCTTAGGAATTCCAGATGAACCTGCTATCGCTGGAACGAGCCAAGAAATCTTTGATT
ATTATGGCTTATCTGCTACTGGTATTGTTGCTACAGTTATGAAAAACCTTGGAGACGAAAGAAGATGA

Upstream 100 bases:

>100_bases
ATGGCTGAAAATGCTGCTAAATGGCATCATTACGTACCAAGCAGTGAGGAATACGAAATAGCTATGAAAGATTTAGAGGA
AAGAATGGAGGCGTGCCGTC

Downstream 100 bases:

>100_bases
AGAAACACTATCAAATCGCTATTGATCAAAGCACATCTGGAACGAAAGTATTATTGTTTAAAGCAGGTGAACTTGTAGAT
CGTTTAGATAAAAAGCATCG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MNKIANRQVMCEVLMKEATRNDSNLVVLTSDSRGSASLGAFAEKFPERLVETGIAEQNIVGIAAGLAHSGKRAFVASPAC
FLSMRSIEQVKVDVAYSDTNVKLIGISGGVSYGALGMSHHSLQDIAVTRAIPNLEVILPADRLETEAVFDYLLQSNRPAY
VRLGRNAVEDCYAEKPVFQIGKAGTLRKGNDVSILATGEMVRVALDAREELKLKGISARVLNFSTIKPFDQGAVEAALAE
TKLLISIEEHSIYGGLGAAVSEVVSSSPTSIRHLILGIPDEPAIAGTSQEIFDYYGLSATGIVATVMKNLGDERR

Sequences:

>Translated_315_residues
MNKIANRQVMCEVLMKEATRNDSNLVVLTSDSRGSASLGAFAEKFPERLVETGIAEQNIVGIAAGLAHSGKRAFVASPAC
FLSMRSIEQVKVDVAYSDTNVKLIGISGGVSYGALGMSHHSLQDIAVTRAIPNLEVILPADRLETEAVFDYLLQSNRPAY
VRLGRNAVEDCYAEKPVFQIGKAGTLRKGNDVSILATGEMVRVALDAREELKLKGISARVLNFSTIKPFDQGAVEAALAE
TKLLISIEEHSIYGGLGAAVSEVVSSSPTSIRHLILGIPDEPAIAGTSQEIFDYYGLSATGIVATVMKNLGDERR
>Mature_315_residues
MNKIANRQVMCEVLMKEATRNDSNLVVLTSDSRGSASLGAFAEKFPERLVETGIAEQNIVGIAAGLAHSGKRAFVASPAC
FLSMRSIEQVKVDVAYSDTNVKLIGISGGVSYGALGMSHHSLQDIAVTRAIPNLEVILPADRLETEAVFDYLLQSNRPAY
VRLGRNAVEDCYAEKPVFQIGKAGTLRKGNDVSILATGEMVRVALDAREELKLKGISARVLNFSTIKPFDQGAVEAALAE
TKLLISIEEHSIYGGLGAAVSEVVSSSPTSIRHLILGIPDEPAIAGTSQEIFDYYGLSATGIVATVMKNLGDERR

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637461, Length=311, Percent_Identity=33.1189710610932, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI225637459, Length=311, Percent_Identity=33.1189710610932, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI225637463, Length=311, Percent_Identity=33.1189710610932, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI133778974, Length=314, Percent_Identity=32.8025477707006, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=30.8681672025724, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=30.8681672025724, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI156564403, Length=301, Percent_Identity=24.5847176079734, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI291084858, Length=290, Percent_Identity=23.448275862069, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786622, Length=301, Percent_Identity=30.8970099667774, Blast_Score=117, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=314, Percent_Identity=32.1656050955414, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17538422, Length=279, Percent_Identity=24.7311827956989, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319698, Length=239, Percent_Identity=28.4518828451883, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24645119, Length=298, Percent_Identity=29.8657718120805, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45551847, Length=298, Percent_Identity=29.8657718120805, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45550715, Length=298, Percent_Identity=29.8657718120805, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24666278, Length=309, Percent_Identity=30.0970873786408, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21358145, Length=273, Percent_Identity=26.7399267399267, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650940, Length=273, Percent_Identity=26.7399267399267, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI160714832, Length=232, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI160714828, Length=232, Percent_Identity=25.8620689655172, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33696; Mature: 33696

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIANRQVMCEVLMKEATRNDSNLVVLTSDSRGSASLGAFAEKFPERLVETGIAEQNIV
CCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
GIAAGLAHSGKRAFVASPACFLSMRSIEQVKVDVAYSDTNVKLIGISGGVSYGALGMSHH
EEEHHHCCCCCEEEEECCHHHHHHHHHEEEEEEEEEECCCEEEEEECCCCCCCEECCCCH
SLQDIAVTRAIPNLEVILPADRLETEAVFDYLLQSNRPAYVRLGRNAVEDCYAEKPVFQI
HHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCHHHC
GKAGTLRKGNDVSILATGEMVRVALDAREELKLKGISARVLNFSTIKPFDQGAVEAALAE
CCCCCCCCCCCEEEEECCCEEEEECCCHHHHEECCCEEEEEECEECCCCCCHHHHHHHHC
TKLLISIEEHSIYGGLGAAVSEVVSSSPTSIRHLILGIPDEPAIAGTSQEIFDYYGLSAT
EEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHH
GIVATVMKNLGDERR
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MNKIANRQVMCEVLMKEATRNDSNLVVLTSDSRGSASLGAFAEKFPERLVETGIAEQNIV
CCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
GIAAGLAHSGKRAFVASPACFLSMRSIEQVKVDVAYSDTNVKLIGISGGVSYGALGMSHH
EEEHHHCCCCCEEEEECCHHHHHHHHHEEEEEEEEEECCCEEEEEECCCCCCCEECCCCH
SLQDIAVTRAIPNLEVILPADRLETEAVFDYLLQSNRPAYVRLGRNAVEDCYAEKPVFQI
HHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCHHHC
GKAGTLRKGNDVSILATGEMVRVALDAREELKLKGISARVLNFSTIKPFDQGAVEAALAE
CCCCCCCCCCCEEEEECCCEEEEECCCHHHHEECCCEEEEEECEECCCCCCHHHHHHHHC
TKLLISIEEHSIYGGLGAAVSEVVSSSPTSIRHLILGIPDEPAIAGTSQEIFDYYGLSAT
EEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHH
GIVATVMKNLGDERR
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]