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The map label for this gene is hyuA [H]

Identifier: 226223085

GI number: 226223085

Start: 494382

End: 495932

Strand: Direct

Name: hyuA [H]

Synonym: Lm4b_00482

Alternate gene names: 226223085

Gene position: 494382-495932 (Clockwise)

Preceding gene: 226223084

Following gene: 226223087

Centisome position: 16.97

GC content: 44.49

Gene sequence:

>1551_bases
ATGTATAAAATTGGAATTGACGTTGGTGGTACAAACACCGATGCCGTTATTTTAGATGAAAATCAACAACTCATTCATAG
TGTAAAAATGCCAACGAGTGAAGATATTGAAACAGGAATTACTGAGTCACTTCATCGCGTATTGAGCGAAACGGGCATTG
ATCGCTCGAAAGTAACGCACGCCATGCTTGGAACAACCCAGTGTACGAACGCGATTGTAGAACGTAAAAAATTAGCAAAA
GTTGGCGTTCTTCGTTTAGGCTATCCTGCAACAGCATCCGTTTTACCATATACAGCTTGGCCGGAAGACATGGTTGGCTT
TTTATCTGGAAAATATAAATTAACTGGTGGCGGCTATGAGTATGATGGTCAGGTGCTATCAGAAATCAACGAAGCAGAAA
TCCGTGAAACCTTAGCTAGTTGGAAAGGTGAAGTGGAATCCGTCGCAGTTGTTGGCGTCTTTTCTTCCTTGAAAAACGAT
CAGGAATTAGCTGTTCAAAAAATTATTGAAGAAGAACTAGGCGCAGATATTCCGGTTTCGATTTCCTCTTCCGTAGGTTC
TGTTGGACTGATTGAACGCGAAAATGCGACGATTTTAAACGCAGCCCTTTTCAAAGTTATTGCGGCAACGAGTGATGGTT
TTGAAAAAGCACTAGAACAAGAAGGAATTGCGCATGCTGAAATCTATCTTTGCCAAAACGACGGGACTTTAATGTCACTA
AACTATGCAAGACAATTCCCGATTTTGACAATTGCTTGTGGACCAACGAACAGTATCCGCGGCGCATCCTACTTGGCGGG
ACTTAAAGACGCGATGGTTCTCGATGTTGGTGGCACGACTTCTGATATTGGAGTGCTGACGGATGGTTTCCCTAGAGAGT
CCTCGCTTGCGGTTGATGTTGGCGGAGTGCGTACCAACTTTAGAATGCCAGATATTATTTCCATCGGACTTGGTGGAGGA
AGTATCGTTCGCGAAAAAGATGGCGACATAACAATCGGACCAGATAGCGTTGGCTACCGTATTTCCGAAGAAGCACTAGT
TTTCGGAGGTAAAACGATGACCACTACCGACATCGCGGTTCGTCTAGGTAGGGCAGAAATCGGTAACCCTGAATTAGTCG
CACATATCCCAACCGATTTTGCCGAAAAAGCCTATAAAAAAATTGCTGAAATGACCGAAGATGCGATTGATAAAATGAAA
ACCAGTTCGGGGAGTGTAAGTCTAGTACTTGTTGGCGGTGGTAGCGTGATTATTCCAGACGAAATCTCTGGTGTCGCACA
AATTTTCCGCGACAAAAACGGCCCAGTAGCCAACGCAATCGGCGCATCCATTTCCCAAATCAGCGGACAATACGAACAAA
TCTACATCTATTCTCAAATCGAGCGGGAAGAAGCGCTCCAAGATGCCGAACAAAAAGCGAGAGAACAAGCAACTCTAGCC
GGTGCAGTGACTGACTCGATTGAAGTGGTGGAAGTGGAAGAAATCCCATTAGCGTATCATCCGGGTAATGCAACCAGATT
GCGCGTGAAAGTTGTGGGAAATTTGGTTTAA

Upstream 100 bases:

>100_bases
AGAACGGACAAAGGTATCGAAACAGTTGGACCGCGCTATTTCGGCTATGATGTCGATTTTGAACCACTAGAAGAACTTGT
CAAAAAGGAGGAACGCCGTC

Downstream 100 bases:

>100_bases
GGGAAGTAAGAAGTAAATAGTAGTGCATTGCTGACTTCAGACTGGAAACAAAGTAAGAAATTACTTTGCTTCCAGTCTAT
TTTTGTATAACGTAATCCCA

Product: hydantoinase

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAK
VGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKND
QELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSL
NYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGG
SIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGRAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMK
TSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLA
GAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV

Sequences:

>Translated_516_residues
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAK
VGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKND
QELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSL
NYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGG
SIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGRAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMK
TSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLA
GAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>Mature_516_residues
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAK
VGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKND
QELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSL
NYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGG
SIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGRAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMK
TSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLA
GAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 54948; Mature: 54948

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTH
CEEEEEEECCCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
AMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYE
HHHCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCE
YDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVS
ECCHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEHHHCCCCHHHHHHHHHHHHHCCCCCEE
ISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSL
ECCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCEEEE
NYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDV
ECCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEE
GGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAV
CCCEECCCCCCEEEEECCCCCEEEECCCCEEECCCCCCCEECCCEEEECCCEEEEHHHHE
RLGRAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMKTSSGSVSLVLVGGGSVIIPD
EECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECC
EISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLA
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
GAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
HHHCCCEEEEEEECCCEEECCCCCEEEEEEEECCCC
>Mature Secondary Structure
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTH
CEEEEEEECCCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
AMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYE
HHHCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCE
YDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVS
ECCHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEHHHCCCCHHHHHHHHHHHHHCCCCCEE
ISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSL
ECCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCEEEE
NYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDV
ECCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEE
GGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAV
CCCEECCCCCCEEEEECCCCCEEEECCCCEEECCCCCCCEECCCEEEECCCEEEEHHHHE
RLGRAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMKTSSGSVSLVLVGGGSVIIPD
EECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECC
EISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLA
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
GAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
HHHCCCEEEEEEECCCEEECCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]