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The map label for this gene is ung1 [H]

Identifier: 226223015

GI number: 226223015

Start: 415505

End: 416170

Strand: Direct

Name: ung1 [H]

Synonym: Lm4b_00408

Alternate gene names: 226223015

Gene position: 415505-416170 (Clockwise)

Preceding gene: 226223013

Following gene: 226223016

Centisome position: 14.27

GC content: 40.69

Gene sequence:

>666_bases
ATGGTAAAAACATGGGAAGAATTTTTAAAACAAGAAGCGAAACAGCCTTATTTTATAGAATTAATGGAAGCAGTTAAGGA
CGCGAGAGCAAAGGGGAATGTCTATCCGACTGAAGAAGATATGTTTTCGTGTTTCCGCTTATGTCCGTATGATCAAGTGA
AAGTTGTTATTTTAGGACAAGACCCGTATCATGGTCCTGGACAAGCGCATGGCCTAAGCTTCTCCGTGCAAAAAGGGGTG
CGAATTCCGCCAAGTCTTCGTAATATTTATAAAGAATTAAAGACAGACTTAGATATTGAACCAGCTGACCACGGCTATCT
TGCCAAATGGGCAGAGCAAGGCGTACTTTTAATGAACACGAGTTGGAGCGTGGAAGAAGGCAAAGCTGGTAGCCACAAAA
AACTAGGCTGGGCAACATTTACAGATCACGTTTTAGAAGAACTAAATAATTACGACAAACCACTTGTATTTATTTTATGG
GGGAATCATGCTATAAAAGCCGCAAGTGGCATCACAAACCCGAAACATTTACTTATTAAAGGAGTACACCCATCACCGCT
TGCCGCGAGTCGAGGCTTTTTTGAAAGCAAACCATTTTCGAAAACGAATGCATTTCTTGAGGAACATGGAAGAAAACCAA
TTGATTGGGACTTAAACGAACAGTAA

Upstream 100 bases:

>100_bases
AGTATACCACGTGAATCCGCTTGCCTTTTGACAGTTGCTCGCCGTGAAAAGTATAATGGAAGGACAAAATCATGGAACTA
CTGAGATGGGAGAATTAAAA

Downstream 100 bases:

>100_bases
AAAAATACGTTATTACAAAATTTTGTTTTTTCTATTATATAGTTTTTTACAAAAGTGAAAAAATTTACATAATTCGCCTA
AAAGCTTTTTACATAAGGTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG 1 [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPTEEDMFSCFRLCPYDQVKVVILGQDPYHGPGQAHGLSFSVQKGV
RIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILW
GNHAIKAASGITNPKHLLIKGVHPSPLAASRGFFESKPFSKTNAFLEEHGRKPIDWDLNEQ

Sequences:

>Translated_221_residues
MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPTEEDMFSCFRLCPYDQVKVVILGQDPYHGPGQAHGLSFSVQKGV
RIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILW
GNHAIKAASGITNPKHLLIKGVHPSPLAASRGFFESKPFSKTNAFLEEHGRKPIDWDLNEQ
>Mature_221_residues
MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPTEEDMFSCFRLCPYDQVKVVILGQDPYHGPGQAHGLSFSVQKGV
RIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILW
GNHAIKAASGITNPKHLLIKGVHPSPLAASRGFFESKPFSKTNAFLEEHGRKPIDWDLNEQ

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=50.6976744186047, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=50.6976744186047, Blast_Score=215, Evalue=2e-56,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=50.2325581395349, Blast_Score=226, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=46.5437788018433, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323620, Length=232, Percent_Identity=46.1206896551724, Blast_Score=190, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25065; Mature: 25065

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPTEEDMFSCFRLCPYDQVKVVILGQ
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
DPYHGPGQAHGLSFSVQKGVRIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNT
CCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEC
SWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILWGNHAIKAASGITNPKHLLIK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEHHHCCCCCCCEEEEE
GVHPSPLAASRGFFESKPFSKTNAFLEEHGRKPIDWDLNEQ
CCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPTEEDMFSCFRLCPYDQVKVVILGQ
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
DPYHGPGQAHGLSFSVQKGVRIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNT
CCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEC
SWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILWGNHAIKAASGITNPKHLLIK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEHHHCCCCCCCEEEEE
GVHPSPLAASRGFFESKPFSKTNAFLEEHGRKPIDWDLNEQ
CCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]