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The map label for this gene is metA

Identifier: 225686285

GI number: 225686285

Start: 449366

End: 450286

Strand: Reverse

Name: metA

Synonym: BMEA_B0463

Alternate gene names: 225686285

Gene position: 450286-449366 (Counterclockwise)

Preceding gene: 225686287

Following gene: 225686284

Centisome position: 37.98

GC content: 56.89

Gene sequence:

>921_bases
ATGCCGATTAAAATTCCTGACGATCTGCCTGCAACCAGCGTACTCGAAGCCGAGGGCGTGATGGTGATGCGTGAGGCCGA
TGCCGTACGTCAGGATATTCGTCCGCTGAGGATTGGCCTTCTCAATCTGATGCCCAACAAGGTAACGACCGAGACGCAGA
TTGCACGTCTTCTTGGTGCGACGCCGCTTCAGGTGGAGCTGACGCTCGTGCGCATGACCAACCACGTCGCGCGCCACACA
CCAGCCGACCACATGCTCTCCTTCTATTGCCCTTGGGAGGAGGTGAACGACCAACGGTTCGACGGTTTTGTGATTACCGG
CGCGCCGGTCGAGCGGCTGCCCTTCGAGGAAGTCACCTACTGGGATGAAATGCGGCGCGTATTTGACTGGACGCAGAGCC
ATGTGCACCGCACGCTGAACATTTGCTGGGCCGCGCAGGCTGCGGTCTATCATTTCCACGGCATGAAAAAATATGACCTG
CCGGCAAAAGCATCAGGGGTGTTCCGCCAGCGCAGTCTCGTGCCGGCATCTCCTTATCTGCGTGGTTTTTCAGACGATTT
TGCCATTCCGGTTTCGCGCTGGACCGAAGTGCGAAAGTCCGACATTCCGGCTGATAGCGGGCTGAAGGTTCTGGTGGACA
GCACCGAAACGGGCCTTTGCCTGCTTGATGATCCGCGCCACCGCTCGCTTCATATGTTCAACCATGTCGAATACGACACG
ACCTCGCTTGCAGACGAATATTTCCGCGATATTCAGGTGCAGCCGGAGGCAAAAGTACCTGTGAACTATTTCCCCGGTGA
TGACGCCAAGCGCCCGCCGGAAAATCGCTGGCGCAGCCATGCGCATCTTCTTTTCGGCAACTGGATCAACGAAATGTACC
AGTCCACGCCCTATGATATAGAGCGGATCGGCAAGGTCTGA

Upstream 100 bases:

>100_bases
CAAGGTGGTACTCCCCGAAAGGGAGGATGTGGCCGAACCGGCAATTATACGGATGAAGCCACTTGCGTCTGTCCCATTAA
GAAGTAAGGACCGACGCGAC

Downstream 100 bases:

>100_bases
ACATCTTTGAAACAGAAAGCCCGGAACATGTGGGTTCCGGGCTTTCTTTTGTGCTGTGTGGCTGGCATCAACTGGTGACG
CGCCCGACCCATCGGTGCCA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPIKIPDDLPATSVLEAEGVMVMREADAVRQDIRPLRIGLLNLMPNKVTTETQIARLLGATPLQVELTLVRMTNHVARHT
PADHMLSFYCPWEEVNDQRFDGFVITGAPVERLPFEEVTYWDEMRRVFDWTQSHVHRTLNICWAAQAAVYHFHGMKKYDL
PAKASGVFRQRSLVPASPYLRGFSDDFAIPVSRWTEVRKSDIPADSGLKVLVDSTETGLCLLDDPRHRSLHMFNHVEYDT
TSLADEYFRDIQVQPEAKVPVNYFPGDDAKRPPENRWRSHAHLLFGNWINEMYQSTPYDIERIGKV

Sequences:

>Translated_306_residues
MPIKIPDDLPATSVLEAEGVMVMREADAVRQDIRPLRIGLLNLMPNKVTTETQIARLLGATPLQVELTLVRMTNHVARHT
PADHMLSFYCPWEEVNDQRFDGFVITGAPVERLPFEEVTYWDEMRRVFDWTQSHVHRTLNICWAAQAAVYHFHGMKKYDL
PAKASGVFRQRSLVPASPYLRGFSDDFAIPVSRWTEVRKSDIPADSGLKVLVDSTETGLCLLDDPRHRSLHMFNHVEYDT
TSLADEYFRDIQVQPEAKVPVNYFPGDDAKRPPENRWRSHAHLLFGNWINEMYQSTPYDIERIGKV
>Mature_305_residues
PIKIPDDLPATSVLEAEGVMVMREADAVRQDIRPLRIGLLNLMPNKVTTETQIARLLGATPLQVELTLVRMTNHVARHTP
ADHMLSFYCPWEEVNDQRFDGFVITGAPVERLPFEEVTYWDEMRRVFDWTQSHVHRTLNICWAAQAAVYHFHGMKKYDLP
AKASGVFRQRSLVPASPYLRGFSDDFAIPVSRWTEVRKSDIPADSGLKVLVDSTETGLCLLDDPRHRSLHMFNHVEYDTT
SLADEYFRDIQVQPEAKVPVNYFPGDDAKRPPENRWRSHAHLLFGNWINEMYQSTPYDIERIGKV

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=305, Percent_Identity=41.6393442622951, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_BRUA1 (B2SBF6)

Other databases:

- EMBL:   CP000888
- RefSeq:   YP_001932639.1
- ProteinModelPortal:   B2SBF6
- SMR:   B2SBF6
- GeneID:   6326087
- GenomeReviews:   CP000888_GR
- KEGG:   bmc:BAbS19_II06980
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35245; Mature: 35114

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKIPDDLPATSVLEAEGVMVMREADAVRQDIRPLRIGLLNLMPNKVTTETQIARLLGA
CCCCCCCCCCCCCEECCCCEEEEEHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHCC
TPLQVELTLVRMTNHVARHTPADHMLSFYCPWEEVNDQRFDGFVITGAPVERLPFEEVTY
CCCEEEEEEEHHHHHHHHCCCHHHHEEEECCHHHCCCCCCCCEEEECCCHHHCCHHHHHH
WDEMRRVFDWTQSHVHRTLNICWAAQAAVYHFHGMKKYDLPAKASGVFRQRSLVPASPYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHH
RGFSDDFAIPVSRWTEVRKSDIPADSGLKVLVDSTETGLCLLDDPRHRSLHMFNHVEYDT
CCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCEEHHHCCCCCH
TSLADEYFRDIQVQPEAKVPVNYFPGDDAKRPPENRWRSHAHLLFGNWINEMYQSTPYDI
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
ERIGKV
HHHCCC
>Mature Secondary Structure 
PIKIPDDLPATSVLEAEGVMVMREADAVRQDIRPLRIGLLNLMPNKVTTETQIARLLGA
CCCCCCCCCCCCEECCCCEEEEEHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHCC
TPLQVELTLVRMTNHVARHTPADHMLSFYCPWEEVNDQRFDGFVITGAPVERLPFEEVTY
CCCEEEEEEEHHHHHHHHCCCHHHHEEEECCHHHCCCCCCCCEEEECCCHHHCCHHHHHH
WDEMRRVFDWTQSHVHRTLNICWAAQAAVYHFHGMKKYDLPAKASGVFRQRSLVPASPYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHH
RGFSDDFAIPVSRWTEVRKSDIPADSGLKVLVDSTETGLCLLDDPRHRSLHMFNHVEYDT
CCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCEEHHHCCCCCH
TSLADEYFRDIQVQPEAKVPVNYFPGDDAKRPPENRWRSHAHLLFGNWINEMYQSTPYDI
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
ERIGKV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA