Definition Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession NC_012442
Length 1,185,518

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The map label for this gene is virB4 [H]

Identifier: 225685933

GI number: 225685933

Start: 62915

End: 65410

Strand: Reverse

Name: virB4 [H]

Synonym: BMEA_B0070

Alternate gene names: 225685933

Gene position: 65410-62915 (Counterclockwise)

Preceding gene: 225685934

Following gene: 225685932

Centisome position: 5.52

GC content: 55.61

Gene sequence:

>2496_bases
ATGGGCGCTCAATCCAAATACGCGCAACAGCTCAATAATGAACGGTCACTTGCACCGTTCATTCCCTTCAGGAGCCAGGT
TGGCCCGACCACCGTGATAACGCGTGACGGTGATTTCGTGCGCACATGGCGCATCGCGGGCCTGGCTTTCGAGACGCAGG
ACAAGGAGAAACTGTTGATCCGCAAGGACCAGCTTAACACCTTGTTCCGTGCCATCGCCTCAAACAATGTGGCGCTGTGG
TCCCACAACGTACGGCGCAGAACCTGGGATCACTTGAAATCCTTCTTTTCCAATCCGTTCTGCGACGCTCTCGACAAGAA
GTATTACGGATCGTTTTCCGGCTACCGAATGATGTCAAACGAACTGTATCTGACGGTTATTTACCGGCCAGTGCCGGCGA
AGATCAGCAGGTTGTTCAACGTGGCCGTTCATCGTTCGCATGCGGAAATCTTACAGGAGCAGCAGCTTGCCATCCGCAAG
CTGGACGAAATCGGCAATCAAATTGAAACCAGCTTGCGTCGCTACGGTGGCGATGACGGGCGTGGCATCGAAGTGCTGAG
CACCTATGAGGACAAACACGGCGCACTGTGCTCACAGCAGCTTGAATTTTATAACTTCCTTCTCTCAGGCGAATGGCAGA
AGGTGCGCGTGCCATCCTGCCCACTGGATGAATATCTGGGCACCGGGTGGGTGTATGCTGGCACTGAAACCATCGAGATA
CGCACCGCGAGCGCGACGCGCTATGCGCGTGGCATCGATTTCAAGGACTATGCGAACCACACCGAGCCGGGCATTTTGAA
CGGCCTGATGTATAGCGATTACGAGTACGTCATCACACAATCCTTCAGCTTCATGACAAAGCGGGATGGCAAGGAGTTCC
TGACACGGCAAAAGCAGCGGCTCCAAAATACCGAAGACGGCAGCGCATCCCAGATCATGGAAATGGACATTGCCATCGAC
CAGCTCGGCCGGGGCGATTTCGTCATGGGTGAATATCATTATTCGCTGCTGGTATTTGCCGAAGACATGGAGACGGTGCG
CCACAACACATCACATGCGATGAACATCCTGCAAGACAATGGTTTTCTGGCGACGGTGATCGCCACGGCCACGGATGCGG
CGTTCTATGCACAACTGCCATGTAACTGGCGGTATCGGCCGCGCGTGGCGGGCCTGACCTCGCTCAACTTCGCCGGTCTG
TCATGTTTCCATAATTTCCGCGCAGGCAAGCGGGATGGCAACCCCTGGGGGCAGGCATTGACGCTGCTCAAAACCCCTTC
CGGACAGCCCGCCTACCTGAACTTCCACTATTCAAAAGGCGACGAAGACAACTTCGACAAGAAGCTTCTGGGCAATACCC
GCATCATCGGCCAGTCCGGCGCTGGTAAAACTGTCCTGATGAACTTCTGCCTCGCGCAAGCGCAGAAGTATTTGCACAAT
GCTCCGATGGGTATGTGCAACGTCTTTTTCGACAAGGATCAAGGCGCGAAAGGGACTATTCTTGCCATTGGCGGCAAATA
CCTTGCCATCAGGAACGGCGAACCCACCGGGTTCAACCCATTCCAGATGGAGCCAACAGCGGGGAACATCCTGTTCCTTG
AAAAACTCGTACAGGTACTGGTATCGCGTGATGGCCAGCACGTGACCACAACGGACGAAAGCCGGATCAGTCATGCCATA
CGTACGGTCATGCGCATGCGCCCGGAGCTGCGGCGTCTGTCGACGGTGCTGCAAAACGTTACCGAAGGCAGCGACCGCCA
AGATCGTGAAAACAGCGTGGCGAAGCGGCTCGCGAAGTGGTGTTTTGATGACGGCACCGGCAAGCGGGGCACATTCTGGT
GGGTGCTGGATTGCCCGCAAGACCAGATCGACTTCAACACGCATAGCAATTACGGTTTCGATGGCACCGACTTCCTCGAC
AACGCCGACGTGCGTACGCCGATTTCCATGTACCTGCTGCATCGTATGGAATTGGCTATCGACGGGCGTCGTTTCATCTA
CTGGATGGACGAGGCGTGGAAGTGGGTAGACGACGAAGCATTCAGCGAGTTCGCCAATAACAAGCAGCTTACCATCCGCA
AGCAAAACGGCCTGGGCGTGTTTGCCACGCAAATGCCCTCCAGCCTGCTCAACTCCAAAGTCGCGTCGGCCCTGGTGCAA
CAGGTGGCGACGGAAATCTATCTGCCGAATCCGAAAGCCGATTATCACGAGTACACGGACGGCTTCAAGGTGACGAACGA
GGAGTTCGACATCATCCGCAGTATGAGCGAGGAAAGCCGCATGTTCCTGGTCAAGCAGGGGCATCATTCGATGATTTGCC
GCCTGGAGCTTAATGGCTTTGATGACGAACTGGCGATCCTCTCAGGCAGCTCGGACAACAACGAGTTGCTGGACCAGGTC
ATTGCCGAAGTCGGGGACGACCCTTCGGTATGGCTTCCGGTGTTCCAGGAGCGCCGGAAAGCACGCATTGCGTCGTCCAA
ATCAACAGGAAGGTGA

Upstream 100 bases:

>100_bases
AGGCGCAATTCCGCCTGATCCACTTCAACCGCACCGGGCGCTTCTGGCGGGCATCCGCCTATAGCCCGATTGCCTTCACA
AAGCGCAAAAGAGAATCATA

Downstream 100 bases:

>100_bases
CACTATGAAGAAGATAATTCTCAGCTTCGCATTCGCCCTGACTGTAACCAGCACGGCGCACGCACAGCTCCCGGTGACAG
ATGCCGGCTCCATCGCGCAG

Product: type IV secretion/conjugal transfer ATPase, VirB4 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 831; Mature: 830

Protein sequence:

>831_residues
MGAQSKYAQQLNNERSLAPFIPFRSQVGPTTVITRDGDFVRTWRIAGLAFETQDKEKLLIRKDQLNTLFRAIASNNVALW
SHNVRRRTWDHLKSFFSNPFCDALDKKYYGSFSGYRMMSNELYLTVIYRPVPAKISRLFNVAVHRSHAEILQEQQLAIRK
LDEIGNQIETSLRRYGGDDGRGIEVLSTYEDKHGALCSQQLEFYNFLLSGEWQKVRVPSCPLDEYLGTGWVYAGTETIEI
RTASATRYARGIDFKDYANHTEPGILNGLMYSDYEYVITQSFSFMTKRDGKEFLTRQKQRLQNTEDGSASQIMEMDIAID
QLGRGDFVMGEYHYSLLVFAEDMETVRHNTSHAMNILQDNGFLATVIATATDAAFYAQLPCNWRYRPRVAGLTSLNFAGL
SCFHNFRAGKRDGNPWGQALTLLKTPSGQPAYLNFHYSKGDEDNFDKKLLGNTRIIGQSGAGKTVLMNFCLAQAQKYLHN
APMGMCNVFFDKDQGAKGTILAIGGKYLAIRNGEPTGFNPFQMEPTAGNILFLEKLVQVLVSRDGQHVTTTDESRISHAI
RTVMRMRPELRRLSTVLQNVTEGSDRQDRENSVAKRLAKWCFDDGTGKRGTFWWVLDCPQDQIDFNTHSNYGFDGTDFLD
NADVRTPISMYLLHRMELAIDGRRFIYWMDEAWKWVDDEAFSEFANNKQLTIRKQNGLGVFATQMPSSLLNSKVASALVQ
QVATEIYLPNPKADYHEYTDGFKVTNEEFDIIRSMSEESRMFLVKQGHHSMICRLELNGFDDELAILSGSSDNNELLDQV
IAEVGDDPSVWLPVFQERRKARIASSKSTGR

Sequences:

>Translated_831_residues
MGAQSKYAQQLNNERSLAPFIPFRSQVGPTTVITRDGDFVRTWRIAGLAFETQDKEKLLIRKDQLNTLFRAIASNNVALW
SHNVRRRTWDHLKSFFSNPFCDALDKKYYGSFSGYRMMSNELYLTVIYRPVPAKISRLFNVAVHRSHAEILQEQQLAIRK
LDEIGNQIETSLRRYGGDDGRGIEVLSTYEDKHGALCSQQLEFYNFLLSGEWQKVRVPSCPLDEYLGTGWVYAGTETIEI
RTASATRYARGIDFKDYANHTEPGILNGLMYSDYEYVITQSFSFMTKRDGKEFLTRQKQRLQNTEDGSASQIMEMDIAID
QLGRGDFVMGEYHYSLLVFAEDMETVRHNTSHAMNILQDNGFLATVIATATDAAFYAQLPCNWRYRPRVAGLTSLNFAGL
SCFHNFRAGKRDGNPWGQALTLLKTPSGQPAYLNFHYSKGDEDNFDKKLLGNTRIIGQSGAGKTVLMNFCLAQAQKYLHN
APMGMCNVFFDKDQGAKGTILAIGGKYLAIRNGEPTGFNPFQMEPTAGNILFLEKLVQVLVSRDGQHVTTTDESRISHAI
RTVMRMRPELRRLSTVLQNVTEGSDRQDRENSVAKRLAKWCFDDGTGKRGTFWWVLDCPQDQIDFNTHSNYGFDGTDFLD
NADVRTPISMYLLHRMELAIDGRRFIYWMDEAWKWVDDEAFSEFANNKQLTIRKQNGLGVFATQMPSSLLNSKVASALVQ
QVATEIYLPNPKADYHEYTDGFKVTNEEFDIIRSMSEESRMFLVKQGHHSMICRLELNGFDDELAILSGSSDNNELLDQV
IAEVGDDPSVWLPVFQERRKARIASSKSTGR
>Mature_830_residues
GAQSKYAQQLNNERSLAPFIPFRSQVGPTTVITRDGDFVRTWRIAGLAFETQDKEKLLIRKDQLNTLFRAIASNNVALWS
HNVRRRTWDHLKSFFSNPFCDALDKKYYGSFSGYRMMSNELYLTVIYRPVPAKISRLFNVAVHRSHAEILQEQQLAIRKL
DEIGNQIETSLRRYGGDDGRGIEVLSTYEDKHGALCSQQLEFYNFLLSGEWQKVRVPSCPLDEYLGTGWVYAGTETIEIR
TASATRYARGIDFKDYANHTEPGILNGLMYSDYEYVITQSFSFMTKRDGKEFLTRQKQRLQNTEDGSASQIMEMDIAIDQ
LGRGDFVMGEYHYSLLVFAEDMETVRHNTSHAMNILQDNGFLATVIATATDAAFYAQLPCNWRYRPRVAGLTSLNFAGLS
CFHNFRAGKRDGNPWGQALTLLKTPSGQPAYLNFHYSKGDEDNFDKKLLGNTRIIGQSGAGKTVLMNFCLAQAQKYLHNA
PMGMCNVFFDKDQGAKGTILAIGGKYLAIRNGEPTGFNPFQMEPTAGNILFLEKLVQVLVSRDGQHVTTTDESRISHAIR
TVMRMRPELRRLSTVLQNVTEGSDRQDRENSVAKRLAKWCFDDGTGKRGTFWWVLDCPQDQIDFNTHSNYGFDGTDFLDN
ADVRTPISMYLLHRMELAIDGRRFIYWMDEAWKWVDDEAFSEFANNKQLTIRKQNGLGVFATQMPSSLLNSKVASALVQQ
VATEIYLPNPKADYHEYTDGFKVTNEEFDIIRSMSEESRMFLVKQGHHSMICRLELNGFDDELAILSGSSDNNELLDQVI
AEVGDDPSVWLPVFQERRKARIASSKSTGR

Specific function: The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice [H]

COG id: COG3451

COG function: function code U; Type IV secretory pathway, VirB4 components

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbE/virB4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004346
- InterPro:   IPR018145 [H]

Pfam domain/function: PF03135 CagE_TrbE_VirB [H]

EC number: NA

Molecular weight: Translated: 94546; Mature: 94415

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAQSKYAQQLNNERSLAPFIPFRSQVGPTTVITRDGDFVRTWRIAGLAFETQDKEKLLI
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEEECCCCHHHHE
RKDQLNTLFRAIASNNVALWSHNVRRRTWDHLKSFFSNPFCDALDKKYYGSFSGYRMMSN
EHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEECC
ELYLTVIYRPVPAKISRLFNVAVHRSHAEILQEQQLAIRKLDEIGNQIETSLRRYGGDDG
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RGIEVLSTYEDKHGALCSQQLEFYNFLLSGEWQKVRVPSCPLDEYLGTGWVYAGTETIEI
CCEEEEEECCCHHCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHCCCCEEEECCEEEEE
RTASATRYARGIDFKDYANHTEPGILNGLMYSDYEYVITQSFSFMTKRDGKEFLTRQKQR
EECCHHHHHCCCCHHHHCCCCCCCHHCCCCCCCCCEEEECCHHHHHHCCCHHHHHHHHHH
LQNTEDGSASQIMEMDIAIDQLGRGDFVMGEYHYSLLVFAEDMETVRHNTSHAMNILQDN
HCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEHHHHHHHCCCHHHHHHHHCC
GFLATVIATATDAAFYAQLPCNWRYRPRVAGLTSLNFAGLSCFHNFRAGKRDGNPWGQAL
CEEEEEEEHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHEE
TLLKTPSGQPAYLNFHYSKGDEDNFDKKLLGNTRIIGQSGAGKTVLMNFCLAQAQKYLHN
EEEECCCCCCEEEEEEECCCCCCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
APMGMCNVFFDKDQGAKGTILAIGGKYLAIRNGEPTGFNPFQMEPTAGNILFLEKLVQVL
CCCCEEEEEEECCCCCCEEEEEECCEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHH
VSRDGQHVTTTDESRISHAIRTVMRMRPELRRLSTVLQNVTEGSDRQDRENSVAKRLAKW
HCCCCCEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
CFDDGTGKRGTFWWVLDCPQDQIDFNTHSNYGFDGTDFLDNADVRTPISMYLLHRMELAI
HCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEE
DGRRFIYWMDEAWKWVDDEAFSEFANNKQLTIRKQNGLGVFATQMPSSLLNSKVASALVQ
CCCEEEEEECCHHCCCCHHHHHHHCCCCEEEEEECCCCEEEHHHCCHHHHHHHHHHHHHH
QVATEIYLPNPKADYHEYTDGFKVTNEEFDIIRSMSEESRMFLVKQGHHSMICRLELNGF
HHHHHEECCCCCCCHHHHCCCCEECCHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCC
DDELAILSGSSDNNELLDQVIAEVGDDPSVWLPVFQERRKARIASSKSTGR
CCCEEEEECCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GAQSKYAQQLNNERSLAPFIPFRSQVGPTTVITRDGDFVRTWRIAGLAFETQDKEKLLI
CCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEEECCCCHHHHE
RKDQLNTLFRAIASNNVALWSHNVRRRTWDHLKSFFSNPFCDALDKKYYGSFSGYRMMSN
EHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEECC
ELYLTVIYRPVPAKISRLFNVAVHRSHAEILQEQQLAIRKLDEIGNQIETSLRRYGGDDG
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RGIEVLSTYEDKHGALCSQQLEFYNFLLSGEWQKVRVPSCPLDEYLGTGWVYAGTETIEI
CCEEEEEECCCHHCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHCCCCEEEECCEEEEE
RTASATRYARGIDFKDYANHTEPGILNGLMYSDYEYVITQSFSFMTKRDGKEFLTRQKQR
EECCHHHHHCCCCHHHHCCCCCCCHHCCCCCCCCCEEEECCHHHHHHCCCHHHHHHHHHH
LQNTEDGSASQIMEMDIAIDQLGRGDFVMGEYHYSLLVFAEDMETVRHNTSHAMNILQDN
HCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEHHHHHHHCCCHHHHHHHHCC
GFLATVIATATDAAFYAQLPCNWRYRPRVAGLTSLNFAGLSCFHNFRAGKRDGNPWGQAL
CEEEEEEEHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHEE
TLLKTPSGQPAYLNFHYSKGDEDNFDKKLLGNTRIIGQSGAGKTVLMNFCLAQAQKYLHN
EEEECCCCCCEEEEEEECCCCCCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
APMGMCNVFFDKDQGAKGTILAIGGKYLAIRNGEPTGFNPFQMEPTAGNILFLEKLVQVL
CCCCEEEEEEECCCCCCEEEEEECCEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHH
VSRDGQHVTTTDESRISHAIRTVMRMRPELRRLSTVLQNVTEGSDRQDRENSVAKRLAKW
HCCCCCEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
CFDDGTGKRGTFWWVLDCPQDQIDFNTHSNYGFDGTDFLDNADVRTPISMYLLHRMELAI
HCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEE
DGRRFIYWMDEAWKWVDDEAFSEFANNKQLTIRKQNGLGVFATQMPSSLLNSKVASALVQ
CCCEEEEEECCHHCCCCHHHHHHHCCCCEEEEEECCCCEEEHHHCCHHHHHHHHHHHHHH
QVATEIYLPNPKADYHEYTDGFKVTNEEFDIIRSMSEESRMFLVKQGHHSMICRLELNGF
HHHHHEECCCCCCCHHHHCCCCEECCHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCC
DDELAILSGSSDNNELLDQVIAEVGDDPSVWLPVFQERRKARIASSKSTGR
CCCEEEEECCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10940027 [H]