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The map label for this gene is mvaA [H]

Identifier: 226223445

GI number: 226223445

Start: 852950

End: 854230

Strand: Direct

Name: mvaA [H]

Synonym: Lm4b_00843

Alternate gene names: 226223445

Gene position: 852950-854230 (Clockwise)

Preceding gene: 226223444

Following gene: 226223446

Centisome position: 29.28

GC content: 42.47

Gene sequence:

>1281_bases
ATGAATGCTTTTGATAAATTTTACAAAAAAACAGTAGAAGAACGACGCGCAATTTTGGCGGAATATGCCGACTTAAATGA
AGAAGAGCAGGCATTTTTAGCTTCTACAGGGGCGCTTTCTTTTGATAAAGCGAATCATATGATTGAAAACACGATTGGCA
TTTACTCGCTGCCGCTCGGATTAGGAATGAACATGCTTTTAAATGATAAACATTATGTGGTACCGATGGCGATGGAAGAG
CCTTCTGTTGTGGCGGCCCAAAGCGCTGGGGCGAAACTTATTGGACAAAATGGCGGGATAACTGGAAGTGCAACAAAACG
AAAAATGATTGGTCAGATTGAGTTGATTTCTGTTTCTGATATCCAAGCAGCAAAAGAAAACATCATTGCGAACGAAGAAC
AACTAATTGCTATCGCTAACCAAGCTCATCCATCGTTACAAAAGCGTGGCGGTGGTGCGGTTGAAATTCAAGTCAGAACA
GCACAAACAGCGAATGACGAAACGTTACTTATCGTTCATTTACTCGTAGACACCCAAGAAGCAATGGGCGCGAATATGGT
CAATACGATGGTCGAAACCTTAGCGCCAGAATTAGAAATGTTGACGAACGGAACAGCCAATATGCGCATTTTATCTAATT
TAGTAGATGAAGCGACCGCAACGGCTGTTTGCCGGATTAATCCAGAAAGCTTAGCAACCAAAACCCAGAGTGGTGAATGG
GTTCGTGATCGAATCATTGCTGCATATGAATTTGCTGATGCAGACATTTACCGAGCAGCAACCCATAATAAAGGAATAAT
GAATGGTATTGATGCGGTAATTATGGCGTTTGGGAACGATTGGCGCGCGGTAGAAGCGGCAAGTCACGCCTACGCAGCTA
GAACAGGAAGCTATAAACCGATGTCTAAATGGTCAAAAGATGCGGAGGGGTATTTGGTTGGGGAATTAACGTTACCGATG
CCAGTAGCCTTTGTAGGAGGTTCTATCGGCATCCATCCAATCGCAACACTTTCGAAAAAAATTGCTCGAGTAGAATCAGC
GAAGGAATTAGCGATGTTAGTTTGTGCCGTTGGATTAACGCAAAATCTCGCTGCTTTAAAAGCACTCGTAACAGAAGGAA
TTCAACGCGGACATATGTCGCTACAAGCGAAATCACTAGCCATGACAGCCGGTGCAGAAGCAGATGAAATCGAAAAAGTA
GCCACATTTTTACAAGAAAGCAAACAATTAAATGTAGTTGCTGCAAAAGAATTTATTAACAAATTACGCAGTGGAAAATA
A

Upstream 100 bases:

>100_bases
CGTGCTGAATTAGACGGAGATTTCTGGGACCGTTACATCCAGTTTCGAAATATGCTATAGTCAAGTAGATGGATAAATTT
TAATTTGAGGTGATAAAGCT

Downstream 100 bases:

>100_bases
AATAAATTATTAAGCCTACCTTTACAAAAACTTAACAATACATTCGGAACGTGATAAAGCCTTTAGTATCAACAACTTTT
AGAGATTTGCTTGGACTTCA

Product: 3-hydroxy-3-methylglutaryl-coenzyme a reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNAFDKFYKKTVEERRAILAEYADLNEEEQAFLASTGALSFDKANHMIENTIGIYSLPLGLGMNMLLNDKHYVVPMAMEE
PSVVAAQSAGAKLIGQNGGITGSATKRKMIGQIELISVSDIQAAKENIIANEEQLIAIANQAHPSLQKRGGGAVEIQVRT
AQTANDETLLIVHLLVDTQEAMGANMVNTMVETLAPELEMLTNGTANMRILSNLVDEATATAVCRINPESLATKTQSGEW
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYAARTGSYKPMSKWSKDAEGYLVGELTLPM
PVAFVGGSIGIHPIATLSKKIARVESAKELAMLVCAVGLTQNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEADEIEKV
ATFLQESKQLNVVAAKEFINKLRSGK

Sequences:

>Translated_426_residues
MNAFDKFYKKTVEERRAILAEYADLNEEEQAFLASTGALSFDKANHMIENTIGIYSLPLGLGMNMLLNDKHYVVPMAMEE
PSVVAAQSAGAKLIGQNGGITGSATKRKMIGQIELISVSDIQAAKENIIANEEQLIAIANQAHPSLQKRGGGAVEIQVRT
AQTANDETLLIVHLLVDTQEAMGANMVNTMVETLAPELEMLTNGTANMRILSNLVDEATATAVCRINPESLATKTQSGEW
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYAARTGSYKPMSKWSKDAEGYLVGELTLPM
PVAFVGGSIGIHPIATLSKKIARVESAKELAMLVCAVGLTQNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEADEIEKV
ATFLQESKQLNVVAAKEFINKLRSGK
>Mature_426_residues
MNAFDKFYKKTVEERRAILAEYADLNEEEQAFLASTGALSFDKANHMIENTIGIYSLPLGLGMNMLLNDKHYVVPMAMEE
PSVVAAQSAGAKLIGQNGGITGSATKRKMIGQIELISVSDIQAAKENIIANEEQLIAIANQAHPSLQKRGGGAVEIQVRT
AQTANDETLLIVHLLVDTQEAMGANMVNTMVETLAPELEMLTNGTANMRILSNLVDEATATAVCRINPESLATKTQSGEW
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYAARTGSYKPMSKWSKDAEGYLVGELTLPM
PVAFVGGSIGIHPIATLSKKIARVESAKELAMLVCAVGLTQNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEADEIEKV
ATFLQESKQLNVVAAKEFINKLRSGK

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 45808; Mature: 45808

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFDKFYKKTVEERRAILAEYADLNEEEQAFLASTGALSFDKANHMIENTIGIYSLPLG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHHH
LGMNMLLNDKHYVVPMAMEEPSVVAAQSAGAKLIGQNGGITGSATKRKMIGQIELISVSD
CCCCEEECCCEEEEEEECCCCCEEEECCCCCEEEECCCCCCCCCHHHHHHCEEEEEEEHH
IQAAKENIIANEEQLIAIANQAHPSLQKRGGGAVEIQVRTAQTANDETLLIVHLLVDTQE
HHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCEEEEEEEECCCCCCCEEEEEEEECCCHH
AMGANMVNTMVETLAPELEMLTNGTANMRILSNLVDEATATAVCRINPESLATKTQSGEW
HHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECHHHHHCCCCCCCH
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYAARTGSYKP
HHHHHHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
MSKWSKDAEGYLVGELTLPMPVAFVGGSIGIHPIATLSKKIARVESAKELAMLVCAVGLT
HHHHCCCCCCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEADEIEKVATFLQESKQLNVVAAKEFIN
HHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
KLRSGK
HHHCCC
>Mature Secondary Structure
MNAFDKFYKKTVEERRAILAEYADLNEEEQAFLASTGALSFDKANHMIENTIGIYSLPLG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHHH
LGMNMLLNDKHYVVPMAMEEPSVVAAQSAGAKLIGQNGGITGSATKRKMIGQIELISVSD
CCCCEEECCCEEEEEEECCCCCEEEECCCCCEEEECCCCCCCCCHHHHHHCEEEEEEEHH
IQAAKENIIANEEQLIAIANQAHPSLQKRGGGAVEIQVRTAQTANDETLLIVHLLVDTQE
HHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCEEEEEEEECCCCCCCEEEEEEEECCCHH
AMGANMVNTMVETLAPELEMLTNGTANMRILSNLVDEATATAVCRINPESLATKTQSGEW
HHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECHHHHHCCCCCCCH
VRDRIIAAYEFADADIYRAATHNKGIMNGIDAVIMAFGNDWRAVEAASHAYAARTGSYKP
HHHHHHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
MSKWSKDAEGYLVGELTLPMPVAFVGGSIGIHPIATLSKKIARVESAKELAMLVCAVGLT
HHHHCCCCCCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNLAALKALVTEGIQRGHMSLQAKSLAMTAGAEADEIEKVATFLQESKQLNVVAAKEFIN
HHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
KLRSGK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]