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The map label for this gene is agcS [H]

Identifier: 225686284

GI number: 225686284

Start: 446939

End: 448372

Strand: Reverse

Name: agcS [H]

Synonym: BMEA_B0461

Alternate gene names: 225686284

Gene position: 448372-446939 (Counterclockwise)

Preceding gene: 225686285

Following gene: 225686283

Centisome position: 37.82

GC content: 55.79

Gene sequence:

>1434_bases
ATGGCGACAATCATTGATTTTCTGAATAATGTTTTCTGGAATTATGTTCTAGTTTATGGGCTGCTTGCAGTCGGACTTTT
CTTTACAATCCGGCTGAAATTTGTCCAGTTCGTTCATTTTCCTGAACTTTTCAGAGTCGTTTTTGCCGCCGGCAGGCGTG
ATGAAGCCGGTATTTCTCCGTTTCAGGCTCTCACCATCAGCATTGCCTCGCGCGTTGGTACCGGCAACATTACGGGCGTT
GCTGTTGCACTCTATCTTGGCGGGCCCGGCGCAATTTTCTGGATGTGGATAGTGGCGCTTGTAGGGCTTGCAACCGCCTA
TTCGGAAAGTGCGCTGGCGCAACTTTATAAAATCCGCAATCAGGATGGCCAGTATCGCGGCGGCCCTGCCTTCTATATTG
CGCGCGGCCTCGGCCTGCCATGGGCTGGCGCCTTGTTTTCCATCTGCCTCATCCTTTCCTTCGGCCTTGTTTTCAATGCG
GTGCAGGCCAACGCCATTGCCGATTCCATGGTTATGGCTTTCAACATGCCCAAGCTTGGCACGGGTATCGTGCTCGCCAT
TCTTTCGGGCGTGGTGATTTTCGGCGGTATCCGCCAGATCGCGCGCGTGGCTGAAGTGGTCGTGCCTTTCATGGCCTTCG
CCTATATCCTGATGGCAATCTGCATTCTTGCAATCAACTTCCAAGCGGTCCCGTCGACAATCGCACTGATCTTCTCCAGT
GCCTTTGGCCTGCATGAAGCAGTGGGCGGTGTGACGGGCGGCATTACCGCGGCCATGCTCAATGGCGTAAAGCGCGGTCT
TTTCTCCAACGAGGCGGGCATGGGTTCTGCCCCCAATATTGCCGCCGTGGCGACACCTGCGCCGCACCATCCCTCCTCGC
AGGGCTTCGTACAATCGCTTGGCGTCTTCATCGATACGATTCTGGTCTGCACGGCGACGGCGATCATGATCCTCTTGTCC
GGCATTCTGGAGCCCGGTTCAGGCCTCACCGGCACGCAACTCACCCAAATGGCAATGACCCATCATATCGGTGACGTGGG
CGTTTATTTCATCGCCGCCGCGATCTTCTTCTTCGCCTTCACCTCCATCATCGGCAATTATTCCTATGCGGAAAGCGCCA
TGACCTTTCTGGGGCTTGGCGGCAAGGTGCCGATCACCATTCTGCGCTGCGCGCTTCTCGCCATGGTCGTCTGGGGCGCT
TATGAAAGCATCCATACCGTGTTTGACGCGGCCGATGCCTCGATGGGCCTGATGGCGACGATCAACCTGATTGCCATCGT
TCTGCTTTCGGGAACGGTGAAGAAGCTCACGGTTGACTATTTCGCGCAGAGGCGCGCGGGGCAGGTTCCCACCTTCCACG
CCGCCGATTACCCGGAACTGCAAGGCCAGATCGACATGGAAATCTGGTCTGAACAGAATACGACGAACAAGTAA

Upstream 100 bases:

>100_bases
GCATTGCGCGCGTTCCACATTATCAAAATCAAAATTTCCGTCAGGACTCGACAGAAGCCCATGATTATCGTTAAACCGCC
CCACCAAACGAGGATTTTTC

Downstream 100 bases:

>100_bases
CATCATCGCAATTTCCATAGGCTACCTCCAGCCGACGGAACCAAGCATGCAACCGCGCGTTTCCCTTCATGCCCCGCCTG
TGCTTCGTGCAACGGCGGGC

Product: amino acid carrier protein

Products: Na (I) [Cytoplasm]; L-alanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MATIIDFLNNVFWNYVLVYGLLAVGLFFTIRLKFVQFVHFPELFRVVFAAGRRDEAGISPFQALTISIASRVGTGNITGV
AVALYLGGPGAIFWMWIVALVGLATAYSESALAQLYKIRNQDGQYRGGPAFYIARGLGLPWAGALFSICLILSFGLVFNA
VQANAIADSMVMAFNMPKLGTGIVLAILSGVVIFGGIRQIARVAEVVVPFMAFAYILMAICILAINFQAVPSTIALIFSS
AFGLHEAVGGVTGGITAAMLNGVKRGLFSNEAGMGSAPNIAAVATPAPHHPSSQGFVQSLGVFIDTILVCTATAIMILLS
GILEPGSGLTGTQLTQMAMTHHIGDVGVYFIAAAIFFFAFTSIIGNYSYAESAMTFLGLGGKVPITILRCALLAMVVWGA
YESIHTVFDAADASMGLMATINLIAIVLLSGTVKKLTVDYFAQRRAGQVPTFHAADYPELQGQIDMEIWSEQNTTNK

Sequences:

>Translated_477_residues
MATIIDFLNNVFWNYVLVYGLLAVGLFFTIRLKFVQFVHFPELFRVVFAAGRRDEAGISPFQALTISIASRVGTGNITGV
AVALYLGGPGAIFWMWIVALVGLATAYSESALAQLYKIRNQDGQYRGGPAFYIARGLGLPWAGALFSICLILSFGLVFNA
VQANAIADSMVMAFNMPKLGTGIVLAILSGVVIFGGIRQIARVAEVVVPFMAFAYILMAICILAINFQAVPSTIALIFSS
AFGLHEAVGGVTGGITAAMLNGVKRGLFSNEAGMGSAPNIAAVATPAPHHPSSQGFVQSLGVFIDTILVCTATAIMILLS
GILEPGSGLTGTQLTQMAMTHHIGDVGVYFIAAAIFFFAFTSIIGNYSYAESAMTFLGLGGKVPITILRCALLAMVVWGA
YESIHTVFDAADASMGLMATINLIAIVLLSGTVKKLTVDYFAQRRAGQVPTFHAADYPELQGQIDMEIWSEQNTTNK
>Mature_476_residues
ATIIDFLNNVFWNYVLVYGLLAVGLFFTIRLKFVQFVHFPELFRVVFAAGRRDEAGISPFQALTISIASRVGTGNITGVA
VALYLGGPGAIFWMWIVALVGLATAYSESALAQLYKIRNQDGQYRGGPAFYIARGLGLPWAGALFSICLILSFGLVFNAV
QANAIADSMVMAFNMPKLGTGIVLAILSGVVIFGGIRQIARVAEVVVPFMAFAYILMAICILAINFQAVPSTIALIFSSA
FGLHEAVGGVTGGITAAMLNGVKRGLFSNEAGMGSAPNIAAVATPAPHHPSSQGFVQSLGVFIDTILVCTATAIMILLSG
ILEPGSGLTGTQLTQMAMTHHIGDVGVYFIAAAIFFFAFTSIIGNYSYAESAMTFLGLGGKVPITILRCALLAMVVWGAY
ESIHTVFDAADASMGLMATINLIAIVLLSGTVKKLTVDYFAQRRAGQVPTFHAADYPELQGQIDMEIWSEQNTTNK

Specific function: Unknown

COG id: COG1115

COG function: function code E; Na+/alanine symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:alanine (SAF) symporter family [H]

Homologues:

Organism=Escherichia coli, GI1786188, Length=472, Percent_Identity=42.7966101694915, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001463 [H]

Pfam domain/function: PF01235 Na_Ala_symp [H]

EC number: NA

Molecular weight: Translated: 50664; Mature: 50533

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00873 NA_ALANINE_SYMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIIDFLNNVFWNYVLVYGLLAVGLFFTIRLKFVQFVHFPELFRVVFAAGRRDEAGISP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
FQALTISIASRVGTGNITGVAVALYLGGPGAIFWMWIVALVGLATAYSESALAQLYKIRN
HHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QDGQYRGGPAFYIARGLGLPWAGALFSICLILSFGLVFNAVQANAIADSMVMAFNMPKLG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TGIVLAILSGVVIFGGIRQIARVAEVVVPFMAFAYILMAICILAINFQAVPSTIALIFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AFGLHEAVGGVTGGITAAMLNGVKRGLFSNEAGMGSAPNIAAVATPAPHHPSSQGFVQSL
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHH
GVFIDTILVCTATAIMILLSGILEPGSGLTGTQLTQMAMTHHIGDVGVYFIAAAIFFFAF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSIIGNYSYAESAMTFLGLGGKVPITILRCALLAMVVWGAYESIHTVFDAADASMGLMAT
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
INLIAIVLLSGTVKKLTVDYFAQRRAGQVPTFHAADYPELQGQIDMEIWSEQNTTNK
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCC
>Mature Secondary Structure 
ATIIDFLNNVFWNYVLVYGLLAVGLFFTIRLKFVQFVHFPELFRVVFAAGRRDEAGISP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
FQALTISIASRVGTGNITGVAVALYLGGPGAIFWMWIVALVGLATAYSESALAQLYKIRN
HHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QDGQYRGGPAFYIARGLGLPWAGALFSICLILSFGLVFNAVQANAIADSMVMAFNMPKLG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TGIVLAILSGVVIFGGIRQIARVAEVVVPFMAFAYILMAICILAINFQAVPSTIALIFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AFGLHEAVGGVTGGITAAMLNGVKRGLFSNEAGMGSAPNIAAVATPAPHHPSSQGFVQSL
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHH
GVFIDTILVCTATAIMILLSGILEPGSGLTGTQLTQMAMTHHIGDVGVYFIAAAIFFFAF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSIIGNYSYAESAMTFLGLGGKVPITILRCALLAMVVWGAYESIHTVFDAADASMGLMAT
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
INLIAIVLLSGTVKKLTVDYFAQRRAGQVPTFHAADYPELQGQIDMEIWSEQNTTNK
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; L-alanine [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + L-alanine [Periplasm] = Na (I) [Cytoplasm] + L-alanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 7710280 [H]