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The map label for this gene is fabF [H]

Identifier: 225852365

GI number: 225852365

Start: 848394

End: 849671

Strand: Reverse

Name: fabF [H]

Synonym: BMEA_A0891

Alternate gene names: 225852365

Gene position: 849671-848394 (Counterclockwise)

Preceding gene: 225852366

Following gene: 225852364

Centisome position: 39.97

GC content: 60.49

Gene sequence:

>1278_bases
ATGACGAAATATACAGACCATCTCGGCCGTCCCATCGTCGCCATCACCGGCGCAGGTGTCGTTTCCTCGCTCGGTCAGGG
CAAGGACGACAACTGGGCGGCACTGACCGGCGGAAAGTCGGGCATCCACACGATCACCCGTTTCCCGACCGAGAACCTCA
ATACGCGCTTTTCCGGTACGGTGGATTTTCTGCCCGAAAGCGAAAGCGGCGCATCAGCGCTTTCGGAAGCCCTGGCGCGG
CTTGCCGGTGAGGAGGCGCTTGCCCAGTCCGGCCTATCCGTGACCGCTTTTGGCGGACCGCTCTTTCTTGCAGCCCCGCC
GGTCGAGCTCGACTGGAAAAGCCGTTTCGCGCTCGATGCGAGCGTCAAGGACGAAGGCCCGGCGAGCTATCAGCTTCTTC
TGGAAGCCTGCCGGCGCGCGCGTCATGATGCGCTCTTCAACACCACGCAGTTCGGTTATATCGCAGAGCGCCTTTCGCAG
GCTTTTGGCACGCGCGGCCTGCCGATCACGCTTTCCACCGCCTGCGCATCCGGCGCAACGGCGATCCAGCTTGGCGTGGA
GGCCATTCGCCGTGGTGAAAGCGACCGTGTGCTTTCCATTGGCACCGATGGTTCGGTTTCGGCAGAAGCATTGATCCGCT
TCTCGCTCCTCTCCGCCCTTTCCACCCAGAACGACAAGCCGGAAAAGGCTTCCAAGCCTTTCTCCAAGGATCGCGACGGT
TTTGCCATGGCCGAAGGTTCCGGCGCGCTCGTCATGGAATCACTTGAGAGCGCCGTTGCGCGCGGCGCAAAAGTGCTGGG
CATTCTGGCCGGTTGCGGCGAAAAGGCCGACGATTTCCACCGCACCCGTTCCAAACCGGACGCTTCGCCTGCCATCGGCA
CGGTGCGCGCCGCCCTTGCCGATGCCGGTCTCACCGAAGACCAGATTTCCTACATCAACGCCCACGGCACCTCAACGCCG
GAAAACGACAAGATGGAATATCTGGCGCTTTCGACTGTTTTCGGCGACAAGCTCGGCTCCATTCTGGTTTCGTCCAACAA
GTCGATGATCGGCCATACGCTGACGGCAGCCGGCGCTATAGAGGCCGTCTTCTCACTGCTCACGATCCAGACCGGCACAC
TGCCGCCGACAATCAATTACGATAATCCGGATCCGGCCATTCCGCTCGATGTCGTGCCGAATGTGAAGCGTGAAGCCAAG
GTTGCAGCCGTGCTTTCCAATTCCTTCGGTTTCGGCGGACAGAATACGAGCCTTGTTTTGACGCCAAATCCGAATTAA

Upstream 100 bases:

>100_bases
GCTTCGGAAAAGCCTGCCAGCGGCGCGGTCAGCGAAGCCATTGTCACCACCATCGGGGCAACCCGCGCTGAAGGCGCAGC
AAAGCTGGTGAGAGCATAAG

Downstream 100 bases:

>100_bases
TCCGTCCGTAATCGAATTCAAATTCCTGATGATCCCGGAAGGCGAAAGCTCTCCGGGATCATGCCATGAAAGGAACAGCC
CATGCGCGCCTTGCAGCTTC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTKYTDHLGRPIVAITGAGVVSSLGQGKDDNWAALTGGKSGIHTITRFPTENLNTRFSGTVDFLPESESGASALSEALAR
LAGEEALAQSGLSVTAFGGPLFLAAPPVELDWKSRFALDASVKDEGPASYQLLLEACRRARHDALFNTTQFGYIAERLSQ
AFGTRGLPITLSTACASGATAIQLGVEAIRRGESDRVLSIGTDGSVSAEALIRFSLLSALSTQNDKPEKASKPFSKDRDG
FAMAEGSGALVMESLESAVARGAKVLGILAGCGEKADDFHRTRSKPDASPAIGTVRAALADAGLTEDQISYINAHGTSTP
ENDKMEYLALSTVFGDKLGSILVSSNKSMIGHTLTAAGAIEAVFSLLTIQTGTLPPTINYDNPDPAIPLDVVPNVKREAK
VAAVLSNSFGFGGQNTSLVLTPNPN

Sequences:

>Translated_425_residues
MTKYTDHLGRPIVAITGAGVVSSLGQGKDDNWAALTGGKSGIHTITRFPTENLNTRFSGTVDFLPESESGASALSEALAR
LAGEEALAQSGLSVTAFGGPLFLAAPPVELDWKSRFALDASVKDEGPASYQLLLEACRRARHDALFNTTQFGYIAERLSQ
AFGTRGLPITLSTACASGATAIQLGVEAIRRGESDRVLSIGTDGSVSAEALIRFSLLSALSTQNDKPEKASKPFSKDRDG
FAMAEGSGALVMESLESAVARGAKVLGILAGCGEKADDFHRTRSKPDASPAIGTVRAALADAGLTEDQISYINAHGTSTP
ENDKMEYLALSTVFGDKLGSILVSSNKSMIGHTLTAAGAIEAVFSLLTIQTGTLPPTINYDNPDPAIPLDVVPNVKREAK
VAAVLSNSFGFGGQNTSLVLTPNPN
>Mature_424_residues
TKYTDHLGRPIVAITGAGVVSSLGQGKDDNWAALTGGKSGIHTITRFPTENLNTRFSGTVDFLPESESGASALSEALARL
AGEEALAQSGLSVTAFGGPLFLAAPPVELDWKSRFALDASVKDEGPASYQLLLEACRRARHDALFNTTQFGYIAERLSQA
FGTRGLPITLSTACASGATAIQLGVEAIRRGESDRVLSIGTDGSVSAEALIRFSLLSALSTQNDKPEKASKPFSKDRDGF
AMAEGSGALVMESLESAVARGAKVLGILAGCGEKADDFHRTRSKPDASPAIGTVRAALADAGLTEDQISYINAHGTSTPE
NDKMEYLALSTVFGDKLGSILVSSNKSMIGHTLTAAGAIEAVFSLLTIQTGTLPPTINYDNPDPAIPLDVVPNVKREAKV
AAVLSNSFGFGGQNTSLVLTPNPN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=429, Percent_Identity=34.032634032634, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI223972627, Length=212, Percent_Identity=36.7924528301887, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI41872631, Length=285, Percent_Identity=29.4736842105263, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=36.3855421686747, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=33.4128878281623, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71983541, Length=281, Percent_Identity=35.9430604982206, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=37.1647509578544, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI212642053, Length=289, Percent_Identity=27.681660899654, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=297, Percent_Identity=24.5791245791246, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=440, Percent_Identity=30.2272727272727, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24644341, Length=439, Percent_Identity=33.4851936218679, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=26.0714285714286, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=26.0714285714286, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=279, Percent_Identity=26.5232974910394, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44301; Mature: 44170

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYTDHLGRPIVAITGAGVVSSLGQGKDDNWAALTGGKSGIHTITRFPTENLNTRFSGT
CCCCCHHHCCCEEEEECCHHHHHHCCCCCCCEEEEECCCCCCCHHEECCCCCCCCCCCCE
VDFLPESESGASALSEALARLAGEEALAQSGLSVTAFGGPLFLAAPPVELDWKSRFALDA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCCCCCEEEEC
SVKDEGPASYQLLLEACRRARHDALFNTTQFGYIAERLSQAFGTRGLPITLSTACASGAT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCH
AIQLGVEAIRRGESDRVLSIGTDGSVSAEALIRFSLLSALSTQNDKPEKASKPFSKDRDG
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
FAMAEGSGALVMESLESAVARGAKVLGILAGCGEKADDFHRTRSKPDASPAIGTVRAALA
EEEECCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
DAGLTEDQISYINAHGTSTPENDKMEYLALSTVFGDKLGSILVSSNKSMIGHTLTAAGAI
HCCCCHHHHHEEECCCCCCCCCCCCCEEEHHHHHHHHHHHEEEECCCCHHHHHHHHHHHH
EAVFSLLTIQTGTLPPTINYDNPDPAIPLDVVPNVKREAKVAAVLSNSFGFGGQNTSLVL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEE
TPNPN
CCCCC
>Mature Secondary Structure 
TKYTDHLGRPIVAITGAGVVSSLGQGKDDNWAALTGGKSGIHTITRFPTENLNTRFSGT
CCCCHHHCCCEEEEECCHHHHHHCCCCCCCEEEEECCCCCCCHHEECCCCCCCCCCCCE
VDFLPESESGASALSEALARLAGEEALAQSGLSVTAFGGPLFLAAPPVELDWKSRFALDA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCCCCCEEEEC
SVKDEGPASYQLLLEACRRARHDALFNTTQFGYIAERLSQAFGTRGLPITLSTACASGAT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCH
AIQLGVEAIRRGESDRVLSIGTDGSVSAEALIRFSLLSALSTQNDKPEKASKPFSKDRDG
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
FAMAEGSGALVMESLESAVARGAKVLGILAGCGEKADDFHRTRSKPDASPAIGTVRAALA
EEEECCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
DAGLTEDQISYINAHGTSTPENDKMEYLALSTVFGDKLGSILVSSNKSMIGHTLTAAGAI
HCCCCHHHHHEEECCCCCCCCCCCCCEEEHHHHHHHHHHHEEEECCCCHHHHHHHHHHHH
EAVFSLLTIQTGTLPPTINYDNPDPAIPLDVVPNVKREAKVAAVLSNSFGFGGQNTSLVL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEE
TPNPN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]