Definition Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession NC_012442
Length 1,185,518

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The map label for this gene is gnd [H]

Identifier: 225685973

GI number: 225685973

Start: 108329

End: 109738

Strand: Direct

Name: gnd [H]

Synonym: BMEA_B0114

Alternate gene names: 225685973

Gene position: 108329-109738 (Clockwise)

Preceding gene: 225685971

Following gene: 225685980

Centisome position: 9.14

GC content: 60.07

Gene sequence:

>1410_bases
ATGGAAAAAGCAGATATCGGAATGGTCGGCCTTGGCGTCATGGGCTCCAACCTGGCGCTGAACATAGCCGAGAAGGGCTA
CACCGTGGCCGTCTATGACCGTGATGAGCCTGTGCTGAAAGCTTTCATCGAAAAGGCTGGCCGGCTGCGCGACAAGATCA
TTCCCTGCCCGACCTTTGAGGAACTGGCCGCGAATATCCGCAAGCCCCGTCCGATCATCTTTCTCATCAAGGCCGGTGCG
CCAGTCGATACCGAGACCACCCGCCTCAAGGCATTCCTTGAGAAGGGCGATATCATGATCGATGCAGGCAATTCCGATTA
TCGCGATACGGTGCGCCGCCTGAAGGCTCTTGGCCCCAATGATCCGACCTTTGTCGGCATGGGCGTTTCGGGTGGGGCGG
AAGGCGCGCGCCATGGTCCGTCGATGATGGTCGGCGGCACGGAGCAGGCCTATGAGCGCATCGCGCCGATCCTGCTTGCT
GTCGCCGCCAAATATCAGGGCGAGCCCTGCTGTGCGCTGGTCGGCCCGGATGGCGCGGGTCATTTCGTCAAAACCATCCA
TAACGGTATTGAATATGCCGATATGCAGATGATCGCCGAAATTTACGGCATTCTGCGCGATGGCCTTGGCCTTTCAGCTC
CGGCCATCGGCGATGTGTTCGAGAAGTGGAACGAAGGTCCGCTCAATTCCTATCTGATTGAAATCACCGCCAAGGTTCTC
AAGTCCACCGACCCGGAAACCGGCAAGGCGATGGTCGATATGATCCTTGATGAAGCCGGCCAGAAGGGTACAGGCCGCTG
GGCTGCCATTGAGGCGCAGATACTGGGCGTTCCGGCCACGGGCATCGAAGCCGCGGTTGCCGCCCGTTCGCTGTCCTCCA
TGAAGGGCGAGCGGGAAGAGGCCGCCAAGGCGTATAAATCCGGTGCACGCACACTTGATATTGCCAACCAGACCCGCTTC
CTTTCCGATCTGGAACAGGGCTTGCTGGCGGGCAAGATCGCCGCTTATGCGCAAGGCTTTGCAGTGATGGAAGCCGCCTC
AAGGGAGCATGGCTGGAACATTCCGCTTGCCACCACGGCGCGCATCTGGCGCGCGGGCTGCATCATCCGCTCGCAGCTTC
TGGATGATATTGCGCAGGCTTTTGAAGGCAATGAAAGCCGCAACCTGCTCATGGCCCCGGCCTTCGTGCCGCGCATGGAA
ACATCTGTGAAAAGCCTTCGCCAGATTGTCGCGCAGGCCGCCCTTGCCAGCCTGCCGCTGCCCGCGCTCGGCTCTGCGCT
CAGCTATTTCGACAGCTATACGCAGGCGCTTGGTACGGCCAATCTCATTCAGGGCCAGCGCGATTTCTTCGGCTCGCACG
GCTTCAAGCGCATTGACAAGGAGGGGGATTTCCACGGCCCCTGGGGCTGA

Upstream 100 bases:

>100_bases
AATTCGGTGGCGCTTTCCCCGGTTCCGGCTCGTTGGTCTTCATTGTTGCGAACGTGTCTGGACATAAGGGCGTCCGGCAA
GTAATTCAGAAAGACACAAA

Downstream 100 bases:

>100_bases
GTTTTCTGCCCCAGACAGCCTGGAACCGCTCTAACTATTTGTTTTGGTGCATTATTCCCCGCATAGGCGTTTCACACTTT
TGGCTCGAAAATGTTCTAAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFEELAANIRKPRPIIFLIKAGA
PVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPNDPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLA
VAAKYQGEPCCALVGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVL
KSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREEAAKAYKSGARTLDIANQTRF
LSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTARIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRME
TSVKSLRQIVAQAALASLPLPALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG

Sequences:

>Translated_469_residues
MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFEELAANIRKPRPIIFLIKAGA
PVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPNDPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLA
VAAKYQGEPCCALVGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVL
KSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREEAAKAYKSGARTLDIANQTRF
LSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTARIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRME
TSVKSLRQIVAQAALASLPLPALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG
>Mature_469_residues
MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFEELAANIRKPRPIIFLIKAGA
PVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPNDPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLA
VAAKYQGEPCCALVGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVL
KSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREEAAKAYKSGARTLDIANQTRF
LSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTARIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRME
TSVKSLRQIVAQAALASLPLPALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=44.5859872611465, Blast_Score=385, Evalue=1e-107,
Organism=Escherichia coli, GI1788341, Length=471, Percent_Identity=45.859872611465, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=43.4322033898305, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321695, Length=471, Percent_Identity=45.6475583864119, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=45.0549450549451, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=46.4516129032258, Blast_Score=394, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 50246; Mature: 50246

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFE
CCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHH
ELAANIRKPRPIIFLIKAGAPVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPN
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCC
DPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLAVAAKYQGEPCCALVGPDGAG
CCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
HFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
KSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREE
HCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHH
AAKAYKSGARTLDIANQTRFLSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTA
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRMETSVKSLRQIVAQAALASLPL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFE
CCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHH
ELAANIRKPRPIIFLIKAGAPVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPN
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCC
DPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLAVAAKYQGEPCCALVGPDGAG
CCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
HFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
KSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREE
HCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHH
AAKAYKSGARTLDIANQTRFLSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTA
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRMETSVKSLRQIVAQAALASLPL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]