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The map label for this gene is bioA [H]

Identifier: 225686288

GI number: 225686288

Start: 452107

End: 453381

Strand: Reverse

Name: bioA [H]

Synonym: BMEA_B0466

Alternate gene names: 225686288

Gene position: 453381-452107 (Counterclockwise)

Preceding gene: 225686289

Following gene: 225686287

Centisome position: 38.24

GC content: 59.84

Gene sequence:

>1275_bases
ATGAACCCGAACACCTCGCCCGTCTGGCACCCCTTTACCCAGCACAGGCTGGAGCCGCGCCCGGACCGGATCGTCCGCAC
CGAAGGCGCCTATCTTTTTCGTGAGGATGGCAGCGCGGTTCTGGACATGATTTCGTCGTGGTGGGTCATCACGCATGGTC
ATCGCCACCCGGCGATCATGGATGCAATCCGGCAGGCGAGCGCAGATCTGGACCAGATCATCTTCGCCGATTTCAGCCAC
CAACCGGCGGAAGAACTTGCAAAGGGCCTTATCGCGCTTGCGCCGGATGGCCTCAGCCATGTTTTCTATTCAGATAGCGG
ATCTACGGCGGTCGAAGTGGCCATCAAGATGGCGCTTGGCTATTTTTACAATCGCGGCGAGCCGCGCTCGCGCATTGCCG
TGCTGCAACACAGCTATCATGGCGACACGATCGGCACCATGTCAGCGGGGGAGCGTGGTGTTTTCAACGCGGCTTACGGT
GCGCTGCTTTTCAATGTCGAAACCCTGCCCTTTCCGTCCCCCGGCCACGAGCAGCCTATGCTCGACCGTCTTGAAGACGT
GTGCCGCGGCGGCGATCTGGCGGCCCTTCTGGTCGAGCCGCTGGTTCTCGGCGCGGGCGGCATGAAAATGTATCCCGCCC
ATATTCTCGCCACCATGCGCGAGATTACAGAACGCCACGGCGTCCTGCTCGCCGTCGATGAAGTGATGACCGGCTGGGGC
CGAACGGGTACGCTTTTTGCCTGCGAGCAGGCGGGCATCACGCCGGATATTCTCTGTACATCCAAAGGGCTGACGGGCGG
CTCGCTTCCGCTTGCGGCAACATTGTGCACTGCTGCCATTTTCGACGCACATTATTCTGACGATCGCAGCAAAACATTTT
TCCATTCAAGCTCCTACACCGCCAACCCGATTGCCTGCGCGGCGGCGCTCGCCAATCTGCAAGTCTGGCTCAGCGAACCG
GTGACAGAACGGATATCGGCCCTCACCCGGATGCAGACGGAACGGCTTCACCGCTTCAAGGATGACAGCCGCTTTGCCGG
TCTTCGCCAGACCGGAACGATAACGGCACTGGAGCTTGACGTTCCCGCAGGCGGTTATCTCAGCGATGCGGGGCCGAAGC
TGCGCACCTTTTTCAAGCAAAACGGCGTTCTGCTGCGCCCGCTTGGCAATGTGATCTATGTGATGCCGCCCTATTGCGTG
ACAGCGGAAGAGCTTGACCGCACCTATGACGTCATTACGCAAGGCGTAGATATGATTGCGGGGCAGACAAGATGA

Upstream 100 bases:

>100_bases
GGTTGGGCCGCCTGCCGCTTCTCGATGATCTTTCGCCGGAAAAGCTGCATCACAGCTTTGCCCGGAATTTCCACATTGAC
GATTTCGCAGGAGTGGCACG

Downstream 100 bases:

>100_bases
CGGTCTGTTCCAGCAGGCTGGCCGGGTTCGGCCATGCCGTTCCCGACCGCAGGGTTGAAAATGCCGAGATCGAGGCGCAA
CTGGGCCTGGAAACGGGCTG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNPNTSPVWHPFTQHRLEPRPDRIVRTEGAYLFREDGSAVLDMISSWWVITHGHRHPAIMDAIRQASADLDQIIFADFSH
QPAEELAKGLIALAPDGLSHVFYSDSGSTAVEVAIKMALGYFYNRGEPRSRIAVLQHSYHGDTIGTMSAGERGVFNAAYG
ALLFNVETLPFPSPGHEQPMLDRLEDVCRGGDLAALLVEPLVLGAGGMKMYPAHILATMREITERHGVLLAVDEVMTGWG
RTGTLFACEQAGITPDILCTSKGLTGGSLPLAATLCTAAIFDAHYSDDRSKTFFHSSSYTANPIACAAALANLQVWLSEP
VTERISALTRMQTERLHRFKDDSRFAGLRQTGTITALELDVPAGGYLSDAGPKLRTFFKQNGVLLRPLGNVIYVMPPYCV
TAEELDRTYDVITQGVDMIAGQTR

Sequences:

>Translated_424_residues
MNPNTSPVWHPFTQHRLEPRPDRIVRTEGAYLFREDGSAVLDMISSWWVITHGHRHPAIMDAIRQASADLDQIIFADFSH
QPAEELAKGLIALAPDGLSHVFYSDSGSTAVEVAIKMALGYFYNRGEPRSRIAVLQHSYHGDTIGTMSAGERGVFNAAYG
ALLFNVETLPFPSPGHEQPMLDRLEDVCRGGDLAALLVEPLVLGAGGMKMYPAHILATMREITERHGVLLAVDEVMTGWG
RTGTLFACEQAGITPDILCTSKGLTGGSLPLAATLCTAAIFDAHYSDDRSKTFFHSSSYTANPIACAAALANLQVWLSEP
VTERISALTRMQTERLHRFKDDSRFAGLRQTGTITALELDVPAGGYLSDAGPKLRTFFKQNGVLLRPLGNVIYVMPPYCV
TAEELDRTYDVITQGVDMIAGQTR
>Mature_424_residues
MNPNTSPVWHPFTQHRLEPRPDRIVRTEGAYLFREDGSAVLDMISSWWVITHGHRHPAIMDAIRQASADLDQIIFADFSH
QPAEELAKGLIALAPDGLSHVFYSDSGSTAVEVAIKMALGYFYNRGEPRSRIAVLQHSYHGDTIGTMSAGERGVFNAAYG
ALLFNVETLPFPSPGHEQPMLDRLEDVCRGGDLAALLVEPLVLGAGGMKMYPAHILATMREITERHGVLLAVDEVMTGWG
RTGTLFACEQAGITPDILCTSKGLTGGSLPLAATLCTAAIFDAHYSDDRSKTFFHSSSYTANPIACAAALANLQVWLSEP
VTERISALTRMQTERLHRFKDDSRFAGLRQTGTITALELDVPAGGYLSDAGPKLRTFFKQNGVLLRPLGNVIYVMPPYCV
TAEELDRTYDVITQGVDMIAGQTR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=26.0869565217391, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI284507298, Length=317, Percent_Identity=27.4447949526814, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI13994255, Length=420, Percent_Identity=24.2857142857143, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI24119277, Length=418, Percent_Identity=24.6411483253589, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1786991, Length=421, Percent_Identity=37.5296912114014, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI145693181, Length=292, Percent_Identity=33.5616438356164, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=28.287841191067, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=27.5184275184275, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=29.0953545232274, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787560, Length=423, Percent_Identity=27.8959810874704, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786349, Length=327, Percent_Identity=27.217125382263, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=24.4019138755981, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=26.5588914549654, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=293, Percent_Identity=25.5972696245734, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=24.4186046511628, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=27.4122807017544, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=26.6666666666667, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=413, Percent_Identity=22.2760290556901, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=23.1884057971014, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574759, Length=421, Percent_Identity=25.6532066508314, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=25.2955082742317, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46335; Mature: 46335

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNTSPVWHPFTQHRLEPRPDRIVRTEGAYLFREDGSAVLDMISSWWVITHGHRHPAIM
CCCCCCCCCCCHHHHCCCCCCCCEEEECCCEEEECCCHHHHHHHHCCEEEECCCCCHHHH
DAIRQASADLDQIIFADFSHQPAEELAKGLIALAPDGLSHVFYSDSGSTAVEVAIKMALG
HHHHHHHCCHHHHHHHCCCCCCHHHHHCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHH
YFYNRGEPRSRIAVLQHSYHGDTIGTMSAGERGVFNAAYGALLFNVETLPFPSPGHEQPM
HHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCCCCCHH
LDRLEDVCRGGDLAALLVEPLVLGAGGMKMYPAHILATMREITERHGVLLAVDEVMTGWG
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCC
RTGTLFACEQAGITPDILCTSKGLTGGSLPLAATLCTAAIFDAHYSDDRSKTFFHSSSYT
CCCCEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
ANPIACAAALANLQVWLSEPVTERISALTRMQTERLHRFKDDSRFAGLRQTGTITALELD
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEEEEE
VPAGGYLSDAGPKLRTFFKQNGVLLRPLGNVIYVMPPYCVTAEELDRTYDVITQGVDMIA
CCCCCCCCCCCHHHHHHHHCCCEEEEECCCEEEECCCCEECHHHHHHHHHHHHHHHHHHC
GQTR
CCCC
>Mature Secondary Structure
MNPNTSPVWHPFTQHRLEPRPDRIVRTEGAYLFREDGSAVLDMISSWWVITHGHRHPAIM
CCCCCCCCCCCHHHHCCCCCCCCEEEECCCEEEECCCHHHHHHHHCCEEEECCCCCHHHH
DAIRQASADLDQIIFADFSHQPAEELAKGLIALAPDGLSHVFYSDSGSTAVEVAIKMALG
HHHHHHHCCHHHHHHHCCCCCCHHHHHCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHH
YFYNRGEPRSRIAVLQHSYHGDTIGTMSAGERGVFNAAYGALLFNVETLPFPSPGHEQPM
HHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCCCCCHH
LDRLEDVCRGGDLAALLVEPLVLGAGGMKMYPAHILATMREITERHGVLLAVDEVMTGWG
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCC
RTGTLFACEQAGITPDILCTSKGLTGGSLPLAATLCTAAIFDAHYSDDRSKTFFHSSSYT
CCCCEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
ANPIACAAALANLQVWLSEPVTERISALTRMQTERLHRFKDDSRFAGLRQTGTITALELD
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEEEEE
VPAGGYLSDAGPKLRTFFKQNGVLLRPLGNVIYVMPPYCVTAEELDRTYDVITQGVDMIA
CCCCCCCCCCCHHHHHHHHCCCEEEEECCCEEEECCCCEECHHHHHHHHHHHHHHHHHHC
GQTR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]