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The map label for this gene is tktA [C]

Identifier: 226223650

GI number: 226223650

Start: 1062338

End: 1063162

Strand: Direct

Name: tktA [C]

Synonym: Lm4b_01052

Alternate gene names: 226223650

Gene position: 1062338-1063162 (Clockwise)

Preceding gene: 226223649

Following gene: 226223651

Centisome position: 36.47

GC content: 39.88

Gene sequence:

>825_bases
ATGAGTGAATTAAAGTTAAAATCGTTTGAAATTAGAAAAGATGTTCTAAAAATGATATATGATGCAAAAACGGGACATAC
TGGTTCAGATTTATCATGTGCGGATATTCTTGTGGCGCTTTACTATGGTGTGCTGAATGTTAATCCGGAAAATCCAGAAG
CTTTAGATCGTGATCGTTACGTTCAAAGTAAAGGACATGCTGTCGAAGTTCTTTGGGCAGTTTTAGCAGATAAAGGGTTT
TTTGCAAAAGAAGAATTGGCTGATTTCTCCGCATTTGGCTCGCGTTTAATCGGGCATCCAAATAATAAAGTAGCTGGAAT
TGAAATGAACACAGGTTCGCTCGGCCATGGTTTATCTGTTTCGGTGGGTATGGCATTAGCTGCTAAAATGGATGGGAAAA
GTTATCACACCTATACACTCATGGGGGACGGGGAACTTGCAGAGGGGTCTGTCTGGGAAGGTGCAATGGCTGCAGCAAAT
TATAAATTAGATAATTTGACTGCGATTATTGATCGGAACTCCTTACAAATCTCCGGTCGAACAGAAGATGTAATGAGTGT
AGAACCTTTGGCAGATAAGTGGCGCGCATTTGGTTGGAATGTTATCGAAGTGGATGGAAATGATCCGGATAAGCTACAAG
CGATTTTTAAAACAGTTAATGTGACTGGAAAACCTCGTCTAATTATTGCAAAAACGATAAAAGGTTATGGGGTTAAAATG
GCTGAAAATGCTGCTAAATGGCATCATTACGTACCAAGCAGTGAGGAATACGAAATAGCTATGAAAGATTTAGAGGAAAG
AATGGAGGCGTGCCGTCATGAATAA

Upstream 100 bases:

>100_bases
TGAAGCATGCAAATACATTGGCATAAAGCCAGACCTCTATGATCCAATTGAAGAAGATATAAAAGCTTATTTACGCGGTG
AATAGAGAAAGGAGTAAAAA

Downstream 100 bases:

>100_bases
AATAGCGAACCGCCAAGTAATGTGTGAAGTTTTAATGAAAGAAGCAACTCGTAACGATAGTAATTTAGTTGTTTTAACAA
GTGATTCAAGAGGATCCGCT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSELKLKSFEIRKDVLKMIYDAKTGHTGSDLSCADILVALYYGVLNVNPENPEALDRDRYVQSKGHAVEVLWAVLADKGF
FAKEELADFSAFGSRLIGHPNNKVAGIEMNTGSLGHGLSVSVGMALAAKMDGKSYHTYTLMGDGELAEGSVWEGAMAAAN
YKLDNLTAIIDRNSLQISGRTEDVMSVEPLADKWRAFGWNVIEVDGNDPDKLQAIFKTVNVTGKPRLIIAKTIKGYGVKM
AENAAKWHHYVPSSEEYEIAMKDLEERMEACRHE

Sequences:

>Translated_274_residues
MSELKLKSFEIRKDVLKMIYDAKTGHTGSDLSCADILVALYYGVLNVNPENPEALDRDRYVQSKGHAVEVLWAVLADKGF
FAKEELADFSAFGSRLIGHPNNKVAGIEMNTGSLGHGLSVSVGMALAAKMDGKSYHTYTLMGDGELAEGSVWEGAMAAAN
YKLDNLTAIIDRNSLQISGRTEDVMSVEPLADKWRAFGWNVIEVDGNDPDKLQAIFKTVNVTGKPRLIIAKTIKGYGVKM
AENAAKWHHYVPSSEEYEIAMKDLEERMEACRHE
>Mature_273_residues
SELKLKSFEIRKDVLKMIYDAKTGHTGSDLSCADILVALYYGVLNVNPENPEALDRDRYVQSKGHAVEVLWAVLADKGFF
AKEELADFSAFGSRLIGHPNNKVAGIEMNTGSLGHGLSVSVGMALAAKMDGKSYHTYTLMGDGELAEGSVWEGAMAAANY
KLDNLTAIIDRNSLQISGRTEDVMSVEPLADKWRAFGWNVIEVDGNDPDKLQAIFKTVNVTGKPRLIIAKTIKGYGVKMA
ENAAKWHHYVPSSEEYEIAMKDLEERMEACRHE

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=249, Percent_Identity=39.3574297188755, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI4507521, Length=249, Percent_Identity=39.3574297188755, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI133778974, Length=268, Percent_Identity=33.955223880597, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI225637459, Length=266, Percent_Identity=30.0751879699248, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI225637461, Length=241, Percent_Identity=31.1203319502075, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI225637463, Length=236, Percent_Identity=31.3559322033898, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI48994911, Length=251, Percent_Identity=36.2549800796813, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788808, Length=268, Percent_Identity=33.5820895522388, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17539652, Length=240, Percent_Identity=41.25, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325331, Length=248, Percent_Identity=36.2903225806452, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319593, Length=252, Percent_Identity=32.9365079365079, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551847, Length=250, Percent_Identity=38, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45550715, Length=250, Percent_Identity=38, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24666278, Length=250, Percent_Identity=37.2, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24645119, Length=211, Percent_Identity=40.2843601895735, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30219; Mature: 30087

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKLKSFEIRKDVLKMIYDAKTGHTGSDLSCADILVALYYGVLNVNPENPEALDRDRY
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHCHHHH
VQSKGHAVEVLWAVLADKGFFAKEELADFSAFGSRLIGHPNNKVAGIEMNTGSLGHGLSV
HHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCH
SVGMALAAKMDGKSYHTYTLMGDGELAEGSVWEGAMAAANYKLDNLTAIIDRNSLQISGR
HHHHHEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCCCEEEEEECCEEEECCC
TEDVMSVEPLADKWRAFGWNVIEVDGNDPDKLQAIFKTVNVTGKPRLIIAKTIKGYGVKM
CCCCEECCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE
AENAAKWHHYVPSSEEYEIAMKDLEERMEACRHE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SELKLKSFEIRKDVLKMIYDAKTGHTGSDLSCADILVALYYGVLNVNPENPEALDRDRY
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHCHHHH
VQSKGHAVEVLWAVLADKGFFAKEELADFSAFGSRLIGHPNNKVAGIEMNTGSLGHGLSV
HHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCH
SVGMALAAKMDGKSYHTYTLMGDGELAEGSVWEGAMAAANYKLDNLTAIIDRNSLQISGR
HHHHHEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCCCEEEEEECCEEEECCC
TEDVMSVEPLADKWRAFGWNVIEVDGNDPDKLQAIFKTVNVTGKPRLIIAKTIKGYGVKM
CCCCEECCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE
AENAAKWHHYVPSSEEYEIAMKDLEERMEACRHE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]