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The map label for this gene is envZ [H]

Identifier: 225686275

GI number: 225686275

Start: 440067

End: 441491

Strand: Reverse

Name: envZ [H]

Synonym: BMEA_B0451

Alternate gene names: 225686275

Gene position: 441491-440067 (Counterclockwise)

Preceding gene: 225686276

Following gene: 225686272

Centisome position: 37.24

GC content: 56.91

Gene sequence:

>1425_bases
ATGAGATTGCCCCTTCCACACTCGCTGCCAATCTGGCTCCTGACCATTCTCATAAGCGGTCTTCTGACCACACAGATCGC
CACACTGTGGATCGTTTCGCAGGACCGCGCCGATGCCAATAATGCGCTGGAACTTTTCCGCCTCAGCGAGCGCGCAACCT
ATCTGGTCAAATTGCTGCATGCCACACCGCCAGACGATTGGAATAATCTGGCTATCCGTGTTTCCGGTTCCGGGGAGGCC
ATGAACATAACGAGCGAGCCAGACGTTACAACCGCGCTTGCTTCCGAAGACGATCTGGCAGAGCTGGAAGACGTGCTCGT
CGCCCGCCTTACACGCTACGGCGTGGTGGATGCCCGTATCCGCCGCGATACGACCGGATATCGCCTGCCGAAAGAAGAAA
CGGCAGTGCATGACAGCACCGAGATGGGCATTATCGAAAAGCAGATCGACAGTCTTGCGGCCACCACCCGCTCCGGCGCG
AGCCTCACCACCTCATTACAGTTCAATGACGGGCGGTGGCTGAATTTTATCACACATATCACTCCGATCGATCCGATTGT
GACAAGCGACACCATTCCGCTTTTCACGCTCGTTGCGCTTTGCGTGATCCTCGGAGCAATATGGGCGACGCAACGCCTGA
TTGCTCCCTATCGCATTCTTGAAGATGCGATAGACCGAATTGGCGGTGATCTGAAAAGCCCGCCTTTGCCGGAAACCGGC
ATTCGCGAATACACGGCGGCGGCACGCGCGGTAAACAGTATGCAGGCCCGGCTTCTCGATTACGTGGCCGAACGCGAGCA
GCTTGCAGCCGCACTGGCGCATGACCTGCGCACACCGTTGACCCGTATGAAATTACGCATGGAACTTCTCGACGACGATG
CTTTGCGGCAATCGCTGTCGCGTGATCTCAACGATATCGAGGCAATATCCCGCTCGGTGATCGATTTTGCCACTTCCGAA
CTTGCGCATGAAAAAGCCGAGCGGCTGGACCTCTGGTCCCTGCTGCTCTCGGTCGCCGACAAATATCCGCAGGTTTCGCT
TGACGAGAAAGGCTCGGACTATCGCGATGCAATCTGCCTGTGCCAGCCCATCTCCATTCAGCGTTGCATCACCAATCTCA
TCGACAATGCGCTGGCCTATGGCGGCAAGGTGCGACTTTCGCTTCATCGCGACGGCGATGATCTGTTGTTGCGCATAAAG
GATAACGGCCCCGGCATTTCCCCCGAACGCATCGAGGAAATGTTCAAACCGTTCAGCCGAGCCGACAAATCCCGCAATCG
CGAATCCGGCGGATTCGGCCTCGGCCTCACCATTGCGCGCAATATTGCGCGGAAAAATGGCGGTGAGATTAGCCTGCGCA
ACGATCCCGCAGGCGGATTGATTGCCGAGCTGCGTCTGCCTGGTTCGAGACTTATGCCGAGATAA

Upstream 100 bases:

>100_bases
GCCGCCTGCGCAAGAAGCTGGAGGACGATCCGTGCGCGCCGAAGCTGATCCTTACCATTCGCGGCGGCGGCTACCAGTTC
GGGCATGAAGTGGAAATAGC

Downstream 100 bases:

>100_bases
AGCAGTTTCTCGATGAAATGGCGTCGATAACAAGATGACTTGCGACCGACGCACTTGAAAGTCGGCCGCTTTTATTTATC
CGGCGTGGAGGCAGTATCGA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRLPLPHSLPIWLLTILISGLLTTQIATLWIVSQDRADANNALELFRLSERATYLVKLLHATPPDDWNNLAIRVSGSGEA
MNITSEPDVTTALASEDDLAELEDVLVARLTRYGVVDARIRRDTTGYRLPKEETAVHDSTEMGIIEKQIDSLAATTRSGA
SLTTSLQFNDGRWLNFITHITPIDPIVTSDTIPLFTLVALCVILGAIWATQRLIAPYRILEDAIDRIGGDLKSPPLPETG
IREYTAAARAVNSMQARLLDYVAEREQLAAALAHDLRTPLTRMKLRMELLDDDALRQSLSRDLNDIEAISRSVIDFATSE
LAHEKAERLDLWSLLLSVADKYPQVSLDEKGSDYRDAICLCQPISIQRCITNLIDNALAYGGKVRLSLHRDGDDLLLRIK
DNGPGISPERIEEMFKPFSRADKSRNRESGGFGLGLTIARNIARKNGGEISLRNDPAGGLIAELRLPGSRLMPR

Sequences:

>Translated_474_residues
MRLPLPHSLPIWLLTILISGLLTTQIATLWIVSQDRADANNALELFRLSERATYLVKLLHATPPDDWNNLAIRVSGSGEA
MNITSEPDVTTALASEDDLAELEDVLVARLTRYGVVDARIRRDTTGYRLPKEETAVHDSTEMGIIEKQIDSLAATTRSGA
SLTTSLQFNDGRWLNFITHITPIDPIVTSDTIPLFTLVALCVILGAIWATQRLIAPYRILEDAIDRIGGDLKSPPLPETG
IREYTAAARAVNSMQARLLDYVAEREQLAAALAHDLRTPLTRMKLRMELLDDDALRQSLSRDLNDIEAISRSVIDFATSE
LAHEKAERLDLWSLLLSVADKYPQVSLDEKGSDYRDAICLCQPISIQRCITNLIDNALAYGGKVRLSLHRDGDDLLLRIK
DNGPGISPERIEEMFKPFSRADKSRNRESGGFGLGLTIARNIARKNGGEISLRNDPAGGLIAELRLPGSRLMPR
>Mature_474_residues
MRLPLPHSLPIWLLTILISGLLTTQIATLWIVSQDRADANNALELFRLSERATYLVKLLHATPPDDWNNLAIRVSGSGEA
MNITSEPDVTTALASEDDLAELEDVLVARLTRYGVVDARIRRDTTGYRLPKEETAVHDSTEMGIIEKQIDSLAATTRSGA
SLTTSLQFNDGRWLNFITHITPIDPIVTSDTIPLFTLVALCVILGAIWATQRLIAPYRILEDAIDRIGGDLKSPPLPETG
IREYTAAARAVNSMQARLLDYVAEREQLAAALAHDLRTPLTRMKLRMELLDDDALRQSLSRDLNDIEAISRSVIDFATSE
LAHEKAERLDLWSLLLSVADKYPQVSLDEKGSDYRDAICLCQPISIQRCITNLIDNALAYGGKVRLSLHRDGDDLLLRIK
DNGPGISPERIEEMFKPFSRADKSRNRESGGFGLGLTIARNIARKNGGEISLRNDPAGGLIAELRLPGSRLMPR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=296, Percent_Identity=32.4324324324324, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=30.4029304029304, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787894, Length=220, Percent_Identity=34.5454545454545, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081816, Length=332, Percent_Identity=28.9156626506024, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=27.6223776223776, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=27.681660899654, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=31.5352697095436, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=286, Percent_Identity=26.2237762237762, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=25.9868421052632, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=31.6742081447964, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=24.8868778280543, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=26.4604810996564, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=24.5535714285714, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=304, Percent_Identity=27.3026315789474, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=23.3766233766234, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52485; Mature: 52485

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPLPHSLPIWLLTILISGLLTTQIATLWIVSQDRADANNALELFRLSERATYLVKLLH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ATPPDDWNNLAIRVSGSGEAMNITSEPDVTTALASEDDLAELEDVLVARLTRYGVVDARI
CCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHH
RRDTTGYRLPKEETAVHDSTEMGIIEKQIDSLAATTRSGASLTTSLQFNDGRWLNFITHI
HCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHC
TPIDPIVTSDTIPLFTLVALCVILGAIWATQRLIAPYRILEDAIDRIGGDLKSPPLPETG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
IREYTAAARAVNSMQARLLDYVAEREQLAAALAHDLRTPLTRMKLRMELLDDDALRQSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RDLNDIEAISRSVIDFATSELAHEKAERLDLWSLLLSVADKYPQVSLDEKGSDYRDAICL
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
CQPISIQRCITNLIDNALAYGGKVRLSLHRDGDDLLLRIKDNGPGISPERIEEMFKPFSR
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
ADKSRNRESGGFGLGLTIARNIARKNGGEISLRNDPAGGLIAELRLPGSRLMPR
HHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MRLPLPHSLPIWLLTILISGLLTTQIATLWIVSQDRADANNALELFRLSERATYLVKLLH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ATPPDDWNNLAIRVSGSGEAMNITSEPDVTTALASEDDLAELEDVLVARLTRYGVVDARI
CCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHH
RRDTTGYRLPKEETAVHDSTEMGIIEKQIDSLAATTRSGASLTTSLQFNDGRWLNFITHI
HCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHC
TPIDPIVTSDTIPLFTLVALCVILGAIWATQRLIAPYRILEDAIDRIGGDLKSPPLPETG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
IREYTAAARAVNSMQARLLDYVAEREQLAAALAHDLRTPLTRMKLRMELLDDDALRQSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RDLNDIEAISRSVIDFATSELAHEKAERLDLWSLLLSVADKYPQVSLDEKGSDYRDAICL
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
CQPISIQRCITNLIDNALAYGGKVRLSLHRDGDDLLLRIKDNGPGISPERIEEMFKPFSR
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
ADKSRNRESGGFGLGLTIARNIARKNGGEISLRNDPAGGLIAELRLPGSRLMPR
HHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]