BacMap

Definition	Listeria monocytogenes Clip81459, complete genome.
Accession	NC_012488
Length	2,912,690

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The map label for this gene is yvgN [H]

Identifier: 226223443

GI number: 226223443

Start: 851038

End: 851862

Strand: Direct

Name: yvgN [H]

Synonym: Lm4b_00841

Alternate gene names: 226223443

Gene position: 851038-851862 (Clockwise)

Preceding gene: 226223441

Following gene: 226223444

Centisome position: 29.22

GC content: 38.42

Gene sequence:

>825_bases
TTGAACTTAAAAGATACAGTAAAACTTGCAAATGGTGTAGAAATGCCCCGTTTAGGATTTGGCGTATGGAAAGTGCAGGA
CGGCGATGAAGCAGTAAATTCTGTTAAATGGGCGATTGAAGCTGGTTACATTAGTATTGATACAGCTGCTGCTTACAAAA
ATGAAGAAGGCGTTGGTCAAGCGATTAAAGAGTCTGGCGTTAAGAGAGAAGACTTATTCGTAACAACGAAACTTTGGAAT
GCGGAGCAAGGTTATGAATCCACTTTGGCTGCATTTGATGAAAGCTTACGTAAATTAGAACTTGATTATGTAGACTTATA
TTTAATTCACTGGCCAGTCAAAGGTAAATTCAAAGACACTTGGCGCGCTTTTGAAAAATTATATAAAGATAAACGCGTTC
GCGCAATCGGCGTATGTAACTTCCACGAACATCACCTAAAAGAATTAATGGAAGACGCGGAAATTGCGCCAATGGTAAAC
CAAATTGAATTACACCCACAACTAACACAAGAACCATTACGTAAATTCTGTGCTGAAAACAACATTGTAGTAGAAGCTTG
GTCTCCACTAGGTAATGGGAAATTACTTTCTAACCCAGAAATCAAAGCGATTGCCGATGCACATGGTAAATCAGTTGCAC
AAGTTATCTTACGTTGGGATTTACAAATCGGTGTCGTGACTATTCCAAAATCCGTTCACCAAGAACGTATTATCCAAAAT
GCTGATATTTTCGACTTCGAATTAAGCGAAGAAGAAGTAGCAAAAATCAGCGGTTTAAATAAAGACGAAAGAACTGGCCC
AGATCCAGACAACTTTAATTTCTAA

Upstream 100 bases:

>100_bases
TTAATAATAGCACCTTGAAAATCGAAAAGCCAAATGTTTGCCTTTGAGTATACTCTAAGGTGTATAGTAAACGTGTTATT
ACTTTTAGGAGGCGGATAAA

Downstream 100 bases:

>100_bases
TAGTGAAAAAATCCCTTCCAGCTTATCGAACTGGAGGGGATTTTTATGCTACAATAAACTAAAAAAAGAGGTTAACAGAT
GGACGCAAAAACAATAATAG

Product: oxydoreductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNLKDTVKLANGVEMPRLGFGVWKVQDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQAIKESGVKREDLFVTTKLWN
AEQGYESTLAAFDESLRKLELDYVDLYLIHWPVKGKFKDTWRAFEKLYKDKRVRAIGVCNFHEHHLKELMEDAEIAPMVN
QIELHPQLTQEPLRKFCAENNIVVEAWSPLGNGKLLSNPEIKAIADAHGKSVAQVILRWDLQIGVVTIPKSVHQERIIQN
ADIFDFELSEEEVAKISGLNKDERTGPDPDNFNF

Sequences:

>Translated_274_residues
MNLKDTVKLANGVEMPRLGFGVWKVQDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQAIKESGVKREDLFVTTKLWN
AEQGYESTLAAFDESLRKLELDYVDLYLIHWPVKGKFKDTWRAFEKLYKDKRVRAIGVCNFHEHHLKELMEDAEIAPMVN
QIELHPQLTQEPLRKFCAENNIVVEAWSPLGNGKLLSNPEIKAIADAHGKSVAQVILRWDLQIGVVTIPKSVHQERIIQN
ADIFDFELSEEEVAKISGLNKDERTGPDPDNFNF
>Mature_274_residues
MNLKDTVKLANGVEMPRLGFGVWKVQDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQAIKESGVKREDLFVTTKLWN
AEQGYESTLAAFDESLRKLELDYVDLYLIHWPVKGKFKDTWRAFEKLYKDKRVRAIGVCNFHEHHLKELMEDAEIAPMVN
QIELHPQLTQEPLRKFCAENNIVVEAWSPLGNGKLLSNPEIKAIADAHGKSVAQVILRWDLQIGVVTIPKSVHQERIIQN
ADIFDFELSEEEVAKISGLNKDERTGPDPDNFNF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=39.7959183673469, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI24497577, Length=295, Percent_Identity=37.2881355932203, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI5174391, Length=295, Percent_Identity=37.2881355932203, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI310109922, Length=279, Percent_Identity=40.1433691756272, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI45446745, Length=299, Percent_Identity=38.7959866220736, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI4503285, Length=299, Percent_Identity=38.7959866220736, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI310109920, Length=299, Percent_Identity=38.4615384615385, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=37.9194630872483, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=36.3934426229508, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI291291012, Length=267, Percent_Identity=38.5767790262172, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=36.241610738255, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI24497583, Length=296, Percent_Identity=36.4864864864865, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=40.7534246575342, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=36.3636363636364, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=36.5942028985507, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=34.2960288808664, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI207028673, Length=117, Percent_Identity=48.7179487179487, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI310109926, Length=117, Percent_Identity=47.8632478632479, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI310109924, Length=145, Percent_Identity=37.2413793103448, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082198, Length=271, Percent_Identity=45.7564575645756, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1786400, Length=258, Percent_Identity=35.6589147286822, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=32.7205882352941, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788070, Length=217, Percent_Identity=27.6497695852535, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87081735, Length=270, Percent_Identity=24.4444444444444, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994888, Length=252, Percent_Identity=24.2063492063492, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=40.1360544217687, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=39.6666666666667, Blast_Score=199, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71998625, Length=279, Percent_Identity=39.426523297491, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17564128, Length=299, Percent_Identity=35.7859531772575, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=34.8684210526316, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17550248, Length=293, Percent_Identity=36.518771331058, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17566692, Length=292, Percent_Identity=36.986301369863, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=37.1323529411765, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=33.9416058394161, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=30.7692307692308, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=33.8181818181818, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17561300, Length=276, Percent_Identity=34.4202898550725, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17550246, Length=81, Percent_Identity=45.679012345679, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=292, Percent_Identity=43.1506849315069, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324694, Length=296, Percent_Identity=39.527027027027, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321896, Length=312, Percent_Identity=34.2948717948718, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322556, Length=257, Percent_Identity=35.408560311284, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319625, Length=284, Percent_Identity=36.6197183098592, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320079, Length=278, Percent_Identity=34.8920863309352, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24663317, Length=300, Percent_Identity=40.6666666666667, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI45553081, Length=296, Percent_Identity=37.5, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24644950, Length=296, Percent_Identity=38.8513513513513, Blast_Score=193, Evalue=9e-50,
Organism=Drosophila melanogaster, GI20129731, Length=294, Percent_Identity=38.0952380952381, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=36.8600682593857, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24657054, Length=292, Percent_Identity=37.6712328767123, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI221378297, Length=316, Percent_Identity=36.3924050632911, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21356425, Length=294, Percent_Identity=37.0748299319728, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24662781, Length=277, Percent_Identity=40.072202166065, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=36.8627450980392, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662785, Length=277, Percent_Identity=38.9891696750903, Blast_Score=161, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31049; Mature: 31049

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDTVKLANGVEMPRLGFGVWKVQDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQ
CCCHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHEEEECEEEEEHHHHHCCCCHHHH
AIKESGVKREDLFVTTKLWNAEQGYESTLAAFDESLRKLELDYVDLYLIHWPVKGKFKDT
HHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHH
WRAFEKLYKDKRVRAIGVCNFHEHHLKELMEDAEIAPMVNQIELHPQLTQEPLRKFCAEN
HHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCHHCCHHHHEECCCCHHHHHHHHHHCCC
NIVVEAWSPLGNGKLLSNPEIKAIADAHGKSVAQVILRWDLQIGVVTIPKSVHQERIIQN
CEEEEECCCCCCCEEECCCCCEEHHHHCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHCC
ADIFDFELSEEEVAKISGLNKDERTGPDPDNFNF
CCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLKDTVKLANGVEMPRLGFGVWKVQDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQ
CCCHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHEEEECEEEEEHHHHHCCCCHHHH
AIKESGVKREDLFVTTKLWNAEQGYESTLAAFDESLRKLELDYVDLYLIHWPVKGKFKDT
HHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHH
WRAFEKLYKDKRVRAIGVCNFHEHHLKELMEDAEIAPMVNQIELHPQLTQEPLRKFCAEN
HHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCHHCCHHHHEECCCCHHHHHHHHHHCCC
NIVVEAWSPLGNGKLLSNPEIKAIADAHGKSVAQVILRWDLQIGVVTIPKSVHQERIIQN
CEEEEECCCCCCCEEECCCCCEEHHHHCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHCC
ADIFDFELSEEEVAKISGLNKDERTGPDPDNFNF
CCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]