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The map label for this gene is wecA [H]

Identifier: 225686237

GI number: 225686237

Start: 394459

End: 395580

Strand: Reverse

Name: wecA [H]

Synonym: BMEA_B0406

Alternate gene names: 225686237

Gene position: 395580-394459 (Counterclockwise)

Preceding gene: 225686238

Following gene: 225686236

Centisome position: 33.37

GC content: 59.71

Gene sequence:

>1122_bases
ATGACAAGTCTTTCCTGGATCACGCTTCTGGCTTTTGTCCTGTCGGTGGCCTTCTGCATGGCTTTTCGTGGGCTTGCGCG
CGAATGGTATCTGATCGACCTGCCCGATTACCGCAAAAGACATGAAGGTGCCGTCCCGCTTTGCGGGGGCATCGCAATCT
TCCTGTCCTTTTTCCTGACAGCTTCACTGGTAAAAGACGGTGCGGGACATGCAGATGCACTGGTGATGATGCCGGGGCTG
ACGATCATCCTCGGCACGGGGGTGCTGGATGATCGCTTCAGGCTGCCGGTGACGCCGCGTTTTGCAATCCAGCTTTTTGC
AGCGGTTCTCATCATCGCCATGGCGGGGGTACAGCAGGTCTTTCTGGACCTCAACCCCTCCTTTATCGACGATAGCGGCA
ATATATTTGCCTTTGAACGGCTGGGCGGCCCCTTTCTATTGCTTTTCGCCGTGGCCTTCATCGTCGGCCTTGTCAATGCG
GTCAATATGAGCGACGGCGTGGACGGGCTTGCAGGATCGGCAAGTGCAGCCTCCTTCTTCTGGCTCGCCGTTATCAGCTT
CGACATCGGCGAACACCGGCTGGGCCTGCAATCGCTGGCGCTTGTCGCCGCCTGCCTTGGTTTCCTCGTTTTCAACATGC
GCCATAGGTGGCGGGCAAAGGCAAGCCTCTTTCTGGGTGACGGCGGCAGCACGCTTCTGGGGGCCGCCCTTGCGGGAATA
GTGTTGATCCTCTCCAGCGGCAGGCAAGCAATTGCTTTCCCTGTCTTGCTTTGGATCGTGATTGTGCCGGTCCTCGATAC
GCTTAGCCTCATCGTAAGAAGGCTCGCGGCGCGGCGCAGCCCTTTTTCCGCCGACCGGCAGCATCTCCATCACCTGCTGA
TGGATGCCGGGCTGACCTGCGGGCAGACCGCAATCATCGTCATGGCGCTCAACCTGATTGCAGGCGCAACAGCCTATACG
GCTATTCGCCTCGACCTGCCCGGCTGGCTGATGGCGCTGGCGCTTCTCGCACCGGCCATGGCGCACCTAGCCTTCATCCT
GCGTTGCACCAGAGGTCCGCGCATCGCCGATCCCGCGCAGGCGGCAAAACCGAACATCACCTTTCCGGGGACCACGACAT
GA

Upstream 100 bases:

>100_bases
GAAAGAGGTAGGCCGCTCGCTCAATAGCCAAGTCGTGAGCCGTGGCCGGACCCGGTAAAAATCCTTCCAGAACGACTTTC
GCTCGCTGCTTGGAGGAGGC

Downstream 100 bases:

>100_bases
CCGTTTCCGTGCTCATCATGACGCTCAACGAGGAAGCCAACCTGCCGGCATGTCTGGCTTCGCTCGACTGGTGCGATGAT
ATCGTCGTGCTGGATTCATT

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTSLSWITLLAFVLSVAFCMAFRGLAREWYLIDLPDYRKRHEGAVPLCGGIAIFLSFFLTASLVKDGAGHADALVMMPGL
TIILGTGVLDDRFRLPVTPRFAIQLFAAVLIIAMAGVQQVFLDLNPSFIDDSGNIFAFERLGGPFLLLFAVAFIVGLVNA
VNMSDGVDGLAGSASAASFFWLAVISFDIGEHRLGLQSLALVAACLGFLVFNMRHRWRAKASLFLGDGGSTLLGAALAGI
VLILSSGRQAIAFPVLLWIVIVPVLDTLSLIVRRLAARRSPFSADRQHLHHLLMDAGLTCGQTAIIVMALNLIAGATAYT
AIRLDLPGWLMALALLAPAMAHLAFILRCTRGPRIADPAQAAKPNITFPGTTT

Sequences:

>Translated_373_residues
MTSLSWITLLAFVLSVAFCMAFRGLAREWYLIDLPDYRKRHEGAVPLCGGIAIFLSFFLTASLVKDGAGHADALVMMPGL
TIILGTGVLDDRFRLPVTPRFAIQLFAAVLIIAMAGVQQVFLDLNPSFIDDSGNIFAFERLGGPFLLLFAVAFIVGLVNA
VNMSDGVDGLAGSASAASFFWLAVISFDIGEHRLGLQSLALVAACLGFLVFNMRHRWRAKASLFLGDGGSTLLGAALAGI
VLILSSGRQAIAFPVLLWIVIVPVLDTLSLIVRRLAARRSPFSADRQHLHHLLMDAGLTCGQTAIIVMALNLIAGATAYT
AIRLDLPGWLMALALLAPAMAHLAFILRCTRGPRIADPAQAAKPNITFPGTTT
>Mature_372_residues
TSLSWITLLAFVLSVAFCMAFRGLAREWYLIDLPDYRKRHEGAVPLCGGIAIFLSFFLTASLVKDGAGHADALVMMPGLT
IILGTGVLDDRFRLPVTPRFAIQLFAAVLIIAMAGVQQVFLDLNPSFIDDSGNIFAFERLGGPFLLLFAVAFIVGLVNAV
NMSDGVDGLAGSASAASFFWLAVISFDIGEHRLGLQSLALVAACLGFLVFNMRHRWRAKASLFLGDGGSTLLGAALAGIV
LILSSGRQAIAFPVLLWIVIVPVLDTLSLIVRRLAARRSPFSADRQHLHHLLMDAGLTCGQTAIIVMALNLIAGATAYTA
IRLDLPGWLMALALLAPAMAHLAFILRCTRGPRIADPAQAAKPNITFPGTTT

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=287, Percent_Identity=36.2369337979094, Blast_Score=161, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 39870; Mature: 39739

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLSWITLLAFVLSVAFCMAFRGLAREWYLIDLPDYRKRHEGAVPLCGGIAIFLSFFLT
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHH
ASLVKDGAGHADALVMMPGLTIILGTGVLDDRFRLPVTPRFAIQLFAAVLIIAMAGVQQV
HHHHHCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLDLNPSFIDDSGNIFAFERLGGPFLLLFAVAFIVGLVNAVNMSDGVDGLAGSASAASFF
HHHCCCCEECCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
WLAVISFDIGEHRLGLQSLALVAACLGFLVFNMRHRWRAKASLFLGDGGSTLLGAALAGI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHH
VLILSSGRQAIAFPVLLWIVIVPVLDTLSLIVRRLAARRSPFSADRQHLHHLLMDAGLTC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
GQTAIIVMALNLIAGATAYTAIRLDLPGWLMALALLAPAMAHLAFILRCTRGPRIADPAQ
CHHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AAKPNITFPGTTT
HCCCCCCCCCCCC
>Mature Secondary Structure 
TSLSWITLLAFVLSVAFCMAFRGLAREWYLIDLPDYRKRHEGAVPLCGGIAIFLSFFLT
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHH
ASLVKDGAGHADALVMMPGLTIILGTGVLDDRFRLPVTPRFAIQLFAAVLIIAMAGVQQV
HHHHHCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLDLNPSFIDDSGNIFAFERLGGPFLLLFAVAFIVGLVNAVNMSDGVDGLAGSASAASFF
HHHCCCCEECCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
WLAVISFDIGEHRLGLQSLALVAACLGFLVFNMRHRWRAKASLFLGDGGSTLLGAALAGI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHH
VLILSSGRQAIAFPVLLWIVIVPVLDTLSLIVRRLAARRSPFSADRQHLHHLLMDAGLTC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
GQTAIIVMALNLIAGATAYTAIRLDLPGWLMALALLAPAMAHLAFILRCTRGPRIADPAQ
CHHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AAKPNITFPGTTT
HCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]